Incidental Mutation 'R0107:Vmn1r31'
ID33318
Institutional Source Beutler Lab
Gene Symbol Vmn1r31
Ensembl Gene ENSMUSG00000115404
Gene Namevomeronasal 1 receptor 31
SynonymsGm6709
MMRRC Submission 038393-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.161) question?
Stock #R0107 (G1)
Quality Score225
Status Validated (trace)
Chromosome6
Chromosomal Location58470941-58475330 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 58472743 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Serine at position 46 (T46S)
Ref Sequence ENSEMBL: ENSMUSP00000135472 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000176023] [ENSMUST00000176147] [ENSMUST00000176177] [ENSMUST00000177318] [ENSMUST00000226390] [ENSMUST00000228586]
Predicted Effect probably benign
Transcript: ENSMUST00000176023
SMART Domains Protein: ENSMUSP00000135252
Gene: ENSMUSG00000115404

DomainStartEndE-ValueType
Pfam:V1R 1 58 1.9e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000176147
SMART Domains Protein: ENSMUSP00000135282
Gene: ENSMUSG00000115404

DomainStartEndE-ValueType
Pfam:V1R 1 58 1.9e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000176177
AA Change: T46S

PolyPhen 2 Score 0.052 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000135472
Gene: ENSMUSG00000093379
AA Change: T46S

DomainStartEndE-ValueType
Pfam:V1R 28 293 4.7e-56 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000177318
AA Change: T46S

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000135555
Gene: ENSMUSG00000115404
AA Change: T46S

DomainStartEndE-ValueType
Pfam:V1R 28 107 1.9e-18 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000204999
Predicted Effect probably benign
Transcript: ENSMUST00000226390
AA Change: T46S

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
Predicted Effect probably benign
Transcript: ENSMUST00000228586
AA Change: T46S

