Incidental Mutation 'IGL00562:Trav13n-4'
ID332613
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trav13n-4
Ensembl Gene ENSMUSG00000076823
Gene NameT cell receptor alpha variable 13N-4
SynonymsGm10907, ENSMUSG00000072517
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.046) question?
Stock #IGL00562
Quality Score
Status
Chromosome14
Chromosomal Location53363836-53364102 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to G at 53363966 bp
ZygosityHeterozygous
Amino Acid Change Valine to Glycine at position 64 (V64G)
Ref Sequence ENSEMBL: ENSMUSP00000143372 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103634] [ENSMUST00000196105]
Predicted Effect possibly damaging
Transcript: ENSMUST00000103634
AA Change: V44G

PolyPhen 2 Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000100411
Gene: ENSMUSG00000076823
AA Change: V44G

DomainStartEndE-ValueType
IGv 18 89 2.89e-9 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000196105
AA Change: V64G

PolyPhen 2 Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000143372
Gene: ENSMUSG00000076823
AA Change: V64G

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
IGv 38 109 1.2e-11 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1500035N22Rik T C 5: 24,997,621 probably benign Het
AU016765 C A 17: 64,519,882 noncoding transcript Het
Chaf1b T C 16: 93,900,191 probably benign Het
Clstn2 A G 9: 97,582,452 probably benign Het
Crip1 T A 12: 113,153,612 probably null Het
Cubn A G 2: 13,294,230 S3211P probably benign Het
Dlx6 C T 6: 6,865,143 R172W probably damaging Het
Fktn A T 4: 53,747,007 probably null Het
Focad T A 4: 88,348,809 M1019K unknown Het
Fuca2 A T 10: 13,505,907 D188V probably damaging Het
Kcna3 A G 3: 107,036,730 D103G probably damaging Het
Mrpl19 A G 6: 81,965,872 V19A probably benign Het
Ndufb3 T A 1: 58,595,799 H103Q possibly damaging Het
Pkd1l3 T C 8: 109,656,147 V1675A possibly damaging Het
Ptger4 A T 15: 5,243,133 S2T probably benign Het
Saxo1 C T 4: 86,445,572 E225K probably damaging Het
Sftpb G T 6: 72,309,862 A228S probably benign Het
Slc22a29 T A 19: 8,161,629 T490S probably benign Het
Slc29a1 T C 17: 45,589,992 N50S probably damaging Het
Smc6 T A 12: 11,301,531 S854T probably benign Het
Smim23 T C 11: 32,821,893 T58A probably benign Het
Tas2r134 T C 2: 51,628,088 I193T possibly damaging Het
Thsd7a G T 6: 12,379,659 probably null Het
Trmt10a G A 3: 138,147,416 E13K probably damaging Het
Txndc11 T C 16: 11,104,632 S239G probably damaging Het
Vmn2r96 T A 17: 18,583,815 N442K probably benign Het
Vps13a C T 19: 16,734,714 probably null Het
Other mutations in Trav13n-4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00429:Trav13n-4 APN 14 53363831 missense probably benign 0.03
IGL00563:Trav13n-4 APN 14 53363966 missense possibly damaging 0.94
IGL01620:Trav13n-4 APN 14 53364016 missense probably damaging 0.99
IGL01748:Trav13n-4 APN 14 53364013 missense probably benign 0.15
IGL02327:Trav13n-4 APN 14 53364110 unclassified probably benign
R4197:Trav13n-4 UTSW 14 53363921 missense probably benign
R5467:Trav13n-4 UTSW 14 53363846 missense probably damaging 1.00
R6765:Trav13n-4 UTSW 14 53364100 missense probably benign
R6845:Trav13n-4 UTSW 14 53362399 missense probably damaging 1.00
Posted On2015-08-05