Incidental Mutation 'IGL00585:Zfp648'
ID332711
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp648
Ensembl Gene ENSMUSG00000066797
Gene Namezinc finger protein 648
SynonymsLOC207678, Gm10178
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.083) question?
Stock #IGL00585
Quality Score
Status
Chromosome1
Chromosomal Location154201187-154205689 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 154204189 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 31 (D31E)
Ref Sequence ENSEMBL: ENSMUSP00000083370 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086195]
Predicted Effect possibly damaging
Transcript: ENSMUST00000086195
AA Change: D31E

PolyPhen 2 Score 0.881 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000083370
Gene: ENSMUSG00000066797
AA Change: D31E

DomainStartEndE-ValueType
ZnF_C2H2 236 258 1.82e-3 SMART
ZnF_C2H2 264 286 1.28e-3 SMART
ZnF_C2H2 292 315 1.2e-3 SMART
ZnF_C2H2 321 343 1.95e-3 SMART
ZnF_C2H2 349 371 8.94e-3 SMART
ZnF_C2H2 377 399 8.34e-3 SMART
ZnF_C2H2 405 427 4.54e-4 SMART
ZnF_C2H2 433 455 4.47e-3 SMART
ZnF_C2H2 461 483 5.81e-2 SMART
ZnF_C2H2 489 511 1.2e-3 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 T A 17: 24,300,320 I664F probably damaging Het
Abcg4 A T 9: 44,281,623 M142K probably benign Het
Afdn A G 17: 13,884,628 T1198A probably damaging Het
Angptl2 T C 2: 33,246,227 S475P probably damaging Het
Ap3s2 T C 7: 79,916,076 E34G probably benign Het
C1qtnf9 T C 14: 60,779,993 F324S probably damaging Het
Cacng7 A G 7: 3,366,031 Y170C probably damaging Het
Ceacam18 G A 7: 43,637,011 V103M possibly damaging Het
Chrnb1 G A 11: 69,793,916 P144S probably damaging Het
Chuk T C 19: 44,078,312 H652R probably damaging Het
Ckap5 C T 2: 91,619,825 L1948F probably damaging Het
Clstn1 A T 4: 149,638,312 H469L probably benign Het
Csf2rb2 C T 15: 78,284,847 G594S possibly damaging Het
Ctsq A T 13: 61,037,127 D248E probably benign Het
Ep400 A T 5: 110,755,905 I276K possibly damaging Het
Gbf1 G A 19: 46,284,249 probably null Het
Gldn T A 9: 54,338,464 I433N probably damaging Het
Gm136 T A 4: 34,752,322 E69V probably damaging Het
Gm28177 T C 1: 52,082,579 probably null Het
Gtf2h2 A G 13: 100,480,998 probably benign Het
Ints12 T C 3: 133,100,809 probably null Het
Ltbp4 T C 7: 27,326,733 D615G probably damaging Het
Mgme1 C T 2: 144,271,989 P4S probably benign Het
Nae1 A G 8: 104,526,278 probably null Het
Nup133 G A 8: 123,909,994 A956V probably damaging Het
Oacyl T A 18: 65,749,640 M529K possibly damaging Het
Osbpl1a T A 18: 12,757,626 E519V possibly damaging Het
Pacs1 A T 19: 5,153,698 V333E probably damaging Het
Pik3c3 T G 18: 30,303,078 probably benign Het
Polh C T 17: 46,172,243 probably benign Het
Ppp6r3 A G 19: 3,490,826 C431R probably damaging Het
Pprc1 T C 19: 46,062,648 S206P possibly damaging Het
Rab20 A G 8: 11,454,212 Y163H probably benign Het
Sde2 T A 1: 180,855,818 C46S possibly damaging Het
Serpinb1c T C 13: 32,883,975 K213E probably damaging Het
Spata20 T G 11: 94,479,117 L784F probably damaging Het
Tnnt1 A C 7: 4,507,550 M224R possibly damaging Het
Trank1 T C 9: 111,349,290 F349L possibly damaging Het
Ttf1 T C 2: 29,073,883 probably benign Het
Usp54 T A 14: 20,573,837 S651C probably damaging Het
Vps45 A G 3: 96,000,066 *571R probably null Het
Yod1 G A 1: 130,719,133 G249E probably damaging Het
Ythdc2 A G 18: 44,864,361 Y340C probably damaging Het
Zfp366 G A 13: 99,246,572 probably benign Het
Other mutations in Zfp648
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01150:Zfp648 APN 1 154205364 missense probably damaging 1.00
IGL01557:Zfp648 APN 1 154204680 missense probably benign
IGL01757:Zfp648 APN 1 154204925 missense probably damaging 0.98
IGL02247:Zfp648 APN 1 154204177 missense probably benign 0.01
PIT4519001:Zfp648 UTSW 1 154204941 missense probably damaging 0.98
R0001:Zfp648 UTSW 1 154205286 missense probably damaging 1.00
R0256:Zfp648 UTSW 1 154205668 missense probably benign 0.08
R0266:Zfp648 UTSW 1 154204886 missense probably damaging 1.00
R0371:Zfp648 UTSW 1 154204667 missense possibly damaging 0.66
R1498:Zfp648 UTSW 1 154205373 missense probably damaging 1.00
R1562:Zfp648 UTSW 1 154204392 missense probably benign
R1687:Zfp648 UTSW 1 154204242 missense probably benign 0.15
R2128:Zfp648 UTSW 1 154204607 missense probably benign
R2427:Zfp648 UTSW 1 154205073 missense probably damaging 1.00
R2567:Zfp648 UTSW 1 154204949 missense probably damaging 0.98
R2844:Zfp648 UTSW 1 154205135 nonsense probably null
R3711:Zfp648 UTSW 1 154204558 missense probably benign 0.30
R4491:Zfp648 UTSW 1 154205127 missense probably damaging 1.00
R4693:Zfp648 UTSW 1 154204406 missense probably benign 0.01
R5666:Zfp648 UTSW 1 154204217 missense probably benign 0.00
R5670:Zfp648 UTSW 1 154204217 missense probably benign 0.00
R7432:Zfp648 UTSW 1 154205037 missense possibly damaging 0.84
R8069:Zfp648 UTSW 1 154204116 missense probably benign 0.34
R8137:Zfp648 UTSW 1 154205364 missense probably damaging 1.00
R8282:Zfp648 UTSW 1 154204789 missense probably benign 0.25
Z1088:Zfp648 UTSW 1 154204520 missense probably benign 0.00
Posted On2015-08-05