Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00465:Cyp2c37'

332115

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cyp2c37

Ensembl Gene

ENSMUSG00000042248

Gene Name

cytochrome P450, family 2. subfamily c, polypeptide 37

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.141) question?

Stock #

IGL00465

Quality Score

Status

Chromosome

Chromosomal Location

39980868-40000687 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 39990441 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 380 (F380L)

Ref Sequence

ENSEMBL: ENSMUSP00000045362 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049178]

AlphaFold

P56654

Predicted Effect

probably benign
Transcript: ENSMUST00000049178
AA Change: F380L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000045362
Gene: ENSMUSG00000042248
AA Change: F380L

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:p450	30	487	5e-160	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A1bg	A	T	15: 60,793,102 (GRCm39)	S2T	probably damaging	Het
Adamts13	T	A	2: 26,863,567 (GRCm39)	W7R	probably benign	Het
Anks6	T	A	4: 47,046,054 (GRCm39)	D279V	probably damaging	Het
C4bp	A	T	1: 130,566,871 (GRCm39)	L335Q	probably damaging	Het
Cd109	A	T	9: 78,568,216 (GRCm39)	K299*	probably null	Het
Cd200r2	A	T	16: 44,729,651 (GRCm39)	H102L	probably damaging	Het
Col12a1	A	G	9: 79,604,863 (GRCm39)	Y662H	probably damaging	Het
Deup1	A	G	9: 15,472,666 (GRCm39)	S549P	probably damaging	Het
Dysf	G	T	6: 84,176,830 (GRCm39)		probably null	Het
Etaa1	A	T	11: 17,897,825 (GRCm39)	C166*	probably null	Het
Fam227b	T	C	2: 125,986,245 (GRCm39)		probably null	Het
Gucy1b2	T	G	14: 62,640,649 (GRCm39)	Q752P	probably benign	Het
Hal	T	C	10: 93,325,931 (GRCm39)		probably null	Het
Hao1	C	A	2: 134,396,190 (GRCm39)	K21N	probably damaging	Het
Itga4	T	C	2: 79,122,394 (GRCm39)	F536L	probably benign	Het
Lmod3	A	T	6: 97,224,822 (GRCm39)	I333N	probably damaging	Het
Mgme1	T	A	2: 144,121,436 (GRCm39)	D297E	probably damaging	Het
Myh2	G	T	11: 67,069,659 (GRCm39)		probably benign	Het
Myo7a	A	G	7: 97,751,833 (GRCm39)	M70T	probably damaging	Het
Nav3	T	C	10: 109,688,607 (GRCm39)	T557A	probably damaging	Het
Nif3l1	C	A	1: 58,494,845 (GRCm39)	H271Q	possibly damaging	Het
Nostrin	A	G	2: 69,015,898 (GRCm39)		probably benign	Het
Nxn	C	A	11: 76,165,481 (GRCm39)		probably benign	Het
Pcdhb22	A	T	18: 37,653,185 (GRCm39)	D551V	probably damaging	Het
Pde4d	A	G	13: 110,073,221 (GRCm39)	D339G	possibly damaging	Het
Pkp4	T	A	2: 59,169,099 (GRCm39)	S408T	probably damaging	Het
Pxmp2	T	C	5: 110,431,582 (GRCm39)	T54A	probably benign	Het
Rif1	T	A	2: 52,011,019 (GRCm39)	V2362E	probably damaging	Het
Rps6kl1	A	G	12: 85,186,203 (GRCm39)	S276P	probably benign	Het
Scaf4	C	A	16: 90,044,169 (GRCm39)	M601I	unknown	Het
Scart2	A	G	7: 139,874,755 (GRCm39)	Y411C	probably damaging	Het
Setd7	T	A	3: 51,457,729 (GRCm39)	T33S	probably benign	Het
Shroom1	T	A	11: 53,354,921 (GRCm39)	D280E	probably benign	Het
Slc35f2	G	T	9: 53,705,298 (GRCm39)		probably null	Het
Slitrk3	T	A	3: 72,958,436 (GRCm39)	N112I	probably damaging	Het
Spag1	A	G	15: 36,183,967 (GRCm39)		probably benign	Het
Stx6	C	T	1: 155,077,679 (GRCm39)		probably benign	Het
Sun1	A	T	5: 139,220,440 (GRCm39)		probably null	Het
Tbl1xr1	G	A	3: 22,246,432 (GRCm39)		probably null	Het
Tmc2	T	C	2: 130,103,224 (GRCm39)	S787P	possibly damaging	Het
Traf3ip3	C	T	1: 192,877,128 (GRCm39)		probably benign	Het
Trip12	T	G	1: 84,741,582 (GRCm39)	H559P	probably damaging	Het
Trpm1	G	T	7: 63,897,215 (GRCm39)	M272I	possibly damaging	Het
Ttc21b	T	C	2: 66,073,119 (GRCm39)	E189G	probably benign	Het
Tubd1	T	C	11: 86,445,894 (GRCm39)		probably benign	Het
Vps13a	T	A	19: 16,729,539 (GRCm39)	T167S	probably damaging	Het
Zbtb3	A	G	19: 8,781,029 (GRCm39)	D214G	possibly damaging	Het
Zfp658	A	G	7: 43,216,780 (GRCm39)	D50G	probably benign	Het
Zfp976	T	A	7: 42,263,109 (GRCm39)	I243L	unknown	Het

