Incidental Mutation 'R4532:Or5al6'
ID 333134
Institutional Source Beutler Lab
Gene Symbol Or5al6
Ensembl Gene ENSMUSG00000075203
Gene Name olfactory receptor family 5 subfamily AL member 6
Synonyms Olfr1040, MOR185-12, GA_x6K02T2Q125-47615732-47614791
MMRRC Submission 041772-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.210) question?
Stock # R4532 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 85976135-85977076 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 85976274 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 268 (L268Q)
Ref Sequence ENSEMBL: ENSMUSP00000097493 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099909]
AlphaFold A2ARY1
Predicted Effect possibly damaging
Transcript: ENSMUST00000099909
AA Change: L268Q

PolyPhen 2 Score 0.773 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000097493
Gene: ENSMUSG00000075203
AA Change: L268Q

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 8.2e-48 PFAM
Pfam:7tm_1 41 290 5.1e-16 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215884
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.3%
Validation Efficiency 100% (54/54)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap9 T A 5: 4,093,948 (GRCm39) F2157I probably damaging Het
Aoc1l1 A G 6: 48,955,101 (GRCm39) E647G possibly damaging Het
Ap3b1 A G 13: 94,702,243 (GRCm39) K1099E unknown Het
Arhgap42 T C 9: 9,011,433 (GRCm39) D451G probably damaging Het
Cd19 C T 7: 126,011,281 (GRCm39) C301Y probably damaging Het
Cdh23 T C 10: 60,370,202 (GRCm39) T198A probably benign Het
Cdt1 T C 8: 123,298,495 (GRCm39) S407P probably benign Het
Cyp26c1 A G 19: 37,674,227 (GRCm39) T34A probably damaging Het
Dbh C A 2: 27,067,343 (GRCm39) H409Q possibly damaging Het
Eif5 T A 12: 111,506,318 (GRCm39) C52* probably null Het
Fhod3 A G 18: 25,243,278 (GRCm39) Y1212C probably damaging Het
Ggh T A 4: 20,046,225 (GRCm39) F44L probably benign Het
Gm12185 T C 11: 48,798,747 (GRCm39) Y582C probably damaging Het
Gm12185 T C 11: 48,798,921 (GRCm39) N524S possibly damaging Het
Gm21095 A G Y: 84,131,953 (GRCm39) N149S probably damaging Het
Gys2 T A 6: 142,400,867 (GRCm39) H311L probably damaging Het
Hcn4 C T 9: 58,765,081 (GRCm39) R558C unknown Het
Heatr6 T C 11: 83,660,498 (GRCm39) L546P probably damaging Het
Lin54 G A 5: 100,594,419 (GRCm39) T582I possibly damaging Het
Lpin1 C T 12: 16,603,963 (GRCm39) G623S probably benign Het
Lrfn2 A G 17: 49,377,564 (GRCm39) D215G probably damaging Het
Lrrc3c C A 11: 98,489,859 (GRCm39) S72* probably null Het
Me3 G A 7: 89,282,108 (GRCm39) probably benign Het
Msln A G 17: 25,969,698 (GRCm39) I344T probably damaging Het
Oma1 G A 4: 103,176,571 (GRCm39) V112I probably benign Het
Or5p4 T C 7: 107,680,756 (GRCm39) Y252H probably benign Het
Orc4 G A 2: 48,827,501 (GRCm39) P31S probably benign Het
Pabir3 G A X: 52,382,376 (GRCm39) R94H possibly damaging Het
Pdgfra A G 5: 75,341,744 (GRCm39) N659S probably damaging Het
Rmnd5a A T 6: 71,376,109 (GRCm39) probably null Het
Slc12a8 C A 16: 33,371,403 (GRCm39) R180S probably damaging Het
Slc6a15 G A 10: 103,245,648 (GRCm39) V544M possibly damaging Het
Slco5a1 T A 1: 12,949,447 (GRCm39) T648S probably damaging Het
Snx13 T C 12: 35,194,219 (GRCm39) F921L probably damaging Het
Stard6 A C 18: 70,616,605 (GRCm39) D88A probably damaging Het
Svep1 G T 4: 58,068,886 (GRCm39) H2967N possibly damaging Het
Tcaf2 A C 6: 42,603,371 (GRCm39) Y730D probably damaging Het
Tes G A 6: 17,097,407 (GRCm39) V172M possibly damaging Het
Ttc3 T A 16: 94,267,736 (GRCm39) probably benign Het
Vmn1r23 A G 6: 57,902,914 (GRCm39) I288T probably benign Het
Vmn1r38 G T 6: 66,754,016 (GRCm39) H33Q probably benign Het
Vmn2r75 G T 7: 85,797,349 (GRCm39) C821* probably null Het
Zfp282 C T 6: 47,867,567 (GRCm39) P248S probably benign Het
Zfp655 T A 5: 145,181,507 (GRCm39) I455N probably benign Het
Other mutations in Or5al6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01081:Or5al6 APN 2 85,976,955 (GRCm39) missense probably benign 0.22
IGL01106:Or5al6 APN 2 85,976,560 (GRCm39) missense probably benign 0.09
IGL02193:Or5al6 APN 2 85,977,059 (GRCm39) missense probably benign 0.00
IGL02730:Or5al6 APN 2 85,976,443 (GRCm39) missense probably benign 0.05
IGL03032:Or5al6 APN 2 85,977,043 (GRCm39) missense probably damaging 1.00
IGL03165:Or5al6 APN 2 85,976,412 (GRCm39) missense possibly damaging 0.91
R0388:Or5al6 UTSW 2 85,976,974 (GRCm39) missense probably damaging 1.00
R2971:Or5al6 UTSW 2 85,976,908 (GRCm39) missense probably damaging 0.96
R4168:Or5al6 UTSW 2 85,976,523 (GRCm39) missense probably benign 0.03
R5024:Or5al6 UTSW 2 85,976,877 (GRCm39) missense probably damaging 1.00
R5175:Or5al6 UTSW 2 85,976,301 (GRCm39) missense probably damaging 1.00
R5574:Or5al6 UTSW 2 85,976,535 (GRCm39) missense probably damaging 1.00
R6033:Or5al6 UTSW 2 85,976,613 (GRCm39) missense probably damaging 0.97
R6033:Or5al6 UTSW 2 85,976,613 (GRCm39) missense probably damaging 0.97
R6137:Or5al6 UTSW 2 85,976,313 (GRCm39) missense probably benign
R6945:Or5al6 UTSW 2 85,976,428 (GRCm39) missense probably damaging 1.00
R6980:Or5al6 UTSW 2 85,976,681 (GRCm39) nonsense probably null
R7065:Or5al6 UTSW 2 85,976,345 (GRCm39) missense probably damaging 1.00
R8264:Or5al6 UTSW 2 85,976,538 (GRCm39) missense probably damaging 1.00
R9039:Or5al6 UTSW 2 85,976,625 (GRCm39) missense probably damaging 1.00
R9224:Or5al6 UTSW 2 85,976,220 (GRCm39) missense probably damaging 1.00
R9745:Or5al6 UTSW 2 85,976,251 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TGAGTCATGGAGCTCTTCATG -3'
(R):5'- CATTGCTGGCTTCAACACTC -3'

Sequencing Primer
(F):5'- GGAGCTCTTCATGAATATTGGAACTG -3'
(R):5'- AACACTCTTTGCTCTCTGGTGATTG -3'
Posted On 2015-08-18