Mutagenetix > Incidental Mutation

Incidental Mutation 'R4555:Myo15'

341843

Institutional Source

Beutler Lab

Gene Symbol

Myo15

Ensembl Gene

ENSMUSG00000042678

Gene Name

myosin XV

Synonyms

sh2; sh-2; Myo15a

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R4555 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

60469339-60528369 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 60496937 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Glycine at position 746 (R746G)

Ref Sequence

ENSEMBL: ENSMUSP00000080507 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071880] [ENSMUST00000081823] [ENSMUST00000094135]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000071880
AA Change: R1933G

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000071777
Gene: ENSMUSG00000042678
AA Change: R1933G

Domain	Start	End	E-Value	Type
low complexity region	4	24	N/A	INTRINSIC
low complexity region	87	100	N/A	INTRINSIC
low complexity region	107	120	N/A	INTRINSIC
low complexity region	269	292	N/A	INTRINSIC
low complexity region	295	306	N/A	INTRINSIC
low complexity region	311	325	N/A	INTRINSIC
low complexity region	349	384	N/A	INTRINSIC
low complexity region	425	435	N/A	INTRINSIC
low complexity region	487	498	N/A	INTRINSIC
low complexity region	502	509	N/A	INTRINSIC
low complexity region	653	681	N/A	INTRINSIC
low complexity region	692	705	N/A	INTRINSIC
low complexity region	737	747	N/A	INTRINSIC
low complexity region	758	775	N/A	INTRINSIC
low complexity region	781	792	N/A	INTRINSIC
low complexity region	796	809	N/A	INTRINSIC
low complexity region	825	849	N/A	INTRINSIC
low complexity region	883	897	N/A	INTRINSIC
low complexity region	1067	1082	N/A	INTRINSIC
low complexity region	1115	1130	N/A	INTRINSIC
MYSc	1200	1884	N/A	SMART
IQ	1885	1907	1.63e-1	SMART
IQ	1908	1930	1.77e-2	SMART
IQ	1931	1953	2.97e2	SMART
low complexity region	1955	1974	N/A	INTRINSIC
low complexity region	1992	2006	N/A	INTRINSIC
MyTH4	2049	2195	1.8e-42	SMART
low complexity region	2396	2405	N/A	INTRINSIC
low complexity region	2451	2461	N/A	INTRINSIC
Blast:MYSc	2665	2848	2e-14	BLAST
SH3	2851	2933	1.55e-4	SMART
low complexity region	2949	2962	N/A	INTRINSIC
MyTH4	3031	3185	5.59e-48	SMART
B41	3188	3400	6.94e-3	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000081823
AA Change: R746G

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000080507
Gene: ENSMUSG00000042678
AA Change: R746G

Domain	Start	End	E-Value	Type
MYSc	13	697	N/A	SMART
IQ	698	720	1.63e-1	SMART
IQ	721	743	1.77e-2	SMART
IQ	744	766	2.97e2	SMART
low complexity region	787	801	N/A	INTRINSIC
MyTH4	844	990	1.8e-42	SMART
low complexity region	1191	1200	N/A	INTRINSIC
low complexity region	1246	1256	N/A	INTRINSIC
Blast:MYSc	1460	1643	7e-15	BLAST
SH3	1646	1728	1.55e-4	SMART
low complexity region	1744	1757	N/A	INTRINSIC
MyTH4	1826	1980	5.59e-48	SMART
B41	1983	2195	6.94e-3	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000094135
AA Change: R1933G

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000091686
Gene: ENSMUSG00000042678
AA Change: R1933G

