Incidental Mutation 'IGL00465:Zfp976'
ID 332128
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp976
Ensembl Gene ENSMUSG00000074158
Gene Name zinc finger protein 976
Synonyms 9830147E19Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # IGL00465
Quality Score
Status
Chromosome 7
Chromosomal Location 42258950-42292012 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 42263109 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 243 (I243L)
Ref Sequence ENSEMBL: ENSMUSP00000141023 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098503] [ENSMUST00000187616]
AlphaFold E9Q981
Predicted Effect unknown
Transcript: ENSMUST00000098503
AA Change: I244L
SMART Domains Protein: ENSMUSP00000096105
Gene: ENSMUSG00000074158
AA Change: I244L

DomainStartEndE-ValueType
KRAB 4 66 1.73e-18 SMART
ZnF_C2H2 131 153 7.78e-3 SMART
ZnF_C2H2 159 181 1.67e-2 SMART
ZnF_C2H2 187 209 5.9e-3 SMART
ZnF_C2H2 215 237 1.38e-3 SMART
ZnF_C2H2 243 265 8.94e-3 SMART
ZnF_C2H2 271 293 2.24e-3 SMART
ZnF_C2H2 299 321 1.03e-2 SMART
ZnF_C2H2 327 349 1.58e-3 SMART
ZnF_C2H2 355 377 7.9e-4 SMART
ZnF_C2H2 383 405 5.9e-3 SMART
ZnF_C2H2 411 433 2.57e-3 SMART
ZnF_C2H2 439 461 3.16e-3 SMART
ZnF_C2H2 467 489 1.26e-2 SMART
ZnF_C2H2 495 517 8.34e-3 SMART
ZnF_C2H2 523 545 3.63e-3 SMART
ZnF_C2H2 551 573 4.79e-3 SMART
ZnF_C2H2 579 601 9.73e-4 SMART
ZnF_C2H2 607 629 3.63e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000107994
Predicted Effect unknown
Transcript: ENSMUST00000187616
AA Change: I243L
SMART Domains Protein: ENSMUSP00000141023
Gene: ENSMUSG00000074158
AA Change: I243L

DomainStartEndE-ValueType
KRAB 3 65 7.4e-21 SMART
ZnF_C2H2 130 152 3.2e-5 SMART
ZnF_C2H2 158 180 7.1e-5 SMART
ZnF_C2H2 186 208 2.4e-5 SMART
ZnF_C2H2 214 236 5.7e-6 SMART
ZnF_C2H2 242 264 3.8e-5 SMART
ZnF_C2H2 270 292 9.7e-6 SMART
ZnF_C2H2 298 320 4.2e-5 SMART
ZnF_C2H2 326 348 6.6e-6 SMART
ZnF_C2H2 354 376 3.3e-6 SMART
ZnF_C2H2 382 404 2.5e-5 SMART
ZnF_C2H2 410 432 1e-5 SMART
ZnF_C2H2 438 460 1.3e-5 SMART
ZnF_C2H2 466 488 5.2e-5 SMART
ZnF_C2H2 494 516 3.6e-5 SMART
ZnF_C2H2 522 544 1.6e-5 SMART
ZnF_C2H2 550 572 2e-5 SMART
ZnF_C2H2 578 600 4e-6 SMART
ZnF_C2H2 606 628 1.5e-5 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A1bg A T 15: 60,793,102 (GRCm39) S2T probably damaging Het
Adamts13 T A 2: 26,863,567 (GRCm39) W7R probably benign Het
Anks6 T A 4: 47,046,054 (GRCm39) D279V probably damaging Het
C4bp A T 1: 130,566,871 (GRCm39) L335Q probably damaging Het
Cd109 A T 9: 78,568,216 (GRCm39) K299* probably null Het
Cd200r2 A T 16: 44,729,651 (GRCm39) H102L probably damaging Het
Col12a1 A G 9: 79,604,863 (GRCm39) Y662H probably damaging Het
