Incidental Mutation 'R0217:Vmn2r82'
| ID |
33624 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r82
|
| Ensembl Gene |
ENSMUSG00000091468 |
| Gene Name |
vomeronasal 2, receptor 82 |
| Synonyms |
EG624845 |
| MMRRC Submission |
038466-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.068)
|
| Stock # |
R0217 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
(trace)
|
| Chromosome |
10 |
| Chromosomal Location |
79192425-79232600 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 79214634 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Valine
at position 206
(M206V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000130114
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170596]
|
| AlphaFold |
G3UWA2 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000170596
AA Change: M206V
PolyPhen 2
Score 0.463 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000130114
Gene: ENSMUSG00000091468
AA Change: M206V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
79 |
474 |
6e-35 |
PFAM |
|
Pfam:NCD3G
|
517 |
570 |
9.3e-22 |
PFAM |
|
Pfam:7tm_3
|
603 |
838 |
6.5e-49 |
PFAM |
|
| Meta Mutation Damage Score |
0.1795 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.0%
- 20x: 94.8%
|
| Validation Efficiency |
100% (62/62) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 59 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acte1 |
T |
C |
7: 143,447,956 (GRCm39) |
|
probably benign |
Het |
| Actr3 |
A |
G |
1: 125,335,150 (GRCm39) |
|
probably benign |
Het |
| Adamts13 |
A |
G |
2: 26,886,933 (GRCm39) |
|
probably benign |
Het |
| Afap1l1 |
A |
G |
18: 61,879,940 (GRCm39) |
V310A |
probably damaging |
Het |
| Alms1 |
T |
A |
6: 85,599,912 (GRCm39) |
S2048R |
probably damaging |
Het |
| Aspm |
T |
A |
1: 139,385,618 (GRCm39) |
S421T |
possibly damaging |
Het |
| Bcl2 |
G |
A |
1: 106,640,292 (GRCm39) |
R107C |
probably damaging |
Het |
| Ccdc150 |
T |
G |
1: 54,339,589 (GRCm39) |
S478A |
possibly damaging |
Het |
| Ccnyl1 |
T |
A |
1: 64,752,257 (GRCm39) |
|
probably benign |
Het |
| Cdc23 |
T |
C |
18: 34,784,718 (GRCm39) |
T15A |
unknown |
Het |
| Cdk19 |
C |
T |
10: 40,352,254 (GRCm39) |
|
probably benign |
Het |
| Comp |
A |
C |
8: 70,831,558 (GRCm39) |
D420A |
probably damaging |
Het |
| Ctnnal1 |
T |
C |
4: 56,813,230 (GRCm39) |
H667R |
probably benign |
Het |
| Cyp20a1 |
C |
A |
1: 60,382,625 (GRCm39) |
|
probably benign |
Het |
| Eci3 |
A |
C |
13: 35,132,072 (GRCm39) |
S259A |
probably benign |
Het |
| Fcnb |
T |
C |
2: 27,969,689 (GRCm39) |
D126G |
probably benign |
Het |
| Foxk1 |
T |
C |
5: 142,387,649 (GRCm39) |
M124T |
possibly damaging |
Het |
| Gm12790 |
T |
C |
4: 101,825,231 (GRCm39) |
Y61C |
probably damaging |
Het |
| Hmgcr |
A |
C |
13: 96,788,488 (GRCm39) |
I777S |
probably damaging |
Het |
| Hsdl2 |
A |
G |
4: 59,597,311 (GRCm39) |
E100G |
probably damaging |
Het |
| Itgb2 |
G |
T |
10: 77,384,370 (GRCm39) |
|
probably benign |
Het |
| Jak2 |
T |
A |
19: 29,274,050 (GRCm39) |
|
probably null |
Het |
| Lrba |
T |
C |
3: 86,550,029 (GRCm39) |
S2333P |
probably damaging |
Het |
| Man1a2 |
A |
G |
3: 100,524,353 (GRCm39) |
L365P |
possibly damaging |
Het |
| Map2k5 |
A |
T |
9: 63,164,257 (GRCm39) |
|
probably null |
Het |
| Mcc |
C |
G |
18: 44,652,583 (GRCm39) |
|
probably benign |
Het |
| Megf8 |
T |
A |
7: 25,063,504 (GRCm39) |
L2620Q |
probably damaging |
Het |
| Nf1 |
A |
T |
11: 79,319,400 (GRCm39) |
|
probably benign |
Het |
| Or11h7 |
A |
G |
14: 50,891,552 (GRCm39) |
N286S |
probably damaging |
Het |
| Or1e30 |
T |
A |
11: 73,678,214 (GRCm39) |
V150E |
possibly damaging |
Het |
| Or5p1 |
C |
A |
7: 107,916,505 (GRCm39) |
H135N |
probably benign |
Het |
| Pank3 |
T |
A |
11: 35,668,555 (GRCm39) |
D181E |
probably benign |
Het |
| Pip5k1a |
A |
G |
3: 94,981,302 (GRCm39) |
|
probably null |
Het |
| Plag1 |
A |
C |
4: 3,904,379 (GRCm39) |
S271A |
probably benign |
Het |
| Plxna2 |
T |
A |
1: 194,326,906 (GRCm39) |
I280N |
probably damaging |
Het |
| Polr1a |
T |
C |
6: 71,940,687 (GRCm39) |
V1007A |
probably benign |
Het |
| Ppm1h |
T |
A |
10: 122,756,640 (GRCm39) |
D428E |
probably damaging |
Het |
| Prelid2 |
A |
T |
18: 42,068,317 (GRCm39) |
|
probably benign |
Het |
| Ptk2b |
T |
C |
14: 66,393,830 (GRCm39) |
Y881C |
probably damaging |
Het |
| Rptor |
T |
C |
11: 119,785,738 (GRCm39) |
|
probably benign |
