Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00550:Zfp984'

332588

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp984

Ensembl Gene

ENSMUSG00000078495

Gene Name

zinc finger protein 984

Synonyms

Gm13157

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.501) question?

Stock #

IGL00550

Quality Score

Status

Chromosome

Chromosomal Location

147838431-147894245 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 147839343 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Serine at position 503 (G503S)

Ref Sequence

ENSEMBL: ENSMUSP00000114023 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000105734] [ENSMUST00000122309]

AlphaFold

A2A7A2

Predicted Effect

probably benign
Transcript: ENSMUST00000105734
AA Change: G503S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000101360
Gene: ENSMUSG00000078495
AA Change: G503S

Domain	Start	End	E-Value	Type
KRAB	13	72	5.24e-18	SMART
ZnF_C2H2	238	260	1.69e-3	SMART
ZnF_C2H2	266	288	1.18e-2	SMART
ZnF_C2H2	294	316	1.38e-3	SMART
ZnF_C2H2	322	344	1.58e-3	SMART
ZnF_C2H2	350	372	4.24e-4	SMART
ZnF_C2H2	378	400	3.69e-4	SMART
ZnF_C2H2	406	428	1.58e-3	SMART
ZnF_C2H2	434	456	3.39e-3	SMART
ZnF_C2H2	462	484	1.3e-4	SMART
ZnF_C2H2	490	512	1.4e-4	SMART
ZnF_C2H2	518	540	4.79e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000122309
AA Change: G503S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000114023
Gene: ENSMUSG00000078495
AA Change: G503S

Domain	Start	End	E-Value	Type
KRAB	13	72	5.24e-18	SMART
ZnF_C2H2	238	260	1.69e-3	SMART
ZnF_C2H2	266	288	1.18e-2	SMART
ZnF_C2H2	294	316	1.38e-3	SMART
ZnF_C2H2	322	344	1.58e-3	SMART
ZnF_C2H2	350	372	4.24e-4	SMART
ZnF_C2H2	378	400	3.69e-4	SMART
ZnF_C2H2	406	428	1.58e-3	SMART
ZnF_C2H2	434	456	3.39e-3	SMART
ZnF_C2H2	462	484	1.3e-4	SMART
ZnF_C2H2	490	512	1.4e-4	SMART
ZnF_C2H2	518	540	4.79e-3	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 6 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Atg13	A	T	2: 91,522,804 (GRCm39)	M80K	probably damaging	Het
Ccr1	T	C	9: 123,763,673 (GRCm39)	T286A	probably damaging	Het
Hoxd11	A	G	2: 74,514,385 (GRCm39)	D305G	probably damaging	Het
Nup85	A	G	11: 115,472,582 (GRCm39)	K213E	probably damaging	Het
Samd9l	G	T	6: 3,374,594 (GRCm39)	T889K	probably benign	Het
Tas2r138	A	G	6: 40,589,520 (GRCm39)	I242T	probably benign	Het

Other mutations in Zfp984

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00428:Zfp984	APN	4	147,839,343 (GRCm39)	missense	probably benign	0.00
IGL00469:Zfp984	APN	4	147,839,343 (GRCm39)	missense	probably benign	0.00
PIT4791001:Zfp984	UTSW	4	147,840,603 (GRCm39)	missense	probably benign	0.15
R0281:Zfp984	UTSW	4	147,839,722 (GRCm39)	missense	probably benign
R0731:Zfp984	UTSW	4	147,840,689 (GRCm39)	missense	probably damaging	1.00
R1170:Zfp984	UTSW	4	147,840,446 (GRCm39)	missense	probably benign	0.24
R1293:Zfp984	UTSW	4	147,840,398 (GRCm39)	missense	possibly damaging	0.85
R1518:Zfp984	UTSW	4	147,840,002 (GRCm39)	missense	probably benign
R2041:Zfp984	UTSW	4	147,839,796 (GRCm39)	missense	probably damaging	1.00
R2360:Zfp984	UTSW	4	147,839,234 (GRCm39)	missense	possibly damaging	0.92
R5038:Zfp984	UTSW	4	147,839,903 (GRCm39)	missense	probably damaging	1.00
R5554:Zfp984	UTSW	4	147,840,362 (GRCm39)	missense	probably benign	0.00
R6254:Zfp984	UTSW	4	147,840,643 (GRCm39)	missense	possibly damaging	0.76
R6418:Zfp984	UTSW	4	147,845,703 (GRCm39)	missense	probably benign	0.00
R6527:Zfp984	UTSW	4	147,840,381 (GRCm39)	missense	probably benign	0.45
R6974:Zfp984	UTSW	4	147,845,707 (GRCm39)	start codon destroyed	possibly damaging	0.94
R7058:Zfp984	UTSW	4	147,840,002 (GRCm39)	missense	probably benign
R7495:Zfp984	UTSW	4	147,839,287 (GRCm39)	missense	possibly damaging	0.94
R7843:Zfp984	UTSW	4	147,842,165 (GRCm39)	missense	probably damaging	1.00
R8462:Zfp984	UTSW	4	147,839,796 (GRCm39)	missense	probably damaging	1.00
R8520:Zfp984	UTSW	4	147,840,668 (GRCm39)	missense	probably benign	0.01
R8918:Zfp984	UTSW	4	147,840,623 (GRCm39)	missense	possibly damaging	0.88
R9387:Zfp984	UTSW	4	147,840,002 (GRCm39)	missense	probably benign
Z1176:Zfp984	UTSW	4	147,839,921 (GRCm39)	missense	probably benign	0.00
Z1177:Zfp984	UTSW	4	147,840,577 (GRCm39)	missense	probably benign	0.04

Posted On

2015-08-05