Incidental Mutation 'R0227:Ceacam18'
ID 33994
Institutional Source Beutler Lab
Gene Symbol Ceacam18
Ensembl Gene ENSMUSG00000030472
Gene Name CEA cell adhesion molecule 18
Synonyms 2010110O04Rik
MMRRC Submission 038472-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # R0227 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 43284131-43298719 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 43288815 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Cysteine at position 189 (G189C)
Ref Sequence ENSEMBL: ENSMUSP00000032663 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032663]
AlphaFold Q9D871
Predicted Effect probably damaging
Transcript: ENSMUST00000032663
AA Change: G189C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000032663
Gene: ENSMUSG00000030472
AA Change: G189C

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
IG_like 36 135 1.03e2 SMART
IG_like 148 226 5.56e0 SMART
IGc2 248 305 5.24e-7 SMART
transmembrane domain 334 356 N/A INTRINSIC
Meta Mutation Damage Score 0.2241 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 93.5%
Validation Efficiency 86% (37/43)
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9430038I01Rik A T 7: 136,989,438 (GRCm39) probably benign Het
Ankrd12 T A 17: 66,294,222 (GRCm39) T404S probably benign Het
Ap4m1 T C 5: 138,174,538 (GRCm39) probably benign Het
Atn1 A T 6: 124,723,893 (GRCm39) probably benign Het
Bcl9l A G 9: 44,416,533 (GRCm39) Y202C possibly damaging Het
Cfap65 C T 1: 74,971,117 (GRCm39) W67* probably null Het
Col2a1 C T 15: 97,874,636 (GRCm39) E1334K unknown Het
Crim1 A G 17: 78,651,938 (GRCm39) probably benign Het
Csmd1 A G 8: 16,441,836 (GRCm39) S343P probably benign Het
D430041D05Rik G T 2: 104,035,545 (GRCm39) D1594E possibly damaging Het
Ess2 C T 16: 17,720,135 (GRCm39) V406I probably damaging Het
Gcm2 C T 13: 41,259,332 (GRCm39) V46M probably damaging Het
Gm3486 A T 14: 41,206,518 (GRCm39) V185E probably benign Het
Gtf3a C A 5: 146,892,199 (GRCm39) R317S probably damaging Het
Ice2 A G 9: 69,319,510 (GRCm39) I320V probably benign Het
Jag1 A G 2: 136,957,538 (GRCm39) V58A probably benign Het
Macf1 T C 4: 123,293,184 (GRCm39) E1241G probably benign Het
Mogat2 T A 7: 98,872,339 (GRCm39) I171F probably benign Het
Muc6 G A 7: 141,223,981 (GRCm39) probably benign Het
Myo1c A T 11: 75,549,520 (GRCm39) Y201F probably benign Het
Myo9b A G 8: 71,796,806 (GRCm39) I884V probably damaging Het
Nudt9 T C 5: 104,209,541 (GRCm39) I264T possibly damaging Het
Or8g30 A G 9: 39,229,974 (GRCm39) V312A probably benign Het
Pdcd11 AGAGGAGGAGGAGGAGGAGGAGGAG AGAGGAGGAGGAGGAGGAGGAG 19: 47,101,876 (GRCm39) probably benign Het
Rabgef1 T C 5: 130,219,831 (GRCm39) V98A probably damaging Het
Raly A G 2: 154,707,841 (GRCm39) D287G probably damaging Het
Raph1 A G 1: 60,565,136 (GRCm39) V117A probably benign Het
Slc34a2 T C 5: 53,226,968 (GRCm39) F697S possibly damaging Het
Son T A 16: 91,453,761 (GRCm39) M836K probably damaging Het
Spock1 T C 13: 57,588,290 (GRCm39) M258V possibly damaging Het
Stk10 G T 11: 32,567,859 (GRCm39) C887F probably damaging Het
Synpo2 A G 3: 122,907,442 (GRCm39) S625P probably benign Het
Synrg T A 11: 83,900,258 (GRCm39) D821E probably damaging Het
Tafa5 T C 15: 87,604,691 (GRCm39) probably benign Het
Tg C A 15: 66,570,295 (GRCm39) A1389E possibly damaging Het
Tspan33 G A 6: 29,713,477 (GRCm39) V134M probably damaging Het
Ubr4 T C 4: 139,158,960 (GRCm39) F2438L probably benign Het
Vmn1r210 C T 13: 23,011,561 (GRCm39) V242I probably benign Het
Vmn1r63 C T 7: 5,805,741 (GRCm39) W297* probably null Het
Vmn2r92 C T 17: 18,388,219 (GRCm39) A408V probably damaging Het
Zic5 A G 14: 122,697,073 (GRCm39) I514T unknown Het
Other mutations in Ceacam18
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00426:Ceacam18 APN 7 43,288,780 (GRCm39) missense probably benign 0.00
IGL00585:Ceacam18 APN 7 43,286,435 (GRCm39) missense possibly damaging 0.90
IGL01669:Ceacam18 APN 7 43,294,939 (GRCm39) missense probably damaging 1.00
R0001:Ceacam18 UTSW 7 43,286,300 (GRCm39) missense possibly damaging 0.58
R1524:Ceacam18 UTSW 7 43,288,779 (GRCm39) missense possibly damaging 0.95
R1647:Ceacam18 UTSW 7 43,288,689 (GRCm39) missense possibly damaging 0.78
R1768:Ceacam18 UTSW 7 43,297,918 (GRCm39) missense probably benign 0.00
R1828:Ceacam18 UTSW 7 43,288,880 (GRCm39) missense probably benign 0.19
R3751:Ceacam18 UTSW 7 43,291,372 (GRCm39) missense probably damaging 1.00
R4870:Ceacam18 UTSW 7 43,291,328 (GRCm39) missense probably damaging 1.00
R5259:Ceacam18 UTSW 7 43,286,536 (GRCm39) critical splice donor site probably null
R5358:Ceacam18 UTSW 7 43,286,497 (GRCm39) missense possibly damaging 0.57
R5368:Ceacam18 UTSW 7 43,291,458 (GRCm39) missense probably benign 0.08
R5810:Ceacam18 UTSW 7 43,286,382 (GRCm39) missense probably benign 0.00
R5817:Ceacam18 UTSW 7 43,291,265 (GRCm39) missense probably benign 0.07
R5835:Ceacam18 UTSW 7 43,286,382 (GRCm39) missense probably benign 0.00
R7113:Ceacam18 UTSW 7 43,291,400 (GRCm39) missense probably benign
R7138:Ceacam18 UTSW 7 43,288,706 (GRCm39) missense possibly damaging 0.80
R7275:Ceacam18 UTSW 7 43,291,308 (GRCm39) missense probably damaging 1.00
R7502:Ceacam18 UTSW 7 43,286,298 (GRCm39) missense probably damaging 0.99
R8849:Ceacam18 UTSW 7 43,294,967 (GRCm39) missense probably benign 0.00
R9119:Ceacam18 UTSW 7 43,288,909 (GRCm39) missense probably benign
R9347:Ceacam18 UTSW 7 43,294,915 (GRCm39) missense possibly damaging 0.70
R9663:Ceacam18 UTSW 7 43,288,764 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGCCTCAAAGCTTGAAGAAGCTGAC -3'
(R):5'- GGCTCAGCCATTTTCCTGGATACAC -3'

Sequencing Primer
(F):5'- GAAGCTGACACTATACCTGACTTG -3'
(R):5'- TTTTCCTGGATACACACAGACG -3'
Posted On 2013-05-09