Mutagenetix > Incidental Mutation

Incidental Mutation 'R4537:Vmn2r93'

333395

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r93

Ensembl Gene

ENSMUSG00000079698

Gene Name

vomeronasal 2, receptor 93

Synonyms

EG627132

MMRRC Submission

041774-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.084) question?

Stock #

R4537 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

18518543-18546703 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 18525194 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 284 (M284K)

Ref Sequence

ENSEMBL: ENSMUSP00000156230 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079206] [ENSMUST00000231879] [ENSMUST00000231938]

AlphaFold

L7N1Z9

Predicted Effect

possibly damaging
Transcript: ENSMUST00000079206
AA Change: M284K

PolyPhen 2 Score 0.814 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000078200
Gene: ENSMUSG00000079698
AA Change: M284K

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	453	5.9e-40	PFAM
Pfam:NCD3G	509	562	2.6e-21	PFAM
Pfam:7tm_3	594	830	1.5e-50	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000231879
AA Change: M284K

PolyPhen 2 Score 0.861 (Sensitivity: 0.83; Specificity: 0.93)

Predicted Effect

possibly damaging
Transcript: ENSMUST00000231938
AA Change: M284K

PolyPhen 2 Score 0.633 (Sensitivity: 0.87; Specificity: 0.91)

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.1%
20x: 94.8%

Validation Efficiency

100% (41/41)

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arid4b	T	A	13: 14,294,746 (GRCm39)	Y9*	probably null	Het
Aspm	T	C	1: 139,402,041 (GRCm39)	I1235T	probably benign	Het
Defb30	T	C	14: 63,273,525 (GRCm39)	I29M	probably damaging	Het
Dnajc13	CT	C	9: 104,064,004 (GRCm39)		probably benign	Het
Dpy19l3	T	C	7: 35,411,326 (GRCm39)	T428A	probably benign	Het
Fam83b	T	C	9: 76,399,424 (GRCm39)	T560A	probably benign	Het
Fnip2	A	G	3: 79,373,021 (GRCm39)	V1019A	probably damaging	Het
Fus	A	G	7: 127,575,087 (GRCm39)	D268G	probably damaging	Het
Gm14412	T	A	2: 177,006,352 (GRCm39)	K514N	probably benign	Het
Gphn	T	C	12: 78,540,788 (GRCm39)	L265P	probably benign	Het
Grm3	A	G	5: 9,562,083 (GRCm39)	M589T	probably benign	Het
Hoxa1	G	T	6: 52,134,973 (GRCm39)	Q77K	probably benign	Het
Ighv14-2	A	G	12: 113,958,512 (GRCm39)	C3R	probably benign	Het
Itgb2	G	A	10: 77,397,050 (GRCm39)		probably null	Het
Mrpl24	A	C	3: 87,829,719 (GRCm39)	K102Q	probably benign	Het
Ogfod2	C	T	5: 124,252,591 (GRCm39)		probably benign	Het
Olig2	A	G	16: 91,023,732 (GRCm39)	I149V	probably damaging	Het
Or10g9	T	A	9: 39,911,616 (GRCm39)	K302N	probably benign	Het
Or56a3b	T	A	7: 104,776,227 (GRCm39)	I84F	probably damaging	Het
Or7g19	T	A	9: 18,856,526 (GRCm39)	I194N	possibly damaging	Het
Oxr1	A	G	15: 41,683,915 (GRCm39)	Q515R	possibly damaging	Het
Rae1	G	T	2: 172,857,185 (GRCm39)		probably benign	Het
Slc25a12	T	A	2: 71,105,450 (GRCm39)		probably benign	Het
Slc2a3	C	A	6: 122,714,063 (GRCm39)	G157V	probably damaging	Het
Slc5a4a	C	T	10: 76,013,929 (GRCm39)	R379*	probably null	Het
Sost	G	A	11: 101,857,670 (GRCm39)	P44S	probably damaging	Het
Sprr2f	A	T	3: 92,273,366 (GRCm39)	Q55L	unknown	Het
Srd5a3	G	A	5: 76,297,798 (GRCm39)		probably null	Het
Tmtc1	C	T	6: 148,164,280 (GRCm39)		probably null	Het
Tns2	C	T	15: 102,017,369 (GRCm39)	R281C	probably damaging	Het
Tob1	ACAGCAGCAGCAGCAGCAGCAGCAGCA	ACAGCAGCAGCAGCAGCAGCAGCA	11: 94,105,278 (GRCm39)		probably benign	Het
Ulk4	G	A	9: 121,092,704 (GRCm39)	R178*	probably null	Het
Uspl1	A	G	5: 149,124,588 (GRCm39)	T2A	possibly damaging	Het
Vmn2r87	T	G	10: 130,308,054 (GRCm39)	H728P	probably benign	Het
Zfp101	T	A	17: 33,601,466 (GRCm39)	M59L	possibly damaging	Het
Zfp558	T	C	9: 18,368,798 (GRCm39)	E146G	probably null	Het

