Incidental Mutation 'R4521:Rpl10l'
ID 334234
Institutional Source Beutler Lab
Gene Symbol Rpl10l
Ensembl Gene ENSMUSG00000060499
Gene Name ribosomal protein L10-like
Synonyms EG238217
MMRRC Submission 041764-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.674) question?
Stock # R4521 (G1)
Quality Score 225
Status Validated
Chromosome 12
Chromosomal Location 66330153-66331175 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 66330512 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 207 (D207G)
Ref Sequence ENSEMBL: ENSMUSP00000100795 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081908]
AlphaFold P86048
Predicted Effect probably benign
Transcript: ENSMUST00000081908
AA Change: D207G

PolyPhen 2 Score 0.190 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000100795
Gene: ENSMUSG00000060499
AA Change: D207G

Pfam:Ribosomal_L16 12 166 4.6e-45 PFAM
Meta Mutation Damage Score 0.0627 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.8%
Validation Efficiency 100% (49/49)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein sharing sequence similarity with ribosomal protein L10. It is not currently known whether the encoded protein is a functional ribosomal protein or whether it has evolved a function that is independent of the ribosome. This gene is intronless. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ascc3 A G 10: 50,536,766 (GRCm39) N700D probably benign Het
Bora G T 14: 99,305,984 (GRCm39) S451I probably damaging Het
Cadm3 A T 1: 173,172,630 (GRCm39) probably null Het
Car14 A G 3: 95,811,690 (GRCm39) probably benign Het
Ccdc88c G T 12: 100,879,591 (GRCm39) S1843R possibly damaging Het
Cdc20b A G 13: 113,217,725 (GRCm39) I381M probably damaging Het
Col12a1 C T 9: 79,540,639 (GRCm39) V2449I probably benign Het
Crb2 T C 2: 37,685,349 (GRCm39) probably benign Het
Dcaf6 A T 1: 165,218,059 (GRCm39) D347E probably damaging Het
Dlgap2 G A 8: 14,777,871 (GRCm39) R372H probably damaging Het
Fat3 T C 9: 15,834,238 (GRCm39) N4118S probably null Het
Fbxo41 A G 6: 85,461,024 (GRCm39) I228T probably damaging Het
Fpr2 A C 17: 18,113,509 (GRCm39) R168S probably benign Het
Ghr A G 15: 3,355,440 (GRCm39) I281T probably damaging Het
Glmp C A 3: 88,235,346 (GRCm39) N259K possibly damaging Het
Grhl3 T C 4: 135,273,561 (GRCm39) K564E probably damaging Het
Helz2 T C 2: 180,870,626 (GRCm39) H2875R probably benign Het
Lcp1 A G 14: 75,452,608 (GRCm39) D438G possibly damaging Het
Lrfn2 T A 17: 49,376,922 (GRCm39) M1K probably null Het
Lrp6 A G 6: 134,462,825 (GRCm39) C612R probably damaging Het
Map3k13 T C 16: 21,724,525 (GRCm39) V341A possibly damaging Het
Megf8 T A 7: 25,042,126 (GRCm39) C1315S probably benign Het
Mrgpra9 A T 7: 46,884,938 (GRCm39) L243H probably damaging Het
Mrgprx1 T C 7: 47,671,447 (GRCm39) D100G probably benign Het
Nop2 G T 6: 125,110,515 (GRCm39) R47L probably damaging Het
Nup93 T C 8: 95,041,264 (GRCm39) Y801H probably damaging Het
Or51b6b C T 7: 103,309,539 (GRCm39) R306H probably benign Het
Or6c69b T A 10: 129,627,050 (GRCm39) N136I possibly damaging Het
Orc4 G A 2: 48,827,501 (GRCm39) P31S probably benign Het
Plce1 T C 19: 38,512,763 (GRCm39) S21P possibly damaging Het
Plpp2 A G 10: 79,366,459 (GRCm39) Y118H probably damaging Het
Ppwd1 A G 13: 104,346,167 (GRCm39) V496A probably benign Het
Rbm20 A G 19: 53,805,633 (GRCm39) N466S probably benign Het
Skida1 T C 2: 18,050,683 (GRCm39) probably benign Het
Stk17b A G 1: 53,803,197 (GRCm39) Y73H probably damaging Het
Tapbpl A G 6: 125,205,085 (GRCm39) I287T probably damaging Het
Tmem38a C T 8: 73,326,005 (GRCm39) P20S possibly damaging Het
Topbp1 T C 9: 103,211,401 (GRCm39) probably benign Het
Tsen54 G A 11: 115,707,932 (GRCm39) probably null Het
Ttn G A 2: 76,555,560 (GRCm39) R28736* probably null Het
Wdr36 G A 18: 32,974,201 (GRCm39) probably null Het
Other mutations in Rpl10l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01013:Rpl10l APN 12 66,331,001 (GRCm39) missense probably benign 0.00
G1citation:Rpl10l UTSW 12 66,330,987 (GRCm39) missense possibly damaging 0.93
R0278:Rpl10l UTSW 12 66,331,130 (GRCm39) start codon destroyed probably null 0.99
R4043:Rpl10l UTSW 12 66,330,977 (GRCm39) missense probably damaging 0.99
R4520:Rpl10l UTSW 12 66,330,512 (GRCm39) missense probably benign 0.19
R4522:Rpl10l UTSW 12 66,330,512 (GRCm39) missense probably benign 0.19
R4523:Rpl10l UTSW 12 66,330,512 (GRCm39) missense probably benign 0.19
R4524:Rpl10l UTSW 12 66,330,512 (GRCm39) missense probably benign 0.19
R6822:Rpl10l UTSW 12 66,330,987 (GRCm39) missense possibly damaging 0.93
R7682:Rpl10l UTSW 12 66,331,004 (GRCm39) missense probably benign 0.03
R7773:Rpl10l UTSW 12 66,331,041 (GRCm39) missense probably benign 0.18
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2015-08-18