Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00340:Drc7'

332353

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Drc7

Ensembl Gene

ENSMUSG00000031786

Gene Name

dynein regulatory complex subunit 7

Synonyms

SRG-L, LOC330830, Ccdc135

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00340

Quality Score

Status

Chromosome

Chromosomal Location

95055103-95078141 bp(+) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

C to A at 95056001 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000053972 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000058479]

AlphaFold

Q6V3W6

Predicted Effect

probably benign
Transcript: ENSMUST00000058479

SMART Domains

Protein: ENSMUSP00000053972
Gene: ENSMUSG00000031786

Domain	Start	End	E-Value	Type
coiled coil region	1	33	N/A	INTRINSIC
low complexity region	229	246	N/A	INTRINSIC
coiled coil region	258	295	N/A	INTRINSIC
low complexity region	388	411	N/A	INTRINSIC
low complexity region	544	555	N/A	INTRINSIC
low complexity region	695	710	N/A	INTRINSIC
low complexity region	798	809	N/A	INTRINSIC
low complexity region	848	864	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000212986

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 62 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930430A15Rik	G	T	2: 111,220,762 (GRCm38)	L230I	probably damaging	Het
Adamts3	G	A	5: 89,701,666 (GRCm38)	H632Y	probably damaging	Het
Adgre5	T	A	8: 83,728,401 (GRCm38)	M221L	probably benign	Het
Apba2	A	T	7: 64,736,941 (GRCm38)	I439F	possibly damaging	Het
Arid1b	C	A	17: 5,321,284 (GRCm38)	N632K	probably damaging	Het
Bcas3	A	T	11: 85,365,591 (GRCm38)	I60L	probably damaging	Het
Brd9	T	C	13: 73,938,547 (GRCm38)	S56P	probably damaging	Het
Ccdc57	T	A	11: 120,860,469 (GRCm38)	D925V	possibly damaging	Het
Ccna1	A	G	3: 55,050,655 (GRCm38)	V143A	probably damaging	Het
Cdhr3	T	C	12: 33,052,209 (GRCm38)	T410A	probably benign	Het
Cimap3	A	G	3: 106,014,508 (GRCm38)	V33A	probably benign	Het
Ddx60	G	T	8: 61,958,646 (GRCm38)	D511Y	probably damaging	Het
Dysf	A	G	6: 84,141,951 (GRCm38)	E1290G	probably benign	Het
Fam168b	T	C	1: 34,836,802 (GRCm38)	M1V	probably null	Het
Farsa	A	G	8: 84,864,257 (GRCm38)	K208R	probably damaging	Het
Fnip2	A	G	3: 79,518,061 (GRCm38)		probably benign	Het
Gm17535	A	T	9: 3,035,111 (GRCm38)	H170L	probably benign	Het
Gm4553	T	C	7: 142,165,227 (GRCm38)	S155G	unknown	Het
Gm5852	T	C	3: 93,727,194 (GRCm38)		noncoding transcript	Het
Gnb2	T	C	5: 137,530,706 (GRCm38)		probably benign	Het
