Incidental Mutation 'IGL00429:Zfp930'
ID332404
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp930
Ensembl Gene ENSMUSG00000059897
Gene Namezinc finger protein 930
SynonymsD10627, zinc finger protein
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00429
Quality Score
Status
Chromosome8
Chromosomal Location69209038-69230536 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 69227982 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Asparagine at position 90 (K90N)
Ref Sequence ENSEMBL: ENSMUSP00000148604 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000110216] [ENSMUST00000212312] [ENSMUST00000212681]
Predicted Effect possibly damaging
Transcript: ENSMUST00000110216
AA Change: A109S

PolyPhen 2 Score 0.946 (Sensitivity: 0.80; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000105845
Gene: ENSMUSG00000059897
AA Change: A109S

DomainStartEndE-ValueType
KRAB 3 62 1.39e-13 SMART
ZnF_C2H2 73 95 1.07e0 SMART
ZnF_C2H2 101 123 6.88e-4 SMART
ZnF_C2H2 129 151 1.98e-4 SMART
ZnF_C2H2 157 179 2.63e0 SMART
ZnF_C2H2 185 207 1.3e-4 SMART
ZnF_C2H2 213 235 1.22e-4 SMART
ZnF_C2H2 241 263 7.49e-5 SMART
ZnF_C2H2 269 291 1.13e-4 SMART
ZnF_C2H2 297 319 1.84e-4 SMART
ZnF_C2H2 325 347 2.27e-4 SMART
ZnF_C2H2 353 375 1.22e-4 SMART
ZnF_C2H2 381 403 5.29e-5 SMART
ZnF_C2H2 409 431 1.72e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212090
Predicted Effect probably damaging
Transcript: ENSMUST00000212312
AA Change: K90N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect possibly damaging
Transcript: ENSMUST00000212681
AA Change: A110S

PolyPhen 2 Score 0.686 (Sensitivity: 0.86; Specificity: 0.92)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700009J07Rik G A 10: 77,893,839 probably benign Het
4933411K16Rik T C 19: 42,052,544 L38P probably damaging Het
Abca1 A G 4: 53,059,255 probably null Het
Abca15 T A 7: 120,397,054 I1401N probably damaging Het
Adam3 A C 8: 24,694,278 Y569D probably damaging Het
Ap2a1 T C 7: 44,905,768 S458G probably damaging Het
Asxl3 C T 18: 22,525,223 P2097S probably benign Het
AW551984 T C 9: 39,592,849 D607G probably benign Het
Ccdc158 C A 5: 92,657,881 M338I probably benign Het
Cdh23 A G 10: 60,421,141 S735P probably damaging Het
Cdh9 T C 15: 16,828,362 V180A probably damaging Het
Cyp4a31 A T 4: 115,574,974 probably benign Het
Dus4l A G 12: 31,641,669 V180A probably benign Het
Dysf A T 6: 84,189,844 T1672S probably damaging Het
F830016B08Rik T A 18: 60,300,268 L141Q probably damaging Het
Fhod3 A G 18: 24,994,540 E313G probably damaging Het
Gm4884 A G 7: 41,044,385 T593A probably benign Het
Hist1h2bm T C 13: 21,722,140 S15P possibly damaging Het
Il18r1 G A 1: 40,498,652 E526K possibly damaging Het
Lama4 A T 10: 39,011,026 H109L possibly damaging Het
Mab21l1 A C 3: 55,783,136 Q48P probably damaging Het
Magi3 T A 3: 104,014,978 K1474N probably damaging Het
Mre11a T C 9: 14,802,813 F237L probably damaging Het
Mst1r A T 9: 107,913,250 probably benign Het
Myh2 C T 11: 67,180,790 Q478* probably null Het
Mylip C A 13: 45,408,567 P282T probably benign Het
Mymk T C 2: 27,062,787 Y103C probably damaging Het
Necab1 A T 4: 15,052,656 N107K probably damaging Het
Pclo T C 5: 14,680,739 probably benign Het
Phgdh T C 3: 98,328,315 K129E probably damaging Het
Plxna4 T C 6: 32,162,091 Y1714C probably damaging Het
Pm20d2 A G 4: 33,187,205 probably benign Het
Ppfibp2 A G 7: 107,697,594 T172A probably benign Het
Prkca T C 11: 108,343,508 T54A probably benign Het
Prlr A G 15: 10,328,324 D295G probably benign Het
Rdh12 A G 12: 79,211,402 I68V probably benign Het
Slc14a2 A G 18: 78,150,438 F850L possibly damaging Het
Smad2 A T 18: 76,298,495 S185C possibly damaging Het
Soga1 A C 2: 157,030,864 F909C probably damaging Het
Trav13n-4 T A 14: 53,363,831 L19Q probably benign Het
Ush2a T A 1: 188,400,114 C844* probably null Het
Vwce T A 19: 10,664,511 probably null Het
Wdr95 T C 5: 149,595,244 probably benign Het
Zfp143 T C 7: 110,091,772 I510T probably damaging Het
Other mutations in Zfp930
AlleleSourceChrCoordTypePredicted EffectPPH Score
Bodyguard UTSW 8 69228685 missense probably damaging 1.00
R0389:Zfp930 UTSW 8 69228296 nonsense probably null
R1275:Zfp930 UTSW 8 69227979 missense possibly damaging 0.73
R1322:Zfp930 UTSW 8 69228168 missense probably benign 0.02
R1802:Zfp930 UTSW 8 69226394 missense possibly damaging 0.50
R1917:Zfp930 UTSW 8 69228705 missense probably benign 0.02
R1918:Zfp930 UTSW 8 69228705 missense probably benign 0.02
R1981:Zfp930 UTSW 8 69228172 missense probably damaging 1.00
R4492:Zfp930 UTSW 8 69228246 nonsense probably null
R4530:Zfp930 UTSW 8 69228831 nonsense probably null
R4769:Zfp930 UTSW 8 69226692 missense probably benign 0.09
R4906:Zfp930 UTSW 8 69228945 missense probably benign 0.11
R5314:Zfp930 UTSW 8 69226721 missense probably benign 0.27
R5708:Zfp930 UTSW 8 69226461 missense probably benign 0.08
R6004:Zfp930 UTSW 8 69227904 missense probably benign
R6385:Zfp930 UTSW 8 69228631 missense probably damaging 1.00
R7095:Zfp930 UTSW 8 69228541 missense probably benign
R7619:Zfp930 UTSW 8 69209158 start codon destroyed probably null 0.95
R7641:Zfp930 UTSW 8 69228685 missense probably damaging 1.00
R7674:Zfp930 UTSW 8 69228685 missense probably damaging 1.00
R8300:Zfp930 UTSW 8 69228346 missense probably benign 0.00
Posted On2015-08-05