Incidental Mutation 'R4529:Inmt'
Institutional Source Beutler Lab
Gene Symbol Inmt
Ensembl Gene ENSMUSG00000003477
Gene Nameindolethylamine N-methyltransferase
MMRRC Submission 041592-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.048) question?
Stock #R4529 (G1)
Quality Score225
Status Not validated
Chromosomal Location55170626-55175043 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 55171027 bp
Amino Acid Change Methionine to Valine at position 206 (M206V)
Ref Sequence ENSEMBL: ENSMUSP00000003569 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000003569]
Predicted Effect probably benign
Transcript: ENSMUST00000003569
AA Change: M206V

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000003569
Gene: ENSMUSG00000003477
AA Change: M206V

Pfam:NNMT_PNMT_TEMT 1 260 4.9e-113 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152720
Predicted Effect noncoding transcript
Transcript: ENSMUST00000204585
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream FAM188B (family with sequence similarity 188, member B) gene. [provided by RefSeq, Nov 2010]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgre1 A G 17: 57,420,519 Y483C possibly damaging Het
Akap9 T A 5: 4,043,948 F2157I probably damaging Het
Aldh1a3 T C 7: 66,401,994 N404D probably benign Het
Ankrd2 A T 19: 42,043,801 I231F probably benign Het
Apba1 A G 19: 23,936,535 N641D probably damaging Het
C1qbp T C 11: 70,978,724 T178A probably benign Het
Chtf18 T C 17: 25,720,618 Y64C probably damaging Het
Cyp1a1 A G 9: 57,701,679 H281R probably benign Het
Ehmt2 A G 17: 34,913,731 I1235V probably damaging Het
Fam122c G A X: 53,293,499 R94H possibly damaging Het
Fcamr A G 1: 130,804,576 H44R probably damaging Het
Gm12185 T C 11: 48,907,920 Y582C probably damaging Het
Gm12185 T C 11: 48,908,094 N524S possibly damaging Het
Gm5460 A C 14: 34,045,812 D459A probably damaging Het
H2-Q6 C T 17: 35,425,844 T203I probably null Het
Khdc3 T C 9: 73,104,019 S360P possibly damaging Het
Lin54 G A 5: 100,446,560 T582I possibly damaging Het
Ltbp1 T G 17: 75,151,360 V312G probably benign Het
Nlrp9a T C 7: 26,571,407 L899P probably damaging Het
Olfr786 T C 10: 129,437,418 V202A probably benign Het
Orc4 G A 2: 48,937,489 P31S probably benign Het
Pappa A G 4: 65,231,182 I920V probably benign Het
Parp1 T A 1: 180,591,312 V679E probably damaging Het
Pla2g4f C T 2: 120,300,619 R785Q probably damaging Het
Plbd1 T A 6: 136,651,825 I82F probably benign Het
Plekhm3 A G 1: 64,937,825 V162A probably benign Het
Plin4 A G 17: 56,104,274 L919P probably damaging Het
Plxna4 C T 6: 32,496,896 probably null Het
Pou3f3 C A 1: 42,698,554 T470K probably benign Het
Prss38 T C 11: 59,373,499 Y214C probably damaging Het
Retreg1 T A 15: 25,968,514 Y109N probably damaging Het
Slco1c1 A G 6: 141,555,181 Y413C probably damaging Het
Stk32a T C 18: 43,242,979 C38R possibly damaging Het
Themis T C 10: 28,782,335 F453L possibly damaging Het
Tmem38a C T 8: 72,572,161 P20S possibly damaging Het
Tubgcp3 G T 8: 12,663,932 L62I probably damaging Het
Ubqlnl C T 7: 104,149,718 V191M probably benign Het
Xpo7 G A 14: 70,668,748 T986M probably damaging Het
Zfp51 C T 17: 21,464,736 L538F probably damaging Het
Zfy1 A G Y: 726,511 L418S possibly damaging Het
Other mutations in Inmt
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01520:Inmt APN 6 55171228 missense probably damaging 1.00
IGL02404:Inmt APN 6 55171110 missense possibly damaging 0.67
IGL02478:Inmt APN 6 55173370 missense probably damaging 1.00
IGL02585:Inmt APN 6 55173446 missense probably damaging 1.00
R0639:Inmt UTSW 6 55171227 missense probably damaging 1.00
R0673:Inmt UTSW 6 55171227 missense probably damaging 1.00
R1818:Inmt UTSW 6 55173419 missense possibly damaging 0.92
R1862:Inmt UTSW 6 55174883 missense probably damaging 1.00
R4383:Inmt UTSW 6 55171218 missense probably damaging 1.00
R5057:Inmt UTSW 6 55174898 missense probably benign 0.00
R5999:Inmt UTSW 6 55174948 nonsense probably null
R7135:Inmt UTSW 6 55171028 nonsense probably null
X0021:Inmt UTSW 6 55173296 missense probably damaging 0.98
X0022:Inmt UTSW 6 55173475 missense probably benign 0.40
Predicted Primers PCR Primer

Sequencing Primer
Posted On2015-08-18