Domain	Start	End	E-Value	Type
low complexity region	4	24	N/A	INTRINSIC
low complexity region	87	100	N/A	INTRINSIC
low complexity region	107	120	N/A	INTRINSIC
low complexity region	269	292	N/A	INTRINSIC
low complexity region	295	306	N/A	INTRINSIC
low complexity region	311	325	N/A	INTRINSIC
low complexity region	349	384	N/A	INTRINSIC
low complexity region	425	435	N/A	INTRINSIC
low complexity region	487	498	N/A	INTRINSIC
low complexity region	502	509	N/A	INTRINSIC
low complexity region	653	681	N/A	INTRINSIC
low complexity region	692	705	N/A	INTRINSIC
low complexity region	737	747	N/A	INTRINSIC
low complexity region	758	775	N/A	INTRINSIC
low complexity region	781	792	N/A	INTRINSIC
low complexity region	796	809	N/A	INTRINSIC
low complexity region	825	849	N/A	INTRINSIC
low complexity region	883	897	N/A	INTRINSIC
low complexity region	1067	1082	N/A	INTRINSIC
low complexity region	1115	1130	N/A	INTRINSIC
MYSc	1200	1884	N/A	SMART
IQ	1885	1907	1.63e-1	SMART
IQ	1908	1930	1.77e-2	SMART
IQ	1931	1953	2.97e2	SMART
low complexity region	1974	1988	N/A	INTRINSIC
MyTH4	2031	2177	1.8e-42	SMART
low complexity region	2378	2387	N/A	INTRINSIC
low complexity region	2433	2443	N/A	INTRINSIC
Blast:MYSc	2647	2830	2e-14	BLAST
SH3	2833	2915	1.55e-4	SMART
low complexity region	2931	2944	N/A	INTRINSIC
MyTH4	3013	3167	5.59e-48	SMART
B41	3170	3382	6.94e-3	SMART

Predicted Effect

unknown
Transcript: ENSMUST00000126522
AA Change: R764G

SMART Domains

Protein: ENSMUSP00000120839
Gene: ENSMUSG00000042678
AA Change: R764G

Domain	Start	End	E-Value	Type
MYSc	34	716	N/A	SMART
IQ	717	739	1.63e-1	SMART
IQ	740	762	1.77e-2	SMART
IQ	763	785	2.97e2	SMART
low complexity region	806	820	N/A	INTRINSIC
MyTH4	863	1009	1.8e-42	SMART
low complexity region	1210	1219	N/A	INTRINSIC
low complexity region	1265	1275	N/A	INTRINSIC
Blast:MYSc	1479	1662	5e-15	BLAST
SH3	1665	1747	1.55e-4	SMART
low complexity region	1763	1776	N/A	INTRINSIC

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.3%
20x: 95.2%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an unconventional myosin. This protein differs from other myosins in that it has a long N-terminal extension preceding the conserved motor domain. Studies in mice suggest that this protein is necessary for actin organization in the hair cells of the cochlea. Mutations in this gene have been associated with profound, congenital, neurosensory, nonsyndromal deafness. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Read-through transcripts containing an upstream gene and this gene have been identified, but they are not thought to encode a fusion protein. Several alternatively spliced transcript variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mutations in this gene result in profound deafness and neurological behavior. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 22 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A830005F24Rik	T	C	13: 48,514,461 (GRCm38)		probably benign	Het
Adamts16	G	A	13: 70,779,518 (GRCm38)		probably benign	Het
Adamts17	A	T	7: 67,027,893 (GRCm38)	E518D	probably damaging	Het
Afp	T	G	5: 90,506,687 (GRCm38)	I528S	possibly damaging	Het
Cul9	T	C	17: 46,501,829 (GRCm38)	D2407G	possibly damaging	Het
Cyp19a1	T	C	9: 54,166,821 (GRCm38)	E483G	probably damaging	Het
Dennd2c	G	A	3: 103,131,886 (GRCm38)	V117I	probably benign	Het
Inha	C	T	1: 75,509,583 (GRCm38)	P174L	possibly damaging	Het
Ndufaf7	T	C	17: 78,942,087 (GRCm38)	S138P	probably benign	Het
Osmr	T	C	15: 6,815,720 (GRCm38)	Q855R	possibly damaging	Het
Pip4k2a	C	T	2: 18,872,292 (GRCm38)	D211N	probably damaging	Het
Pitpnm1	A	G	19: 4,103,085 (GRCm38)	Q135R	probably benign	Het
Plxna1	G	T	6: 89,323,328 (GRCm38)	T1591K	probably damaging	Het
Rdh19	T	A	10: 127,850,151 (GRCm38)	L44Q	probably benign	Het
Rom1	T	C	19: 8,928,016 (GRCm38)	T267A	possibly damaging	Het
Smad3	C	T	9: 63,654,788 (GRCm38)	V108I	possibly damaging	Het
Sptb	A	C	12: 76,612,851 (GRCm38)	S1092A	probably benign	Het
Thap12	A	G	7: 98,715,845 (GRCm38)	N407D	probably benign	Het
Tmc5	T	C	7: 118,670,733 (GRCm38)	I902T	probably benign	Het
Ugt1a6a	C	T	1: 88,138,627 (GRCm38)	R52*	probably null	Het
Usp54	C	T	14: 20,561,022 (GRCm38)	R1242H	probably benign	Het
Vps16	T	C	2: 130,443,576 (GRCm38)	V813A	probably damaging	Het

