Incidental Mutation 'R4528:Zbtb43'
ID 332976
Institutional Source Beutler Lab
Gene Symbol Zbtb43
Ensembl Gene ENSMUSG00000026788
Gene Name zinc finger and BTB domain containing 43
Synonyms Zfp297b, 1700010E06Rik
MMRRC Submission 041769-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4528 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 33340299-33358571 bp(-) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) A to G at 33352337 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000120989 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028125] [ENSMUST00000095035] [ENSMUST00000113156] [ENSMUST00000126442] [ENSMUST00000155198]
AlphaFold Q9DAI4
Predicted Effect probably benign
Transcript: ENSMUST00000028125
SMART Domains Protein: ENSMUSP00000028125
Gene: ENSMUSG00000026788

DomainStartEndE-ValueType
low complexity region 20 32 N/A INTRINSIC
BTB 33 127 4.98e-25 SMART
ZnF_C2H2 373 394 1.2e1 SMART
ZnF_C2H2 400 422 4.47e-3 SMART
ZnF_C2H2 428 448 2.01e1 SMART
Predicted Effect unknown
Transcript: ENSMUST00000095035
AA Change: I10T
SMART Domains Protein: ENSMUSP00000092645
Gene: ENSMUSG00000026788
AA Change: I10T

DomainStartEndE-ValueType
low complexity region 57 69 N/A INTRINSIC
BTB 70 164 4.98e-25 SMART
ZnF_C2H2 410 431 1.2e1 SMART
ZnF_C2H2 437 459 4.47e-3 SMART
ZnF_C2H2 465 485 2.01e1 SMART
Predicted Effect unknown
Transcript: ENSMUST00000113156
AA Change: I10T
SMART Domains Protein: ENSMUSP00000108781
Gene: ENSMUSG00000026788
AA Change: I10T

DomainStartEndE-ValueType
low complexity region 20 32 N/A INTRINSIC
BTB 33 127 4.98e-25 SMART
ZnF_C2H2 373 394 1.2e1 SMART
ZnF_C2H2 400 422 4.47e-3 SMART
ZnF_C2H2 428 448 2.01e1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000126442
SMART Domains Protein: ENSMUSP00000122729
Gene: ENSMUSG00000026788

DomainStartEndE-ValueType
Pfam:BTB 23 69 6.1e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000155198
SMART Domains Protein: ENSMUSP00000120989
Gene: ENSMUSG00000026788

