Incidental Mutation 'R0226:Lrig3'
ID 33944
Institutional Source Beutler Lab
Gene Symbol Lrig3
Ensembl Gene ENSMUSG00000020105
Gene Name leucine-rich repeats and immunoglobulin-like domains 3
Synonyms 9430095K15Rik, 9030421L11Rik, 9130004I02Rik
MMRRC Submission 038471-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.249) question?
Stock # R0226 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 125802088-125851228 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 125807986 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000074360 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074807]
AlphaFold Q6P1C6
PDB Structure Crystal structure of an Immunoglobulin I-set domain of Lrig3 protein (Lrig3) from MUS MUSCULUS at 1.70 A resolution [X-RAY DIFFRACTION]
Predicted Effect probably benign
Transcript: ENSMUST00000074807
SMART Domains Protein: ENSMUSP00000074360
Gene: ENSMUSG00000020105

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
LRRNT 46 78 6.74e-2 SMART
LRR 72 96 4.45e1 SMART
LRR 97 120 1.06e1 SMART
LRR 144 166 1.14e0 SMART
LRR 168 189 1.62e2 SMART
LRR 190 214 1.09e1 SMART
LRR 215 237 1.71e1 SMART
LRR 238 261 2.29e0 SMART
LRR 262 285 3.07e-1 SMART
LRR 286 309 2.49e-1 SMART
LRR 310 333 1.29e1 SMART
LRR 334 357 6.22e0 SMART
LRR 358 384 6.05e0 SMART
LRR_TYP 385 408 1.56e-2 SMART
LRR_TYP 409 432 1.79e-2 SMART
LRRCT 444 494 2.35e-7 SMART
IGc2 511 588 1.65e-4 SMART
IGc2 615 683 1.33e-8 SMART
IGc2 709 774 2.78e-11 SMART
transmembrane domain 805 827 N/A INTRINSIC
low complexity region 1069 1081 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217813
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218363
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220332
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.4%
Validation Efficiency 100% (98/98)
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele or severely hypomorphic gene trap allele exhibit fusion of the lateral semicircular canal and circling behavior. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 90 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700129C05Rik G T 14: 59,379,569 (GRCm39) T54K possibly damaging Het
2210408I21Rik A T 13: 77,451,544 (GRCm39) E876V possibly damaging Het
Aasdh A T 5: 77,049,849 (GRCm39) L49Q probably damaging Het
Abca8b T C 11: 109,847,844 (GRCm39) probably null Het
Ablim1 A T 19: 57,032,302 (GRCm39) L556Q probably damaging Het
Afdn A G 17: 14,119,408 (GRCm39) T1700A probably benign Het
Agl G A 3: 116,545,720 (GRCm39) R1359C probably damaging Het
Agpat3 T A 10: 78,113,863 (GRCm39) H275L possibly damaging Het
Ahcyl1 A T 3: 107,577,586 (GRCm39) C180* probably null Het
Aim2 A G 1: 173,289,899 (GRCm39) probably benign Het
Angpt1 T C 15: 42,331,631 (GRCm39) N320S probably benign Het
Ankrd52 T A 10: 128,225,727 (GRCm39) probably null Het
Ap1g1 C T 8: 110,581,694 (GRCm39) S654L probably benign Het
Bpifa1 T A 2: 153,987,977 (GRCm39) S173R probably benign Het
Brd8 T C 18: 34,736,947 (GRCm39) probably benign Het
Btbd9 C T 17: 30,493,916 (GRCm39) D492N possibly damaging Het
C1qtnf2 A G 11: 43,381,670 (GRCm39) T161A probably benign Het
Car6 T C 4: 150,271,965 (GRCm39) Y228C probably damaging Het
