Incidental Mutation 'R4552:Odf4'
ID 334027
Institutional Source Beutler Lab
Gene Symbol Odf4
Ensembl Gene ENSMUSG00000032921
Gene Name outer dense fiber of sperm tails 4
Synonyms Oppo1
MMRRC Submission 041783-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4552 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 68812661-68817907 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 68812866 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Asparagine at position 264 (S264N)
Ref Sequence ENSEMBL: ENSMUSP00000040050 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038932] [ENSMUST00000125134] [ENSMUST00000130271]
AlphaFold Q8VI88
Predicted Effect probably benign
Transcript: ENSMUST00000038932
AA Change: S264N

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000040050
Gene: ENSMUSG00000032921
AA Change: S264N

DomainStartEndE-ValueType
Pfam:PMP22_Claudin 42 222 1.1e-8 PFAM
low complexity region 272 287 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000125134
SMART Domains Protein: ENSMUSP00000133636
Gene: ENSMUSG00000032921

DomainStartEndE-ValueType
transmembrane domain 41 63 N/A INTRINSIC
transmembrane domain 125 147 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000130271
SMART Domains Protein: ENSMUSP00000134383
Gene: ENSMUSG00000032921

DomainStartEndE-ValueType
transmembrane domain 42 64 N/A INTRINSIC
transmembrane domain 126 148 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000156828
SMART Domains Protein: ENSMUSP00000133569
Gene: ENSMUSG00000032921