Other mutations in Myo15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00845:Myo15	APN	11	60,477,779 (GRCm38)	missense	probably damaging	1.00
IGL01011:Myo15	APN	11	60,476,992 (GRCm38)	missense	probably benign	0.33
IGL01100:Myo15	APN	11	60,511,158 (GRCm38)	missense	probably damaging	1.00
IGL01357:Myo15	APN	11	60,502,289 (GRCm38)	splice site	probably benign
IGL01634:Myo15	APN	11	60,495,472 (GRCm38)	missense	probably damaging	1.00
IGL01763:Myo15	APN	11	60,521,738 (GRCm38)	missense	probably benign	0.07
IGL01901:Myo15	APN	11	60,527,434 (GRCm38)	utr 3 prime	probably benign
IGL01931:Myo15	APN	11	60,496,138 (GRCm38)	missense	probably damaging	1.00
IGL02006:Myo15	APN	11	60,511,128 (GRCm38)	missense	probably damaging	1.00
IGL02041:Myo15	APN	11	60,506,863 (GRCm38)	missense	probably damaging	0.99
IGL02094:Myo15	APN	11	60,510,647 (GRCm38)	unclassified	probably benign
IGL02122:Myo15	APN	11	60,483,466 (GRCm38)	missense	probably benign	0.23
IGL02153:Myo15	APN	11	60,498,397 (GRCm38)	missense	probably damaging	1.00
IGL02328:Myo15	APN	11	60,526,607 (GRCm38)	missense	probably benign	0.13
IGL02330:Myo15	APN	11	60,477,161 (GRCm38)	missense	possibly damaging	0.94
IGL02431:Myo15	APN	11	60,510,639 (GRCm38)	missense	possibly damaging	0.73
IGL02639:Myo15	APN	11	60,478,621 (GRCm38)	missense	probably benign
IGL02659:Myo15	APN	11	60,491,783 (GRCm38)	splice site	probably benign
IGL02800:Myo15	APN	11	60,502,369 (GRCm38)	missense	probably damaging	1.00
IGL02812:Myo15	APN	11	60,477,179 (GRCm38)	missense	probably benign	0.15
IGL02863:Myo15	APN	11	60,478,127 (GRCm38)	missense	probably damaging	1.00
IGL02873:Myo15	APN	11	60,483,482 (GRCm38)	missense	probably damaging	1.00
IGL02990:Myo15	APN	11	60,479,440 (GRCm38)	missense	probably benign	0.02
IGL03011:Myo15	APN	11	60,509,531 (GRCm38)	splice site	probably benign
IGL03243:Myo15	APN	11	60,496,518 (GRCm38)	missense	probably damaging	1.00
IGL03297:Myo15	APN	11	60,479,141 (GRCm38)	missense	probably damaging	1.00
novichok	UTSW	11	60,481,740 (GRCm38)	critical splice donor site	probably null
parker	UTSW	11	60,520,914 (GRCm38)	critical splice donor site	probably null
Typhoon	UTSW	11	60,487,425 (GRCm38)	critical splice donor site	probably null
PIT4131001:Myo15	UTSW	11	60,495,454 (GRCm38)	missense	probably damaging	1.00
PIT4131001:Myo15	UTSW	11	60,483,127 (GRCm38)	missense	probably damaging	1.00
R0133:Myo15	UTSW	11	60,477,850 (GRCm38)	missense	possibly damaging	0.94