Gpr158	A	G	2: 21,368,683 (GRCm38)	N143S	probably damaging	Het
Hcn1	C	A	13: 117,602,977 (GRCm38)	Q92K	unknown	Het
Helb	T	C	10: 120,098,245 (GRCm38)	I678V	possibly damaging	Het
Hnrnpl	C	A	7: 28,813,373 (GRCm38)	A118D	probably damaging	Het
Klhl14	G	A	18: 21,651,864 (GRCm38)	P169S	probably benign	Het
Kndc1	T	C	7: 139,901,988 (GRCm38)		probably benign	Het
Lmod2	A	G	6: 24,598,052 (GRCm38)	E57G	probably damaging	Het
Lrch4	T	C	5: 137,637,747 (GRCm38)	I300T	possibly damaging	Het
Lrp6	A	G	6: 134,456,090 (GRCm38)	V1426A	probably benign	Het
Lrrc39	A	G	3: 116,570,981 (GRCm38)		probably benign	Het
Mamstr	G	A	7: 45,644,285 (GRCm38)	V262I	probably benign	Het
Mob1b	A	T	5: 88,756,155 (GRCm38)	T217S	probably benign	Het
Mocs3	G	A	2: 168,231,491 (GRCm38)	R286H	possibly damaging	Het
Mpo	A	T	11: 87,802,617 (GRCm38)	Q27L	probably benign	Het
Ncdn	A	T	4: 126,747,188 (GRCm38)	D506E	probably benign	Het
Noxa1	A	G	2: 25,094,902 (GRCm38)	I8T	probably benign	Het
Oma1	G	T	4: 103,319,368 (GRCm38)	A110S	probably benign	Het
Or10a48	C	T	7: 108,825,073 (GRCm38)	V309I	probably benign	Het
Or13a18	T	A	7: 140,610,753 (GRCm38)	S196T	probably damaging	Het
Or8b4	A	G	9: 37,919,050 (GRCm38)	Y131C	probably damaging	Het
Pde4a	A	C	9: 21,211,061 (GRCm38)	K694T	probably benign	Het
Phc1	A	G	6: 122,322,999 (GRCm38)		probably benign	Het
Pias1	A	G	9: 62,923,296 (GRCm38)	V187A	probably damaging	Het
Pigf	C	A	17: 87,020,448 (GRCm38)	L130F	probably null	Het
Pkd1	G	T	17: 24,580,095 (GRCm38)	V2763L	probably damaging	Het
Ppp1r8	T	C	4: 132,834,681 (GRCm38)	Y76C	probably damaging	Het
Ppp6r3	C	A	19: 3,518,324 (GRCm38)	G158V	probably damaging	Het
Ptpn13	A	G	5: 103,551,058 (GRCm38)	I1136V	probably damaging	Het
Ptprq	T	C	10: 107,576,929 (GRCm38)	I1770V	probably damaging	Het
Rhpn2	A	T	7: 35,370,760 (GRCm38)	I148F	probably damaging	Het
Stard3	T	C	11: 98,377,459 (GRCm38)	Y239H	probably damaging	Het
Stau1	T	C	2: 166,950,809 (GRCm38)	Y412C	probably benign	Het
Sucnr1	A	G	3: 60,086,632 (GRCm38)	I194V	probably benign	Het
Tanc1	A	G	2: 59,790,841 (GRCm38)	T335A	possibly damaging	Het
Tmem126a	T	C	7: 90,452,755 (GRCm38)	T79A	probably benign	Het
Trav9-2	A	T	14: 53,591,383 (GRCm38)	Y70F	probably benign	Het
Tspear	A	G	10: 77,873,236 (GRCm38)	E432G	probably benign	Het
Ube2o	T	C	11: 116,544,754 (GRCm38)	R403G	probably benign	Het
Unc80	C	A	1: 66,606,459 (GRCm38)	S1431R	possibly damaging	Het
Usp24	G	A	4: 106,401,139 (GRCm38)	C1578Y	probably damaging	Het
Vsig10	A	T	5: 117,351,587 (GRCm38)	M473L	probably benign	Het
Xpot	T	A	10: 121,605,644 (GRCm38)	M559L	probably benign	Het

