Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00429:Zfp930'

332404

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp930

Ensembl Gene

ENSMUSG00000059897

Gene Name

zinc finger protein 930

Synonyms

zinc finger protein, D10627

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00429

Quality Score

Status

Chromosome

Chromosomal Location

69661690-69683188 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 69680634 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Asparagine at position 90 (K90N)

Ref Sequence

ENSEMBL: ENSMUSP00000148604 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000110216] [ENSMUST00000212312] [ENSMUST00000212681]

AlphaFold

A0A1D5RM15

Predicted Effect

possibly damaging
Transcript: ENSMUST00000110216
AA Change: A109S

PolyPhen 2 Score 0.946 (Sensitivity: 0.80; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000105845
Gene: ENSMUSG00000059897
AA Change: A109S

Domain	Start	End	E-Value	Type
KRAB	3	62	1.39e-13	SMART
ZnF_C2H2	73	95	1.07e0	SMART
ZnF_C2H2	101	123	6.88e-4	SMART
ZnF_C2H2	129	151	1.98e-4	SMART
ZnF_C2H2	157	179	2.63e0	SMART
ZnF_C2H2	185	207	1.3e-4	SMART
ZnF_C2H2	213	235	1.22e-4	SMART
ZnF_C2H2	241	263	7.49e-5	SMART
ZnF_C2H2	269	291	1.13e-4	SMART
ZnF_C2H2	297	319	1.84e-4	SMART
ZnF_C2H2	325	347	2.27e-4	SMART
ZnF_C2H2	353	375	1.22e-4	SMART
ZnF_C2H2	381	403	5.29e-5	SMART
ZnF_C2H2	409	431	1.72e-4	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000212090

Predicted Effect

probably damaging
Transcript: ENSMUST00000212312
AA Change: K90N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

Predicted Effect

possibly damaging
Transcript: ENSMUST00000212681
AA Change: A110S

PolyPhen 2 Score 0.686 (Sensitivity: 0.86; Specificity: 0.92)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700009J07Rik	G	A	10: 77,729,673 (GRCm39)		probably benign	Het
4933411K16Rik	T	C	19: 42,040,983 (GRCm39)	L38P	probably damaging	Het
Abca1	A	G	4: 53,059,255 (GRCm39)		probably null	Het
Abca15	T	A	7: 119,996,277 (GRCm39)	I1401N	probably damaging	Het
Adam3	A	C	8: 25,184,294 (GRCm39)	Y569D	probably damaging	Het
Ap2a1	T	C	7: 44,555,192 (GRCm39)	S458G	probably damaging	Het
Asxl3	C	T	18: 22,658,280 (GRCm39)	P2097S	probably benign	Het
AW551984	T	C	9: 39,504,145 (GRCm39)	D607G	probably benign	Het
Ccdc158	C	A	5: 92,805,740 (GRCm39)	M338I	probably benign	Het
Cdh23	A	G	10: 60,256,920 (GRCm39)	S735P	probably damaging	Het
Cdh9	T	C	15: 16,828,448 (GRCm39)	V180A	probably damaging	Het
Cyp4a31	A	T	4: 115,432,171 (GRCm39)		probably benign	Het
Dus4l	A	G	12: 31,691,668 (GRCm39)	V180A	probably benign	Het
Dysf	A	T	6: 84,166,826 (GRCm39)	T1672S	probably damaging	Het
F830016B08Rik	T	A	18: 60,433,340 (GRCm39)	L141Q	probably damaging	Het
Fhod3	A	G	18: 25,127,597 (GRCm39)	E313G	probably damaging	Het
Gm4884	A	G	7: 40,693,809 (GRCm39)	T593A	probably benign	Het
H2bc14	T	C	13: 21,906,310 (GRCm39)	S15P	possibly damaging	Het
Il18r1	G	A	1: 40,537,812 (GRCm39)	E526K	possibly damaging	Het
Lama4	A	T	10: 38,887,022 (GRCm39)	H109L	possibly damaging	Het
Mab21l1	A	C	3: 55,690,557 (GRCm39)	Q48P	probably damaging	Het
Magi3	T	A	3: 103,922,294 (GRCm39)	K1474N	probably damaging	Het
Mre11a	T	C	9: 14,714,109 (GRCm39)	F237L	probably damaging	Het
Mst1r	A	T	9: 107,790,449 (GRCm39)		probably benign	Het
Mtcl2	A	C	2: 156,872,784 (GRCm39)	F909C	probably damaging	Het
Myh2	C	T	11: 67,071,616 (GRCm39)	Q478*	probably null	Het
Mylip	C	A	13: 45,562,043 (GRCm39)	P282T	probably benign	Het
Mymk	T	C	2: 26,952,799 (GRCm39)	Y103C	probably damaging	Het
Necab1	A	T	4: 15,052,656 (GRCm39)	N107K	probably damaging	Het
Pclo	T	C	5: 14,730,753 (GRCm39)		probably benign	Het
Phgdh	T	C	3: 98,235,631 (GRCm39)	K129E	probably damaging	Het
Plxna4	T	C	6: 32,139,026 (GRCm39)	Y1714C	probably damaging	Het
Pm20d2	A	G	4: 33,187,205 (GRCm39)		probably benign	Het
Ppfibp2	A	G	7: 107,296,801 (GRCm39)	T172A	probably benign	Het
Prkca	T	C	11: 108,234,334 (GRCm39)	T54A	probably benign	Het
Prlr	A	G	15: 10,328,410 (GRCm39)	D295G	probably benign	Het
Rdh12	A	G	12: 79,258,176 (GRCm39)	I68V	probably benign	Het
Slc14a2	A	G	18: 78,193,653 (GRCm39)	F850L	possibly damaging	Het
Smad2	A	T	18: 76,431,566 (GRCm39)	S185C	possibly damaging	Het
Trav13n-4	T	A	14: 53,601,288 (GRCm39)	L19Q	probably benign	Het
Ush2a	T	A	1: 188,132,311 (GRCm39)	C844*	probably null	Het
Vwce	T	A	19: 10,641,875 (GRCm39)		probably null	Het
Wdr95	T	C	5: 149,518,709 (GRCm39)		probably benign	Het
Zfp143	T	C	7: 109,690,979 (GRCm39)	I510T	probably damaging	Het

