Incidental Mutation 'R4570:Vmn2r98'
ID |
342101 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r98
|
Ensembl Gene |
ENSMUSG00000096717 |
Gene Name |
vomeronasal 2, receptor 98 |
Synonyms |
EG224552 |
MMRRC Submission |
041794-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.096)
|
Stock # |
R4570 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
17 |
Chromosomal Location |
19273755-19301573 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 19286354 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Methionine to Lysine
at position 284
(M284K)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000131261
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170424]
|
AlphaFold |
E9PZ56 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000170424
AA Change: M284K
PolyPhen 2
Score 0.112 (Sensitivity: 0.93; Specificity: 0.86)
|
SMART Domains |
Protein: ENSMUSP00000131261 Gene: ENSMUSG00000096717 AA Change: M284K
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
82 |
460 |
2.6e-35 |
PFAM |
Pfam:NCD3G
|
509 |
562 |
7.4e-22 |
PFAM |
Pfam:7tm_3
|
594 |
830 |
1.4e-52 |
PFAM |
low complexity region
|
844 |
856 |
N/A |
INTRINSIC |
|
Meta Mutation Damage Score |
0.0898 |
Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 94.9%
|
Validation Efficiency |
99% (78/79) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 71 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abca7 |
A |
G |
10: 79,842,528 (GRCm39) |
D1154G |
probably damaging |
Het |
Acsl5 |
T |
A |
19: 55,280,206 (GRCm39) |
I493N |
probably damaging |
Het |
Adgrf5 |
T |
A |
17: 43,756,006 (GRCm39) |
S450T |
probably benign |
Het |
Ak2 |
T |
C |
4: 128,895,960 (GRCm39) |
V79A |
probably damaging |
Het |
Alkbh2 |
C |
T |
5: 114,262,287 (GRCm39) |
E148K |
probably damaging |
Het |
Arfgef2 |
C |
A |
2: 166,698,458 (GRCm39) |
Q643K |
probably damaging |
Het |
Asap3 |
A |
G |
4: 135,967,496 (GRCm39) |
D605G |
probably damaging |
Het |
Ccr5 |
C |
T |
9: 123,924,912 (GRCm39) |
Q172* |
probably null |
Het |
Cpxm2 |
T |
C |
7: 131,745,435 (GRCm39) |
D130G |
probably benign |
Het |
Cspg4b |
T |
A |
13: 113,454,725 (GRCm39) |
V257D |
probably damaging |
Het |
Cxcl12 |
T |
C |
6: 117,145,633 (GRCm39) |
V6A |
probably benign |
Het |
Cyp19a1 |
G |
A |
9: 54,100,607 (GRCm39) |
P27S |
probably benign |
Het |
Dmxl1 |
T |
C |
18: 49,985,427 (GRCm39) |
Y225H |
probably damaging |
Het |
Dzip1l |
A |
T |
9: 99,529,221 (GRCm39) |
K317* |
probably null |
Het |
Edil3 |
A |
G |
13: 89,280,016 (GRCm39) |
|
probably benign |
Het |
Enpep |
A |
T |
3: 129,075,197 (GRCm39) |
I707K |
possibly damaging |
Het |
Fcrlb |
A |
G |
1: 170,740,189 (GRCm39) |
|
probably null |
Het |
Flt1 |
C |
T |
5: 147,531,423 (GRCm39) |
A847T |
probably damaging |
Het |
Fsd2 |
T |
C |
7: 81,209,518 (GRCm39) |
D108G |
probably benign |
Het |
Gemin6 |
C |
T |
17: 80,535,498 (GRCm39) |
R153* |
probably null |
Het |
Gldc |
T |
A |
19: 30,151,839 (GRCm39) |
M112L |
probably benign |
Het |
Gm10267 |
C |
T |
18: 44,289,492 (GRCm39) |
M79I |
probably benign |
Het |
Gm10803 |
A |
G |
2: 93,394,597 (GRCm39) |
Y123C |
unknown |
Het |
Gm28040 |
C |
A |
1: 133,257,119 (GRCm39) |
|
probably benign |
Het |
Gm8674 |
T |
A |
13: 50,056,570 (GRCm39) |