Other mutations in Cyp2c37

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01307:Cyp2c37	APN	19	39,981,023 (GRCm39)	missense	probably benign	0.00
IGL01959:Cyp2c37	APN	19	39,984,277 (GRCm39)	nonsense	probably null
IGL02580:Cyp2c37	APN	19	39,982,942 (GRCm39)	missense	probably damaging	1.00
IGL02611:Cyp2c37	APN	19	39,982,309 (GRCm39)	missense	probably benign	0.00
R0124:Cyp2c37	UTSW	19	39,982,546 (GRCm39)	missense	probably damaging	1.00
R0391:Cyp2c37	UTSW	19	39,982,950 (GRCm39)	missense	probably damaging	1.00
R0420:Cyp2c37	UTSW	19	39,984,238 (GRCm39)	missense	probably benign	0.00
R0782:Cyp2c37	UTSW	19	39,982,269 (GRCm39)	missense	probably benign	0.00
R1413:Cyp2c37	UTSW	19	39,982,542 (GRCm39)	missense	probably benign	0.21
R1637:Cyp2c37	UTSW	19	39,990,426 (GRCm39)	nonsense	probably null
R1688:Cyp2c37	UTSW	19	39,982,887 (GRCm39)	splice site	probably null
R2258:Cyp2c37	UTSW	19	39,984,303 (GRCm39)	missense	possibly damaging	0.49
R4353:Cyp2c37	UTSW	19	39,988,989 (GRCm39)	missense	possibly damaging	0.66
R4640:Cyp2c37	UTSW	19	40,000,276 (GRCm39)	missense	possibly damaging	0.67
R4965:Cyp2c37	UTSW	19	40,000,206 (GRCm39)	missense	possibly damaging	0.79
R5053:Cyp2c37	UTSW	19	39,990,331 (GRCm39)	missense	probably benign	0.00
R5645:Cyp2c37	UTSW	19	39,982,596 (GRCm39)	missense	probably benign	0.04
R5847:Cyp2c37	UTSW	19	40,000,176 (GRCm39)	missense	probably damaging	0.98
R6487:Cyp2c37	UTSW	19	39,983,025 (GRCm39)	missense	probably benign
R6631:Cyp2c37	UTSW	19	39,998,287 (GRCm39)	missense	probably damaging	1.00
R7062:Cyp2c37	UTSW	19	39,983,990 (GRCm39)	splice site	probably null
R7937:Cyp2c37	UTSW	19	39,982,202 (GRCm39)	missense	probably damaging	1.00
R9640:Cyp2c37	UTSW	19	40,000,180 (GRCm39)	missense	probably benign	0.01
R9779:Cyp2c37	UTSW	19	39,998,323 (GRCm39)	missense	probably benign	0.09
R9784:Cyp2c37	UTSW	19	39,988,943 (GRCm39)	missense	possibly damaging	0.85

Posted On

2015-08-05