Cyp2c37 T C 19: 39,990,441 (GRCm39) F380L probably benign Het
Deup1 A G 9: 15,472,666 (GRCm39) S549P probably damaging Het
Dysf G T 6: 84,176,830 (GRCm39) probably null Het
Etaa1 A T 11: 17,897,825 (GRCm39) C166* probably null Het
Fam227b T C 2: 125,986,245 (GRCm39) probably null Het
Gucy1b2 T G 14: 62,640,649 (GRCm39) Q752P probably benign Het
Hal T C 10: 93,325,931 (GRCm39) probably null Het
Hao1 C A 2: 134,396,190 (GRCm39) K21N probably damaging Het
Itga4 T C 2: 79,122,394 (GRCm39) F536L probably benign Het
Lmod3 A T 6: 97,224,822 (GRCm39) I333N probably damaging Het
Mgme1 T A 2: 144,121,436 (GRCm39) D297E probably damaging Het
Myh2 G T 11: 67,069,659 (GRCm39) probably benign Het
Myo7a A G 7: 97,751,833 (GRCm39) M70T probably damaging Het
Nav3 T C 10: 109,688,607 (GRCm39) T557A probably damaging Het
Nif3l1 C A 1: 58,494,845 (GRCm39) H271Q possibly damaging Het
Nostrin A G 2: 69,015,898 (GRCm39) probably benign Het
Nxn C A 11: 76,165,481 (GRCm39) probably benign Het
Pcdhb22 A T 18: 37,653,185 (GRCm39) D551V probably damaging Het
Pde4d A G 13: 110,073,221 (GRCm39) D339G possibly damaging Het
Pkp4 T A 2: 59,169,099 (GRCm39) S408T probably damaging Het
Pxmp2 T C 5: 110,431,582 (GRCm39) T54A probably benign Het
Rif1 T A 2: 52,011,019 (GRCm39) V2362E probably damaging Het
Rps6kl1 A G 12: 85,186,203 (GRCm39) S276P probably benign Het
Scaf4 C A 16: 90,044,169 (GRCm39) M601I unknown Het
Scart2 A G 7: 139,874,755 (GRCm39) Y411C probably damaging Het
Setd7 T A 3: 51,457,729 (GRCm39) T33S probably benign Het
Shroom1 T A 11: 53,354,921 (GRCm39) D280E probably benign Het
Slc35f2 G T 9: 53,705,298 (GRCm39) probably null Het
Slitrk3 T A 3: 72,958,436 (GRCm39) N112I probably damaging Het
Spag1 A G 15: 36,183,967 (GRCm39) probably benign Het
Stx6 C T 1: 155,077,679 (GRCm39) probably benign Het
Sun1 A T 5: 139,220,440 (GRCm39) probably null Het
Tbl1xr1 G A 3: 22,246,432 (GRCm39) probably null Het
Tmc2 T C 2: 130,103,224 (GRCm39) S787P possibly damaging Het
Traf3ip3 C T 1: 192,877,128 (GRCm39) probably benign Het
Trip12 T G 1: 84,741,582 (GRCm39) H559P probably damaging Het
Trpm1 G T 7: 63,897,215 (GRCm39) M272I possibly damaging Het
Ttc21b T C 2: 66,073,119 (GRCm39) E189G probably benign Het
Tubd1 T C 11: 86,445,894 (GRCm39) probably benign Het
Vps13a T A 19: 16,729,539 (GRCm39) T167S probably damaging Het
Zbtb3 A G 19: 8,781,029 (GRCm39) D214G possibly damaging Het
Zfp658 A G 7: 43,216,780 (GRCm39) D50G probably benign Het
Other mutations in Zfp976
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01102:Zfp976 APN 7 42,263,333 (GRCm39) nonsense probably null
IGL01111:Zfp976 APN 7 42,265,711 (GRCm39) missense probably damaging 0.99
