Incidental Mutation 'IGL00593:Zfp141'
ID332739
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp141
Ensembl Gene ENSMUSG00000092416
Gene Namezinc finger protein 141
Synonyms
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00593
Quality Score
Status
Chromosome7
Chromosomal Location42473386-42505740 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) A to T at 42475307 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Stop codon at position 580 (C580*)
Ref Sequence ENSEMBL: ENSMUSP00000133899 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000173489] [ENSMUST00000174407]
Predicted Effect probably benign
Transcript: ENSMUST00000173489
Predicted Effect probably null
Transcript: ENSMUST00000174407
AA Change: C580*
SMART Domains Protein: ENSMUSP00000133899
Gene: ENSMUSG00000092416
AA Change: C580*

DomainStartEndE-ValueType
KRAB 18 78 4.41e-34 SMART
internal_repeat_1 146 405 8.73e-7 PROSPERO
ZnF_C2H2 410 432 4.54e-4 SMART
ZnF_C2H2 438 460 2.2e-2 SMART
ZnF_C2H2 466 488 2.95e-3 SMART
ZnF_C2H2 494 516 4.24e-4 SMART
ZnF_C2H2 522 544 9.58e-3 SMART
ZnF_C2H2 550 572 4.01e-5 SMART
ZnF_C2H2 578 600 3.21e-4 SMART
ZnF_C2H2 606 628 4.87e-4 SMART
ZnF_C2H2 634 656 5.99e-4 SMART
ZnF_C2H2 662 684 4.87e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000174489
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous mutation of this gene results in abnormal skin pigmentation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 15 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agtr2 A T X: 21,486,480 K118* probably null Het
Akap14 A T X: 37,150,831 H525Q possibly damaging Het
Crb1 T C 1: 139,323,245 I323V probably benign Het
H60b T C 10: 22,287,063 I179T possibly damaging Het
Krt34 A G 11: 100,038,694 probably benign Het
Mroh9 T C 1: 163,045,781 N541D possibly damaging Het
Plxnb1 A T 9: 109,113,868 I1841F probably benign Het
Ppp4r3b A G 11: 29,197,205 D3G possibly damaging Het
Rp1 T C 1: 4,345,403 T1829A possibly damaging Het
Ssx2ip T C 3: 146,436,552 F468L probably damaging Het
Togaram1 A G 12: 65,006,399 E1301G probably damaging Het
Tpd52l2 A T 2: 181,499,896 D24V probably damaging Het
Trmo A G 4: 46,382,490 V209A probably benign Het
Zfp422 C A 6: 116,626,958 A27S probably benign Het
Zfp786 A T 6: 47,819,671 *778R probably null Het
Other mutations in Zfp141
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00595:Zfp141 APN 7 42476655 missense probably benign 0.08
R0577:Zfp141 UTSW 7 42476514 missense probably benign 0.14
R0883:Zfp141 UTSW 7 42476056 missense possibly damaging 0.85
R1701:Zfp141 UTSW 7 42476046 missense probably benign 0.35
R2290:Zfp141 UTSW 7 42475225 missense probably damaging 1.00
R4176:Zfp141 UTSW 7 42476281 missense probably benign 0.04
R4719:Zfp141 UTSW 7 42476687 splice site probably null
R4897:Zfp141 UTSW 7 42476205 missense probably benign 0.24
R5372:Zfp141 UTSW 7 42477196 missense possibly damaging 0.91
R5438:Zfp141 UTSW 7 42489470 missense probably damaging 1.00
R5447:Zfp141 UTSW 7 42475559 nonsense probably null
R5743:Zfp141 UTSW 7 42476431 missense possibly damaging 0.68
R5969:Zfp141 UTSW 7 42489488 missense probably damaging 0.98
R6731:Zfp141 UTSW 7 42489500 missense probably damaging 0.99
R7127:Zfp141 UTSW 7 42475429 missense probably damaging 1.00
R7474:Zfp141 UTSW 7 42476254 nonsense probably null
R7572:Zfp141 UTSW 7 42475432 missense probably benign 0.03
R7830:Zfp141 UTSW 7 42475188 missense probably benign 0.01
Posted On2015-08-05