Other mutations in Vmn2r93

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00743:Vmn2r93	APN	17	18,546,504 (GRCm39)	missense	probably damaging	1.00
IGL01326:Vmn2r93	APN	17	18,536,906 (GRCm39)	missense	possibly damaging	0.92
IGL01328:Vmn2r93	APN	17	18,545,819 (GRCm39)	missense	probably benign	0.00
IGL01360:Vmn2r93	APN	17	18,525,510 (GRCm39)	missense	possibly damaging	0.71
IGL01382:Vmn2r93	APN	17	18,533,578 (GRCm39)	nonsense	probably null
IGL01463:Vmn2r93	APN	17	18,525,150 (GRCm39)	missense	probably damaging	1.00
IGL02057:Vmn2r93	APN	17	18,546,032 (GRCm39)	missense	probably damaging	1.00
IGL02257:Vmn2r93	APN	17	18,545,770 (GRCm39)	unclassified	probably benign
IGL02686:Vmn2r93	APN	17	18,533,526 (GRCm39)	missense	possibly damaging	0.89
IGL02720:Vmn2r93	APN	17	18,525,296 (GRCm39)	missense	probably damaging	1.00
IGL03328:Vmn2r93	APN	17	18,525,220 (GRCm39)	missense	probably damaging	1.00
PIT4576001:Vmn2r93	UTSW	17	18,533,473 (GRCm39)	missense	probably benign
R0067:Vmn2r93	UTSW	17	18,546,672 (GRCm39)	missense	probably benign	0.00
R0067:Vmn2r93	UTSW	17	18,546,672 (GRCm39)	missense	probably benign	0.00
R0240:Vmn2r93	UTSW	17	18,525,061 (GRCm39)	missense	probably benign	0.00
R0240:Vmn2r93	UTSW	17	18,525,061 (GRCm39)	missense	probably benign	0.00
R0488:Vmn2r93	UTSW	17	18,546,311 (GRCm39)	missense	probably damaging	1.00
R0667:Vmn2r93	UTSW	17	18,546,503 (GRCm39)	missense	probably damaging	1.00
R0668:Vmn2r93	UTSW	17	18,518,667 (GRCm39)	missense	probably benign	0.00
R0850:Vmn2r93	UTSW	17	18,525,279 (GRCm39)	missense	possibly damaging	0.93
R0924:Vmn2r93	UTSW	17	18,524,443 (GRCm39)	missense	probably benign
R0947:Vmn2r93	UTSW	17	18,524,343 (GRCm39)	missense	probably benign	0.06
R1124:Vmn2r93	UTSW	17	18,518,710 (GRCm39)	missense	probably benign	0.00
R1584:Vmn2r93	UTSW	17	18,525,413 (GRCm39)	missense	possibly damaging	0.84
R1943:Vmn2r93	UTSW	17	18,546,063 (GRCm39)	missense	probably benign	0.04
R2012:Vmn2r93	UTSW	17	18,536,840 (GRCm39)	missense	probably benign	0.01
R2018:Vmn2r93	UTSW	17	18,546,324 (GRCm39)	missense	probably damaging	1.00
R2196:Vmn2r93	UTSW	17	18,525,428 (GRCm39)	missense	probably damaging	1.00
R2373:Vmn2r93	UTSW	17	18,518,665 (GRCm39)	missense	probably benign
R2864:Vmn2r93	UTSW	17	18,546,323 (GRCm39)	missense	probably damaging	1.00
R4276:Vmn2r93	UTSW	17	18,525,092 (GRCm39)	missense	possibly damaging	0.47
R4446:Vmn2r93	UTSW	17	18,524,312 (GRCm39)	missense	possibly damaging	0.93
R4674:Vmn2r93	UTSW	17	18,525,255 (GRCm39)	missense	probably benign	0.34
R4726:Vmn2r93	UTSW	17	18,536,960 (GRCm39)	missense	probably damaging	1.00
R4936:Vmn2r93	UTSW	17	18,524,327 (GRCm39)	missense	possibly damaging	0.95
R4984:Vmn2r93	UTSW	17	18,533,389 (GRCm39)	splice site	probably null
R5111:Vmn2r93	UTSW	17	18,546,326 (GRCm39)	missense	probably damaging	0.99
R5749:Vmn2r93	UTSW	17	18,518,546 (GRCm39)	missense	probably benign	0.06
R5918:Vmn2r93	UTSW	17	18,546,030 (GRCm39)	missense	probably damaging	1.00
R5921:Vmn2r93	UTSW	17	18,546,030 (GRCm39)	missense	probably damaging	1.00