IGL01628:Zfp976 APN 7 42,261,935 (GRCm39) missense unknown
IGL02008:Zfp976 APN 7 42,263,656 (GRCm39) splice site probably benign
IGL02548:Zfp976 APN 7 42,261,953 (GRCm39) missense unknown
R0190:Zfp976 UTSW 7 42,291,948 (GRCm39) start gained probably benign
R0685:Zfp976 UTSW 7 42,263,141 (GRCm39) missense probably damaging 0.98
R1310:Zfp976 UTSW 7 42,262,610 (GRCm39) missense probably damaging 1.00
R1353:Zfp976 UTSW 7 42,265,442 (GRCm39) missense probably damaging 0.99
R1447:Zfp976 UTSW 7 42,262,023 (GRCm39) missense possibly damaging 0.79
R1569:Zfp976 UTSW 7 42,262,806 (GRCm39) missense probably damaging 1.00
R1702:Zfp976 UTSW 7 42,265,424 (GRCm39) missense possibly damaging 0.86
R1829:Zfp976 UTSW 7 42,265,735 (GRCm39) missense probably damaging 1.00
R1939:Zfp976 UTSW 7 42,263,105 (GRCm39) missense unknown
R1978:Zfp976 UTSW 7 42,263,265 (GRCm39) missense probably damaging 1.00
R1981:Zfp976 UTSW 7 42,263,046 (GRCm39) missense probably damaging 0.99
R2160:Zfp976 UTSW 7 42,263,354 (GRCm39) missense probably benign
R2192:Zfp976 UTSW 7 42,262,695 (GRCm39) missense probably damaging 1.00
R3121:Zfp976 UTSW 7 42,262,938 (GRCm39) missense probably damaging 1.00
R4210:Zfp976 UTSW 7 42,265,749 (GRCm39) missense probably damaging 0.99
R4724:Zfp976 UTSW 7 42,262,457 (GRCm39) missense possibly damaging 0.91
R4943:Zfp976 UTSW 7 42,261,846 (GRCm39) unclassified probably benign
R5047:Zfp976 UTSW 7 42,262,843 (GRCm39) nonsense probably null
R5071:Zfp976 UTSW 7 42,262,354 (GRCm39) nonsense probably null
R5125:Zfp976 UTSW 7 42,261,925 (GRCm39) splice site probably null
R5178:Zfp976 UTSW 7 42,261,925 (GRCm39) splice site probably null
R5305:Zfp976 UTSW 7 42,262,902 (GRCm39) missense probably benign 0.00
R5777:Zfp976 UTSW 7 42,263,504 (GRCm39) missense probably benign 0.00
R6153:Zfp976 UTSW 7 42,263,610 (GRCm39) missense probably damaging 0.99
R6694:Zfp976 UTSW 7 42,263,610 (GRCm39) missense probably damaging 0.99
R7226:Zfp976 UTSW 7 42,262,684 (GRCm39) nonsense probably null
R7479:Zfp976 UTSW 7 42,262,603 (GRCm39) missense probably benign 0.01
R7561:Zfp976 UTSW 7 42,265,701 (GRCm39) missense probably damaging 1.00
R8178:Zfp976 UTSW 7 42,262,959 (GRCm39) missense probably benign 0.03
R8261:Zfp976 UTSW 7 42,262,125 (GRCm39) missense unknown
R8715:Zfp976 UTSW 7 42,262,869 (GRCm39) missense possibly damaging 0.89
R8921:Zfp976 UTSW 7 42,262,575 (GRCm39) missense possibly damaging 0.57
R9168:Zfp976 UTSW 7 42,263,011 (GRCm39) nonsense probably null
R9575:Zfp976 UTSW 7 42,262,041 (GRCm39) missense unknown
Z1088:Zfp976 UTSW 7 42,262,184 (GRCm39) missense possibly damaging 0.71
Posted On 2015-08-05