Incidental Mutation 'R4521:Rpl10l'
Institutional Source Beutler Lab
Gene Symbol Rpl10l
Ensembl Gene ENSMUSG00000060499
Gene Nameribosomal protein L10-like
MMRRC Submission 041764-MU
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.384) question?
Stock #R4521 (G1)
Quality Score225
Status Validated
Chromosomal Location66283379-66284401 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 66283738 bp
Amino Acid Change Aspartic acid to Glycine at position 207 (D207G)
Ref Sequence ENSEMBL: ENSMUSP00000100795 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081908]
Predicted Effect probably benign
Transcript: ENSMUST00000081908
AA Change: D207G

PolyPhen 2 Score 0.190 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000100795
Gene: ENSMUSG00000060499
AA Change: D207G

Pfam:Ribosomal_L16 12 166 4.6e-45 PFAM
Meta Mutation Damage Score 0.0627 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.8%
Validation Efficiency 100% (49/49)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein sharing sequence similarity with ribosomal protein L10. It is not currently known whether the encoded protein is a functional ribosomal protein or whether it has evolved a function that is independent of the ribosome. This gene is intronless. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ascc3 A G 10: 50,660,670 N700D probably benign Het
Bora G T 14: 99,068,548 S451I probably damaging Het
Cadm3 A T 1: 173,345,063 probably null Het
Car14 A G 3: 95,904,378 probably benign Het
Ccdc88c G T 12: 100,913,332 S1843R possibly damaging Het
Cdc20b A G 13: 113,081,191 I381M probably damaging Het
Col12a1 C T 9: 79,633,357 V2449I probably benign Het
Crb2 T C 2: 37,795,337 probably benign Het
Dcaf6 A T 1: 165,390,490 D347E probably damaging Het
Dlgap2 G A 8: 14,727,871 R372H probably damaging Het
Fat3 T C 9: 15,922,942 N4118S probably null Het
Fbxo41 A G 6: 85,484,042 I228T probably damaging Het
Fpr2 A C 17: 17,893,247 R168S probably benign Het
Ghr A G 15: 3,325,958 I281T probably damaging Het
Glmp C A 3: 88,328,039 N259K possibly damaging Het
Grhl3 T C 4: 135,546,250 K564E probably damaging Het
Helz2 T C 2: 181,228,833 H2875R probably benign Het
Lcp1 A G 14: 75,215,168 D438G possibly damaging Het
Lrfn2 T A 17: 49,069,894 M1K probably null Het
Lrp6 A G 6: 134,485,862 C612R probably damaging Het
Map3k13 T C 16: 21,905,775 V341A possibly damaging Het
Megf8 T A 7: 25,342,701 C1315S probably benign Het
Mrgpra9 A T 7: 47,235,190 L243H probably damaging Het
Mrgprx1 T C 7: 48,021,699 D100G probably benign Het
Nop2 G T 6: 125,133,552 R47L probably damaging Het
Nup93 T C 8: 94,314,636 Y801H probably damaging Het
Olfr623 C T 7: 103,660,332 R306H probably benign Het
Olfr810 T A 10: 129,791,181 N136I possibly damaging Het
Orc4 G A 2: 48,937,489 P31S probably benign Het
Plce1 T C 19: 38,524,319 S21P possibly damaging Het
Plpp2 A G 10: 79,530,625 Y118H probably damaging Het
Ppwd1 A G 13: 104,209,659 V496A probably benign Het
Rbm20 A G 19: 53,817,202 N466S probably benign Het
Skida1 T C 2: 18,045,872 probably benign Het
Stk17b A G 1: 53,764,038 Y73H probably damaging Het
Tapbpl A G 6: 125,228,122 I287T probably damaging Het
Tmem38a C T 8: 72,572,161 P20S possibly damaging Het
Topbp1 T C 9: 103,334,202 probably benign Het
Tsen54 G A 11: 115,817,106 probably null Het
Ttn G A 2: 76,725,216 R28736* probably null Het
Wdr36 G A 18: 32,841,148 probably null Het
Other mutations in Rpl10l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01013:Rpl10l APN 12 66284227 missense probably benign 0.00
R0278:Rpl10l UTSW 12 66284356 start codon destroyed probably null 0.99
R4043:Rpl10l UTSW 12 66284203 missense probably damaging 0.99
R4520:Rpl10l UTSW 12 66283738 missense probably benign 0.19
R4522:Rpl10l UTSW 12 66283738 missense probably benign 0.19
R4523:Rpl10l UTSW 12 66283738 missense probably benign 0.19
R4524:Rpl10l UTSW 12 66283738 missense probably benign 0.19
R6822:Rpl10l UTSW 12 66284213 missense possibly damaging 0.93
R7682:Rpl10l UTSW 12 66284230 missense probably benign 0.03
R7773:Rpl10l UTSW 12 66284267 missense probably benign 0.18
Predicted Primers PCR Primer

Sequencing Primer
Posted On2015-08-18