Incidental Mutation 'R4543:Crp'
ID 333611
Institutional Source Beutler Lab
Gene Symbol Crp
Ensembl Gene ENSMUSG00000037942
Gene Name C-reactive protein, pentraxin-related
Synonyms
MMRRC Submission 041778-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4543 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 172525623-172527533 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 172526304 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 130 (I130L)
Ref Sequence ENSEMBL: ENSMUSP00000044665 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038495]
AlphaFold P14847
Predicted Effect probably benign
Transcript: ENSMUST00000038495
AA Change: I130L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000044665
Gene: ENSMUSG00000037942
AA Change: I130L

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
PTX 20 225 4.55e-132 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000194251
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency 94% (44/47)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]
PHENOTYPE: Mice homozygous for a knock-out allele lack detectable C-reactive protein in the serum but are otherwise healthy and fertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A1bg A T 15: 60,789,749 (GRCm39) S500T probably damaging Het
Abhd3 T C 18: 10,706,672 (GRCm39) D2G possibly damaging Het
Ablim1 C T 19: 57,065,874 (GRCm39) R366H possibly damaging Het
Adgre1 T A 17: 57,713,874 (GRCm39) H186Q probably benign Het
Ankmy1 G T 1: 92,812,572 (GRCm39) A579E probably damaging Het
Ap2b1 C A 11: 83,215,476 (GRCm39) T140K probably damaging Het
Arhgef28 T A 13: 98,211,508 (GRCm39) E158D probably benign Het
Atp8b4 A G 2: 126,199,986 (GRCm39) F885L probably damaging Het
Barx2 A G 9: 31,758,092 (GRCm39) L282S unknown Het
Catsper2 C T 2: 121,237,890 (GRCm39) W163* probably null Het
Cep295 T C 9: 15,246,549 (GRCm39) T588A possibly damaging Het
Chil3 T G 3: 106,067,686 (GRCm39) K160Q probably benign Het
Clca3a1 T A 3: 144,452,749 (GRCm39) Q578L probably damaging Het
Dtwd2 C A 18: 49,857,175 (GRCm39) probably null Het
Fads3 T C 19: 10,019,175 (GRCm39) F27S possibly damaging Het
Gm3604 T C 13: 62,517,970 (GRCm39) D109G probably benign Het
Gtf2ird1 A G 5: 134,392,754 (GRCm39) probably null Het
H2-K2 C T 17: 34,218,532 (GRCm39) probably null Het
Hdac5 T C 11: 102,104,770 (GRCm39) probably benign Het
Il6st G A 13: 112,617,993 (GRCm39) V136M probably damaging Het
Immt T C 6: 71,828,762 (GRCm39) S106P probably damaging Het
Kat2b T C 17: 53,960,168 (GRCm39) I492T probably benign Het
Kcnn2 T C 18: 45,692,715 (GRCm39) F97S probably benign Het
Kdm4c A G 4: 74,248,997 (GRCm39) I84V probably benign Het
Kif7 G A 7: 79,357,296 (GRCm39) P637S probably benign Het
Lrrcc1 T A 3: 14,604,851 (GRCm39) I109K probably damaging Het
Med12l T A 3: 58,998,929 (GRCm39) C619S probably damaging Het
Mgat4f T A 1: 134,317,531 (GRCm39) M101K probably benign Het
Or8g51 A G 9: 38,608,841 (GRCm39) S274P possibly damaging Het
Polq T C 16: 36,881,147 (GRCm39) C1104R probably benign Het
Rbfox2 A T 15: 77,190,568 (GRCm39) M59K probably benign Het
Rft1 T C 14: 30,383,290 (GRCm39) V110A probably benign Het
Rsf1 GCGGCGGCG GCGGCGGCGTCGGCGGCG 7: 97,229,129 (GRCm39) probably benign Het
Slc2a12 T A 10: 22,540,685 (GRCm39) V180D probably damaging Het
Sox21 CCAGCGGCGGCGGCGGCAGCGGCGGCGGCGGCAGCGGC CCAGCGGCGGCGGCGGCAGCGGC 14: 118,472,548 (GRCm39) probably benign Het
Stap2 C T 17: 56,304,604 (GRCm39) probably null Het
Tenm4 A G 7: 96,545,022 (GRCm39) N2375S probably benign Het
Tmem132c A G 5: 127,582,041 (GRCm39) T419A probably benign Het
Tmprss11a G A 5: 86,559,668 (GRCm39) Q375* probably null Het
Trav12-3 CTCTG CTCTGTCTG 14: 53,859,693 (GRCm39) probably null Het
Vmn1r88 T A 7: 12,911,907 (GRCm39) S88T possibly damaging Het
Zfp622 T A 15: 25,991,623 (GRCm39) D143E possibly damaging Het
Other mutations in Crp
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00586:Crp APN 1 172,526,568 (GRCm39) missense probably benign 0.19
R0920:Crp UTSW 1 172,526,089 (GRCm39) missense probably damaging 1.00
R1871:Crp UTSW 1 172,526,172 (GRCm39) missense possibly damaging 0.79
R4648:Crp UTSW 1 172,525,704 (GRCm39) start codon destroyed probably null 0.24
R5213:Crp UTSW 1 172,526,086 (GRCm39) missense probably benign 0.00
R5407:Crp UTSW 1 172,525,676 (GRCm39) start gained probably null
R5822:Crp UTSW 1 172,525,635 (GRCm39) utr 5 prime probably benign
R7816:Crp UTSW 1 172,526,277 (GRCm39) missense possibly damaging 0.73
R8786:Crp UTSW 1 172,526,293 (GRCm39) missense probably benign 0.00
R9234:Crp UTSW 1 172,526,413 (GRCm39) missense probably damaging 0.99
R9274:Crp UTSW 1 172,526,072 (GRCm39) missense possibly damaging 0.76
Predicted Primers PCR Primer
(F):5'- AGCCACTGAACACCTTTACTG -3'
(R):5'- TGGAGATAGCACAAAGTCCCAC -3'

Sequencing Primer
(F):5'- GTGTCTTCTCTTATGCTACCAAGAAG -3'
(R):5'- GAGATAGCACAAAGTCCCACATGTTC -3'
Posted On 2015-08-18