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.8%
  • 20x: 90.6%
Validation Efficiency 99% (71/72)
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca1 A G 4: 53,080,834 V825A probably benign Het
Adamts7 T C 9: 90,180,720 I409T possibly damaging Het
Adck1 T C 12: 88,446,656 W253R possibly damaging Het
Afg3l2 A G 18: 67,431,766 F213L probably damaging Het
Ankle2 T C 5: 110,253,027 V743A probably benign Het
Ankrd34c C T 9: 89,729,484 R268H probably benign Het
Bcl2 G A 1: 106,712,562 R107C probably damaging Het
Ccdc7b T G 8: 129,178,197 probably benign Het
Cd320 A T 17: 33,848,085 M169L probably benign Het
Chn1 A G 2: 73,614,684 Y338H probably damaging Het
Chuk T A 19: 44,096,919 S263C probably damaging Het
Dennd4b C A 3: 90,272,736 P663T possibly damaging Het
Dnajc24 T G 2: 106,001,914 probably benign Het
Fam172a A G 13: 77,902,814 D145G probably damaging Het
Fbn2 A G 18: 58,056,203 V1617A probably benign Het
Fermt2 T C 14: 45,464,822 N502D probably damaging Het
Frrs1 A T 3: 116,896,716 I3F probably damaging Het
Fut1 C A 7: 45,618,846 Q20K possibly damaging Het
Gbf1 T C 19: 46,284,828 V1709A probably benign Het
Gfra3 G T 18: 34,711,306 H60Q probably benign Het
Gm10750 T A 2: 149,016,053 M93L unknown Het
Gm5538 T A 3: 59,752,316 L397I possibly damaging Het
Hmcn1 T A 1: 150,587,015 I5124L probably benign Het
Hps3 A C 3: 20,030,796 L76R probably damaging Het
Ifrd1 T A 12: 40,214,081 Q105L probably damaging Het
Irs2 A T 8: 11,004,691 V1247E probably damaging Het
Itgal T C 7: 127,328,559 probably benign Het
Ivns1abp A T 1: 151,361,570 N495I probably damaging Het
Kank1 T A 19: 25,430,366 probably benign Het
Mroh8 T C 2: 157,225,468 Q657R probably benign Het
Mthfd1l T C 10: 4,041,838 Y597H probably benign Het
Myom1 G A 17: 71,077,365 V692I probably damaging Het
Olfr347 T G 2: 36,734,718 Y132* probably null Het
Olfr45 A T 7: 140,691,345 M147L probably benign Het
Olfr835 A G 9: 19,035,333 D70G probably damaging Het
Palmd A T 3: 116,924,076 H257Q probably damaging Het
Pcnx2 A T 8: 125,753,586 V1994D probably benign Het
Phkb G A 8: 86,016,931 G553S probably benign Het
Plekha5 G A 6: 140,591,747 R646K possibly damaging Het
Ptprn A T 1: 75,255,712 L453M probably damaging Het
Ptprz1 T A 6: 23,000,570 D886E probably damaging Het
Rcn1 T A 2: 105,394,781 I110F possibly damaging Het
Scn1a T A 2: 66,324,633 T661S probably benign Het
Slc6a19 A G 13: 73,684,057 Y467H possibly damaging Het
Slc9c1 T A 16: 45,575,420 D611E probably benign Het
Slitrk6 T C 14: 110,751,963 E104G possibly damaging Het
Spag17 A T 3: 100,050,787 K920N possibly damaging Het
St3gal5 A G 6: 72,142,149 S82G probably benign Het
Tlk1 T C 2: 70,713,989 *767W probably null Het
Tln2 A G 9: 67,370,706 V342A probably damaging Het
Tmem104 T A 11: 115,202,180 M132K probably damaging Het
Tmem184c A G 8: 77,597,073 S387P possibly damaging Het
Tmtc1 A G 6: 148,425,913 V34A possibly damaging Het
Trim46 A G 3: 89,236,333 F596S probably damaging Het
Unc79 T A 12: 103,134,525 D1870E possibly damaging Het
Utp20 T C 10: 88,778,391 T1234A probably benign Het
Vps13a A T 19: 16,691,824 L1341Q probably benign Het
Wdr72 A T 9: 74,210,433 D821V probably damaging Het
Zfhx4 T C 3: 5,398,982 L1400P probably damaging Het
Zfp217 T A 2: 170,114,874 K735* probably null Het
Zfp235 A G 7: 24,137,116 Q29R probably damaging Het
Zfp628 A G 7: 4,920,168 Y463C probably damaging Het
Zkscan4 A G 13: 21,484,581 T401A possibly damaging Het
Other mutations in Vmn1r31
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01326:Vmn1r31 APN 6 58472799 missense probably benign 0.06
IGL01386:Vmn1r31 APN 6 58472602 missense probably benign 0.22
IGL01785:Vmn1r31 APN 6 58472724 missense possibly damaging 0.95
IGL02527:Vmn1r31 APN 6 58472793 missense probably benign 0.01
PIT4791001:Vmn1r31 UTSW 6 58472043 missense probably damaging 0.97
R1250:Vmn1r31 UTSW 6 58472658 missense probably benign 0.01
R1616:Vmn1r31 UTSW 6 58472058 missense probably damaging 0.97
R1883:Vmn1r31 UTSW 6 58472044 missense probably damaging 0.97
R1884:Vmn1r31 UTSW 6 58472044 missense probably damaging 0.97
R2942:Vmn1r31 UTSW 6 58472598 missense possibly damaging 0.87
R4589:Vmn1r31 UTSW 6 58472611 missense probably damaging 1.00
R4672:Vmn1r31 UTSW 6 58472071 missense probably damaging 0.97
R4676:Vmn1r31 UTSW 6 58472013 missense probably damaging 0.97
R4702:Vmn1r31 UTSW 6 58471968 makesense probably null
R4703:Vmn1r31 UTSW 6 58471968 makesense probably null
R4705:Vmn1r31 UTSW 6 58471968 makesense probably null
R6341:Vmn1r31 UTSW 6 58472010 missense probably benign 0.35
R6549:Vmn1r31 UTSW 6 58472663 missense possibly damaging 0.92
R7238:Vmn1r31 UTSW 6 58472873 missense
R7609:Vmn1r31 UTSW 6 58472470 missense probably damaging 0.97
R8438:Vmn1r31 UTSW 6 58472661 missense
Z1176:Vmn1r31 UTSW 6 58472391 missense unknown
Predicted Primers PCR Primer
(F):5'- TGGGACTGATAGTGACAGCCTGG -3'
(R):5'- GCTCACCATGACTGTTTTGGATGC -3'

Sequencing Primer
(F):5'- CCTGGAACACACTTAGGAGGC -3'
(R):5'- CAACAGGATTGGATTTCTAAGGTG -3'
Posted On2013-05-09