|
noncoding transcript |
Het |
Gprasp1 |
C |
T |
X: 134,703,592 (GRCm39) |
R1262C |
probably damaging |
Het |
Hba-a2 |
T |
C |
11: 32,247,200 (GRCm39) |
Y141H |
probably damaging |
Het |
Hmbox1 |
T |
A |
14: 65,061,111 (GRCm39) |
I388F |
possibly damaging |
Het |
Hs6st1 |
G |
T |
1: 36,142,628 (GRCm39) |
V188L |
possibly damaging |
Het |
Ipmk |
T |
G |
10: 71,208,569 (GRCm39) |
H118Q |
probably benign |
Het |
Jhy |
A |
G |
9: 40,822,389 (GRCm39) |
I583T |
probably benign |
Het |
Kcna2 |
A |
G |
3: 107,012,111 (GRCm39) |
I231V |
probably benign |
Het |
Kcnh7 |
T |
C |
2: 62,667,439 (GRCm39) |
T367A |
possibly damaging |
Het |
Kcp |
A |
T |
6: 29,491,847 (GRCm39) |
C197* |
probably null |
Het |
Klra2 |
C |
A |
6: 131,220,900 (GRCm39) |
C54F |
probably damaging |
Het |
Lcn9 |
T |
C |
2: 25,713,591 (GRCm39) |
L39P |
probably benign |
Het |
Lct |
T |
C |
1: 128,227,641 (GRCm39) |
N1284S |
probably benign |
Het |
Map6 |
T |
G |
7: 98,985,763 (GRCm39) |
S556A |
possibly damaging |
Het |
Mdn1 |
C |
A |
4: 32,741,812 (GRCm39) |
T3861K |
probably damaging |
Het |
Mrps12 |
A |
G |
7: 28,439,388 (GRCm39) |
L109P |
probably damaging |
Het |
Mucl3 |
T |
C |
17: 35,948,883 (GRCm39) |
T239A |
possibly damaging |
Het |
Mybphl |
G |
A |
3: 108,272,347 (GRCm39) |
C12Y |
possibly damaging |
Het |
Nek9 |
T |
C |
12: 85,367,508 (GRCm39) |
K388E |
probably damaging |
Het |
Nvl |
A |
G |
1: 180,971,647 (GRCm39) |
V9A |
probably benign |
Het |
Obscn |
T |
C |
11: 58,897,654 (GRCm39) |
|
probably null |
Het |
Or2h2 |
T |
C |
17: 37,396,471 (GRCm39) |
I195M |
probably damaging |
Het |
Pik3c3 |
T |
A |
18: 30,423,603 (GRCm39) |
I233N |
possibly damaging |
Het |
Pkhd1 |
T |
A |
1: 20,451,747 (GRCm39) |
I2183F |
probably damaging |
Het |
Ppara |
A |
G |
15: 85,671,398 (GRCm39) |
I100V |
probably benign |
Het |
Rem2 |
T |
C |
14: 54,715,116 (GRCm39) |
S98P |
probably damaging |
Het |
Rpl5-ps2 |
G |
T |
2: 154,546,156 (GRCm39) |
|
noncoding transcript |
Het |
Scmh1 |
T |
A |
4: 120,385,495 (GRCm39) |
H623Q |
probably damaging |
Het |
Scn9a |
A |
G |
2: 66,313,902 (GRCm39) |
S1939P |
possibly damaging |
Het |
Slc6a13 |
T |
C |
6: 121,313,101 (GRCm39) |
|
probably null |
Het |
Slc7a4 |
G |
A |
16: 17,392,141 (GRCm39) |
T431I |
probably benign |
Het |
Snupn |
A |
G |
9: 56,885,346 (GRCm39) |
E217G |
probably benign |
Het |
Spopl |
T |
A |
2: 23,427,497 (GRCm39) |
K212* |
probably null |
Het |
Strn |
T |
A |
17: 78,984,801 (GRCm39) |
T281S |
possibly damaging |
Het |
Supt3 |
T |
A |
17: 45,352,116 (GRCm39) |
L265* |
probably null |
Het |
Taf5l |
G |
A |
8: 124,724,289 (GRCm39) |
T510M |
probably damaging |
Het |
Tapbp |
C |
A |
17: 34,145,427 (GRCm39) |
D415E |
probably damaging |
Het |
Tarbp1 |
A |
T |
8: 127,178,972 (GRCm39) |
D702E |
probably benign |
Het |
Tfap2c |
C |
A |
2: 172,399,247 (GRCm39) |
P473Q |
probably damaging |
Het |
Tnc |
T |
C |
4: 63,913,909 (GRCm39) |
N1301S |
probably damaging |
Het |
Trim33 |
A |
G |
3: 103,237,481 (GRCm39) |
Q179R |
probably damaging |
Het |
Txnrd2 |
A |
G |
16: 18,287,554 (GRCm39) |
N335S |
probably benign |
Het |
Uggt1 |
T |
A |
1: 36,189,154 (GRCm39) |
D1444V |
probably damaging |
Het |
Ugt3a1 |
T |
C |
15: 9,338,807 (GRCm39) |
L57P |
probably benign |