Ccdc149 A G 5: 52,557,559 (GRCm39) L273P probably damaging Het
Cit G A 5: 116,122,899 (GRCm39) R1405Q probably damaging Het
Cox17 T C 16: 38,169,638 (GRCm39) L48P probably damaging Het
Cttn A G 7: 143,995,589 (GRCm39) probably benign Het
Cyp4f18 T C 8: 72,743,619 (GRCm39) probably benign Het
Dtnbp1 A G 13: 45,076,669 (GRCm39) L175P probably damaging Het
Efl1 T C 7: 82,342,219 (GRCm39) probably benign Het
Fbn1 C T 2: 125,162,830 (GRCm39) R2152Q possibly damaging Het
Fignl1 A T 11: 11,751,061 (GRCm39) S665T probably benign Het
Gm9843 A T 16: 76,200,449 (GRCm39) noncoding transcript Het
Gpr155 C T 2: 73,197,936 (GRCm39) V395I probably benign Het
Greb1l T C 18: 10,522,076 (GRCm39) probably benign Het
Hdgfl1 A T 13: 26,953,979 (GRCm39) H31Q probably benign Het
Heatr1 T C 13: 12,425,443 (GRCm39) S628P probably damaging Het
Hivep2 A G 10: 14,005,456 (GRCm39) T685A probably benign Het
Hmgcl T G 4: 135,686,039 (GRCm39) V168G probably damaging Het
Itch T C 2: 155,041,314 (GRCm39) I454T probably benign Het
Itih2 T C 2: 10,120,110 (GRCm39) D309G possibly damaging Het
Kcmf1 T C 6: 72,819,935 (GRCm39) I304V probably benign Het
Kcnh1 G A 1: 191,959,112 (GRCm39) W222* probably null Het
Kcnh1 G T 1: 191,959,113 (GRCm39) W222C probably damaging Het
Kif24 T A 4: 41,414,939 (GRCm39) K287* probably null Het
Lrp2 A T 2: 69,367,907 (GRCm39) C202S probably null Het
Lrrc37 A T 11: 103,494,067 (GRCm39) F663L probably benign Het
Lrrn2 A G 1: 132,865,558 (GRCm39) N208D probably damaging Het
Mcm5 C T 8: 75,852,880 (GRCm39) T664I possibly damaging Het
Mfsd10 A G 5: 34,791,790 (GRCm39) L365S probably benign Het
Mfsd6 A G 1: 52,697,849 (GRCm39) probably benign Het
Mgat4e A G 1: 134,468,841 (GRCm39) V401A probably benign Het
Mllt3 C A 4: 87,758,969 (GRCm39) V360L probably benign Het
Mrm1 G A 11: 84,709,996 (GRCm39) A68V possibly damaging Het
Myo19 A G 11: 84,788,558 (GRCm39) probably benign Het
Myo3b A G 2: 70,047,510 (GRCm39) T311A probably benign Het
Myo5b T C 18: 74,875,251 (GRCm39) F1552L probably benign Het
Myo7b C T 18: 32,105,949 (GRCm39) V1353I probably benign Het
Myo9b T C 8: 71,806,476 (GRCm39) S1512P probably damaging Het
Nanos3 C T 8: 84,902,763 (GRCm39) R133Q probably damaging Het
Osbpl3 A G 6: 50,329,988 (GRCm39) W63R probably damaging Het
Pcdh17 T C 14: 84,685,641 (GRCm39) S703P probably damaging Het
Pclo T C 5: 14,815,237 (GRCm39) I1231T probably damaging Het
Pex16 A C 2: 92,206,032 (GRCm39) probably benign Het
Pfkl T C 10: 77,828,368 (GRCm39) N399S probably benign Het
Pkhd1l1 G A 15: 44,390,180 (GRCm39) R1432K possibly damaging Het
Prdm1 T A 10: 44,332,692 (GRCm39) T106S probably benign Het
Prrc1 A G 18: 57,496,363 (GRCm39) M105V probably benign Het
Psg26 A G 7: 18,217,883 (GRCm39) C12R possibly damaging Het
Rnf43 A T 11: 87,622,263 (GRCm39) S455C probably damaging Het
Ryr2 T C 13: 11,787,442 (GRCm39) K977R probably damaging Het
Sart1 C T 19: 5,431,150 (GRCm39) probably benign Het
Sec14l5 A G 16: 4,998,167 (GRCm39) S509G probably benign Het
Sin3b A T 8: 73,471,136 (GRCm39) E361V probably benign Het
Slc35e3 C T 10: 117,576,795 (GRCm39) E179K possibly damaging Het
Sntb2 T C 8: 107,728,215 (GRCm39) S388P probably damaging Het
Srms A G 2: 180,854,175 (GRCm39) S131P probably benign Het
