Incidental Mutation 'IGL00503:Zscan26'
ID332492
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zscan26
Ensembl Gene ENSMUSG00000022228
Gene Namezinc finger and SCAN domain containing 26
SynonymsZfp187
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.127) question?
Stock #IGL00503
Quality Score
Status
Chromosome13
Chromosomal Location21442180-21453730 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to G at 21445101 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Glutamine at position 285 (K285Q)
Ref Sequence ENSEMBL: ENSMUSP00000032820 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032820] [ENSMUST00000099719] [ENSMUST00000110485] [ENSMUST00000122872] [ENSMUST00000145494] [ENSMUST00000148071] [ENSMUST00000151743]
Predicted Effect probably damaging
Transcript: ENSMUST00000032820
AA Change: K285Q

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000032820
Gene: ENSMUSG00000022228
AA Change: K285Q

DomainStartEndE-ValueType
ZnF_C2H2 144 166 1.58e-3 SMART
ZnF_C2H2 172 194 6.99e-5 SMART
ZnF_C2H2 200 222 1.67e-2 SMART
ZnF_C2H2 228 250 1.45e-2 SMART
ZnF_C2H2 256 278 2.53e-2 SMART
ZnF_C2H2 284 306 5.14e-3 SMART
ZnF_C2H2 312 334 2.95e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000099719
SMART Domains Protein: ENSMUSP00000097307
Gene: ENSMUSG00000055313

DomainStartEndE-ValueType
Blast:SCAN 1 65 7e-14 BLAST
low complexity region 192 204 N/A INTRINSIC
Pfam:DDE_Tnp_1_7 250 411 1.1e-45 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000110485
AA Change: K411Q

PolyPhen 2 Score 0.561 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000106111
Gene: ENSMUSG00000022228
AA Change: K411Q

DomainStartEndE-ValueType
SCAN 38 151 1.58e-48 SMART
ZnF_C2H2 270 292 1.58e-3 SMART
ZnF_C2H2 298 320 6.99e-5 SMART
ZnF_C2H2 326 348 1.67e-2 SMART
ZnF_C2H2 354 376 1.45e-2 SMART
ZnF_C2H2 382 404 2.53e-2 SMART
ZnF_C2H2 410 432 5.14e-3 SMART
ZnF_C2H2 438 460 2.95e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000122641
Predicted Effect probably benign
Transcript: ENSMUST00000122872
SMART Domains Protein: ENSMUSP00000120175
Gene: ENSMUSG00000055313

DomainStartEndE-ValueType
Blast:SCAN 1 65 1e-13 BLAST
low complexity region 155 167 N/A INTRINSIC
Pfam:DDE_Tnp_1_7 213 374 1.4e-42 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000122926
Predicted Effect probably benign
Transcript: ENSMUST00000145494
SMART Domains Protein: ENSMUSP00000118503
Gene: ENSMUSG00000055313

DomainStartEndE-ValueType
Blast:SCAN 1 65 8e-15 BLAST
low complexity region 192 204 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000148071
SMART Domains Protein: ENSMUSP00000114882
Gene: ENSMUSG00000055313

DomainStartEndE-ValueType
Blast:SCAN 1 65 3e-16 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000151743
SMART Domains Protein: ENSMUSP00000117669
Gene: ENSMUSG00000055313

DomainStartEndE-ValueType
Blast:SCAN 1 65 7e-14 BLAST
low complexity region 192 204 N/A INTRINSIC
Pfam:DDE_Tnp_1_7 250 411 1.7e-42 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930546C10Rik T A 18: 68,950,102 R14* probably null Het
Abcb5 A G 12: 118,907,601 S688P probably benign Het
Adgb T A 10: 10,406,099 Q597L possibly damaging Het
Aga G A 8: 53,518,921 V210I probably benign Het
Akap17b A G X: 36,612,310 S515P probably damaging Het
Brinp3 A T 1: 146,901,167 T451S probably benign Het
Cabcoco1 G T 10: 68,541,805 T18N possibly damaging Het
Ccar2 C T 14: 70,142,531 W402* probably null Het
Ccdc15 G A 9: 37,320,473 A185V probably damaging Het
Ccdc50 G A 16: 27,409,352 E90K probably damaging Het
Cckbr G A 7: 105,434,242 M217I probably benign Het
Clec16a A G 16: 10,694,649 T398A possibly damaging Het
Col4a1 A G 8: 11,240,076 probably benign Het
Cyp4v3 T A 8: 45,307,021 E498V probably damaging Het
Dgke T C 11: 89,041,501 I488V probably benign Het
Dip2c A G 13: 9,567,898 D443G probably damaging Het
Edem3 T G 1: 151,818,513 S852A probably benign Het
Fbxo8 T A 8: 56,588,023 M158K probably benign Het
Galnt15 C T 14: 32,052,356 T359M possibly damaging Het
Herc6 A G 6: 57,607,145 N330D probably benign Het
Kdf1 T C 4: 133,528,157 S62P probably damaging Het
Larp4 T A 15: 99,987,421 I51N probably damaging Het
Mfsd6l T A 11: 68,556,473 I50N probably damaging Het
Mroh2b A G 15: 4,899,197 Y4C probably benign Het
Muc3 G T 5: 137,137,123 Y343* probably null Het
Myom2 A C 8: 15,114,289 probably null Het
Npat A T 9: 53,572,649 probably benign Het
Pamr1 A T 2: 102,642,272 I639F possibly damaging Het
Pcsk2 A G 2: 143,793,239 S345G probably damaging Het
Pcyt1a A G 16: 32,467,101 T197A probably damaging Het
Pkd1 A G 17: 24,565,427 M316V probably benign Het
Plekhs1 T C 19: 56,464,599 probably null Het
Sema3e G T 5: 14,240,572 R557M probably damaging Het
Sgsm1 T C 5: 113,276,142 N154S probably benign Het
Smg1 A T 7: 118,185,483 probably benign Het
Sp110 A C 1: 85,577,329 F434C probably benign Het
Spats1 A T 17: 45,454,085 probably null Het
Tnfaip6 T G 2: 52,055,847 V235G probably damaging Het
Trim34a A T 7: 104,261,331 T447S probably damaging Het
Tut1 G A 19: 8,959,096 A95T probably damaging Het
Urgcp C T 11: 5,716,448 R630Q possibly damaging Het
Vmn1r125 G T 7: 21,272,181 M1I probably null Het
Vmn2r99 A G 17: 19,378,854 T267A probably benign Het
Wdr5 A G 2: 27,520,867 K162E probably benign Het
Other mutations in Zscan26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00720:Zscan26 APN 13 21445199 missense probably benign 0.00
R0558:Zscan26 UTSW 13 21445055 missense probably benign 0.37
R1236:Zscan26 UTSW 13 21445770 missense probably benign
R1912:Zscan26 UTSW 13 21445140 missense possibly damaging 0.84
R4692:Zscan26 UTSW 13 21445257 missense probably damaging 1.00
R5818:Zscan26 UTSW 13 21445761 missense probably benign 0.00
R6089:Zscan26 UTSW 13 21448329 missense probably damaging 0.97
R8029:Zscan26 UTSW 13 21445350 missense probably damaging 1.00
Z1088:Zscan26 UTSW 13 21445463 missense probably damaging 1.00
Posted On2015-08-05