Incidental Mutation 'R4544:Hdac1-ps'
ID 333697
Institutional Source Beutler Lab
Gene Symbol Hdac1-ps
Ensembl Gene ENSMUSG00000061062
Gene Name histone deacetylase 1, pseudogene
Synonyms EG15181, Gm10093
MMRRC Submission 041779-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.908) question?
Stock # R4544 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 78799011-78800454 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 78800388 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 460 (T460S)
Ref Sequence ENSEMBL: ENSMUSP00000078339 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079363]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000079363
AA Change: T460S

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000078339
Gene: ENSMUSG00000061062
AA Change: T460S

DomainStartEndE-ValueType
Pfam:Hist_deacetyl 18 320 3.2e-84 PFAM
low complexity region 390 402 N/A INTRINSIC
low complexity region 417 430 N/A INTRINSIC
low complexity region 443 471 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency 100% (58/58)
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akr1c20 A C 13: 4,557,843 (GRCm39) V201G probably damaging Het
Alg9 C T 9: 50,716,654 (GRCm39) T409M possibly damaging Het
Atf7 A G 15: 102,442,762 (GRCm39) V449A probably benign Het
C1s1 A G 6: 124,508,499 (GRCm39) S497P probably benign Het
Ccnyl1 G T 1: 64,762,735 (GRCm39) M347I probably benign Het
Chil4 C A 3: 106,117,922 (GRCm39) R116L probably damaging Het
Cmpk2 A G 12: 26,528,016 (GRCm39) E411G probably damaging Het
Cmya5 G A 13: 93,228,426 (GRCm39) R2221* probably null Het
Csmd1 A T 8: 16,760,652 (GRCm39) F161Y possibly damaging Het
Cspg4 T A 9: 56,795,913 (GRCm39) L1216Q possibly damaging Het
Dppa3 A G 6: 122,603,726 (GRCm39) probably benign Het
Ednra A G 8: 78,401,540 (GRCm39) probably null Het
Fancd2 A G 6: 113,549,603 (GRCm39) probably null Het
Fastkd1 C T 2: 69,542,655 (GRCm39) E51K probably damaging Het
Fndc1 T A 17: 7,992,376 (GRCm39) D440V unknown Het
Gm9934 A G 7: 92,702,188 (GRCm39) noncoding transcript Het
Ifi205 T C 1: 173,854,139 (GRCm39) I171M possibly damaging Het
Ifi213 T C 1: 173,409,693 (GRCm39) probably null Het
Insig2 A T 1: 121,239,921 (GRCm39) probably benign Het
Kdm7a T C 6: 39,152,406 (GRCm39) R97G probably benign Het
Krt23 G A 11: 99,369,102 (GRCm39) T397M probably benign Het
Lepr G A 4: 101,625,425 (GRCm39) V527I possibly damaging Het
Lmo2 C T 2: 103,806,382 (GRCm39) P25L probably damaging Het
Lsr C T 7: 30,671,401 (GRCm39) V111M probably damaging Het
Mest T C 6: 30,740,679 (GRCm39) W13R probably damaging Het
Mfn2 A G 4: 147,971,909 (GRCm39) V224A probably benign Het
Mkx T C 18: 7,000,651 (GRCm39) Y97C probably damaging Het
Mndal A T 1: 173,703,230 (GRCm39) Y58* probably null Het
Myo9b T C 8: 71,780,585 (GRCm39) V494A probably damaging Het
Nek1 C T 8: 61,469,338 (GRCm39) Q132* probably null Het
Or2a12 C T 6: 42,904,348 (GRCm39) S61L probably damaging Het
Or6c5 A C 10: 129,074,027 (GRCm39) N3T probably damaging Het
Osbpl6 T C 2: 76,414,836 (GRCm39) V409A possibly damaging Het
Pde8a A T 7: 80,977,847 (GRCm39) R713S probably damaging Het
Pex10 T C 4: 155,154,952 (GRCm39) Y235H probably benign Het
