Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00476:Cylc2'

332174

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cylc2

Ensembl Gene

ENSMUSG00000039555

Gene Name

cylicin, basic protein of sperm head cytoskeleton 2

Synonyms

4930488P18Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.051) question?

Stock #

IGL00476

Quality Score

Status

Chromosome

Chromosomal Location

51216678-51250622 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 51228157 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Threonine at position 76 (M76T)

Ref Sequence

ENSEMBL: ENSMUSP00000125758 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000041392] [ENSMUST00000166749]

AlphaFold

A0A571BEE2

Predicted Effect

probably damaging
Transcript: ENSMUST00000041392
AA Change: M76T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000039750
Gene: ENSMUSG00000039555
AA Change: M76T

Domain	Start	End	E-Value	Type
Pfam:Cylicin_N	7	115	1.1e-43	PFAM
low complexity region	122	131	N/A	INTRINSIC
low complexity region	174	220	N/A	INTRINSIC
low complexity region	224	245	N/A	INTRINSIC
low complexity region	249	272	N/A	INTRINSIC
low complexity region	278	300	N/A	INTRINSIC
low complexity region	312	329	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000156384

Predicted Effect

probably damaging
Transcript: ENSMUST00000166749
AA Change: M76T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000125758
Gene: ENSMUSG00000039555
AA Change: M76T

Domain	Start	End	E-Value	Type
Pfam:Cylicin_N	8	113	4.6e-46	PFAM
low complexity region	122	131	N/A	INTRINSIC
low complexity region	174	220	N/A	INTRINSIC
low complexity region	224	245	N/A	INTRINSIC
low complexity region	249	272	N/A	INTRINSIC
low complexity region	278	300	N/A	INTRINSIC
low complexity region	312	329	N/A	INTRINSIC
low complexity region	338	420	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 28 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4931414P19Rik	T	C	14: 54,833,035 (GRCm39)	T47A	possibly damaging	Het
Adgrv1	A	G	13: 81,637,193 (GRCm39)	F3416S	probably damaging	Het
Arhgap42	T	C	9: 9,006,344 (GRCm39)	D684G	probably damaging	Het
Atp13a1	T	C	8: 70,249,547 (GRCm39)	L270P	probably damaging	Het
Baz2b	T	C	2: 59,744,083 (GRCm39)	N1474S	probably benign	Het
Chmp1b2	A	C	X: 106,859,766 (GRCm39)		probably benign	Het
Chrna6	A	G	8: 27,896,560 (GRCm39)	I439T	probably damaging	Het
Ddx19a	T	C	8: 111,703,102 (GRCm39)	K445R	probably benign	Het
Dennd4a	A	T	9: 64,819,044 (GRCm39)	Y1733F	probably damaging	Het
Dop1b	G	A	16: 93,596,914 (GRCm39)		probably benign	Het
Ephb3	T	A	16: 21,039,165 (GRCm39)		probably null	Het
Gpc2	G	A	5: 138,272,571 (GRCm39)		probably benign	Het
Ift172	A	G	5: 31,433,240 (GRCm39)	Y550H	probably damaging	Het
Kat2a	G	A	11: 100,596,210 (GRCm39)	R782W	probably damaging	Het
Ldhd	G	T	8: 112,355,270 (GRCm39)	R238S	possibly damaging	Het
Men1	G	A	19: 6,387,237 (GRCm39)		probably null	Het
Mipep	T	G	14: 61,064,810 (GRCm39)	L388R	probably damaging	Het
Mucl3	G	T	17: 35,948,994 (GRCm39)	H202N	possibly damaging	Het
Naa35	A	G	13: 59,777,869 (GRCm39)	D610G	probably damaging	Het
Nae1	A	T	8: 105,253,013 (GRCm39)	L137Q	possibly damaging	Het
Nt5dc3	T	C	10: 86,669,838 (GRCm39)		probably null	Het
Nyx	T	C	X: 13,353,264 (GRCm39)	F373L	possibly damaging	Het
Scaf11	A	T	15: 96,316,461 (GRCm39)	D1034E	possibly damaging	Het
Sp2	C	T	11: 96,845,387 (GRCm39)	R578H	probably damaging	Het
Taar7a	A	T	10: 23,868,294 (GRCm39)		probably benign	Het
Tcf23	G	T	5: 31,130,869 (GRCm39)	C169F	probably benign	Het
Trim7	A	T	11: 48,738,905 (GRCm39)	N308I	probably benign	Het
Ubxn8	T	C	8: 34,125,333 (GRCm39)	E89G	probably benign	Het

Other mutations in Cylc2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01669:Cylc2	APN	4	51,228,360 (GRCm39)	missense	probably benign	0.01
IGL02662:Cylc2	APN	4	51,216,698 (GRCm39)	utr 5 prime	probably benign
R0277:Cylc2	UTSW	4	51,228,477 (GRCm39)	missense	unknown
R0323:Cylc2	UTSW	4	51,228,477 (GRCm39)	missense	unknown
R0968:Cylc2	UTSW	4	51,216,706 (GRCm39)	start codon destroyed	probably null	0.50
R1395:Cylc2	UTSW	4	51,228,366 (GRCm39)	missense	possibly damaging	0.53
R1639:Cylc2	UTSW	4	51,228,310 (GRCm39)	missense	probably benign	0.23
R1643:Cylc2	UTSW	4	51,225,173 (GRCm39)	missense	probably benign	0.38
R2829:Cylc2	UTSW	4	51,229,798 (GRCm39)	missense	unknown
R4464:Cylc2	UTSW	4	51,229,651 (GRCm39)	missense	unknown
R4467:Cylc2	UTSW	4	51,229,651 (GRCm39)	missense	unknown
R4496:Cylc2	UTSW	4	51,229,651 (GRCm39)	missense	unknown
R4505:Cylc2	UTSW	4	51,229,651 (GRCm39)	missense	unknown
R4514:Cylc2	UTSW	4	51,229,651 (GRCm39)	missense	unknown
R4546:Cylc2	UTSW	4	51,229,840 (GRCm39)	missense	unknown
R4546:Cylc2	UTSW	4	51,229,651 (GRCm39)	missense	unknown
R4654:Cylc2	UTSW	4	51,228,279 (GRCm39)	missense	probably benign	0.00
R4949:Cylc2	UTSW	4	51,229,804 (GRCm39)	missense	unknown
R5141:Cylc2	UTSW	4	51,228,587 (GRCm39)	intron	probably benign
R5176:Cylc2	UTSW	4	51,228,587 (GRCm39)	intron	probably benign
R5177:Cylc2	UTSW	4	51,228,587 (GRCm39)	intron	probably benign
R5179:Cylc2	UTSW	4	51,228,587 (GRCm39)	intron	probably benign
R7469:Cylc2	UTSW	4	51,227,970 (GRCm39)	splice site	probably null
R7508:Cylc2	UTSW	4	51,229,256 (GRCm39)	splice site	probably null
R7699:Cylc2	UTSW	4	51,229,335 (GRCm39)	missense	unknown
R8685:Cylc2	UTSW	4	51,229,651 (GRCm39)	missense	unknown
R8686:Cylc2	UTSW	4	51,229,651 (GRCm39)	missense	unknown
R8951:Cylc2	UTSW	4	51,229,469 (GRCm39)	missense	unknown
R9801:Cylc2	UTSW	4	51,228,466 (GRCm39)	missense	probably null

Posted On

2015-08-05