Incidental Mutation 'R4526:Lcn9'
ID 334429
Institutional Source Beutler Lab
Gene Symbol Lcn9
Ensembl Gene ENSMUSG00000023210
Gene Name lipocalin 9
Synonyms
MMRRC Submission 041591-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.048) question?
Stock # R4526 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 25713165-25715549 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 25714520 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Threonine at position 128 (K128T)
Ref Sequence ENSEMBL: ENSMUSP00000023978 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023978]
AlphaFold Q9D267
Predicted Effect possibly damaging
Transcript: ENSMUST00000023978
AA Change: K128T

PolyPhen 2 Score 0.850 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000023978
Gene: ENSMUSG00000023210
AA Change: K128T

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
Pfam:Lipocalin 34 174 6e-37 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the lipocalin family, such as LCN9, have a common structure consisting of an 8-stranded antiparallel beta-barrel that forms a cup-shaped ligand-binding pocket or calyx. Lipocalins generally bind small hydrophobic ligands and transport them to specific cells (Suzuki et al., 2004 [PubMed 15363845]).[supplied by OMIM, Aug 2009]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930474N05Rik C T 14: 35,818,535 (GRCm39) R178C probably damaging Het
Adamts16 G A 13: 70,927,637 (GRCm39) probably benign Het
Adgre4 C A 17: 56,092,016 (GRCm39) S92* probably null Het
Arl13b T C 16: 62,632,374 (GRCm39) D73G probably damaging Het
Cd109 CATTTATTTATTTATTTATTTATTTATTTATTTAT CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT 9: 78,619,782 (GRCm39) probably benign Het
Crebzf A C 7: 90,092,968 (GRCm39) E16A possibly damaging Het
D430041D05Rik A G 2: 104,022,778 (GRCm39) probably null Het
Dnah1 C A 14: 31,007,955 (GRCm39) D2151Y probably benign Het
Gli3 A G 13: 15,888,216 (GRCm39) K544E probably damaging Het
Gm17542 T C 10: 58,549,435 (GRCm39) D31G probably null Het
Lman2l T C 1: 36,477,844 (GRCm39) E164G probably damaging Het
Lpin2 T A 17: 71,544,373 (GRCm39) probably null Het
Ly75 G A 2: 60,161,117 (GRCm39) T900M probably benign Het
Mapk15 A T 15: 75,867,104 (GRCm39) I74F possibly damaging Het
Myh10 C T 11: 68,705,875 (GRCm39) T2007I probably benign Het
Nek1 T C 8: 61,559,978 (GRCm39) S937P probably damaging Het
Oas1b T A 5: 120,960,167 (GRCm39) probably null Het
Or4x6 T C 2: 89,949,016 (GRCm39) K309E probably benign Het
Or5l13 T C 2: 87,779,753 (GRCm39) T275A probably benign Het
Or8h8 C T 2: 86,753,339 (GRCm39) C179Y possibly damaging Het
Otogl G A 10: 107,722,841 (GRCm39) P297S probably damaging Het
Plekhm1 A G 11: 103,286,130 (GRCm39) S102P probably damaging Het
Plvap G A 8: 71,960,415 (GRCm39) R334W probably damaging Het
Polr2b T G 5: 77,474,561 (GRCm39) V466G probably damaging Het
Ptpn13 T C 5: 103,649,335 (GRCm39) I246T probably benign Het
Rims2 A T 15: 39,301,113 (GRCm39) K281N probably damaging Het
Scamp4 T C 10: 80,446,891 (GRCm39) F108S probably damaging Het
Snrnp200 A G 2: 127,071,022 (GRCm39) N1101S probably benign Het
Sntb2 C A 8: 107,736,595 (GRCm39) L490M probably damaging Het
Ssu2 A G 6: 112,359,383 (GRCm39) V79A possibly damaging Het
Stard7 A G 2: 127,139,128 (GRCm39) S347G probably benign Het
Usp5 C G 6: 124,799,593 (GRCm39) K318N possibly damaging Het
Vmn2r6 A G 3: 64,445,145 (GRCm39) V860A probably benign Het
Vmn2r60 A G 7: 41,844,667 (GRCm39) T677A probably damaging Het
Zfp318 T A 17: 46,723,284 (GRCm39) H1762Q probably benign Het
Zmynd8 TTGCTGCTGCTGCTGCTG TTGCTGCTGCTGCTG 2: 165,649,527 (GRCm39) probably benign Het
Zng1 A G 19: 24,935,328 (GRCm39) Y59H probably benign Het
Other mutations in Lcn9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01952:Lcn9 APN 2 25,714,550 (GRCm39) missense probably damaging 1.00
IGL02417:Lcn9 APN 2 25,713,692 (GRCm39) missense possibly damaging 0.91
PIT4418001:Lcn9 UTSW 2 25,714,553 (GRCm39) missense probably damaging 1.00
R1479:Lcn9 UTSW 2 25,713,715 (GRCm39) splice site probably benign
R1657:Lcn9 UTSW 2 25,714,722 (GRCm39) missense probably benign 0.17
R4199:Lcn9 UTSW 2 25,714,773 (GRCm39) missense probably benign 0.15
R4570:Lcn9 UTSW 2 25,713,591 (GRCm39) missense probably benign 0.04
R5232:Lcn9 UTSW 2 25,714,067 (GRCm39) critical splice donor site probably null
R5577:Lcn9 UTSW 2 25,713,663 (GRCm39) missense probably damaging 1.00
R5849:Lcn9 UTSW 2 25,713,268 (GRCm39) critical splice donor site probably null
R6059:Lcn9 UTSW 2 25,714,737 (GRCm39) missense possibly damaging 0.62
R7748:Lcn9 UTSW 2 25,714,926 (GRCm39) makesense probably null
R9257:Lcn9 UTSW 2 25,714,784 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- GCACTGGGCATTCAAACTCTC -3'
(R):5'- AGTCTTGTCAAGCAGTATGGAG -3'

Sequencing Primer
(F):5'- CCTTCCAATGCTTGCTTTAACAGAAG -3'
(R):5'- TCAAGCAGTATGGAGCGCCC -3'
Posted On 2015-08-18