Het |
| Sbno1 |
T |
C |
5: 124,542,387 (GRCm39) |
|
probably null |
Het |
| Scaf4 |
T |
C |
16: 90,039,570 (GRCm39) |
D843G |
probably damaging |
Het |
| Serpina3b |
C |
T |
12: 104,096,986 (GRCm39) |
A89V |
probably damaging |
Het |
| Serpinb9d |
C |
A |
13: 33,382,005 (GRCm39) |
T158N |
possibly damaging |
Het |
| Slc39a10 |
C |
T |
1: 46,874,700 (GRCm39) |
V201I |
probably benign |
Het |
| Slc6a13 |
T |
A |
6: 121,301,279 (GRCm39) |
N189K |
probably damaging |
Het |
| Smco1 |
G |
T |
16: 32,092,599 (GRCm39) |
R90L |
possibly damaging |
Het |
| Stim1 |
T |
A |
7: 102,085,007 (GRCm39) |
M653K |
probably benign |
Het |
| Stxbp1 |
T |
C |
2: 32,691,882 (GRCm39) |
S437G |
possibly damaging |
Het |
| Stxbp3-ps |
T |
G |
19: 9,536,496 (GRCm39) |
|
noncoding transcript |
Het |
| Tgtp1 |
A |
C |
11: 48,878,146 (GRCm39) |
S186R |
probably benign |
Het |
| Trpc7 |
C |
T |
13: 56,937,581 (GRCm39) |
W570* |
probably null |
Het |
| Trpv4 |
C |
A |
5: 114,772,722 (GRCm39) |
R289L |
possibly damaging |
Het |
| Wdr47 |
T |
A |
3: 108,544,336 (GRCm39) |
V653E |
probably damaging |
Het |
| Zfp113 |
T |
C |
5: 138,148,953 (GRCm39) |
R64G |
probably benign |
Het |
| Zfp661 |
C |
T |
2: 127,419,211 (GRCm39) |
E310K |
probably damaging |
Het |
| Zfp735 |
T |
A |
11: 73,602,112 (GRCm39) |
I352N |
possibly damaging |
Het |
| Zswim4 |
A |
G |
8: 84,939,293 (GRCm39) |
L863P |
probably damaging |
Het |
| Zzef1 |
T |
A |
11: 72,779,894 (GRCm39) |
I1889N |
probably damaging |
Het |
|
| Other mutations in Vmn2r82 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01800:Vmn2r82
|
APN |
10 |
79,192,581 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01860:Vmn2r82
|
APN |
10 |
79,214,691 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01927:Vmn2r82
|
APN |
10 |
79,213,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01929:Vmn2r82
|
APN |
10 |
79,214,545 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02028:Vmn2r82
|
APN |
10 |
79,215,057 (GRCm39) |
missense |
probably benign |
|
|
IGL02112:Vmn2r82
|
APN |
10 |
79,231,833 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL02632:Vmn2r82
|
APN |
10 |
79,192,542 (GRCm39) |
missense |
probably benign |
0.45 |
|
IGL02665:Vmn2r82
|
APN |
10 |
79,215,205 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02716:Vmn2r82
|
APN |
10 |
79,213,678 (GRCm39) |
missense |
probably benign |
0.20 |
|
IGL03030:Vmn2r82
|
APN |
10 |
79,217,149 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL03190:Vmn2r82
|
APN |
10 |
79,192,643 (GRCm39) |
splice site |
probably null |
|
|
IGL03349:Vmn2r82
|
APN |
10 |
79,213,703 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL03048:Vmn2r82
|
UTSW |
10 |
79,232,460 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0080:Vmn2r82
|
UTSW |
10 |
79,232,339 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0193:Vmn2r82
|
UTSW |
10 |
79,217,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0285:Vmn2r82
|
UTSW |
10 |
79,232,391 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1193:Vmn2r82
|
UTSW |
10 |
79,213,739 (GRCm39) |
nonsense |
probably null |
|
|
R1385:Vmn2r82
|
UTSW |
10 |
79,232,325 (GRCm39) |
nonsense |
probably null |
|
|
R1386:Vmn2r82
|
UTSW |
10 |
79,214,545 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1442:Vmn2r82
|
UTSW |
10 |
79,215,201 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1467:Vmn2r82
|
UTSW |
10 |
79,232,133 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1467:Vmn2r82
|
UTSW |
10 |
79,232,133 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1518:Vmn2r82
|
UTSW |
10 |
79,214,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1538:Vmn2r82
|
UTSW |
10 |
79,192,578 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1607:Vmn2r82
|
UTSW |
10 |
79,215,253 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R1812:Vmn2r82
|
UTSW |
10 |
79,215,046 (GRCm39) |
missense |
probably benign |
0.33 |
|
R1906:Vmn2r82
|
UTSW |
10 |
79,232,344 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1954:Vmn2r82
|
UTSW |
10 |
79,231,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1972:Vmn2r82
|
UTSW |
10 |
79,214,680 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2093:Vmn2r82
|
UTSW |
10 |
79,231,813 (GRCm39) |
missense |
probably benign |
0.30 |
|
R2156:Vmn2r82
|
UTSW |
10 |
79,214,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2202:Vmn2r82
