Incidental Mutation 'IGL00503:Muc3'
ID332505
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Muc3
Ensembl Gene ENSMUSG00000037390
Gene Namemucin 3, intestinal
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.072) question?
Stock #IGL00503
Quality Score
Status
Chromosome5
Chromosomal Location137134922-137149322 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) G to T at 137137123 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Stop codon at position 343 (Y343*)
Ref Sequence ENSEMBL: ENSMUSP00000045196 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041226]
Predicted Effect probably null
Transcript: ENSMUST00000041226
AA Change: Y343*
SMART Domains Protein: ENSMUSP00000045196
Gene: ENSMUSG00000037390
AA Change: Y343*

DomainStartEndE-ValueType
low complexity region 1 62 N/A INTRINSIC
EGF_like 85 118 3.64e1 SMART
SEA 128 241 3.05e-32 SMART
EGF_like 290 331 3.72e1 SMART
transmembrane domain 340 362 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160630
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930546C10Rik T A 18: 68,950,102 R14* probably null Het
Abcb5 A G 12: 118,907,601 S688P probably benign Het
Adgb T A 10: 10,406,099 Q597L possibly damaging Het
Aga G A 8: 53,518,921 V210I probably benign Het
Akap17b A G X: 36,612,310 S515P probably damaging Het
Brinp3 A T 1: 146,901,167 T451S probably benign Het
Cabcoco1 G T 10: 68,541,805 T18N possibly damaging Het
Ccar2 C T 14: 70,142,531 W402* probably null Het
Ccdc15 G A 9: 37,320,473 A185V probably damaging Het
Ccdc50 G A 16: 27,409,352 E90K probably damaging Het
Cckbr G A 7: 105,434,242 M217I probably benign Het
Clec16a A G 16: 10,694,649 T398A possibly damaging Het
Col4a1 A G 8: 11,240,076 probably benign Het
Cyp4v3 T A 8: 45,307,021 E498V probably damaging Het
Dgke T C 11: 89,041,501 I488V probably benign Het
Dip2c A G 13: 9,567,898 D443G probably damaging Het
Edem3 T G 1: 151,818,513 S852A probably benign Het
Fbxo8 T A 8: 56,588,023 M158K probably benign Het
Galnt15 C T 14: 32,052,356 T359M possibly damaging Het
Herc6 A G 6: 57,607,145 N330D probably benign Het
Kdf1 T C 4: 133,528,157 S62P probably damaging Het
Larp4 T A 15: 99,987,421 I51N probably damaging Het
Mfsd6l T A 11: 68,556,473 I50N probably damaging Het
Mroh2b A G 15: 4,899,197 Y4C probably benign Het
Myom2 A C 8: 15,114,289 probably null Het
Npat A T 9: 53,572,649 probably benign Het
Pamr1 A T 2: 102,642,272 I639F possibly damaging Het
Pcsk2 A G 2: 143,793,239 S345G probably damaging Het
Pcyt1a A G 16: 32,467,101 T197A probably damaging Het
Pkd1 A G 17: 24,565,427 M316V probably benign Het
Plekhs1 T C 19: 56,464,599 probably null Het
Sema3e G T 5: 14,240,572 R557M probably damaging Het
Sgsm1 T C 5: 113,276,142 N154S probably benign Het
Smg1 A T 7: 118,185,483 probably benign Het
Sp110 A C 1: 85,577,329 F434C probably benign Het
Spats1 A T 17: 45,454,085 probably null Het
Tnfaip6 T G 2: 52,055,847 V235G probably damaging Het
Trim34a A T 7: 104,261,331 T447S probably damaging Het
Tut1 G A 19: 8,959,096 A95T probably damaging Het
Urgcp C T 11: 5,716,448 R630Q possibly damaging Het
Vmn1r125 G T 7: 21,272,181 M1I probably null Het
Vmn2r99 A G 17: 19,378,854 T267A probably benign Het
Wdr5 A G 2: 27,520,867 K162E probably benign Het
Zscan26 T G 13: 21,445,101 K285Q probably damaging Het
Other mutations in Muc3
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0256:Muc3 UTSW 5 137146691 missense probably damaging 1.00
R0884:Muc3 UTSW 5 137142298 missense possibly damaging 0.88
R1368:Muc3 UTSW 5 137146826 splice site probably benign
R1456:Muc3 UTSW 5 137137951 missense probably benign 0.01
R1670:Muc3 UTSW 5 137143995 missense probably benign 0.22
R2401:Muc3 UTSW 5 137154041 unclassified probably benign
R2698:Muc3 UTSW 5 137146636 missense probably damaging 0.99
R4637:Muc3 UTSW 5 137146654 missense probably damaging 0.98
R5128:Muc3 UTSW 5 137138186 critical splice donor site probably null
R5323:Muc3 UTSW 5 137146689 nonsense probably null
R5601:Muc3 UTSW 5 137138015 missense probably damaging 1.00
R5967:Muc3 UTSW 5 137146637 missense probably benign 0.03
R6480:Muc3 UTSW 5 137142390 missense probably damaging 1.00
R7777:Muc3 UTSW 5 137146716 synonymous silent
R7868:Muc3 UTSW 5 137146777 missense
R7974:Muc3 UTSW 5 137146816 missense
R8393:Muc3 UTSW 5 137142331 missense
R8415:Muc3 UTSW 5 137143950 missense
R8419:Muc3 UTSW 5 137146722 missense
Posted On2015-08-05