Incidental Mutation 'R4551:Vmn2r105'
| ID |
333978 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r105
|
| Ensembl Gene |
ENSMUSG00000091670 |
| Gene Name |
vomeronasal 2, receptor 105 |
| Synonyms |
EG627743 |
| MMRRC Submission |
041782-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4551 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
20428492-20455134 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 20446613 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 462
(V462A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129762
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167382]
|
| AlphaFold |
E9Q3A5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000167382
AA Change: V462A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000129762
Gene: ENSMUSG00000091670
AA Change: V462A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
85 |
469 |
6.5e-42 |
PFAM |
|
Pfam:NCD3G
|
512 |
565 |
3.2e-21 |
PFAM |
|
Pfam:7tm_3
|
598 |
833 |
2.5e-51 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.5%
|
| Validation Efficiency |
100% (71/71) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 62 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aatk |
T |
G |
11: 119,902,395 (GRCm39) |
E610A |
probably benign |
Het |
| Abhd17b |
T |
C |
19: 21,658,290 (GRCm39) |
S176P |
possibly damaging |
Het |
| Adgrg7 |
A |
G |
16: 56,568,375 (GRCm39) |
Y427H |
probably damaging |
Het |
| Alox15 |
T |
A |
11: 70,235,422 (GRCm39) |
I647L |
probably benign |
Het |
| Ankhd1 |
C |
A |
18: 36,788,560 (GRCm39) |
|
probably null |
Het |
| Arid1a |
A |
C |
4: 133,423,010 (GRCm39) |
|
probably benign |
Het |
| Armcx5 |
T |
A |
X: 134,647,256 (GRCm39) |
V444D |
probably damaging |
Het |
| C4bp |
A |
G |
1: 130,564,464 (GRCm39) |
Y407H |
possibly damaging |
Het |
| Cog6 |
T |
A |
3: 52,905,741 (GRCm39) |
E96V |
probably damaging |
Het |
| Cox20 |
A |
C |
1: 178,150,114 (GRCm39) |
N96T |
probably benign |
Het |
| Cpa3 |
T |
C |
3: 20,273,934 (GRCm39) |
I351V |
probably benign |
Het |
| Cpd |
C |
T |
11: 76,702,712 (GRCm39) |
G552D |
probably damaging |
Het |
| Cyld |
A |
G |
8: 89,433,762 (GRCm39) |
K184E |
possibly damaging |
Het |
| Dab2 |
G |
A |
15: 6,464,775 (GRCm39) |
G324D |
probably damaging |
Het |
| Depdc1a |
T |
A |
3: 159,228,221 (GRCm39) |
D324E |
probably damaging |
Het |
| Dnah9 |
T |
C |
11: 65,732,192 (GRCm39) |
E4238G |
probably damaging |
Het |
| Dync1i1 |
T |
A |
6: 5,923,206 (GRCm39) |
D275E |
probably benign |
Het |
| Epgn |
A |
T |
5: 91,175,421 (GRCm39) |
K14* |
probably null |
Het |
| Farp2 |
T |
A |
1: 93,546,314 (GRCm39) |
L868Q |
possibly damaging |
Het |
| Gpr45 |
A |
G |
1: 43,071,950 (GRCm39) |
T198A |
probably benign |
Het |
| Grk2 |
C |
T |
19: 4,336,084 (GRCm39) |
V402M |
possibly damaging |
Het |
| Gsap |
A |
T |
5: 21,495,569 (GRCm39) |
D79V |
probably damaging |
Het |
| Gtf2h3 |
A |
G |
5: 124,728,482 (GRCm39) |
|
probably benign |
Het |
| Hus1b |
C |
A |
13: 31,131,059 (GRCm39) |
S200I |
probably damaging |
Het |
| Hypk |
A |
G |
2: 121,283,961 (GRCm39) |
|
probably null |
Het |
| Ikbke |
T |
C |
1: 131,185,770 (GRCm39) |
|
probably benign |
Het |
| Kat6b |
A |
G |
14: 21,711,516 (GRCm39) |
E670G |
probably damaging |
Het |
| Kif26b |
T |
A |
1: 178,711,600 (GRCm39) |
I740N |
probably damaging |
Het |
| Lhx3 |
G |
A |
2: 26,091,202 (GRCm39) |
P369L |
probably damaging |
Het |
| Man2c1 |
T |
C |
9: 57,038,445 (GRCm39) |
L35P |
probably damaging |
Het |
| Mical2 |
T |
A |
7: 111,981,123 (GRCm39) |
S366T |
possibly damaging |
Het |
| Mroh9 |
A |
T |
1: 162,871,662 (GRCm39) |
I607N |
probably damaging |
Het |
| Mybphl |
T |
C |
3: 108,281,479 (GRCm39) |
I65T |
possibly damaging |
Het |
| Myo1g |
A |
G |
11: 6,467,874 (GRCm39) |
I187T |
probably damaging |
Het |
| Myo7b |
T |
C |
18: 32,118,161 (GRCm39) |
S822G |
probably benign |