Sting1 A T 18: 35,872,141 (GRCm39) F120L probably benign Het
Stxbp5 T C 10: 9,742,442 (GRCm39) probably benign Het
Taar2 T C 10: 23,816,961 (GRCm39) V167A probably damaging Het
Taar2 G A 10: 23,817,393 (GRCm39) R311H probably benign Het
Thsd7a A G 6: 12,321,899 (GRCm39) Y1516H possibly damaging Het
Tlk1 T A 2: 70,544,513 (GRCm39) probably benign Het
Tnfaip3 T C 10: 18,878,495 (GRCm39) K771R probably damaging Het
Treml1 C T 17: 48,667,486 (GRCm39) L124F probably damaging Het
Ttn G T 2: 76,611,141 (GRCm39) Q9137K possibly damaging Het
Unkl T A 17: 25,449,685 (GRCm39) I469N probably damaging Het
Vmn1r173 G T 7: 23,402,508 (GRCm39) V248L possibly damaging Het
Vps35 T C 8: 86,000,204 (GRCm39) Q474R probably damaging Het
Wdr17 T A 8: 55,116,043 (GRCm39) T580S probably benign Het
Xpnpep1 T C 19: 52,998,583 (GRCm39) K222E probably benign Het
Ylpm1 A G 12: 85,096,511 (GRCm39) T1446A probably benign Het
Zfp277 A G 12: 40,414,161 (GRCm39) L228S possibly damaging Het
Zfp941 T A 7: 140,393,188 (GRCm39) K57M probably damaging Het
Zmpste24 A T 4: 120,938,406 (GRCm39) S244R probably benign Het
Other mutations in Lrig3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00333:Lrig3 APN 10 125,849,017 (GRCm39) missense probably benign 0.00
IGL00426:Lrig3 APN 10 125,808,006 (GRCm39) nonsense probably null
IGL00969:Lrig3 APN 10 125,832,984 (GRCm39) missense probably damaging 1.00
IGL01376:Lrig3 APN 10 125,830,335 (GRCm39) missense probably benign 0.01
IGL01510:Lrig3 APN 10 125,844,567 (GRCm39) missense probably damaging 1.00
IGL01825:Lrig3 APN 10 125,845,886 (GRCm39) missense probably damaging 0.98
IGL02231:Lrig3 APN 10 125,833,041 (GRCm39) missense probably damaging 1.00
IGL02377:Lrig3 APN 10 125,850,743 (GRCm39) missense probably benign 0.00
IGL02648:Lrig3 APN 10 125,802,463 (GRCm39) missense probably benign
IGL02832:Lrig3 APN 10 125,842,871 (GRCm39) missense probably benign 0.37
IGL03266:Lrig3 APN 10 125,849,151 (GRCm39) missense probably benign 0.28
R0023:Lrig3 UTSW 10 125,846,088 (GRCm39) missense probably damaging 1.00
R0129:Lrig3 UTSW 10 125,842,812 (GRCm39) missense probably damaging 1.00
R0183:Lrig3 UTSW 10 125,846,061 (GRCm39) missense probably damaging 1.00
R0233:Lrig3 UTSW 10 125,849,395 (GRCm39) splice site probably null
R0233:Lrig3 UTSW 10 125,849,395 (GRCm39) splice site probably null
R0336:Lrig3 UTSW 10 125,802,574 (GRCm39) missense probably benign 0.04
R0348:Lrig3 UTSW 10 125,849,317 (GRCm39) nonsense probably null
R0502:Lrig3 UTSW 10 125,844,605 (GRCm39) missense probably damaging 1.00
R0639:Lrig3 UTSW 10 125,846,090 (GRCm39) missense probably damaging 1.00
R1099:Lrig3 UTSW 10 125,842,883 (GRCm39) splice site probably null
R1220:Lrig3 UTSW 10 125,832,945 (GRCm39) missense probably damaging 1.00
R1230:Lrig3 UTSW 10 125,838,840 (GRCm39) missense probably damaging 1.00
R1398:Lrig3 UTSW 10 125,838,957 (GRCm39) missense probably benign 0.00
R1451:Lrig3 UTSW 10 125,845,926 (GRCm39) missense possibly damaging 0.92
R1523:Lrig3 UTSW 10 125,844,567 (GRCm39) missense probably damaging 1.00
R1545:Lrig3 UTSW 10 125,844,416 (GRCm39) missense possibly damaging 0.80
R1661:Lrig3 UTSW 10 125,833,570 (GRCm39) missense probably benign 0.12