R0265:Myo15	UTSW	11	60,514,897 (GRCm38)	critical splice acceptor site	probably null
R0389:Myo15	UTSW	11	60,478,538 (GRCm38)	missense	probably benign
R0416:Myo15	UTSW	11	60,511,174 (GRCm38)	missense	probably damaging	1.00
R0449:Myo15	UTSW	11	60,509,596 (GRCm38)	missense	possibly damaging	0.92
R0477:Myo15	UTSW	11	60,520,914 (GRCm38)	critical splice donor site	probably null
R0543:Myo15	UTSW	11	60,479,051 (GRCm38)	missense	probably benign
R0546:Myo15	UTSW	11	60,506,313 (GRCm38)	missense	probably damaging	1.00
R0555:Myo15	UTSW	11	60,521,638 (GRCm38)	missense	probably damaging	1.00
R0639:Myo15	UTSW	11	60,479,336 (GRCm38)	missense	probably benign	0.12
R0723:Myo15	UTSW	11	60,478,977 (GRCm38)	missense	possibly damaging	0.94
R0837:Myo15	UTSW	11	60,487,251 (GRCm38)	missense	probably damaging	0.98
R0865:Myo15	UTSW	11	60,491,688 (GRCm38)	missense	probably damaging	1.00
R0899:Myo15	UTSW	11	60,477,185 (GRCm38)	missense	possibly damaging	0.87
R1022:Myo15	UTSW	11	60,479,616 (GRCm38)	missense	probably benign	0.00
R1024:Myo15	UTSW	11	60,479,616 (GRCm38)	missense	probably benign	0.00
R1035:Myo15	UTSW	11	60,510,558 (GRCm38)	unclassified	probably benign
R1109:Myo15	UTSW	11	60,493,066 (GRCm38)	missense	probably damaging	1.00
R1170:Myo15	UTSW	11	60,479,407 (GRCm38)	missense	probably benign	0.04
R1241:Myo15	UTSW	11	60,499,430 (GRCm38)	missense	possibly damaging	0.58
R1392:Myo15	UTSW	11	60,477,974 (GRCm38)	missense	possibly damaging	0.95
R1392:Myo15	UTSW	11	60,477,974 (GRCm38)	missense	possibly damaging	0.95
R1434:Myo15	UTSW	11	60,504,331 (GRCm38)	missense	probably benign	0.00
R1450:Myo15	UTSW	11	60,495,482 (GRCm38)	missense	probably damaging	1.00
R1456:Myo15	UTSW	11	60,508,202 (GRCm38)	missense	probably damaging	1.00
R1468:Myo15	UTSW	11	60,506,006 (GRCm38)	missense	probably damaging	1.00
R1468:Myo15	UTSW	11	60,506,006 (GRCm38)	missense	probably damaging	1.00
R1548:Myo15	UTSW	11	60,488,238 (GRCm38)	missense	probably damaging	1.00
R1551:Myo15	UTSW	11	60,492,965 (GRCm38)	missense	possibly damaging	0.70
R1571:Myo15	UTSW	11	60,518,464 (GRCm38)	missense	probably damaging	1.00
R1662:Myo15	UTSW	11	60,501,701 (GRCm38)	missense	probably damaging	1.00
R1777:Myo15	UTSW	11	60,514,936 (GRCm38)	missense	probably benign
R1778:Myo15	UTSW	11	60,478,412 (GRCm38)	missense	possibly damaging	0.57
R1847:Myo15	UTSW	11	60,499,495 (GRCm38)	nonsense	probably null
R1875:Myo15	UTSW	11	60,507,528 (GRCm38)	missense	probably damaging	0.99
R1944:Myo15	UTSW	11	60,502,083 (GRCm38)	missense	probably damaging	0.99
