Incidental Mutation 'IGL00324:Fcrlb'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fcrlb
Ensembl Gene ENSMUSG00000070524
Gene NameFc receptor-like B
SynonymsFcry, FREB2, FREB-2, mFCRL2, FcRL2
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00324
Quality Score
Chromosomal Location170907273-170912941 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to C at 170908824 bp
Amino Acid Change Tyrosine to Aspartic acid at position 128 (Y128D)
Ref Sequence ENSEMBL: ENSMUSP00000091895 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094337]
Predicted Effect possibly damaging
Transcript: ENSMUST00000094337
AA Change: Y128D

PolyPhen 2 Score 0.813 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000091895
Gene: ENSMUSG00000070524
AA Change: Y128D

signal peptide 1 17 N/A INTRINSIC
IG_like 29 101 1.17e1 SMART
IG 109 191 9.34e-4 SMART
Blast:IG_like 209 281 2e-38 BLAST
low complexity region 290 306 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] FCRL2 belongs to the Fc receptor family. Fc receptors are involved in phagocytosis, antibody-dependent cell cytotoxicity, immediate hypersensitivity, and transcytosis of immunoglobulins via their ability to bind immunoglobulin (Ig) constant regions (Chikaev et al., 2005 [PubMed 15676285]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit an enhanced antibody response to a T-dependent antigen. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcd3 T C 3: 121,776,993 probably benign Het
Cdk12 T A 11: 98,245,388 L1156Q unknown Het
Ctsl T C 13: 64,368,168 Y66C probably damaging Het
Esd C T 14: 74,736,027 H21Y probably damaging Het
Gm17027 A T 14: 42,159,310 N196K unknown Het
Gm4553 T C 7: 142,165,227 S155G unknown Het
Hpcal1 A G 12: 17,791,145 S175G probably benign Het
Itgam A T 7: 128,085,661 D401V probably damaging Het
Kank1 A G 19: 25,411,758 T932A probably benign Het
Lmod1 A G 1: 135,364,478 K357R probably benign Het
Muc4 A G 16: 32,778,812 I3271V probably benign Het
Nlrc5 A G 8: 94,521,479 K1692E probably damaging Het
Ocln A G 13: 100,535,013 W279R probably damaging Het
Olfr1181 T C 2: 88,423,786 I80V probably benign Het
Pcsk1 A G 13: 75,132,087 K677R probably benign Het
Pitrm1 T A 13: 6,568,666 L586Q probably damaging Het
Plppr3 G A 10: 79,866,669 S217L probably damaging Het
Pnldc1 A T 17: 12,905,758 probably benign Het
Pramef12 A G 4: 144,394,740 L238P possibly damaging Het
Pramef8 T A 4: 143,416,667 M1K probably null Het
Sema6b C T 17: 56,130,048 D204N probably damaging Het
Slc12a5 A G 2: 164,997,121 N1063S probably damaging Het
Tg T C 15: 66,693,424 V1205A probably benign Het
Tmem260 T C 14: 48,486,879 F205L probably benign Het
Trappc11 A T 8: 47,503,302 probably benign Het
Tsen34 A G 7: 3,700,531 *296W probably null Het
Ubr2 A G 17: 46,986,060 probably benign Het
Vmn2r23 T A 6: 123,729,725 W505R possibly damaging Het
Wbp11 A G 6: 136,821,670 probably benign Het
Znfx1 A T 2: 167,036,729 M1909K possibly damaging Het
Other mutations in Fcrlb
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02124:Fcrlb APN 1 170907358 missense probably benign 0.15
IGL02142:Fcrlb APN 1 170908679 missense probably damaging 1.00
IGL02385:Fcrlb APN 1 170907599 missense probably damaging 0.99
R0928:Fcrlb UTSW 1 170907940 missense possibly damaging 0.87
R1460:Fcrlb UTSW 1 170912284 splice site probably benign
R1735:Fcrlb UTSW 1 170907332 missense probably benign
R1806:Fcrlb UTSW 1 170907527 missense probably benign 0.01
R2078:Fcrlb UTSW 1 170908081 missense probably damaging 1.00
R3806:Fcrlb UTSW 1 170907614 missense probably benign 0.00
R4570:Fcrlb UTSW 1 170912620 critical splice donor site probably null
R5457:Fcrlb UTSW 1 170912157 missense probably damaging 0.99
R5854:Fcrlb UTSW 1 170907961 missense probably damaging 1.00
R6233:Fcrlb UTSW 1 170908889 missense probably damaging 1.00
R7502:Fcrlb UTSW 1 170908641 missense probably damaging 0.98
R7579:Fcrlb UTSW 1 170907847 splice site probably null
R7879:Fcrlb UTSW 1 170908796 missense probably damaging 1.00
R8287:Fcrlb UTSW 1 170912084 missense probably damaging 1.00
Posted On2015-08-05