Other mutations in Drc7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00922:Drc7	APN	8	95,077,978 (GRCm38)	missense	probably benign	0.00
IGL01610:Drc7	APN	8	95,077,802 (GRCm38)	missense	probably damaging	1.00
IGL01642:Drc7	APN	8	95,059,139 (GRCm38)	missense	probably benign	0.34
IGL01793:Drc7	APN	8	95,071,277 (GRCm38)	missense	probably benign	0.25
IGL01936:Drc7	APN	8	95,074,132 (GRCm38)	missense	possibly damaging	0.89
IGL01953:Drc7	APN	8	95,059,125 (GRCm38)	missense	probably damaging	1.00
IGL01998:Drc7	APN	8	95,059,193 (GRCm38)	missense	probably damaging	1.00
IGL02237:Drc7	APN	8	95,072,879 (GRCm38)	missense	probably damaging	1.00
IGL02259:Drc7	APN	8	95,056,105 (GRCm38)	missense	probably benign
IGL02285:Drc7	APN	8	95,071,233 (GRCm38)	splice site	probably benign
IGL02940:Drc7	APN	8	95,074,297 (GRCm38)	missense	probably damaging	0.99
IGL03032:Drc7	APN	8	95,076,247 (GRCm38)	splice site	probably benign
IGL03181:Drc7	APN	8	95,068,127 (GRCm38)	missense	probably benign	0.00
R0018:Drc7	UTSW	8	95,074,234 (GRCm38)	missense	probably damaging	0.99
R0018:Drc7	UTSW	8	95,074,234 (GRCm38)	missense	probably damaging	0.99
R0281:Drc7	UTSW	8	95,071,253 (GRCm38)	missense	possibly damaging	0.61
R0304:Drc7	UTSW	8	95,059,128 (GRCm38)	missense	probably damaging	1.00
R0362:Drc7	UTSW	8	95,072,855 (GRCm38)	missense	probably benign	0.00
R1127:Drc7	UTSW	8	95,072,788 (GRCm38)	missense	probably damaging	0.98
R1635:Drc7	UTSW	8	95,074,332 (GRCm38)	critical splice donor site	probably null
R1921:Drc7	UTSW	8	95,056,016 (GRCm38)	missense	unknown
R1931:Drc7	UTSW	8	95,071,253 (GRCm38)	missense	possibly damaging	0.61
R2256:Drc7	UTSW	8	95,075,009 (GRCm38)	missense	probably benign	0.16
R3851:Drc7	UTSW	8	95,061,836 (GRCm38)	nonsense	probably null
R4797:Drc7	UTSW	8	95,074,297 (GRCm38)	missense	probably damaging	0.96
R4827:Drc7	UTSW	8	95,071,639 (GRCm38)	missense	probably damaging	0.98
R4966:Drc7	UTSW	8	95,071,596 (GRCm38)	missense	probably benign	0.45
R5194:Drc7	UTSW	8	95,061,717 (GRCm38)	missense	probably benign	0.00
R5721:Drc7	UTSW	8	95,074,333 (GRCm38)	critical splice donor site	probably null
R5911:Drc7	UTSW	8	95,074,126 (GRCm38)	missense	probably damaging	1.00
R5993:Drc7	UTSW	8	95,074,192 (GRCm38)	missense	probably benign
R6056:Drc7	UTSW	8	95,075,051 (GRCm38)	missense	probably damaging	1.00
R6534:Drc7	UTSW	8	95,071,282 (GRCm38)	missense	probably damaging	1.00
R6576:Drc7	UTSW	8	95,075,258 (GRCm38)	missense	probably damaging	0.98
R6861:Drc7	UTSW	8	95,062,397 (GRCm38)	critical splice donor site	probably null
R7104:Drc7	UTSW	8	95,059,083 (GRCm38)	missense	probably damaging	0.99
R7157:Drc7	UTSW	8	95,074,150 (GRCm38)	missense	probably damaging	0.99
R7205:Drc7	UTSW	8	95,077,921 (GRCm38)	missense	probably damaging	1.00
R7283:Drc7	UTSW	8	95,071,579 (GRCm38)	missense	probably damaging	0.99
R7351:Drc7	UTSW	8	95,058,507 (GRCm38)	missense	probably benign	0.25
R7567:Drc7	UTSW	8	95,068,056 (GRCm38)	missense	probably benign	0.00
R8211:Drc7	UTSW	8	95,056,079 (GRCm38)	missense	unknown
R8281:Drc7	UTSW	8	95,062,177 (GRCm38)	missense	possibly damaging	0.81
R8401:Drc7	UTSW	8	95,074,135 (GRCm38)	missense	probably benign
R8821:Drc7	UTSW	8	95,062,217 (GRCm38)	missense	probably damaging	1.00
R8831:Drc7	UTSW	8	95,062,217 (GRCm38)	missense	probably damaging	1.00
R9044:Drc7	UTSW	8	95,070,449 (GRCm38)	missense	probably damaging	0.98
R9326:Drc7	UTSW	8	95,075,258 (GRCm38)	missense	probably benign	0.02
R9565:Drc7	UTSW	8	95,075,238 (GRCm38)	missense	probably damaging	0.98
R9581:Drc7	UTSW	8	95,059,154 (GRCm38)	missense	probably damaging	0.98
Y5404:Drc7	UTSW	8	95,068,150 (GRCm38)	small deletion	probably benign

Posted On

2015-08-05