|Institutional Source||Beutler Lab|
|Gene Name||serine/threonine kinase 11|
|Is this an essential gene?||Essential (E-score: 1.000)|
|Stock #||R4515 (G1)|
|Chromosomal Location||80115803-80130682 bp(+) (GRCm38)|
|Type of Mutation||unclassified|
|DNA Base Change (assembly)||A to G at 80116601 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000150488 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000003152] [ENSMUST00000105371] [ENSMUST00000144883] [ENSMUST00000213772]|
|Coding Region Coverage||
|Validation Efficiency||96% (65/68)|
FUNCTION: This gene encodes a member of the serine/threonine kinase family. The encoded protein, a known tumor suppressor, activates (via phosphorylation) adenine monophosphate-activated protein kinase (AMPK) and AMPK-related kinase proteins. This upstream regulation of the AMPK pathway is thought to regulate a number of different processes, including cell metabolism, cell polarity, apoptosis and DNA damage response. Mutations in a similar gene in human have been associated with Peutz-Jeghers syndrome. Alternative splicing results in multiple transcript variants, including the S isoform which plays a potential role in spermiogenesis. [provided by RefSeq, Sep 2014]
PHENOTYPE: Targeted heterozygous mutants with one inactivated allele develop benign gastrointestinal polyps. Homozygous null mutant are embryonic lethal. Homozygotes for a hypomorphic allele survive and apparently normal, but male mice are infertile. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Stk11||
(F):5'- AGTGAAGAATTGGCGCCCAG -3'
(R):5'- ATAAGGTCTCGGAGTCCAGC -3'
(F):5'- AATTGGCGCCCAGGAAGC -3'
(R):5'- TCACCTTGCCGTACGAGC -3'