Incidental Mutation 'IGL00557:Gm12258'
ID332602
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm12258
Ensembl Gene ENSMUSG00000072915
Gene Namepredicted gene 12258
Synonyms
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00557
Quality Score
Status
Chromosome11
Chromosomal Location58847158-58861956 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 58856070 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 51 (D51G)
Ref Sequence ENSEMBL: ENSMUSP00000117644 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093768] [ENSMUST00000139337]
Predicted Effect probably benign
Transcript: ENSMUST00000093768
SMART Domains Protein: ENSMUSP00000091282
Gene: ENSMUSG00000072915

DomainStartEndE-ValueType
ZnF_C2H2 8 30 5.21e-4 SMART
ZnF_C2H2 36 58 1.03e-2 SMART
ZnF_C2H2 64 86 2.4e-3 SMART
ZnF_C2H2 92 114 4.17e-3 SMART
ZnF_C2H2 120 142 8.34e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000139337
AA Change: D51G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000117644
Gene: ENSMUSG00000072915
AA Change: D51G

DomainStartEndE-ValueType
KRAB 56 116 1.8e-32 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143407
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932431P20Rik A G 7: 29,535,802 noncoding transcript Het
Agpat3 A T 10: 78,273,682 probably benign Het
Arhgap35 T C 7: 16,564,415 T242A probably benign Het
Asb15 C A 6: 24,558,650 R55S probably benign Het
Brca2 C T 5: 150,560,538 R2941W probably benign Het
Chrng T C 1: 87,206,747 V135A probably damaging Het
Corin G T 5: 72,304,888 H859Q probably damaging Het
Cul7 A G 17: 46,652,508 E208G probably damaging Het
Dnah6 T C 6: 73,195,620 N285S possibly damaging Het
Ell2 T A 13: 75,756,290 I166N probably damaging Het
Fsip2 A G 2: 82,991,313 R5797G possibly damaging Het
Galntl6 T C 8: 58,911,417 I20V possibly damaging Het
Glra2 A G X: 165,289,637 F78L possibly damaging Het
Gsta2 T A 9: 78,331,243 K185* probably null Het
Hmgcr C T 13: 96,659,278 D294N probably benign Het
Iglv2 A G 16: 19,260,797 probably benign Het
Myo10 T A 15: 25,776,380 L63H probably damaging Het
P2ry10b T C X: 107,171,637 V201A probably benign Het
Psmb2 A G 4: 126,677,849 probably null Het
Samd4 T A 14: 47,052,898 L154H probably damaging Het
Sult2a4 A T 7: 13,984,945 D124E probably damaging Het
Trav9-1 A T 14: 53,488,358 Y43F probably damaging Het
Trpv2 A G 11: 62,592,855 N506S probably damaging Het
Ube3c T C 5: 29,619,229 S474P probably damaging Het
Zfp942 A T 17: 21,929,061 C196S probably benign Het
Other mutations in Gm12258
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01391:Gm12258 APN 11 58848694 missense probably benign 0.03
IGL03081:Gm12258 APN 11 58858259 missense probably benign 0.07
R1521:Gm12258 UTSW 11 58859555 missense probably damaging 1.00
R1653:Gm12258 UTSW 11 58858287 missense possibly damaging 0.68
R3895:Gm12258 UTSW 11 58858549 nonsense probably null
R4065:Gm12258 UTSW 11 58858526 missense probably benign 0.08
R4066:Gm12258 UTSW 11 58858526 missense probably benign 0.08
R4747:Gm12258 UTSW 11 58859596 missense probably damaging 1.00
R4803:Gm12258 UTSW 11 58859030 missense probably benign 0.06
R5554:Gm12258 UTSW 11 58858468 missense possibly damaging 0.92
