Incidental Mutation 'R4506:Fcer2a'
ID 332015
Institutional Source Beutler Lab
Gene Symbol Fcer2a
Ensembl Gene ENSMUSG00000005540
Gene Name Fc receptor, IgE, low affinity II, alpha polypeptide
Synonyms Ly-42, FC epsilon RII, Fce2, CD23, low-affinity IgE receptor
MMRRC Submission 041584-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4506 (G1)
Quality Score 225
Status Validated
Chromosome 8
Chromosomal Location 3731737-3744175 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 3738603 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000146380 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000005678] [ENSMUST00000207463] [ENSMUST00000207635] [ENSMUST00000208145] [ENSMUST00000208438] [ENSMUST00000208492] [ENSMUST00000208603]
AlphaFold P20693
Predicted Effect probably null
Transcript: ENSMUST00000005678
SMART Domains Protein: ENSMUSP00000005678
Gene: ENSMUSG00000005540

transmembrane domain 26 48 N/A INTRINSIC
coiled coil region 80 150 N/A INTRINSIC
CLECT 186 306 2.11e-41 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207327
Predicted Effect probably null
Transcript: ENSMUST00000207463
Predicted Effect probably null
Transcript: ENSMUST00000207635
Predicted Effect probably null
Transcript: ENSMUST00000208145
Predicted Effect probably benign
Transcript: ENSMUST00000208438
Predicted Effect probably null
Transcript: ENSMUST00000208492
Predicted Effect probably null
Transcript: ENSMUST00000208603
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.8%
Validation Efficiency 98% (42/43)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
PHENOTYPE: Mice homozygous for mutations in this gene are essentially normal although IgE levels or IgE mediated responses may be abnormal. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700012B07Rik G T 11: 109,685,087 (GRCm39) P137T probably damaging Het
Abcc5 A T 16: 20,152,445 (GRCm39) I1367N probably damaging Het
Ace T A 11: 105,867,492 (GRCm39) L152Q probably damaging Het
Adam19 G A 11: 46,009,271 (GRCm39) D232N possibly damaging Het
Anapc4 A T 5: 52,993,072 (GRCm39) N61I possibly damaging Het
Ap5m1 T C 14: 49,311,218 (GRCm39) V96A probably damaging Het
Atr T A 9: 95,747,290 (GRCm39) C191S probably benign Het
Carmil3 GGACGA GGA 14: 55,736,933 (GRCm39) probably benign Het
Cnot6l A T 5: 96,234,033 (GRCm39) V326E possibly damaging Het
Fgfr3 A G 5: 33,887,343 (GRCm39) T221A probably damaging Het
Gm6632 C T 5: 59,211,821 (GRCm39) noncoding transcript Het
Gpr158 T A 2: 21,831,810 (GRCm39) M970K probably damaging Het
H2-T5 A T 17: 36,472,372 (GRCm39) probably benign Het
Ip6k3 A T 17: 27,364,154 (GRCm39) L298Q possibly damaging Het
Itpr1 A G 6: 108,409,647 (GRCm39) D1727G probably damaging Het
Kdm2b T C 5: 123,026,688 (GRCm39) T589A possibly damaging Het
Krtcap2 A G 3: 89,153,563 (GRCm39) probably benign Het
Map3k13 A G 16: 21,740,928 (GRCm39) S752G probably benign Het
Mvb12a G T 8: 71,996,103 (GRCm39) A86S probably benign Het
Nktr T A 9: 121,577,949 (GRCm39) probably benign Het
Or1e33 A T 11: 73,738,521 (GRCm39) C143* probably null Het
Or8a1b C T 9: 37,622,760 (GRCm39) V272I probably benign Het
Parp4 T A 14: 56,889,761 (GRCm39) N1847K unknown Het
Pcdhga8 G C 18: 37,949,816 (GRCm39) V411L probably damaging Het
Piwil4 T C 9: 14,637,259 (GRCm39) T352A probably damaging Het
Ric8a A G 7: 140,438,429 (GRCm39) I223V probably benign Het
Slc25a51 C T 4: 45,399,768 (GRCm39) V141M probably benign Het
Slc7a5 A T 8: 122,614,234 (GRCm39) probably null Het
Slc7a9 A T 7: 35,152,845 (GRCm39) T88S probably damaging Het
Tbrg1 T A 9: 37,565,691 (GRCm39) E87V probably damaging Het
Tnfsf4 T C 1: 161,244,745 (GRCm39) S145P probably damaging Het
Tomm34 C A 2: 163,896,292 (GRCm39) probably null Het
Trpv3 A G 11: 73,186,150 (GRCm39) N647S probably benign Het
Upf1 G A 8: 70,790,216 (GRCm39) R637C probably damaging Het
Vmn2r23 A T 6: 123,679,884 (GRCm39) Q35H probably damaging Het
Wdtc1 C T 4: 133,036,130 (GRCm39) V137M probably damaging Het
Zfp276 G A 8: 123,991,666 (GRCm39) probably null Het
Zfp90 C T 8: 107,151,496 (GRCm39) P403L possibly damaging Het
Other mutations in Fcer2a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01102:Fcer2a APN 8 3,738,842 (GRCm39) missense possibly damaging 0.94
IGL01458:Fcer2a APN 8 3,738,151 (GRCm39) missense probably benign 0.45
IGL01545:Fcer2a APN 8 3,733,598 (GRCm39) nonsense probably null
IGL01994:Fcer2a APN 8 3,738,302 (GRCm39) missense possibly damaging 0.94
IGL03340:Fcer2a APN 8 3,738,310 (GRCm39) missense possibly damaging 0.75
anemone UTSW 8 3,738,796 (GRCm39) critical splice donor site probably null
R0058:Fcer2a UTSW 8 3,738,111 (GRCm39) splice site probably benign
R0058:Fcer2a UTSW 8 3,738,111 (GRCm39) splice site probably benign
R0241:Fcer2a UTSW 8 3,738,796 (GRCm39) critical splice donor site probably null
R0241:Fcer2a UTSW 8 3,738,796 (GRCm39) critical splice donor site probably null
R0276:Fcer2a UTSW 8 3,739,811 (GRCm39) missense possibly damaging 0.89
R1530:Fcer2a UTSW 8 3,732,976 (GRCm39) missense probably damaging 0.98
R2202:Fcer2a UTSW 8 3,738,557 (GRCm39) missense possibly damaging 0.72
R4133:Fcer2a UTSW 8 3,741,130 (GRCm39) missense possibly damaging 0.60
R4249:Fcer2a UTSW 8 3,738,831 (GRCm39) missense probably benign 0.00
R4273:Fcer2a UTSW 8 3,732,848 (GRCm39) missense possibly damaging 0.81
R6796:Fcer2a UTSW 8 3,739,830 (GRCm39) missense possibly damaging 0.92
R6861:Fcer2a UTSW 8 3,732,910 (GRCm39) missense probably damaging 0.98
R7421:Fcer2a UTSW 8 3,740,335 (GRCm39) missense probably benign
R7795:Fcer2a UTSW 8 3,732,910 (GRCm39) missense probably benign
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2015-07-21