R6091:Vmn2r93	UTSW	17	18,545,958 (GRCm39)	missense	probably benign	0.06
R6283:Vmn2r93	UTSW	17	18,524,366 (GRCm39)	missense	probably benign	0.02
R6680:Vmn2r93	UTSW	17	18,536,920 (GRCm39)	nonsense	probably null
R6876:Vmn2r93	UTSW	17	18,525,450 (GRCm39)	missense	probably benign	0.00
R6963:Vmn2r93	UTSW	17	18,536,849 (GRCm39)	missense	probably damaging	1.00
R6996:Vmn2r93	UTSW	17	18,524,903 (GRCm39)	missense	probably damaging	1.00
R7027:Vmn2r93	UTSW	17	18,533,548 (GRCm39)	missense	probably benign	0.01
R7034:Vmn2r93	UTSW	17	18,546,672 (GRCm39)	missense	probably benign	0.00
R7036:Vmn2r93	UTSW	17	18,546,672 (GRCm39)	missense	probably benign	0.00
R7246:Vmn2r93	UTSW	17	18,546,012 (GRCm39)	missense	possibly damaging	0.89
R7258:Vmn2r93	UTSW	17	18,525,403 (GRCm39)	missense	probably benign	0.32
R7323:Vmn2r93	UTSW	17	18,533,497 (GRCm39)	nonsense	probably null
R7325:Vmn2r93	UTSW	17	18,524,249 (GRCm39)	missense	probably benign	0.01
R7390:Vmn2r93	UTSW	17	18,525,329 (GRCm39)	missense	probably damaging	1.00
R7427:Vmn2r93	UTSW	17	18,546,672 (GRCm39)	missense	probably benign	0.00
R7428:Vmn2r93	UTSW	17	18,546,672 (GRCm39)	missense	probably benign	0.00
R7448:Vmn2r93	UTSW	17	18,546,248 (GRCm39)	missense	probably benign	0.19
R7453:Vmn2r93	UTSW	17	18,533,580 (GRCm39)	missense	probably benign	0.10
R7562:Vmn2r93	UTSW	17	18,518,731 (GRCm39)	missense	probably benign	0.01
R7662:Vmn2r93	UTSW	17	18,525,631 (GRCm39)	missense	probably benign	0.00
R7682:Vmn2r93	UTSW	17	18,525,583 (GRCm39)	missense	probably benign	0.03
R7704:Vmn2r93	UTSW	17	18,536,910 (GRCm39)	missense	probably benign	0.01
R7772:Vmn2r93	UTSW	17	18,533,482 (GRCm39)	missense	probably damaging	0.99
R7957:Vmn2r93	UTSW	17	18,545,954 (GRCm39)	nonsense	probably null
R8276:Vmn2r93	UTSW	17	18,525,649 (GRCm39)	critical splice donor site	probably null
R8290:Vmn2r93	UTSW	17	18,524,291 (GRCm39)	missense	probably damaging	1.00
R8362:Vmn2r93	UTSW	17	18,546,353 (GRCm39)	missense	probably benign	0.02
R8376:Vmn2r93	UTSW	17	18,525,230 (GRCm39)	missense	probably damaging	1.00
R8870:Vmn2r93	UTSW	17	18,525,320 (GRCm39)	missense	possibly damaging	0.91
R8925:Vmn2r93	UTSW	17	18,546,500 (GRCm39)	missense	probably damaging	0.99
R8927:Vmn2r93	UTSW	17	18,546,500 (GRCm39)	missense	probably damaging	0.99
R8954:Vmn2r93	UTSW	17	18,546,252 (GRCm39)	missense	probably damaging	0.99
R9038:Vmn2r93	UTSW	17	18,524,471 (GRCm39)	missense	probably benign
R9131:Vmn2r93	UTSW	17	18,546,143 (GRCm39)	missense	probably damaging	0.99
R9205:Vmn2r93	UTSW	17	18,524,281 (GRCm39)	missense	probably damaging	1.00
R9530:Vmn2r93	UTSW	17	18,518,562 (GRCm39)	missense	probably damaging	0.96
Z1088:Vmn2r93	UTSW	17	18,546,665 (GRCm39)	missense	probably damaging	1.00
Z1177:Vmn2r93	UTSW	17	18,525,600 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGGTCTCATCCTCCCAGATGAC -3'
(R):5'- TGTGAGCCAGAGCATATACACC -3'

Sequencing Primer
(F):5'- TCCCAGATGACCACAAGGG -3'
(R):5'- AATACTTGTGCTCTCTTCAGTCATAG -3'

Posted On

2015-08-18