Incidental Mutation 'IGL00575:Mrgpra9'
ID332677
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mrgpra9
Ensembl Gene ENSMUSG00000074111
Gene NameMAS-related GPR, member A9
SynonymsEG668725, MrgA9
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.050) question?
Stock #IGL00575
Quality Score
Status
Chromosome7
Chromosomal Location47234861-47252848 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 47235305 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 205 (F205I)
Ref Sequence ENSEMBL: ENSMUSP00000136396 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098436] [ENSMUST00000179005]
Predicted Effect possibly damaging
Transcript: ENSMUST00000098436
AA Change: F204I

PolyPhen 2 Score 0.762 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000096035
Gene: ENSMUSG00000074111
AA Change: F204I

DomainStartEndE-ValueType
low complexity region 37 48 N/A INTRINSIC
Pfam:7tm_1 56 225 1.5e-11 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000179005
AA Change: F205I

PolyPhen 2 Score 0.762 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000136396
Gene: ENSMUSG00000074111
AA Change: F205I

DomainStartEndE-ValueType
Pfam:7tm_1 12 178 3.4e-9 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 9 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931408C20Rik T A 1: 26,682,932 T1056S possibly damaging Het
Fabp9 A G 3: 10,193,783 V99A probably damaging Het
Gm906 C A 13: 50,246,716 G525W probably damaging Het
Gramd1b T A 9: 40,327,411 probably benign Het
Nav3 A T 10: 109,764,765 S1334T probably damaging Het
Pglyrp4 A T 3: 90,730,791 Q137H probably damaging Het
Serpinb1c T C 13: 32,883,975 K213E probably damaging Het
Tubb2b A G 13: 34,129,261 Y51H probably damaging Het
Zfp112 A T 7: 24,126,332 Y573F probably damaging Het
Other mutations in Mrgpra9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00095:Mrgpra9 APN 7 47235091 missense possibly damaging 0.85
IGL01649:Mrgpra9 APN 7 47235152 missense probably benign 0.22
IGL03207:Mrgpra9 APN 7 47235637 missense possibly damaging 0.68
R0388:Mrgpra9 UTSW 7 47252794 start codon destroyed probably null 0.08
R0972:Mrgpra9 UTSW 7 47235455 missense probably damaging 0.99
R1270:Mrgpra9 UTSW 7 47252783 critical splice donor site probably null
R1381:Mrgpra9 UTSW 7 47235302 missense possibly damaging 0.75
R1403:Mrgpra9 UTSW 7 47235638 missense probably benign 0.24
R1403:Mrgpra9 UTSW 7 47235638 missense probably benign 0.24
R1448:Mrgpra9 UTSW 7 47235813 missense probably benign 0.02
R2045:Mrgpra9 UTSW 7 47235835 missense probably benign
R2144:Mrgpra9 UTSW 7 47235463 missense probably benign 0.31
R2187:Mrgpra9 UTSW 7 47235049 missense probably damaging 1.00
R2507:Mrgpra9 UTSW 7 47235494 missense possibly damaging 0.63
R2913:Mrgpra9 UTSW 7 47235080 missense probably benign
R3810:Mrgpra9 UTSW 7 47235779 missense probably damaging 0.98
R4177:Mrgpra9 UTSW 7 47235554 missense probably damaging 1.00
R4521:Mrgpra9 UTSW 7 47235190 missense probably damaging 1.00
R4781:Mrgpra9 UTSW 7 47235047 missense possibly damaging 0.88
R4926:Mrgpra9 UTSW 7 47235011 missense possibly damaging 0.62
R6469:Mrgpra9 UTSW 7 47235106 missense probably benign 0.02
R6505:Mrgpra9 UTSW 7 47235136 missense probably benign 0.00
R6724:Mrgpra9 UTSW 7 47235038 missense probably damaging 1.00
R7398:Mrgpra9 UTSW 7 47235637 missense possibly damaging 0.68
Posted On2015-08-05