Pik3cb T A 9: 98,921,812 (GRCm39) K1050I probably damaging Het
Prss56 A G 1: 87,112,364 (GRCm39) D85G probably damaging Het
Psg26 T C 7: 18,212,464 (GRCm39) N297S probably damaging Het
Rdh16f1 T C 10: 127,626,706 (GRCm39) L253S probably benign Het
Slc15a4 A G 5: 127,681,600 (GRCm39) probably null Het
Slc7a8 C G 14: 54,973,247 (GRCm39) G240A possibly damaging Het
Slc8b1 G A 5: 120,669,218 (GRCm39) probably null Het
Sorbs1 G A 19: 40,300,294 (GRCm39) T575M probably damaging Het
Syne3 T A 12: 104,925,728 (GRCm39) K313M probably damaging Het
Tas2r108 A G 6: 40,470,742 (GRCm39) T73A probably benign Het
Ttn T C 2: 76,652,932 (GRCm39) probably null Het
Uba52rt C T 4: 3,973,244 (GRCm39) R106H probably benign Het
Ubr3 G A 2: 69,786,437 (GRCm39) M850I probably benign Het
Vmn2r78 A T 7: 86,570,399 (GRCm39) M306L probably benign Het
Vmn2r9 T G 5: 108,995,551 (GRCm39) M366L probably benign Het
Zan C G 5: 137,382,096 (GRCm39) M5150I unknown Het
Other mutations in Hdac1-ps
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01936:Hdac1-ps APN 17 78,799,558 (GRCm39) missense probably damaging 1.00
IGL01983:Hdac1-ps APN 17 78,800,282 (GRCm39) missense probably benign
IGL02543:Hdac1-ps APN 17 78,799,303 (GRCm39) missense probably damaging 0.97
buttress UTSW 17 78,800,343 (GRCm39) missense possibly damaging 0.91
Chartre UTSW 17 78,799,969 (GRCm39) missense probably damaging 0.99
R1174:Hdac1-ps UTSW 17 78,799,507 (GRCm39) missense probably benign 0.01
R1605:Hdac1-ps UTSW 17 78,799,537 (GRCm39) missense probably damaging 0.98
R2416:Hdac1-ps UTSW 17 78,799,945 (GRCm39) missense probably damaging 1.00
R2919:Hdac1-ps UTSW 17 78,800,275 (GRCm39) missense probably damaging 0.98
R2920:Hdac1-ps UTSW 17 78,800,275 (GRCm39) missense probably damaging 0.98
R3846:Hdac1-ps UTSW 17 78,800,401 (GRCm39) missense possibly damaging 0.91
R4546:Hdac1-ps UTSW 17 78,800,388 (GRCm39) missense probably benign 0.02
R5223:Hdac1-ps UTSW 17 78,799,867 (GRCm39) missense probably benign 0.02
R5297:Hdac1-ps UTSW 17 78,800,187 (GRCm39) missense probably benign
R6164:Hdac1-ps UTSW 17 78,799,716 (GRCm39) missense probably damaging 0.99
R6568:Hdac1-ps UTSW 17 78,800,017 (GRCm39) missense probably damaging 1.00
R6726:Hdac1-ps UTSW 17 78,800,287 (GRCm39) missense probably damaging 0.99
R6901:Hdac1-ps UTSW 17 78,800,089 (GRCm39) missense probably benign 0.07
R6923:Hdac1-ps UTSW 17 78,800,343 (GRCm39) missense possibly damaging 0.91
R7838:Hdac1-ps UTSW 17 78,799,447 (GRCm39) missense probably damaging 1.00
R8002:Hdac1-ps UTSW 17 78,799,716 (GRCm39) missense probably damaging 0.99
R8728:Hdac1-ps UTSW 17 78,800,332 (GRCm39) missense probably benign 0.01
R8821:Hdac1-ps UTSW 17 78,799,969 (GRCm39) missense probably damaging 0.99
R8920:Hdac1-ps UTSW 17 78,799,171 (GRCm39) missense probably benign 0.37
R9618:Hdac1-ps UTSW 17 78,799,114 (GRCm39) missense probably damaging 1.00
R9649:Hdac1-ps UTSW 17 78,799,075 (GRCm39) missense probably benign 0.03
X0060:Hdac1-ps UTSW 17 78,799,557 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- AAACGCATCTCCATCTGCTC -3'
(R):5'- TTCTTTCCACGCAAATGGGG -3'

Sequencing Primer
(F):5'- GCTCCTCTGACAAACGCATTG -3'
(R):5'- ATGGACAAGGTCGCTCTGG -3'
Posted On 2015-08-18