Other mutations in Zfp930

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
Bodyguard	UTSW	8	69,681,337 (GRCm39)	missense	probably damaging	1.00
R0389:Zfp930	UTSW	8	69,680,948 (GRCm39)	nonsense	probably null
R1275:Zfp930	UTSW	8	69,680,631 (GRCm39)	missense	possibly damaging	0.73
R1322:Zfp930	UTSW	8	69,680,820 (GRCm39)	missense	probably benign	0.02
R1802:Zfp930	UTSW	8	69,679,046 (GRCm39)	missense	possibly damaging	0.50
R1917:Zfp930	UTSW	8	69,681,357 (GRCm39)	missense	probably benign	0.02
R1918:Zfp930	UTSW	8	69,681,357 (GRCm39)	missense	probably benign	0.02
R1981:Zfp930	UTSW	8	69,680,824 (GRCm39)	missense	probably damaging	1.00
R4492:Zfp930	UTSW	8	69,680,898 (GRCm39)	nonsense	probably null
R4530:Zfp930	UTSW	8	69,681,483 (GRCm39)	nonsense	probably null
R4769:Zfp930	UTSW	8	69,679,344 (GRCm39)	missense	probably benign	0.09
R4906:Zfp930	UTSW	8	69,681,597 (GRCm39)	missense	probably benign	0.11
R5314:Zfp930	UTSW	8	69,679,373 (GRCm39)	missense	probably benign	0.27
R5708:Zfp930	UTSW	8	69,679,113 (GRCm39)	missense	probably benign	0.08
R6004:Zfp930	UTSW	8	69,680,556 (GRCm39)	missense	probably benign
R6385:Zfp930	UTSW	8	69,681,283 (GRCm39)	missense	probably damaging	1.00
R7095:Zfp930	UTSW	8	69,681,193 (GRCm39)	missense	probably benign
R7619:Zfp930	UTSW	8	69,661,810 (GRCm39)	start codon destroyed	probably null	0.95
R7641:Zfp930	UTSW	8	69,681,337 (GRCm39)	missense	probably damaging	1.00
R7674:Zfp930	UTSW	8	69,681,337 (GRCm39)	missense	probably damaging	1.00
R8300:Zfp930	UTSW	8	69,680,998 (GRCm39)	missense	probably benign	0.00
R8905:Zfp930	UTSW	8	69,681,351 (GRCm39)	missense	possibly damaging	0.78
R8960:Zfp930	UTSW	8	69,680,541 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-08-05