R1945:Myo15	UTSW	11	60,502,083 (GRCm38)	missense	probably damaging	0.99
R2013:Myo15	UTSW	11	60,494,231 (GRCm38)	missense	probably damaging	1.00
R2107:Myo15	UTSW	11	60,491,810 (GRCm38)	missense	probably damaging	1.00
R2108:Myo15	UTSW	11	60,491,810 (GRCm38)	missense	probably damaging	1.00
R2112:Myo15	UTSW	11	60,494,168 (GRCm38)	missense	probably damaging	0.99
R2147:Myo15	UTSW	11	60,510,229 (GRCm38)	missense	possibly damaging	0.66
R2196:Myo15	UTSW	11	60,510,021 (GRCm38)	nonsense	probably null
R2207:Myo15	UTSW	11	60,506,034 (GRCm38)	missense	probably benign	0.01
R2245:Myo15	UTSW	11	60,509,099 (GRCm38)	missense	probably damaging	1.00
R2367:Myo15	UTSW	11	60,517,238 (GRCm38)	missense	probably damaging	0.99
R2374:Myo15	UTSW	11	60,478,843 (GRCm38)	missense	possibly damaging	0.88
R2438:Myo15	UTSW	11	60,483,052 (GRCm38)	missense	probably damaging	1.00
R3154:Myo15	UTSW	11	60,479,360 (GRCm38)	splice site	probably null
R3423:Myo15	UTSW	11	60,510,300 (GRCm38)	critical splice donor site	probably null
R3551:Myo15	UTSW	11	60,509,663 (GRCm38)	missense	possibly damaging	0.93
R3552:Myo15	UTSW	11	60,509,663 (GRCm38)	missense	possibly damaging	0.93
R3612:Myo15	UTSW	11	60,477,679 (GRCm38)	missense	probably damaging	1.00
R3620:Myo15	UTSW	11	60,478,642 (GRCm38)	missense	possibly damaging	0.63
R3713:Myo15	UTSW	11	60,479,231 (GRCm38)	missense	possibly damaging	0.55
R3714:Myo15	UTSW	11	60,479,231 (GRCm38)	missense	possibly damaging	0.55
R3715:Myo15	UTSW	11	60,479,231 (GRCm38)	missense	possibly damaging	0.55
R3783:Myo15	UTSW	11	60,477,572 (GRCm38)	missense	probably damaging	0.97
R3784:Myo15	UTSW	11	60,477,572 (GRCm38)	missense	probably damaging	0.97
R3785:Myo15	UTSW	11	60,477,572 (GRCm38)	missense	probably damaging	0.97
R3786:Myo15	UTSW	11	60,477,572 (GRCm38)	missense	probably damaging	0.97
R3787:Myo15	UTSW	11	60,477,572 (GRCm38)	missense	probably damaging	0.97
R3894:Myo15	UTSW	11	60,504,319 (GRCm38)	missense	probably benign	0.00
R3962:Myo15	UTSW	11	60,479,828 (GRCm38)	missense	probably benign	0.00
R4082:Myo15	UTSW	11	60,487,196 (GRCm38)	missense	possibly damaging	0.92
R4641:Myo15	UTSW	11	60,503,041 (GRCm38)	missense	probably damaging	1.00
R4665:Myo15	UTSW	11	60,504,879 (GRCm38)	critical splice acceptor site	probably null
R4713:Myo15	UTSW	11	60,479,930 (GRCm38)	missense	probably benign	0.21
R4820:Myo15	UTSW	11	60,476,915 (GRCm38)	missense	probably damaging	0.98
