Mutagenetix > Incidental Mutation

Incidental Mutation 'R4551:Vmn2r105'

333978

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r105

Ensembl Gene

ENSMUSG00000091670

Gene Name

vomeronasal 2, receptor 105

Synonyms

EG627743

MMRRC Submission

041782-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R4551 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

20208230-20234872 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 20226351 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 462 (V462A)

Ref Sequence

ENSEMBL: ENSMUSP00000129762 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167382]

AlphaFold

E9Q3A5

Predicted Effect

probably benign
Transcript: ENSMUST00000167382
AA Change: V462A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000129762
Gene: ENSMUSG00000091670
AA Change: V462A

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	85	469	6.5e-42	PFAM
Pfam:NCD3G	512	565	3.2e-21	PFAM
Pfam:7tm_3	598	833	2.5e-51	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 97.0%
20x: 94.5%

Validation Efficiency

100% (71/71)

Allele List at MGI

Other mutations in this stock

Total: 62 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aatk	T	G	11: 120,011,569	E610A	probably benign	Het
Abhd17b	T	C	19: 21,680,926	S176P	possibly damaging	Het
Adgrg7	A	G	16: 56,748,012	Y427H	probably damaging	Het
Alox15	T	A	11: 70,344,596	I647L	probably benign	Het
Ankhd1	C	A	18: 36,655,507		probably null	Het
Arid1a	A	C	4: 133,695,699		probably benign	Het
Armcx5	T	A	X: 135,746,507	V444D	probably damaging	Het
C4bp	A	G	1: 130,636,727	Y407H	possibly damaging	Het
Cog6	T	A	3: 52,998,320	E96V	probably damaging	Het
Cox20	A	C	1: 178,322,549	N96T	probably benign	Het
Cpa3	T	C	3: 20,219,770	I351V	probably benign	Het
Cpd	C	T	11: 76,811,886	G552D	probably damaging	Het
Cyld	A	G	8: 88,707,134	K184E	possibly damaging	Het
Dab2	G	A	15: 6,435,294	G324D	probably damaging	Het
Depdc1a	T	A	3: 159,522,584	D324E	probably damaging	Het
Dnah9	T	C	11: 65,841,366	E4238G	probably damaging	Het
Dync1i1	T	A	6: 5,923,206	D275E	probably benign	Het
Epgn	A	T	5: 91,027,562	K14*	probably null	Het
Farp2	T	A	1: 93,618,592	L868Q	possibly damaging	Het
Gpr45	A	G	1: 43,032,790	T198A	probably benign	Het
Grk2	C	T	19: 4,286,056	V402M	possibly damaging	Het
Gsap	A	T	5: 21,290,571	D79V	probably damaging	Het
Gtf2h3	A	G	5: 124,590,419		probably benign	Het
Hus1b	C	A	13: 30,947,076	S200I	probably damaging	Het
Hypk	A	G	2: 121,453,480		probably null	Het
Ikbke	T	C	1: 131,258,033		probably benign	Het
Kat6b	A	G	14: 21,661,448	E670G	probably damaging	Het
Kif26b	T	A	1: 178,884,035	I740N	probably damaging	Het
Lhx3	G	A	2: 26,201,190	P369L	probably damaging	Het
Man2c1	T	C	9: 57,131,161	L35P	probably damaging	Het
Micalcl	T	A	7: 112,381,916	S366T	possibly damaging	Het
Mroh9	A	T	1: 163,044,093	I607N	probably damaging	Het
Mybphl	T	C	3: 108,374,163	I65T	possibly damaging	Het
Myo1g	A	G	11: 6,517,874	I187T	probably damaging	Het
Myo7b	T	C	18: 31,985,108	S822G	probably benign	Het
Nkx2-4	C	A	2: 147,084,922	A142S	probably benign	Het
Obscn	T	C	11: 59,131,646	R758G	possibly damaging	Het
Odf4	C	T	11: 68,922,040	S264N	probably benign	Het
Olfr360	G	T	2: 37,068,343	V13L	probably benign	Het
Olfr45	A	T	7: 140,691,742	Y279F	probably damaging	Het
Olfr657	A	T	7: 104,636,424	H250L	probably damaging	Het
Papolb	T	C	5: 142,529,178	I237V	probably benign	Het
Parpbp	T	A	10: 88,093,702	Q428L	possibly damaging	Het
Pcdhb16	T	C	18: 37,479,834	F616L	probably damaging	Het
Pdk3	A	T	X: 93,782,240	M253K	probably damaging	Het
Pgap2	C	A	7: 102,226,467		probably benign	Het
Pkhd1l1	C	A	15: 44,550,885	N2849K	probably damaging	Het
Pprc1	A	G	19: 46,067,225		probably benign	Het
Psma2	A	G	13: 14,616,845	Y25C	possibly damaging	Het
Ptgir	A	G	7: 16,906,869	M29V	possibly damaging	Het
Ptpn5	C	A	7: 47,090,852		probably benign	Het
Pxn	G	T	5: 115,552,720		probably benign	Het
Scd3	C	A	19: 44,215,439	A22E	probably benign	Het
Sdr42e1	T	C	8: 117,663,608	E98G	probably benign	Het
Slc14a2	A	C	18: 78,195,853	S184A	probably benign	Het
Tmem236	A	T	2: 14,219,153	Q251L	probably benign	Het
Trappc8	T	C	18: 20,874,672	T129A	probably benign	Het
Vmn1r90	A	C	7: 14,561,969	M68R	possibly damaging	Het
Vmn2r7	T	C	3: 64,690,689	T816A	possibly damaging	Het
Vmn2r81	T	A	10: 79,268,407	I288K	possibly damaging	Het
Zfp180	A	C	7: 24,104,573	K139T	possibly damaging	Het
Zfp932	T	C	5: 110,009,639	V401A	probably benign	Het