|
UTSW |
10 |
79,192,519 (GRCm39) |
missense |
probably benign |
|
|
R2442:Vmn2r82
|
UTSW |
10 |
79,221,210 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2444:Vmn2r82
|
UTSW |
10 |
79,213,702 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R2857:Vmn2r82
|
UTSW |
10 |
79,217,090 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2858:Vmn2r82
|
UTSW |
10 |
79,217,090 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2884:Vmn2r82
|
UTSW |
10 |
79,232,082 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2886:Vmn2r82
|
UTSW |
10 |
79,232,082 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4369:Vmn2r82
|
UTSW |
10 |
79,231,914 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4445:Vmn2r82
|
UTSW |
10 |
79,214,874 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4589:Vmn2r82
|
UTSW |
10 |
79,192,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4703:Vmn2r82
|
UTSW |
10 |
79,214,641 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4908:Vmn2r82
|
UTSW |
10 |
79,214,589 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4937:Vmn2r82
|
UTSW |
10 |
79,215,010 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5199:Vmn2r82
|
UTSW |
10 |
79,231,921 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5391:Vmn2r82
|
UTSW |
10 |
79,192,491 (GRCm39) |
missense |
probably null |
0.01 |
|
R5601:Vmn2r82
|
UTSW |
10 |
79,232,025 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5635:Vmn2r82
|
UTSW |
10 |
79,214,652 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6065:Vmn2r82
|
UTSW |
10 |
79,221,210 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6074:Vmn2r82
|
UTSW |
10 |
79,232,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6340:Vmn2r82
|
UTSW |
10 |
79,231,727 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6474:Vmn2r82
|
UTSW |
10 |
79,214,871 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R6995:Vmn2r82
|
UTSW |
10 |
79,232,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7111:Vmn2r82
|
UTSW |
10 |
79,214,605 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7212:Vmn2r82
|
UTSW |
10 |
79,215,268 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7335:Vmn2r82
|
UTSW |
10 |
79,214,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7353:Vmn2r82
|
UTSW |
10 |
79,232,452 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7354:Vmn2r82
|
UTSW |
10 |
79,192,464 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7362:Vmn2r82
|
UTSW |
10 |
79,232,451 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7378:Vmn2r82
|
UTSW |
10 |
79,232,276 (GRCm39) |
nonsense |
probably null |
|
|
R7430:Vmn2r82
|
UTSW |
10 |
79,217,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7509:Vmn2r82
|
UTSW |
10 |
79,231,842 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7874:Vmn2r82
|
UTSW |
10 |
79,232,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7943:Vmn2r82
|
UTSW |
10 |
79,232,079 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R8158:Vmn2r82
|
UTSW |
10 |
79,213,636 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8324:Vmn2r82
|
UTSW |
10 |
79,214,727 (GRCm39) |
nonsense |
probably null |
|
|
R8340:Vmn2r82
|
UTSW |
10 |
79,217,036 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8787:Vmn2r82
|
UTSW |
10 |
79,213,894 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8929:Vmn2r82
|
UTSW |
10 |
79,232,541 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9018:Vmn2r82
|
UTSW |
10 |
79,232,539 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9399:Vmn2r82
|
UTSW |
10 |
79,214,768 (GRCm39) |
nonsense |
probably null |
|
|
R9517:Vmn2r82
|
UTSW |
10 |
79,213,641 (GRCm39) |
nonsense |
probably null |
|
|
R9587:Vmn2r82
|
UTSW |
10 |
79,214,936 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R9602:Vmn2r82
|
UTSW |
10 |
79,214,880 (GRCm39) |
missense |
probably benign |
0.07 |
|
Z1088:Vmn2r82
|
UTSW |
10 |
79,192,456 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Vmn2r82
|
UTSW |
10 |
79,232,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Vmn2r82
|
UTSW |
10 |
79,192,429 (GRCm39) |
missense |
probably benign |
0.03 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGATGTGAGTGATGAGCAGCCAGA -3'
(R):5'- TGTGATAGCAAACGAAGTAGGGTTTCC -3'
Sequencing Primer
(F):5'- tggagttatcacagagaaaggag -3'
(R):5'- GGGTTTCCCCCAGATATAATACTG -3'
|
| Posted On |
2013-05-09 |
Incidental Mutation