Het |
| Nkx2-4 |
C |
A |
2: 146,926,842 (GRCm39) |
A142S |
probably benign |
Het |
| Obscn |
T |
C |
11: 59,022,472 (GRCm39) |
R758G |
possibly damaging |
Het |
| Odf4 |
C |
T |
11: 68,812,866 (GRCm39) |
S264N |
probably benign |
Het |
| Or12k7 |
G |
T |
2: 36,958,355 (GRCm39) |
V13L |
probably benign |
Het |
| Or13a17 |
A |
T |
7: 140,271,655 (GRCm39) |
Y279F |
probably damaging |
Het |
| Or56b1 |
A |
T |
7: 104,285,631 (GRCm39) |
H250L |
probably damaging |
Het |
| Papolb |
T |
C |
5: 142,514,933 (GRCm39) |
I237V |
probably benign |
Het |
| Parpbp |
T |
A |
10: 87,929,564 (GRCm39) |
Q428L |
possibly damaging |
Het |
| Pcdhb16 |
T |
C |
18: 37,612,887 (GRCm39) |
F616L |
probably damaging |
Het |
| Pdk3 |
A |
T |
X: 92,825,846 (GRCm39) |
M253K |
probably damaging |
Het |
| Pgap2 |
C |
A |
7: 101,875,674 (GRCm39) |
|
probably benign |
Het |
| Pkhd1l1 |
C |
A |
15: 44,414,281 (GRCm39) |
N2849K |
probably damaging |
Het |
| Pprc1 |
A |
G |
19: 46,055,664 (GRCm39) |
|
probably benign |
Het |
| Psma2 |
A |
G |
13: 14,791,430 (GRCm39) |
Y25C |
possibly damaging |
Het |
| Ptgir |
A |
G |
7: 16,640,794 (GRCm39) |
M29V |
possibly damaging |
Het |
| Ptpn5 |
C |
A |
7: 46,740,600 (GRCm39) |
|
probably benign |
Het |
| Pxn |
G |
T |
5: 115,690,779 (GRCm39) |
|
probably benign |
Het |
| Scd3 |
C |
A |
19: 44,203,878 (GRCm39) |
A22E |
probably benign |
Het |
| Sdr42e1 |
T |
C |
8: 118,390,347 (GRCm39) |
E98G |
probably benign |
Het |
| Slc14a2 |
A |
C |
18: 78,239,068 (GRCm39) |
S184A |
probably benign |
Het |
| Tmem236 |
A |
T |
2: 14,223,964 (GRCm39) |
Q251L |
probably benign |
Het |
| Trappc8 |
T |
C |
18: 21,007,729 (GRCm39) |
T129A |
probably benign |
Het |
| Vmn1r90 |
A |
C |
7: 14,295,894 (GRCm39) |
M68R |
possibly damaging |
Het |
| Vmn2r7 |
T |
C |
3: 64,598,110 (GRCm39) |
T816A |
possibly damaging |
Het |
| Vmn2r81 |
T |
A |
10: 79,104,241 (GRCm39) |
I288K |
possibly damaging |
Het |
| Zfp180 |
A |
C |
7: 23,803,998 (GRCm39) |
K139T |
possibly damaging |
Het |
| Zfp932 |
T |
C |
5: 110,157,505 (GRCm39) |
V401A |
probably benign |
Het |
|
| Other mutations in Vmn2r105 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01433:Vmn2r105
|
APN |
17 |
20,448,817 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01909:Vmn2r105
|
APN |
17 |
20,444,918 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01925:Vmn2r105
|
APN |
17 |
20,428,973 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02021:Vmn2r105
|
APN |
17 |
20,448,157 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02828:Vmn2r105
|
APN |
17 |
20,429,345 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL02838:Vmn2r105
|
APN |
17 |
20,447,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03343:Vmn2r105
|
APN |
17 |
20,446,631 (GRCm39) |
nonsense |
probably null |
|
|
R0096:Vmn2r105
|
UTSW |
17 |
20,447,741 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R0096:Vmn2r105
|
UTSW |
17 |
20,447,741 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R0212:Vmn2r105
|
UTSW |
17 |
20,428,827 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0268:Vmn2r105
|
UTSW |
17 |
20,428,938 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0271:Vmn2r105
|
UTSW |
17 |
20,454,965 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0613:Vmn2r105
|
UTSW |
17 |
20,428,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0765:Vmn2r105
|
UTSW |
17 |
20,448,119 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0765:Vmn2r105
|
UTSW |
17 |
20,447,973 (GRCm39) |
missense |
probably benign |
0.20 |
|
R1162:Vmn2r105
|
UTSW |
17 |
20,447,973 (GRCm39) |
missense |
probably benign |
0.20 |
|
R1263:Vmn2r105
|
UTSW |
17 |
20,428,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1363:Vmn2r105
|
UTSW |
17 |
20,428,932 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1464:Vmn2r105
|
UTSW |
17 |
20,449,004 (GRCm39) |
