Incidental Mutation 'R4522:Rpl10l'
ID334274
Institutional Source Beutler Lab
Gene Symbol Rpl10l
Ensembl Gene ENSMUSG00000060499
Gene Nameribosomal protein L10-like
SynonymsEG238217
MMRRC Submission 041765-MU
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.384) question?
Stock #R4522 (G1)
Quality Score225
Status Not validated
Chromosome12
Chromosomal Location66283379-66284401 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 66283738 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 207 (D207G)
Ref Sequence ENSEMBL: ENSMUSP00000100795 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081908]
Predicted Effect probably benign
Transcript: ENSMUST00000081908
AA Change: D207G

PolyPhen 2 Score 0.190 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000100795
Gene: ENSMUSG00000060499
AA Change: D207G

DomainStartEndE-ValueType
Pfam:Ribosomal_L16 12 166 4.6e-45 PFAM
Meta Mutation Damage Score 0.0627 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein sharing sequence similarity with ribosomal protein L10. It is not currently known whether the encoded protein is a functional ribosomal protein or whether it has evolved a function that is independent of the ribosome. This gene is intronless. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ascc3 A G 10: 50,660,670 N700D probably benign Het
Babam2 G A 5: 32,007,242 V287M probably damaging Het
Brip1 T C 11: 86,189,801 I146M possibly damaging Het
Cacna1b C T 2: 24,654,430 R1248H probably damaging Het
Ccdc88c G T 12: 100,913,332 S1843R possibly damaging Het
Chaf1b G A 16: 93,901,295 A485T probably benign Het
Dock7 T C 4: 98,962,224 R1594G probably damaging Het
Fam122c G A X: 53,293,499 R94H possibly damaging Het
Fbxo41 A G 6: 85,484,042 I228T probably damaging Het
Gm3739 T A 14: 7,299,398 K86* probably null Het
Gm7173 A T X: 79,509,995 N291K possibly damaging Het
Mark2 A T 19: 7,285,948 D151E probably damaging Het
Nop2 G T 6: 125,133,552 R47L probably damaging Het
Nwd1 A T 8: 72,670,951 D606V probably damaging Het
Olfr1132 T A 2: 87,635,151 I199L probably benign Het
Pcbp1 T C 6: 86,525,050 N289S probably benign Het
Plce1 T C 19: 38,524,319 S21P possibly damaging Het
Ptpn18 T C 1: 34,472,960 L55P probably benign Het
Rufy4 T C 1: 74,147,663 C537R probably damaging Het
Sec23b T A 2: 144,578,366 I450N possibly damaging Het
Speg A G 1: 75,428,330 E2922G probably damaging Het
Spem1 C A 11: 69,821,805 probably null Het
Stxbp3-ps A T 19: 9,559,110 noncoding transcript Het
Tmem38a C T 8: 72,572,161 P20S possibly damaging Het
Tmod2 T C 9: 75,592,584 T129A probably benign Het
Ttc28 A G 5: 111,280,172 T1845A probably benign Het
Ubqlnl C T 7: 104,149,718 V191M probably benign Het
Ush2a C T 1: 188,864,625 T3854M probably damaging Het
Vmn2r72 T A 7: 85,751,926 H95L probably benign Het
Xdh C A 17: 73,898,344 G1042V probably damaging Het
Zfp105 T A 9: 122,930,056 V264E possibly damaging Het
Other mutations in Rpl10l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01013:Rpl10l APN 12 66284227 missense probably benign 0.00
R0278:Rpl10l UTSW 12 66284356 start codon destroyed probably null 0.99
R4043:Rpl10l UTSW 12 66284203 missense probably damaging 0.99
R4520:Rpl10l UTSW 12 66283738 missense probably benign 0.19
R4521:Rpl10l UTSW 12 66283738 missense probably benign 0.19
R4523:Rpl10l UTSW 12 66283738 missense probably benign 0.19
R4524:Rpl10l UTSW 12 66283738 missense probably benign 0.19
R6822:Rpl10l UTSW 12 66284213 missense possibly damaging 0.93
R7682:Rpl10l UTSW 12 66284230 missense probably benign 0.03
R7773:Rpl10l UTSW 12 66284267 missense probably benign 0.18
Predicted Primers PCR Primer
(F):5'- TGCTACACTGCAGTATACACC -3'
(R):5'- GTCATCATGTCCATCCGCAC -3'

Sequencing Primer
(F):5'- CACCAAAAATTTTAAGTACATGGGTC -3'
(R):5'- CACGTGATCGAGGCCCTAC -3'
Posted On2015-08-18