Incidental Mutation 'R4518:Olfr39'
Institutional Source Beutler Lab
Gene Symbol Olfr39
Ensembl Gene ENSMUSG00000059623
Gene Nameolfactory receptor 39
SynonymsGA_x6K02T2PVTD-14025733-14026668, MOR144-1
MMRRC Submission 041762-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.080) question?
Stock #R4518 (G1)
Quality Score225
Status Validated
Chromosomal Location20282351-20287578 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 20286250 bp
Amino Acid Change Isoleucine to Valine at position 184 (I184V)
Ref Sequence ENSEMBL: ENSMUSP00000148572 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071725] [ENSMUST00000212983]
Predicted Effect probably benign
Transcript: ENSMUST00000071725
AA Change: I192V

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000071641
Gene: ENSMUSG00000059623
AA Change: I192V

Pfam:7tm_4 39 315 1.3e-51 PFAM
Pfam:7TM_GPCR_Srsx 43 307 1e-6 PFAM
Pfam:7tm_1 49 298 3.1e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000212983
AA Change: I184V

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.9%
Validation Efficiency 98% (60/61)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110082J24Rik T A 5: 30,106,008 probably null Het
Abr A G 11: 76,472,518 S167P possibly damaging Het
Adamtsl2 T C 2: 27,095,547 L481P probably benign Het
Atp8b3 C T 10: 80,523,847 M984I probably benign Het
Brip1 G A 11: 86,077,878 A827V possibly damaging Het
Carns1 T G 19: 4,170,070 T389P probably benign Het
Ccdc88a T C 11: 29,482,651 I1219T probably benign Het
Cckar T C 5: 53,699,922 N311S probably damaging Het
Cenpc1 A G 5: 86,047,587 S108P possibly damaging Het
Chpf G T 1: 75,475,045 S588R probably damaging Het
Clca3a2 T A 3: 144,808,705 T414S probably damaging Het
Cntrl A G 2: 35,148,974 E1092G probably damaging Het
Crb2 C A 2: 37,790,389 T443K probably damaging Het
Cwf19l1 A G 19: 44,133,034 V25A probably damaging Het
Cyb561d1 T C 3: 108,199,571 I111V possibly damaging Het
Dbn1 A T 13: 55,476,229 I350N possibly damaging Het
Dnajb4 T C 3: 152,185,176 I329V probably benign Het
Dnmt1 G T 9: 20,911,978 D1055E probably benign Het
Fam122c G A X: 53,293,499 R94H possibly damaging Het
Fam168a C T 7: 100,834,040 A176V probably damaging Het
Farp2 A G 1: 93,620,641 E1016G probably benign Het
Fibcd1 A T 2: 31,817,195 V350E probably damaging Het
Galnt3 C A 2: 66,093,610 R438L probably damaging Het
Golga4 T A 9: 118,559,008 S1733T probably benign Het
Golgb1 G A 16: 36,929,263 E3076K probably damaging Het
Grm7 A G 6: 110,914,546 probably null Het
Hcn2 T C 10: 79,724,702 V289A probably benign Het
Hipk1 G T 3: 103,750,372 H799N probably damaging Het
Ispd G A 12: 36,473,180 V203I possibly damaging Het
Klf14 A G 6: 30,957,932 S256P possibly damaging Het
Muc6 T A 7: 141,644,222 T1214S probably benign Het
Nlrp2 T A 7: 5,325,056 D666V possibly damaging Het
Ntng1 A G 3: 109,935,013 I148T probably damaging Het
Olfr1277 T C 2: 111,269,918 M150V probably benign Het
Olfr845 T A 9: 19,339,260 S267T possibly damaging Het
Orc4 G A 2: 48,937,489 P31S probably benign Het
Pacs2 A G 12: 113,060,669 D360G probably benign Het
Parp8 C A 13: 116,895,673 L321F possibly damaging Het
Pdss2 T A 10: 43,372,150 S217T probably damaging Het
Plekhn1 T C 4: 156,225,531 S109G probably damaging Het
Ppil2 A T 16: 17,096,041 F173I possibly damaging Het
Prlr C A 15: 10,328,999 T520K possibly damaging Het
Prokr2 T A 2: 132,374,092 probably null Het
Rab3gap2 G A 1: 185,267,068 V991I probably benign Het
Reln T C 5: 21,901,743 I3210V probably benign Het
Rims2 T C 15: 39,437,526 Y218H probably damaging Het
Slc41a1 T C 1: 131,839,125 V127A probably damaging Het
St8sia6 T A 2: 13,792,751 probably null Het
Tlr6 A G 5: 64,954,904 F220S possibly damaging Het
Trmt1l C T 1: 151,448,343 Q314* probably null Het
Ubqlnl C T 7: 104,149,718 V191M probably benign Het
Vnn3 G A 10: 23,867,226 V445M possibly damaging Het
Zfhx4 T C 3: 5,412,518 C3398R probably damaging Het
Zfyve16 T C 13: 92,521,312 E697G possibly damaging Het
Other mutations in Olfr39
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02173:Olfr39 APN 9 20286395 missense probably benign 0.00
IGL02219:Olfr39 APN 9 20286460 missense probably benign 0.45
IGL02468:Olfr39 APN 9 20286278 missense probably damaging 1.00
IGL03024:Olfr39 APN 9 20285984 missense probably benign 0.00
R0329:Olfr39 UTSW 9 20285857 missense possibly damaging 0.95
R1656:Olfr39 UTSW 9 20286577 missense probably damaging 1.00
R3116:Olfr39 UTSW 9 20286227 missense probably benign 0.19
R7204:Olfr39 UTSW 9 20285804 missense probably benign 0.19
R7395:Olfr39 UTSW 9 20286530 missense probably damaging 0.99
R7775:Olfr39 UTSW 9 20282412 start gained probably benign
R7778:Olfr39 UTSW 9 20282412 start gained probably benign
Predicted Primers PCR Primer

Sequencing Primer
Posted On2015-08-18