R1665:Lrig3 UTSW 10 125,833,570 (GRCm39) missense probably benign 0.12
R1673:Lrig3 UTSW 10 125,846,036 (GRCm39) missense probably damaging 1.00
R1778:Lrig3 UTSW 10 125,845,944 (GRCm39) missense probably damaging 1.00
R1800:Lrig3 UTSW 10 125,832,920 (GRCm39) splice site probably null
R1840:Lrig3 UTSW 10 125,849,258 (GRCm39) nonsense probably null
R1882:Lrig3 UTSW 10 125,845,694 (GRCm39) missense possibly damaging 0.89
R1900:Lrig3 UTSW 10 125,838,262 (GRCm39) splice site probably benign
R2160:Lrig3 UTSW 10 125,833,565 (GRCm39) missense possibly damaging 0.95
R2200:Lrig3 UTSW 10 125,832,478 (GRCm39) splice site probably null
R2294:Lrig3 UTSW 10 125,802,363 (GRCm39) nonsense probably null
R2518:Lrig3 UTSW 10 125,830,310 (GRCm39) missense probably benign 0.07
R3037:Lrig3 UTSW 10 125,845,901 (GRCm39) missense probably damaging 1.00
R3236:Lrig3 UTSW 10 125,833,056 (GRCm39) missense probably damaging 1.00
R4073:Lrig3 UTSW 10 125,849,277 (GRCm39) missense probably benign
R4074:Lrig3 UTSW 10 125,849,277 (GRCm39) missense probably benign
R4075:Lrig3 UTSW 10 125,849,277 (GRCm39) missense probably benign
R4077:Lrig3 UTSW 10 125,845,656 (GRCm39) missense probably damaging 1.00
R4079:Lrig3 UTSW 10 125,845,656 (GRCm39) missense probably damaging 1.00
R4405:Lrig3 UTSW 10 125,846,877 (GRCm39) missense probably benign 0.00
R4425:Lrig3 UTSW 10 125,849,273 (GRCm39) missense probably benign 0.00
R4505:Lrig3 UTSW 10 125,849,216 (GRCm39) missense probably benign 0.00
R4860:Lrig3 UTSW 10 125,846,921 (GRCm39) missense probably benign 0.36
R4860:Lrig3 UTSW 10 125,846,921 (GRCm39) missense probably benign 0.36
R4903:Lrig3 UTSW 10 125,832,482 (GRCm39) critical splice acceptor site probably null
R5201:Lrig3 UTSW 10 125,849,020 (GRCm39) missense possibly damaging 0.48
R5307:Lrig3 UTSW 10 125,842,559 (GRCm39) missense probably damaging 1.00
R5402:Lrig3 UTSW 10 125,844,609 (GRCm39) missense probably damaging 1.00
R5557:Lrig3 UTSW 10 125,808,003 (GRCm39) missense probably damaging 1.00
R5792:Lrig3 UTSW 10 125,845,788 (GRCm39) missense probably damaging 1.00
R5903:Lrig3 UTSW 10 125,844,347 (GRCm39) missense probably damaging 1.00
R6280:Lrig3 UTSW 10 125,846,848 (GRCm39) missense probably benign 0.18
R6484:Lrig3 UTSW 10 125,832,478 (GRCm39) splice site probably null
R6985:Lrig3 UTSW 10 125,850,738 (GRCm39) missense possibly damaging 0.64
R7089:Lrig3 UTSW 10 125,832,993 (GRCm39) missense probably damaging 1.00
R7177:Lrig3 UTSW 10 125,842,712 (GRCm39) missense probably benign 0.02
R7347:Lrig3 UTSW 10 125,845,835 (GRCm39) missense probably damaging 1.00
R9093:Lrig3 UTSW 10 125,845,950 (GRCm39) missense possibly damaging 0.51
R9188:Lrig3 UTSW 10 125,838,935 (GRCm39) missense possibly damaging 0.80
R9295:Lrig3 UTSW 10 125,850,722 (GRCm39) missense probably benign 0.00
R9378:Lrig3 UTSW 10 125,832,953 (GRCm39) missense probably damaging 0.98
R9526:Lrig3 UTSW 10 125,850,736 (GRCm39) missense probably benign
R9567:Lrig3 UTSW 10 125,845,964 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AAGACCTGTTCACCAAGTGCCAG -3'
(R):5'- AGGTTCGTCCCTTGAAATGGTCCC -3'

Sequencing Primer
(F):5'- TGAATCTGCCAGCCTCTTAAAC -3'
(R):5'- TCCCAGGGGGAAAATACTTTATGC -3'
Posted On 2013-05-09