R5013:Myo15	UTSW	11	60,491,667 (GRCm38)	missense	probably damaging	1.00
R5051:Myo15	UTSW	11	60,487,425 (GRCm38)	critical splice donor site	probably null
R5187:Myo15	UTSW	11	60,503,614 (GRCm38)	missense	probably damaging	1.00
R5230:Myo15	UTSW	11	60,502,848 (GRCm38)	missense	possibly damaging	0.68
R5277:Myo15	UTSW	11	60,477,114 (GRCm38)	nonsense	probably null
R5345:Myo15	UTSW	11	60,497,538 (GRCm38)	missense	probably damaging	0.99
R5349:Myo15	UTSW	11	60,493,583 (GRCm38)	missense	probably damaging	1.00
R5356:Myo15	UTSW	11	60,498,366 (GRCm38)	missense	probably damaging	1.00
R5445:Myo15	UTSW	11	60,520,777 (GRCm38)	nonsense	probably null
R5477:Myo15	UTSW	11	60,477,677 (GRCm38)	missense	probably damaging	1.00
R5629:Myo15	UTSW	11	60,479,752 (GRCm38)	missense	probably benign
R5728:Myo15	UTSW	11	60,488,896 (GRCm38)	missense	probably damaging	1.00
R5818:Myo15	UTSW	11	60,497,951 (GRCm38)	missense	probably benign	0.06
R5952:Myo15	UTSW	11	60,479,420 (GRCm38)	missense	possibly damaging	0.50
R6338:Myo15	UTSW	11	60,478,133 (GRCm38)	missense	probably damaging	0.99
R6467:Myo15	UTSW	11	60,526,661 (GRCm38)	critical splice donor site	probably null
R6488:Myo15	UTSW	11	60,478,487 (GRCm38)	missense	possibly damaging	0.86
R6521:Myo15	UTSW	11	60,502,369 (GRCm38)	missense	probably damaging	1.00
R6645:Myo15	UTSW	11	60,477,292 (GRCm38)	missense	probably benign	0.00
R6702:Myo15	UTSW	11	60,492,992 (GRCm38)	missense	probably benign	0.16
R6703:Myo15	UTSW	11	60,492,992 (GRCm38)	missense	probably benign	0.16
R6821:Myo15	UTSW	11	60,524,475 (GRCm38)	missense	probably damaging	1.00
R6882:Myo15	UTSW	11	60,524,006 (GRCm38)	missense	probably damaging	1.00
R6908:Myo15	UTSW	11	60,506,006 (GRCm38)	missense	probably damaging	1.00
R6932:Myo15	UTSW	11	60,499,494 (GRCm38)	missense	probably damaging	1.00
R6958:Myo15	UTSW	11	60,503,625 (GRCm38)	missense	probably benign	0.07
R7041:Myo15	UTSW	11	60,506,006 (GRCm38)	missense	probably damaging	1.00
R7149:Myo15	UTSW	11	60,510,010 (GRCm38)	missense	possibly damaging	0.56
R7163:Myo15	UTSW	11	60,498,369 (GRCm38)	missense
R7229:Myo15	UTSW	11	60,496,495 (GRCm38)	missense	probably benign	0.08
R7347:Myo15	UTSW	11	60,477,961 (GRCm38)	missense	probably benign
R7368:Myo15	UTSW	11	60,490,915 (GRCm38)	splice site	probably null
R7392:Myo15	UTSW	11	60,505,976 (GRCm38)	missense
R7414:Myo15	UTSW	11	60,483,483 (GRCm38)	missense
R7461:Myo15	UTSW	11	60,505,152 (GRCm38)	missense
R7609:Myo15	UTSW	11	60,488,811 (GRCm38)	missense
R7613:Myo15	UTSW	11	60,505,152 (GRCm38)	missense