splice site |
probably benign |
|
|
R2029:Vmn2r105
|
UTSW |
17 |
20,444,840 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2420:Vmn2r105
|
UTSW |
17 |
20,448,097 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2421:Vmn2r105
|
UTSW |
17 |
20,448,097 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2422:Vmn2r105
|
UTSW |
17 |
20,448,097 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2570:Vmn2r105
|
UTSW |
17 |
20,447,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3847:Vmn2r105
|
UTSW |
17 |
20,428,952 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R3848:Vmn2r105
|
UTSW |
17 |
20,428,952 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4030:Vmn2r105
|
UTSW |
17 |
20,429,016 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4275:Vmn2r105
|
UTSW |
17 |
20,448,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4801:Vmn2r105
|
UTSW |
17 |
20,447,556 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4802:Vmn2r105
|
UTSW |
17 |
20,447,556 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4816:Vmn2r105
|
UTSW |
17 |
20,428,953 (GRCm39) |
missense |
probably benign |
0.27 |
|
R4929:Vmn2r105
|
UTSW |
17 |
20,448,280 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5022:Vmn2r105
|
UTSW |
17 |
20,428,676 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5475:Vmn2r105
|
UTSW |
17 |
20,455,044 (GRCm39) |
missense |
probably benign |
|
|
R5576:Vmn2r105
|
UTSW |
17 |
20,444,836 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5795:Vmn2r105
|
UTSW |
17 |
20,448,998 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5895:Vmn2r105
|
UTSW |
17 |
20,448,929 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6017:Vmn2r105
|
UTSW |
17 |
20,428,889 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6210:Vmn2r105
|
UTSW |
17 |
20,448,758 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6491:Vmn2r105
|
UTSW |
17 |
20,447,992 (GRCm39) |
nonsense |
probably null |
|
|
R6542:Vmn2r105
|
UTSW |
17 |
20,448,803 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6729:Vmn2r105
|
UTSW |
17 |
20,428,605 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7020:Vmn2r105
|
UTSW |
17 |
20,429,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7033:Vmn2r105
|
UTSW |
17 |
20,428,874 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7488:Vmn2r105
|
UTSW |
17 |
20,429,045 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7491:Vmn2r105
|
UTSW |
17 |
20,448,827 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7555:Vmn2r105
|
UTSW |
17 |
20,447,937 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7863:Vmn2r105
|
UTSW |
17 |
20,428,937 (GRCm39) |
missense |
probably benign |
0.18 |
|
R8137:Vmn2r105
|
UTSW |
17 |
20,454,966 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8166:Vmn2r105
|
UTSW |
17 |
20,428,904 (GRCm39) |
missense |
probably benign |
0.07 |
|
R8186:Vmn2r105
|
UTSW |
17 |
20,444,880 (GRCm39) |
nonsense |
probably null |
|
|
R8214:Vmn2r105
|
UTSW |
17 |
20,448,775 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8497:Vmn2r105
|
UTSW |
17 |
20,455,134 (GRCm39) |
start codon destroyed |
probably null |
0.75 |
|
R8850:Vmn2r105
|
UTSW |
17 |
20,428,872 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8880:Vmn2r105
|
UTSW |
17 |
20,429,229 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9272:Vmn2r105
|
UTSW |
17 |
20,447,685 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9506:Vmn2r105
|
UTSW |
17 |
20,429,404 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9549:Vmn2r105
|
UTSW |
17 |
20,448,023 (GRCm39) |
missense |
probably benign |
0.12 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCACTATTGTTCTGGAAAGCAG -3'
(R):5'- GAATGGCATCCCACAAACTTGG -3'
Sequencing Primer
(F):5'- CTTCTGGCCATTGGATGA -3'
(R):5'- GGAAGCTTCATTAATGTTGACATTC -3'
|
| Posted On |
2015-08-18 |
Incidental Mutation