Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00418:Gm14399'

332371

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gm14399

Ensembl Gene

ENSMUSG00000090093

Gene Name

predicted gene 14399

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.110) question?

Stock #

IGL00418

Quality Score

Status

Chromosome

Chromosomal Location

174971286-174983805 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to A at 174973315 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Stop codon at position 147 (R147*)

Ref Sequence

ENSEMBL: ENSMUSP00000104688 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099029] [ENSMUST00000108929] [ENSMUST00000109059] [ENSMUST00000109060] [ENSMUST00000109062]

AlphaFold

A2ARW8

Predicted Effect

probably benign
Transcript: ENSMUST00000099029

SMART Domains

Protein: ENSMUSP00000096627
Gene: ENSMUSG00000090093

Domain	Start	End	E-Value	Type
KRAB	3	63	1.37e-12	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000108929
AA Change: R115*

SMART Domains

Protein: ENSMUSP00000104557
Gene: ENSMUSG00000090093
AA Change: R115*

Domain	Start	End	E-Value	Type
ZnF_C2H2	46	65	1.61e2	SMART
ZnF_C2H2	71	93	4.17e-3	SMART
ZnF_C2H2	99	121	3.83e-2	SMART
ZnF_C2H2	127	149	8.6e-5	SMART
ZnF_C2H2	155	177	1.69e-3	SMART
ZnF_C2H2	183	205	7.37e-4	SMART
ZnF_C2H2	211	233	4.94e-5	SMART
ZnF_C2H2	239	261	1.12e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000109059

SMART Domains

Protein: ENSMUSP00000104687
Gene: ENSMUSG00000090093

Domain	Start	End	E-Value	Type
KRAB	4	64	1.37e-12	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000109060
AA Change: R147*

SMART Domains

Protein: ENSMUSP00000104688
Gene: ENSMUSG00000090093
AA Change: R147*

Domain	Start	End	E-Value	Type
KRAB	4	66	1.84e-13	SMART
ZnF_C2H2	78	97	1.61e2	SMART
ZnF_C2H2	103	125	4.17e-3	SMART
ZnF_C2H2	131	153	3.83e-2	SMART
ZnF_C2H2	159	181	8.6e-5	SMART
ZnF_C2H2	187	209	4.17e-3	SMART
ZnF_C2H2	215	237	6.08e-5	SMART
ZnF_C2H2	243	265	5.99e-4	SMART
ZnF_C2H2	271	293	8.02e-5	SMART
ZnF_C2H2	299	321	3.83e-2	SMART
ZnF_C2H2	327	349	5.14e-3	SMART
ZnF_C2H2	355	377	5.14e-3	SMART
ZnF_C2H2	383	405	9.08e-4	SMART
ZnF_C2H2	411	433	1.69e-3	SMART
ZnF_C2H2	439	461	7.37e-4	SMART
ZnF_C2H2	467	489	9.08e-4	SMART
ZnF_C2H2	495	517	2.57e-3	SMART
ZnF_C2H2	523	545	7.78e-3	SMART
ZnF_C2H2	551	573	4.94e-5	SMART
ZnF_C2H2	579	601	1.12e-3	SMART

