Incidental Mutation 'R4568:Omt2b'
ID341949
Institutional Source Beutler Lab
Gene Symbol Omt2b
Ensembl Gene ENSMUSG00000038750
Gene Nameoocyte maturation, beta
SynonymsOM2b
MMRRC Submission 041792-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.116) question?
Stock #R4568 (G1)
Quality Score225
Status Validated
Chromosome9
Chromosomal Location78327589-78329620 bp(+) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) T to A at 78328247 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000117101 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034902] [ENSMUST00000043734] [ENSMUST00000125479] [ENSMUST00000129247] [ENSMUST00000186336] [ENSMUST00000187667]
Predicted Effect probably benign
Transcript: ENSMUST00000034902
SMART Domains Protein: ENSMUSP00000034902
Gene: ENSMUSG00000057933

DomainStartEndE-ValueType
Pfam:GST_N 5 77 5.1e-23 PFAM
Pfam:GST_C 99 192 8.9e-21 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000043734
AA Change: V37D
SMART Domains Protein: ENSMUSP00000036132
Gene: ENSMUSG00000038750
AA Change: V37D

DomainStartEndE-ValueType
transmembrane domain 69 91 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000125479
SMART Domains Protein: ENSMUSP00000115517
Gene: ENSMUSG00000057933

DomainStartEndE-ValueType
Pfam:GST_N 5 77 1.1e-21 PFAM
Pfam:GST_C 78 182 1.1e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000129247
SMART Domains Protein: ENSMUSP00000117101
Gene: ENSMUSG00000057933

DomainStartEndE-ValueType
Pfam:GST_N 5 77 1.1e-21 PFAM
Pfam:GST_C 78 179 1.2e-13 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000186336
AA Change: V37D
Predicted Effect unknown
Transcript: ENSMUST00000187667
AA Change: V37D
SMART Domains Protein: ENSMUSP00000139767
Gene: ENSMUSG00000038750
AA Change: V37D

DomainStartEndE-ValueType
transmembrane domain 69 91 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000187890
Predicted Effect unknown
Transcript: ENSMUST00000189243
AA Change: V22D
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency 100% (36/36)
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsm2 T A 7: 119,563,517 W5R probably benign Het
Bik T C 15: 83,541,444 probably null Het
Col6a1 A T 10: 76,719,197 probably benign Het
Crem A G 18: 3,299,175 I83T probably damaging Het
Csn1s1 G A 5: 87,680,904 V276I possibly damaging Het
Ctnna3 C T 10: 63,852,809 T344M possibly damaging Het
Dgcr8 G A 16: 18,280,394 P378S probably benign Het
Dnah8 G A 17: 30,748,568 D2585N probably benign Het
Fam208a A T 14: 27,476,701 probably null Het
Gpr139 C T 7: 119,144,805 V186M probably damaging Het
Krba1 A G 6: 48,409,723 T422A probably damaging Het
Lgals8 T G 13: 12,453,373 Y125S probably damaging Het
Map4k1 G A 7: 28,986,654 G107D probably damaging Het
Mfsd6 A T 1: 52,663,289 Y599* probably null Het
Olfr1411 A T 1: 92,597,391 M291L probably benign Het
Olfr412 A G 11: 74,365,209 E180G probably damaging Het
Pga5 A G 19: 10,671,852 Y235H probably damaging Het
Phldb2 T A 16: 45,777,718 K869* probably null Het
Pik3cb T C 9: 99,090,302 M268V probably benign Het
Pla2g4a T C 1: 149,842,226 D624G probably benign Het
Plxna4 T A 6: 32,152,938 I1817F probably damaging Het
Psmg3 A G 5: 139,826,249 I32T probably damaging Het
Ptpn4 T C 1: 119,680,059 E757G probably damaging Het
Rasl2-9 AGG A 7: 5,125,375 probably null Het
Ripply3 T A 16: 94,335,829 D116E probably damaging Het
Robo4 T C 9: 37,404,822 V263A possibly damaging Het
Slc5a9 C A 4: 111,891,744 probably null Het
Spef2 T C 15: 9,647,217 H1008R probably damaging Het
Stag1 T C 9: 100,848,669 V379A probably damaging Het
Tbc1d9 A G 8: 83,271,177 E1121G probably benign Het
Tpr T C 1: 150,392,959 probably benign Het
Trpv6 G T 6: 41,626,569 P206H probably damaging Het
Vmn2r63 T C 7: 42,933,826 probably null Het
Vmn2r65 C T 7: 84,947,469 C126Y probably damaging Het
Other mutations in Omt2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02325:Omt2b APN 9 78328572 missense possibly damaging 0.66
R0497:Omt2b UTSW 9 78328231 unclassified probably benign
R0789:Omt2b UTSW 9 78328165 unclassified probably benign
R1526:Omt2b UTSW 9 78328138 unclassified probably benign
R2191:Omt2b UTSW 9 78328175 unclassified probably benign
R2192:Omt2b UTSW 9 78328175 unclassified probably benign
R5884:Omt2b UTSW 9 78328557 missense probably benign 0.00
R6287:Omt2b UTSW 9 78328261 missense possibly damaging 0.92
R7409:Omt2b UTSW 9 78328612 missense probably benign 0.03
Z1176:Omt2b UTSW 9 78329330 missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- AACCATAGTGTGCCTTGGGG -3'
(R):5'- CGAGAGGCAATCTTAAGACTTGAAG -3'

Sequencing Primer
(F):5'- GCTTGGGGGTGGAGAGAC -3'
(R):5'- ATTCTGGGACTTTGGTAGC -3'
Posted On2015-09-24