|Institutional Source||Beutler Lab|
|Gene Name||epithelial mitogen|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R4551 (G1)|
|Chromosomal Location||91027464-91035215 bp(+) (GRCm38)|
|Type of Mutation||nonsense|
|DNA Base Change (assembly)||A to T at 91027562 bp|
|Amino Acid Change||Lysine to Stop codon at position 14 (K14*)|
|Ref Sequence||ENSEMBL: ENSMUSP00000046987 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000041516] [ENSMUST00000202724]|
|Predicted Effect||probably null
AA Change: K14*
AA Change: K14*
|Predicted Effect||probably benign
|Meta Mutation Damage Score||0.9755|
|Coding Region Coverage||
|Validation Efficiency||100% (71/71)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit moderate increase in absolute pancreas and spleen weight but normal epidermis and pilosebaceous unit development. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Epgn||
(F):5'- TTGGATTGGTAAGAACAGCCAG -3'
(R):5'- ACACTTCAGGCTTCTTTGAGAGAG -3'
(F):5'- GAACAGCCAGATGACGCTTCG -3'
(R):5'- TCAGGCTTCTTTGAGAGAGAGAAAAG -3'