R7734:Myo15	UTSW	11	60,510,282 (GRCm38)	missense	probably benign
R7748:Myo15	UTSW	11	60,504,901 (GRCm38)	missense
R7767:Myo15	UTSW	11	60,502,096 (GRCm38)	missense
R7769:Myo15	UTSW	11	60,509,149 (GRCm38)	missense
R7894:Myo15	UTSW	11	60,491,137 (GRCm38)	missense
R7919:Myo15	UTSW	11	60,526,530 (GRCm38)	missense	probably damaging	1.00
R8100:Myo15	UTSW	11	60,517,190 (GRCm38)	missense	probably damaging	1.00
R8124:Myo15	UTSW	11	60,507,453 (GRCm38)	missense
R8129:Myo15	UTSW	11	60,508,200 (GRCm38)	missense
R8428:Myo15	UTSW	11	60,496,415 (GRCm38)	missense	probably damaging	1.00
R8706:Myo15	UTSW	11	60,479,617 (GRCm38)	missense	probably benign
R8735:Myo15	UTSW	11	60,510,853 (GRCm38)	critical splice acceptor site	probably null
R8739:Myo15	UTSW	11	60,477,262 (GRCm38)	missense	probably benign	0.06
R8790:Myo15	UTSW	11	60,487,221 (GRCm38)	missense
R8790:Myo15	UTSW	11	60,476,536 (GRCm38)	missense	possibly damaging	0.73
R8822:Myo15	UTSW	11	60,476,914 (GRCm38)	missense	probably damaging	0.99
R8907:Myo15	UTSW	11	60,526,608 (GRCm38)	missense
R8931:Myo15	UTSW	11	60,477,194 (GRCm38)	missense	probably benign
R9061:Myo15	UTSW	11	60,502,866 (GRCm38)	missense
R9124:Myo15	UTSW	11	60,479,126 (GRCm38)	missense	probably benign	0.37
R9297:Myo15	UTSW	11	60,495,073 (GRCm38)	missense	probably null
R9347:Myo15	UTSW	11	60,483,729 (GRCm38)	missense
R9417:Myo15	UTSW	11	60,487,417 (GRCm38)	missense
R9456:Myo15	UTSW	11	60,501,842 (GRCm38)	missense
R9460:Myo15	UTSW	11	60,481,740 (GRCm38)	critical splice donor site	probably null
R9615:Myo15	UTSW	11	60,483,494 (GRCm38)	missense
R9630:Myo15	UTSW	11	60,517,162 (GRCm38)	missense	probably damaging	1.00
R9746:Myo15	UTSW	11	60,487,408 (GRCm38)	nonsense	probably null
X0021:Myo15	UTSW	11	60,482,359 (GRCm38)	nonsense	probably null
X0066:Myo15	UTSW	11	60,478,220 (GRCm38)	missense	probably damaging	1.00
X0067:Myo15	UTSW	11	60,478,618 (GRCm38)	missense	possibly damaging	0.88
Z1176:Myo15	UTSW	11	60,498,403 (GRCm38)	missense
Z1176:Myo15	UTSW	11	60,488,258 (GRCm38)	missense
Z1176:Myo15	UTSW	11	60,524,441 (GRCm38)	missense	probably damaging	1.00
Z1177:Myo15	UTSW	11	60,495,475 (GRCm38)	missense
Z1177:Myo15	UTSW	11	60,488,837 (GRCm38)	missense
Z1177:Myo15	UTSW	11	60,477,523 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CATTGTGAGCTCAACCCAGG -3'
(R):5'- GCTGGCTACATCACTCCATAC -3'

Sequencing Primer
(F):5'- CCAGGCCGTGGGTATTG -3'
(R):5'- TGGCTACATCACTCCATACAGTATC -3'

Posted On

2015-09-24