Incidental Mutation 'IGL00264:Gm8237'
ID332463
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm8237
Ensembl Gene ENSMUSG00000090707
Gene Namepredicted gene 8237
Synonyms
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL00264
Quality Score
Status
Chromosome14
Chromosomal Location5857918-5880382 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 5864475 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Histidine at position 29 (L29H)
Ref Sequence ENSEMBL: ENSMUSP00000127555 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000164484] [ENSMUST00000178594]
Predicted Effect probably benign
Transcript: ENSMUST00000164484
AA Change: L29H

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000127555
Gene: ENSMUSG00000090707
AA Change: L29H

DomainStartEndE-ValueType
Pfam:Takusan 48 128 6.5e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000178594
SMART Domains Protein: ENSMUSP00000136613
Gene: ENSMUSG00000090707

DomainStartEndE-ValueType
Pfam:Takusan 1 74 4.5e-27 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110002H16Rik T C 18: 12,179,219 V172A probably benign Het
Actr3 T G 1: 125,397,229 I319L probably benign Het
Akap7 C T 10: 25,171,240 D20N probably benign Het
Ambra1 T A 2: 91,911,589 S1070T probably benign Het
Arhgef9 T C X: 95,081,631 probably null Het
Ascc3 T G 10: 50,714,435 V1083G probably damaging Het
Asns T A 6: 7,680,179 E312D probably damaging Het
Bpifc A C 10: 85,960,528 V472G possibly damaging Het
Ccdc71 T A 9: 108,463,038 S17T probably damaging Het
Cebpzos T C 17: 78,918,348 probably benign Het
Cfi T C 3: 129,873,095 I489T probably damaging Het
Chrm2 T A 6: 36,523,391 F61Y probably damaging Het
Cpxm1 T C 2: 130,395,943 Y149C probably damaging Het
Dnah6 A G 6: 73,195,737 I246T probably benign Het
Ereg C A 5: 91,074,779 S7Y probably benign Het
Ghsr T A 3: 27,374,873 L349Q possibly damaging Het
Gm10754 A G 10: 97,682,412 probably benign Het
Hexim2 A G 11: 103,138,455 E111G probably damaging Het
Itga1 A T 13: 114,992,363 N586K possibly damaging Het
Kat6b A G 14: 21,668,559 D1102G probably benign Het
Kif27 A T 13: 58,337,604 M514K probably benign Het
Matn2 T C 15: 34,428,470 I660T probably damaging Het
Mki67 C A 7: 135,707,820 G301* probably null Het
Olfr1451 A G 19: 12,999,319 Y111C probably damaging Het
Olfr1480 A C 19: 13,529,850 Y103S probably damaging Het
Olfr364-ps1 T C 2: 37,147,067 F285S probably damaging Het
Olfr539 T A 7: 140,667,941 I211N probably benign Het
Pcdhb8 A T 18: 37,355,473 H68L probably benign Het
Pkhd1l1 T C 15: 44,491,029 V272A possibly damaging Het
Pstpip2 T C 18: 77,871,559 probably benign Het
Rdh14 G T 12: 10,391,134 G99W probably damaging Het
Sra1 A T 18: 36,668,739 S99R probably benign Het
Tbrg1 G T 9: 37,651,041 N280K probably benign Het
Ugt8a A G 3: 125,914,636 probably null Het
Usp40 A T 1: 88,004,238 probably benign Het
Vmn1r45 T A 6: 89,933,664 Y108F probably damaging Het
Zfp521 A G 18: 13,846,502 Y285H probably benign Het
Other mutations in Gm8237
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01380:Gm8237 APN 14 5863703 unclassified probably null
IGL02311:Gm8237 APN 14 5864425 splice site probably null
IGL02491:Gm8237 APN 14 5863577 nonsense probably null
IGL03149:Gm8237 APN 14 5864451 missense probably benign 0.00
R2520:Gm8237 UTSW 14 5863642 missense possibly damaging 0.52
Posted On2015-08-05