Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL00503:Galnt15'

332502

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Galnt15

Ensembl Gene

ENSMUSG00000021903

Gene Name

polypeptide N-acetylgalactosaminyltransferase 15

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.068) question?

Stock #

IGL00503

Quality Score

Status

Chromosome

Chromosomal Location

32028989-32062197 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 32052356 bp

Zygosity

Heterozygous

Amino Acid Change

Threonine to Methionine at position 359 (T359M)

Ref Sequence

ENSEMBL: ENSMUSP00000131978 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000022460] [ENSMUST00000164208]

Predicted Effect

probably benign
Transcript: ENSMUST00000022460
AA Change: T483M

PolyPhen 2 Score 0.134 (Sensitivity: 0.92; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000022460
Gene: ENSMUSG00000021903
AA Change: T483M

Domain	Start	End	E-Value	Type
transmembrane domain	13	35	N/A	INTRINSIC
low complexity region	105	116	N/A	INTRINSIC
low complexity region	166	180	N/A	INTRINSIC
Pfam:Glyco_tranf_2_3	191	436	2e-8	PFAM
Pfam:Glycos_transf_2	194	362	9e-32	PFAM
RICIN	505	630	1.19e-6	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000164208
AA Change: T359M

PolyPhen 2 Score 0.473 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000131978
Gene: ENSMUSG00000021903
AA Change: T359M

Domain	Start	End	E-Value	Type
transmembrane domain	13	35	N/A	INTRINSIC
low complexity region	105	116	N/A	INTRINSIC
low complexity region	166	180	N/A	INTRINSIC
low complexity region	228	248	N/A	INTRINSIC
RICIN	381	506	1.19e-6	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930546C10Rik	T	A	18: 68,950,102	R14*	probably null	Het
Abcb5	A	G	12: 118,907,601	S688P	probably benign	Het
Adgb	T	A	10: 10,406,099	Q597L	possibly damaging	Het
Aga	G	A	8: 53,518,921	V210I	probably benign	Het
Akap17b	A	G	X: 36,612,310	S515P	probably damaging	Het
Brinp3	A	T	1: 146,901,167	T451S	probably benign	Het
Cabcoco1	G	T	10: 68,541,805	T18N	possibly damaging	Het
Ccar2	C	T	14: 70,142,531	W402*	probably null	Het
Ccdc15	G	A	9: 37,320,473	A185V	probably damaging	Het
Ccdc50	G	A	16: 27,409,352	E90K	probably damaging	Het
Cckbr	G	A	7: 105,434,242	M217I	probably benign	Het
Clec16a	A	G	16: 10,694,649	T398A	possibly damaging	Het
Col4a1	A	G	8: 11,240,076		probably benign	Het
Cyp4v3	T	A	8: 45,307,021	E498V	probably damaging	Het
Dgke	T	C	11: 89,041,501	I488V	probably benign	Het
Dip2c	A	G	13: 9,567,898	D443G	probably damaging	Het
Edem3	T	G	1: 151,818,513	S852A	probably benign	Het
Fbxo8	T	A	8: 56,588,023	M158K	probably benign	Het
Herc6	A	G	6: 57,607,145	N330D	probably benign	Het
Kdf1	T	C	4: 133,528,157	S62P	probably damaging	Het
Larp4	T	A	15: 99,987,421	I51N	probably damaging	Het
Mfsd6l	T	A	11: 68,556,473	I50N	probably damaging	Het
Mroh2b	A	G	15: 4,899,197	Y4C	probably benign	Het
Muc3	G	T	5: 137,137,123	Y343*	probably null	Het
Myom2	A	C	8: 15,114,289		probably null	Het
Npat	A	T	9: 53,572,649		probably benign	Het
Pamr1	A	T	2: 102,642,272	I639F	possibly damaging	Het
Pcsk2	A	G	2: 143,793,239	S345G	probably damaging	Het
Pcyt1a	A	G	16: 32,467,101	T197A	probably damaging	Het
Pkd1	A	G	17: 24,565,427	M316V	probably benign	Het
Plekhs1	T	C	19: 56,464,599		probably null	Het
Sema3e	G	T	5: 14,240,572	R557M	probably damaging	Het
Sgsm1	T	C	5: 113,276,142	N154S	probably benign	Het
Smg1	A	T	7: 118,185,483		probably benign	Het
Sp110	A	C	1: 85,577,329	F434C	probably benign	Het
Spats1	A	T	17: 45,454,085		probably null	Het
Tnfaip6	T	G	2: 52,055,847	V235G	probably damaging	Het
Trim34a	A	T	7: 104,261,331	T447S	probably damaging	Het
Tut1	G	A	19: 8,959,096	A95T	probably damaging	Het
Urgcp	C	T	11: 5,716,448	R630Q	possibly damaging	Het
Vmn1r125	G	T	7: 21,272,181	M1I	probably null	Het
Vmn2r99	A	G	17: 19,378,854	T267A	probably benign	Het
Wdr5	A	G	2: 27,520,867	K162E	probably benign	Het
Zscan26	T	G	13: 21,445,101	K285Q	probably damaging	Het

Other mutations in Galnt15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02491:Galnt15	APN	14	32056316	missense	probably damaging	1.00
R0323:Galnt15	UTSW	14	32048085	missense	probably damaging	0.99
R1900:Galnt15	UTSW	14	32049865	missense	probably damaging	1.00
R4369:Galnt15	UTSW	14	32029539	missense	possibly damaging	0.90
R4423:Galnt15	UTSW	14	32058269	missense	possibly damaging	0.95
R4979:Galnt15	UTSW	14	32043290	missense	probably damaging	0.99
R5093:Galnt15	UTSW	14	32049829	missense	probably damaging	1.00
R5201:Galnt15	UTSW	14	32049865	missense	probably damaging	1.00
R5254:Galnt15	UTSW	14	32058287	nonsense	probably null
R5434:Galnt15	UTSW	14	32049843	missense	possibly damaging	0.88
R5451:Galnt15	UTSW	14	32029911	missense	probably benign	0.25
R5495:Galnt15	UTSW	14	32029817	missense	probably damaging	0.97
R5874:Galnt15	UTSW	14	32052367	missense	probably damaging	1.00
R6374:Galnt15	UTSW	14	32058159	missense	probably damaging	0.96
R6444:Galnt15	UTSW	14	32040411	missense	probably damaging	1.00
R7798:Galnt15	UTSW	14	32029905	missense	possibly damaging	0.52
Z1177:Galnt15	UTSW	14	32052365	missense	probably damaging	1.00

Posted On

2015-08-05