Predicted Effect

silent
Transcript: ENSMUST00000109062

SMART Domains

Protein: ENSMUSP00000104690
Gene: ENSMUSG00000090093

Domain	Start	End	E-Value	Type
KRAB	4	66	1.27e-16	SMART
low complexity region	80	91	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2700097O09Rik	A	G	12: 55,095,748 (GRCm39)	I238T	probably damaging	Het
Akap4	T	C	X: 6,942,729 (GRCm39)	V344A	possibly damaging	Het
Apex2	T	C	X: 149,355,048 (GRCm39)	K430E	probably benign	Het
Aqp9	C	T	9: 71,040,013 (GRCm39)	A90T	probably damaging	Het
Asb15	T	A	6: 24,558,642 (GRCm39)		probably benign	Het
Barhl2	C	T	5: 106,603,365 (GRCm39)	A265T	possibly damaging	Het
Bspry	G	T	4: 62,414,342 (GRCm39)	D312Y	probably benign	Het
Cdh16	G	A	8: 105,350,045 (GRCm39)	R5W	probably benign	Het
Ciz1	C	T	2: 32,262,400 (GRCm39)	R461C	probably damaging	Het
Cldn14	T	A	16: 93,716,189 (GRCm39)	D219V	probably benign	Het
Clpb	A	T	7: 101,436,952 (GRCm39)	T706S	probably benign	Het
Cyp2d11	A	T	15: 82,276,669 (GRCm39)	M90K	probably benign	Het
Cyp2j8	T	A	4: 96,332,853 (GRCm39)	I498F	possibly damaging	Het
Dnah2	A	G	11: 69,385,892 (GRCm39)		probably benign	Het
Dpyd	T	A	3: 118,737,891 (GRCm39)	F477L	probably damaging	Het
Dscaml1	C	A	9: 45,581,498 (GRCm39)	S439*	probably null	Het
Faxc	A	G	4: 21,958,490 (GRCm39)	K216E	possibly damaging	Het
Fmo1	C	T	1: 162,663,815 (GRCm39)	R238Q	probably damaging	Het
H2-Ab1	G	A	17: 34,486,549 (GRCm39)	V203M	probably damaging	Het
Heatr5b	T	C	17: 79,060,570 (GRCm39)	E2035G	probably damaging	Het
Hip1	A	G	5: 135,455,200 (GRCm39)	I786T	probably damaging	Het
Homer1	T	C	13: 93,524,196 (GRCm39)		probably benign	Het
Igkv9-120	A	G	6: 68,026,971 (GRCm39)	D2G	possibly damaging	Het
Irgm1	A	T	11: 48,756,832 (GRCm39)	Y326*	probably null	Het
Kctd19	A	T	8: 106,115,095 (GRCm39)		probably null	Het
Large1	T	C	8: 73,550,469 (GRCm39)		probably null	Het
Mzf1	G	A	7: 12,778,543 (GRCm39)	A287V	possibly damaging	Het
Nes	A	T	3: 87,883,561 (GRCm39)	K607*	probably null	Het
Pars2	T	A	4: 106,511,247 (GRCm39)	V307E	probably damaging	Het
Pcsk5	T	A	19: 17,488,785 (GRCm39)	I1012F	possibly damaging	Het
Pole	T	C	5: 110,451,431 (GRCm39)		probably benign	Het
Rbm14	T	C	19: 4,852,576 (GRCm39)		probably benign	Het
Scn2a	A	T	2: 65,594,866 (GRCm39)	Q1905L	probably benign	Het
Slc26a2	A	G	18: 61,331,812 (GRCm39)	F540L	probably benign	Het
Slco2a1	T	C	9: 102,956,640 (GRCm39)		probably benign	Het
Tas2r106	T	C	6: 131,654,922 (GRCm39)		probably null	Het
Tmem175	T	A	5: 108,793,732 (GRCm39)	D287E	probably benign	Het
Trappc12	T	C	12: 28,787,835 (GRCm39)	K416R	probably damaging	Het
Trim2	A	G	3: 84,115,596 (GRCm39)	L86P	probably damaging	Het
Vps13c	T	A	9: 67,783,544 (GRCm39)	N240K	probably damaging	Het
Wdr90	A	C	17: 26,068,338 (GRCm39)	I1330S	probably damaging	Het
Wfdc6a	A	G	2: 164,426,914 (GRCm39)		probably null	Het
Zc3h12c	C	T	9: 52,027,965 (GRCm39)	V466M	probably damaging	Het
Zswim8	A	G	14: 20,768,543 (GRCm39)	T1025A	probably damaging	Het

Other mutations in Gm14399

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R2185:Gm14399	UTSW	2	174,973,188 (GRCm39)	missense	probably damaging	1.00
R3711:Gm14399	UTSW	2	174,973,303 (GRCm39)	nonsense	probably null
R4907:Gm14399	UTSW	2	174,973,182 (GRCm39)	intron	probably benign
R5361:Gm14399	UTSW	2	174,973,371 (GRCm39)	missense	probably damaging	1.00
R7252:Gm14399	UTSW	2	174,974,991 (GRCm39)	missense	probably damaging	0.98
R7278:Gm14399	UTSW	2	174,972,252 (GRCm39)	intron	probably benign
R7289:Gm14399	UTSW	2	174,972,204 (GRCm39)	missense	unknown
R7946:Gm14399	UTSW	2	174,973,273 (GRCm39)	missense	probably damaging	1.00
R8390:Gm14399	UTSW	2	174,972,605 (GRCm39)	nonsense	probably null
RF051:Gm14399	UTSW	2	174,972,994 (GRCm39)	missense	probably benign	0.00

Posted On

2015-08-05