DomainStartEndE-ValueType
low complexity region 20 32 N/A INTRINSIC
BTB 33 127 4.98e-25 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atm A T 9: 53,412,059 (GRCm39) I999K probably benign Het
Camsap3 A G 8: 3,656,515 (GRCm39) E535G possibly damaging Het
Cd109 CATTTATTTATTTATTTATTTATTTATTTATTTAT CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT 9: 78,619,782 (GRCm39) probably benign Het
Cenpu G T 8: 47,015,457 (GRCm39) G34* probably null Het
Col7a1 C A 9: 108,788,601 (GRCm39) A739D unknown Het
Coro1b T C 19: 4,199,980 (GRCm39) V107A probably benign Het
Cpeb3 T C 19: 37,116,488 (GRCm39) D381G possibly damaging Het
Cyp2a22 T C 7: 26,634,194 (GRCm39) D320G possibly damaging Het
Dcaf1 A T 9: 106,721,403 (GRCm39) K398N probably damaging Het
Etfa A G 9: 55,407,334 (GRCm39) S52P probably damaging Het
Fat4 T A 3: 38,945,443 (GRCm39) H1445Q probably benign Het
Foxred2 T A 15: 77,827,449 (GRCm39) M637L probably benign Het
Gbe1 A T 16: 70,275,225 (GRCm39) I342L probably benign Het
Gm14410 A T 2: 176,885,736 (GRCm39) I176K probably benign Het
Gm14410 G T 2: 176,885,734 (GRCm39) H177N probably damaging Het
Gm1527 T A 3: 28,968,542 (GRCm39) M198K probably damaging Het
Hr T C 14: 70,803,823 (GRCm39) L838P probably damaging Het
Kmt2e T C 5: 23,678,556 (GRCm39) S212P possibly damaging Het
Lims1 T C 10: 58,245,882 (GRCm39) C180R probably damaging Het
Mki67 A T 7: 135,297,088 (GRCm39) S2649T probably damaging Het
Or10x1 T A 1: 174,196,822 (GRCm39) L113H probably damaging Het
Or4f57 T C 2: 111,791,293 (GRCm39) N42D probably damaging Het
Or51t4 A G 7: 102,598,013 (GRCm39) M104V probably damaging Het
Pde4dip C T 3: 97,624,338 (GRCm39) E1399K probably damaging Het
Pex1 T C 5: 3,681,712 (GRCm39) Y1053H probably damaging Het
Plscr2 G A 9: 92,171,746 (GRCm39) E113K possibly damaging Het
Pus1 T C 5: 110,922,596 (GRCm39) Y309C probably damaging Het
Scube3 T A 17: 28,381,973 (GRCm39) V333D possibly damaging Het
Serpina11 A T 12: 103,952,592 (GRCm39) N66K probably benign Het
Thtpa T A 14: 55,333,039 (GRCm39) D41E probably damaging Het
Timm10b A G 7: 105,332,013 (GRCm39) N828S probably benign Het
Tlr12 A C 4: 128,511,818 (GRCm39) L144R probably damaging Het
Uba7 A G 9: 107,861,102 (GRCm39) E964G possibly damaging Het
Ugt1a6b T A 1: 88,035,301 (GRCm39) I213N probably damaging Het
Usp5 C G 6: 124,799,593 (GRCm39) K318N possibly damaging Het
Zfp985 A T 4: 147,667,347 (GRCm39) I72F possibly damaging Het
Zfpm1 G A 8: 123,062,381 (GRCm39) R480H probably benign Het
Other mutations in Zbtb43
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01021:Zbtb43 APN 2 33,343,771 (GRCm39) missense probably benign 0.23
IGL01302:Zbtb43 APN 2 33,344,103 (GRCm39) missense probably benign 0.19
IGL02163:Zbtb43 APN 2 33,343,795 (GRCm39) missense possibly damaging 0.75
IGL03212:Zbtb43 APN 2 33,344,286 (GRCm39) missense probably benign 0.07
R0084:Zbtb43 UTSW 2 33,343,996 (GRCm39) missense probably damaging 1.00
R0400:Zbtb43 UTSW 2 33,343,909 (GRCm39) missense probably damaging 1.00
R2136:Zbtb43 UTSW 2 33,344,532 (GRCm39) missense probably damaging 1.00
R4609:Zbtb43 UTSW 2 33,344,055 (GRCm39) missense probably benign 0.21
R4856:Zbtb43 UTSW 2 33,343,944 (GRCm39) missense probably damaging 1.00
R5131:Zbtb43 UTSW 2 33,344,778 (GRCm39) missense probably damaging 0.99
R5984:Zbtb43 UTSW 2 33,344,272 (GRCm39) missense probably benign 0.21
R6606:Zbtb43 UTSW 2 33,345,066 (GRCm39) missense probably damaging 1.00
R7189:Zbtb43 UTSW 2 33,352,307 (GRCm39) missense probably benign
R7837:Zbtb43 UTSW 2 33,343,981 (GRCm39) missense probably damaging 1.00
R8355:Zbtb43 UTSW 2 33,345,120 (GRCm39) missense possibly damaging 0.82
Predicted Primers PCR Primer
(F):5'- AGGGGCTTCAGCTATTTCTCC -3'
(R):5'- GCGTATCCACAGAGTTTTGAC -3'

Sequencing Primer
(F):5'- CTCCCCTAGTGAACTATAGGAGGTG -3'
(R):5'- CATTTGAGGGGTAGTCCTAGAACC -3'
Posted On 2015-08-18