Other mutations in Vmn2r105

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01433:Vmn2r105	APN	17	20228555	missense	probably benign	0.01
IGL01909:Vmn2r105	APN	17	20224656	missense	probably damaging	1.00
IGL01925:Vmn2r105	APN	17	20208711	missense	possibly damaging	0.94
IGL02021:Vmn2r105	APN	17	20227895	missense	possibly damaging	0.49
IGL02828:Vmn2r105	APN	17	20209083	missense	possibly damaging	0.80
IGL02838:Vmn2r105	APN	17	20227585	missense	probably damaging	1.00
IGL03343:Vmn2r105	APN	17	20226369	nonsense	probably null
R0096:Vmn2r105	UTSW	17	20227479	missense	possibly damaging	0.49
R0096:Vmn2r105	UTSW	17	20227479	missense	possibly damaging	0.49
R0212:Vmn2r105	UTSW	17	20208565	missense	possibly damaging	0.90
R0268:Vmn2r105	UTSW	17	20208676	missense	probably benign	0.18
R0271:Vmn2r105	UTSW	17	20234703	missense	probably damaging	0.96
R0613:Vmn2r105	UTSW	17	20208316	missense	probably damaging	1.00
R0765:Vmn2r105	UTSW	17	20227711	missense	probably benign	0.20
R0765:Vmn2r105	UTSW	17	20227857	missense	probably damaging	0.98
R1162:Vmn2r105	UTSW	17	20227711	missense	probably benign	0.20
R1263:Vmn2r105	UTSW	17	20208322	missense	probably damaging	1.00
R1363:Vmn2r105	UTSW	17	20208670	missense	probably benign	0.00
R1464:Vmn2r105	UTSW	17	20228742	splice site	probably benign
R2029:Vmn2r105	UTSW	17	20224578	missense	probably damaging	0.99
R2420:Vmn2r105	UTSW	17	20227835	missense	probably benign	0.15
R2421:Vmn2r105	UTSW	17	20227835	missense	probably benign	0.15
R2422:Vmn2r105	UTSW	17	20227835	missense	probably benign	0.15
R2570:Vmn2r105	UTSW	17	20227323	missense	probably damaging	1.00
R3847:Vmn2r105	UTSW	17	20208690	missense	possibly damaging	0.85
R3848:Vmn2r105	UTSW	17	20208690	missense	possibly damaging	0.85
R4030:Vmn2r105	UTSW	17	20208754	missense	probably damaging	0.99
R4275:Vmn2r105	UTSW	17	20228640	missense	probably damaging	1.00
R4801:Vmn2r105	UTSW	17	20227294	missense	probably benign	0.00
R4802:Vmn2r105	UTSW	17	20227294	missense	probably benign	0.00
R4816:Vmn2r105	UTSW	17	20208691	missense	probably benign	0.27
R4929:Vmn2r105	UTSW	17	20228018	missense	probably benign	0.44
R5022:Vmn2r105	UTSW	17	20208414	missense	probably damaging	0.99
R5475:Vmn2r105	UTSW	17	20234782	missense	probably benign
R5576:Vmn2r105	UTSW	17	20224574	critical splice donor site	probably null
R5795:Vmn2r105	UTSW	17	20228736	missense	probably benign	0.00
R5895:Vmn2r105	UTSW	17	20228667	missense	probably benign	0.10
R6017:Vmn2r105	UTSW	17	20208627	missense	probably damaging	0.97
R6210:Vmn2r105	UTSW	17	20228496	missense	probably damaging	1.00
R6491:Vmn2r105	UTSW	17	20227730	nonsense	probably null
R6542:Vmn2r105	UTSW	17	20228541	missense	probably benign	0.03
R6729:Vmn2r105	UTSW	17	20208343	missense	probably damaging	0.99
R7020:Vmn2r105	UTSW	17	20209074	missense	probably damaging	1.00
R7033:Vmn2r105	UTSW	17	20208612	missense	probably damaging	0.97
R7488:Vmn2r105	UTSW	17	20208783	missense	probably damaging	1.00
R7491:Vmn2r105	UTSW	17	20228565	missense	probably benign	0.02
R7555:Vmn2r105	UTSW	17	20227675	missense	probably damaging	0.98
R7863:Vmn2r105	UTSW	17	20208675	missense	probably benign	0.18
R8137:Vmn2r105	UTSW	17	20234704	missense	probably benign	0.02
R8166:Vmn2r105	UTSW	17	20208642	missense	probably benign	0.07
R8186:Vmn2r105	UTSW	17	20224618	nonsense	probably null
R8214:Vmn2r105	UTSW	17	20228513	missense	probably benign	0.02
R8497:Vmn2r105	UTSW	17	20234872	start codon destroyed	probably null	0.75
R8850:Vmn2r105	UTSW	17	20208610	missense	probably damaging	1.00
R8880:Vmn2r105	UTSW	17	20208967	missense	probably damaging	0.99
R9272:Vmn2r105	UTSW	17	20227423	missense	probably damaging	1.00
R9506:Vmn2r105	UTSW	17	20209142	missense	probably benign	0.00
R9549:Vmn2r105	UTSW	17	20227761	missense	probably benign	0.12

Predicted Primers

PCR Primer
(F):5'- GCACTATTGTTCTGGAAAGCAG -3'
(R):5'- GAATGGCATCCCACAAACTTGG -3'

Sequencing Primer
(F):5'- CTTCTGGCCATTGGATGA -3'
(R):5'- GGAAGCTTCATTAATGTTGACATTC -3'

Posted On

2015-08-18