R5896:Gm12258 UTSW 11 58859631 missense probably damaging 1.00
R5956:Gm12258 UTSW 11 58859459 missense probably benign 0.02
R6277:Gm12258 UTSW 11 58854287 missense probably damaging 1.00
R7166:Gm12258 UTSW 11 58858473 missense
R7728:Gm12258 UTSW 11 58859692 missense unknown
R8161:Gm12258 UTSW 11 58859312 missense unknown
R8268:Gm12258 UTSW 11 58854258 critical splice acceptor site probably null
R8491:Gm12258 UTSW 11 58854296 missense
Z1186:Gm12258 UTSW 11 58858300 missense
Z1186:Gm12258 UTSW 11 58858436 missense
Z1186:Gm12258 UTSW 11 58858938 missense unknown
Z1186:Gm12258 UTSW 11 58858950 missense unknown
Z1186:Gm12258 UTSW 11 58859007 missense unknown
Z1186:Gm12258 UTSW 11 58859187 unclassified probably benign
Z1186:Gm12258 UTSW 11 58859188 unclassified probably benign
Z1186:Gm12258 UTSW 11 58859864 missense unknown
Z1187:Gm12258 UTSW 11 58858300 missense
Z1187:Gm12258 UTSW 11 58858436 missense
Z1187:Gm12258 UTSW 11 58858938 missense unknown
Z1187:Gm12258 UTSW 11 58858950 missense unknown
Z1187:Gm12258 UTSW 11 58859007 missense unknown
Z1187:Gm12258 UTSW 11 58859187 unclassified probably benign
Z1187:Gm12258 UTSW 11 58859188 unclassified probably benign
Z1187:Gm12258 UTSW 11 58859864 missense unknown
Z1188:Gm12258 UTSW 11 58858300 missense
Z1188:Gm12258 UTSW 11 58858436 missense
Z1188:Gm12258 UTSW 11 58858938 missense unknown
Z1188:Gm12258 UTSW 11 58858950 missense unknown
Z1188:Gm12258 UTSW 11 58859007 missense unknown
Z1188:Gm12258 UTSW 11 58859187 unclassified probably benign
Z1188:Gm12258 UTSW 11 58859188 unclassified probably benign
Z1188:Gm12258 UTSW 11 58859864 missense unknown
Z1189:Gm12258 UTSW 11 58858300 missense
Z1189:Gm12258 UTSW 11 58858436 missense
Z1189:Gm12258 UTSW 11 58858938 missense unknown
Z1189:Gm12258 UTSW 11 58858950 missense unknown
Z1189:Gm12258 UTSW 11 58859007 missense unknown
Z1189:Gm12258 UTSW 11 58859187 unclassified probably benign
Z1189:Gm12258 UTSW 11 58859188 unclassified probably benign
Z1189:Gm12258 UTSW 11 58859864 missense unknown
Z1190:Gm12258 UTSW 11 58858300 missense
Z1190:Gm12258 UTSW 11 58858436 missense
Z1190:Gm12258 UTSW 11 58858938 missense unknown
Z1190:Gm12258 UTSW 11 58858950 missense unknown
Z1190:Gm12258 UTSW 11 58859007 missense unknown
Z1190:Gm12258 UTSW 11 58859187 unclassified probably benign
Z1190:Gm12258 UTSW 11 58859188 unclassified probably benign
Z1190:Gm12258 UTSW 11 58859864 missense unknown
Z1191:Gm12258 UTSW 11 58858300 missense
Z1191:Gm12258 UTSW 11 58858436 missense
Z1191:Gm12258 UTSW 11 58858938 missense unknown
Z1191:Gm12258 UTSW 11 58858950 missense unknown
Z1191:Gm12258 UTSW 11 58859007 missense unknown
Z1191:Gm12258 UTSW 11 58859187 unclassified probably benign
Z1191:Gm12258 UTSW 11 58859188 unclassified probably benign
Z1191:Gm12258 UTSW 11 58859864 missense unknown
Z1192:Gm12258 UTSW 11 58858300 missense
Z1192:Gm12258 UTSW 11 58858436 missense
Z1192:Gm12258 UTSW 11 58858938 missense unknown
Z1192:Gm12258 UTSW 11 58858950 missense unknown
Z1192:Gm12258 UTSW 11 58859007 missense unknown
Z1192:Gm12258 UTSW 11 58859187 unclassified probably benign
Z1192:Gm12258 UTSW 11 58859188 unclassified probably benign
Z1192:Gm12258 UTSW 11 58859864 missense unknown
Posted On2015-08-05