DomainStartEndE-ValueType
transmembrane domain 27 49 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.4%
Validation Efficiency 97% (62/64)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that is localized in the outer dense fibers of the tails of mature sperm. This protein is thought to have some important role in the sperm tail. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts16 G A 13: 70,927,637 (GRCm39) probably benign Het
Arhgap33 A T 7: 30,218,533 (GRCm39) probably benign Het
Arid1a A C 4: 133,423,010 (GRCm39) probably benign Het
C4bp A G 1: 130,564,464 (GRCm39) Y407H possibly damaging Het
Camta1 T C 4: 151,876,959 (GRCm39) R79G probably damaging Het
Caskin1 G A 17: 24,725,602 (GRCm39) S1296N probably benign Het
Cep128 T C 12: 91,260,936 (GRCm39) E309G probably damaging Het
Chit1 A G 1: 134,071,789 (GRCm39) T100A probably benign Het
Dalrd3 A G 9: 108,449,429 (GRCm39) D454G possibly damaging Het
Ddx19a G A 8: 111,705,198 (GRCm39) Q308* probably null Het
Dmxl2 T C 9: 54,359,047 (GRCm39) N395S probably damaging Het
Dnah17 T C 11: 117,943,769 (GRCm39) D3125G possibly damaging Het
Dnah5 T C 15: 28,397,300 (GRCm39) V3331A probably benign Het
Dnah9 T C 11: 65,732,192 (GRCm39) E4238G probably damaging Het
Dner T C 1: 84,361,578 (GRCm39) Y677C probably damaging Het
Epgn A T 5: 91,175,421 (GRCm39) K14* probably null Het
Hid1 G A 11: 115,249,505 (GRCm39) T240M possibly damaging Het
Igbp1b T A 6: 138,635,112 (GRCm39) M111L probably benign Het
Kif26b T A 1: 178,711,600 (GRCm39) I740N probably damaging Het
Klk4 C A 7: 43,533,443 (GRCm39) H101N probably benign Het
Mrgpra2b C A 7: 47,113,754 (GRCm39) S300I probably benign Het
Mtss2 A G 8: 111,465,137 (GRCm39) T464A probably damaging Het
Nbas T C 12: 13,385,938 (GRCm39) probably null Het
Nif3l1 C T 1: 58,488,483 (GRCm39) probably benign Het
Noct T A 3: 51,157,589 (GRCm39) I309N probably benign Het
Obscn T C 11: 59,022,472 (GRCm39) R758G possibly damaging Het
Odf2l A T 3: 144,856,844 (GRCm39) T600S probably benign Het
Or13a17 A T 7: 140,271,655 (GRCm39) Y279F probably damaging Het
Or1m1 A G 9: 18,666,430 (GRCm39) V167A possibly damaging Het
Or2y1e A T 11: 49,218,777 (GRCm39) M180L probably benign Het
Or6c217 T C 10: 129,737,992 (GRCm39) M196V probably benign Het
Papolb T C 5: 142,514,933 (GRCm39) I237V probably benign Het
Parpbp T A 10: 87,929,564 (GRCm39) Q428L possibly damaging Het
Pclo T C 5: 14,719,285 (GRCm39) S1141P unknown Het
Plcb1 T C 2: 135,177,413 (GRCm39) S582P probably benign Het
Ppargc1a C T 5: 51,620,557 (GRCm39) probably benign Het
Ptchd4 A T 17: 42,813,346 (GRCm39) I416L probably benign Het
Rhpn1 G A 15: 75,585,968 (GRCm39) R627H probably benign Het
Ric8a G A 7: 140,441,250 (GRCm39) G182S probably damaging Het
Rims1 T C 1: 22,443,718 (GRCm39) D895G probably damaging Het
Rrp1b G A 17: 32,274,984 (GRCm39) probably benign Het
Rtf1 T A 2: 119,561,210 (GRCm39) D636E probably benign Het
Scn3a T C 2: 65,354,523 (GRCm39) D333G probably benign Het
Sema6a A G 18: 47,424,990 (GRCm39) L207P probably damaging Het
Shcbp1 A T 8: 4,799,779 (GRCm39) Y160* probably null Het
Slc27a1 A T 8: 72,032,710 (GRCm39) probably null Het
Ston2 C T 12: 91,608,646 (GRCm39) R818Q probably damaging Het
Tipin T A 9: 64,195,385 (GRCm39) probably null Het
Tjap1 A T 17: 46,570,953 (GRCm39) probably null Het
Vmn1r117 A T 7: 20,617,517 (GRCm39) F177Y probably damaging Het
Vmn1r57 A G 7: 5,223,667 (GRCm39) D64G possibly damaging Het
Vmn2r73 T A 7: 85,525,055 (GRCm39) D31V probably benign Het
Vmn2r-ps41 A T 7: 9,180,063 (GRCm39) noncoding transcript Het
Other mutations in Odf4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01090:Odf4 APN 11 68,812,778 (GRCm39) unclassified probably benign
IGL01782:Odf4 APN 11 68,817,459 (GRCm39) missense probably damaging 0.98
BB006:Odf4 UTSW 11 68,813,759 (GRCm39) missense possibly damaging 0.80
BB016:Odf4 UTSW 11 68,813,759 (GRCm39) missense possibly damaging 0.80
R0030:Odf4 UTSW 11 68,817,767 (GRCm39) missense probably benign 0.33
R0030:Odf4 UTSW 11 68,817,767 (GRCm39) missense probably benign 0.33
R1945:Odf4 UTSW 11 68,812,983 (GRCm39) missense possibly damaging 0.53
R4551:Odf4 UTSW 11 68,812,866 (GRCm39) missense probably benign 0.02
R4685:Odf4 UTSW 11 68,813,665 (GRCm39) critical splice donor site probably null
R4707:Odf4 UTSW 11 68,817,514 (GRCm39) missense probably damaging 1.00
R5163:Odf4 UTSW 11 68,813,672 (GRCm39) missense probably damaging 1.00
R6657:Odf4 UTSW 11 68,817,638 (GRCm39) missense probably benign 0.12
R7073:Odf4 UTSW 11 68,817,514 (GRCm39) missense probably damaging 1.00
R7508:Odf4 UTSW 11 68,813,249 (GRCm39) missense possibly damaging 0.71
R7778:Odf4 UTSW 11 68,812,898 (GRCm39) missense probably benign 0.01
R7824:Odf4 UTSW 11 68,812,898 (GRCm39) missense probably benign 0.01
R7929:Odf4 UTSW 11 68,813,759 (GRCm39) missense possibly damaging 0.80
R9425:Odf4 UTSW 11 68,813,810 (GRCm39) missense probably benign
X0025:Odf4 UTSW 11 68,817,616 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TTATTCCACATCACCTGAGCCA -3'
(R):5'- ATGCCACTTTCAGATTCCCC -3'

Sequencing Primer
(F):5'- CCACAGACAAAGCCAAGTTGAGG -3'
(R):5'- TCTTGTCCTCCCCCGCC -3'
Posted On 2015-08-18