Het |
Vmn2r6 |
A |
T |
3: 64,467,068 (GRCm39) |
W144R |
probably benign |
Het |
Zfp558 |
A |
T |
9: 18,367,799 (GRCm39) |
C330S |
possibly damaging |
Het |
Zfp703 |
T |
C |
8: 27,468,981 (GRCm39) |
V215A |
probably benign |
Het |
|
Other mutations in Vmn2r98 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00897:Vmn2r98
|
APN |
17 |
19,286,007 (GRCm39) |
splice site |
probably benign |
|
IGL01296:Vmn2r98
|
APN |
17 |
19,285,447 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01363:Vmn2r98
|
APN |
17 |
19,286,020 (GRCm39) |
missense |
probably benign |
0.01 |
IGL01618:Vmn2r98
|
APN |
17 |
19,285,521 (GRCm39) |
missense |
possibly damaging |
0.93 |
IGL01746:Vmn2r98
|
APN |
17 |
19,286,713 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01747:Vmn2r98
|
APN |
17 |
19,286,702 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01770:Vmn2r98
|
APN |
17 |
19,286,702 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01868:Vmn2r98
|
APN |
17 |
19,286,548 (GRCm39) |
missense |
probably benign |
|
IGL02123:Vmn2r98
|
APN |
17 |
19,300,941 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02323:Vmn2r98
|
APN |
17 |
19,286,113 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02543:Vmn2r98
|
APN |
17 |
19,286,083 (GRCm39) |
missense |
probably benign |
|
IGL02650:Vmn2r98
|
APN |
17 |
19,301,223 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02676:Vmn2r98
|
APN |
17 |
19,285,521 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02803:Vmn2r98
|
APN |
17 |
19,286,275 (GRCm39) |
missense |
probably benign |
|
IGL02807:Vmn2r98
|
APN |
17 |
19,301,283 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03307:Vmn2r98
|
APN |
17 |
19,286,242 (GRCm39) |
missense |
possibly damaging |
0.62 |
IGL03396:Vmn2r98
|
APN |
17 |
19,290,107 (GRCm39) |
missense |
possibly damaging |
0.92 |
PIT4131001:Vmn2r98
|
UTSW |
17 |
19,301,223 (GRCm39) |
missense |
probably benign |
0.00 |
R0122:Vmn2r98
|
UTSW |
17 |
19,286,662 (GRCm39) |
missense |
probably benign |
0.06 |
R0329:Vmn2r98
|
UTSW |
17 |
19,286,609 (GRCm39) |
missense |
probably benign |
0.21 |
R0330:Vmn2r98
|
UTSW |
17 |
19,286,609 (GRCm39) |
missense |
probably benign |
0.21 |
R0368:Vmn2r98
|
UTSW |
17 |
19,286,089 (GRCm39) |
nonsense |
probably null |
|
R0545:Vmn2r98
|
UTSW |
17 |
19,273,875 (GRCm39) |
missense |
probably benign |
0.15 |
R0635:Vmn2r98
|
UTSW |
17 |
19,300,759 (GRCm39) |
missense |
probably benign |
0.00 |
R0689:Vmn2r98
|
UTSW |
17 |
19,300,782 (GRCm39) |
missense |
possibly damaging |
0.83 |
R1035:Vmn2r98
|
UTSW |
17 |
19,301,011 (GRCm39) |
missense |
possibly damaging |
0.90 |
R1243:Vmn2r98
|
UTSW |
17 |
19,286,210 (GRCm39) |
missense |
possibly damaging |
0.52 |
R1421:Vmn2r98
|
UTSW |
17 |
19,285,440 (GRCm39) |
missense |
probably damaging |
1.00 |
R1629:Vmn2r98
|
UTSW |
17 |
19,287,645 (GRCm39) |
missense |
possibly damaging |
0.94 |
R1643:Vmn2r98
|
UTSW |
17 |
19,301,170 (GRCm39) |
missense |
probably damaging |
1.00 |
R1795:Vmn2r98
|
UTSW |
17 |
19,286,702 (GRCm39) |
missense |
probably damaging |
1.00 |
R1958:Vmn2r98
|
UTSW |
17 |
19,286,680 (GRCm39) |
missense |
possibly damaging |
0.70 |
R1962:Vmn2r98
|
UTSW |
17 |
19,285,595 (GRCm39) |
nonsense |
probably null |
|
R2165:Vmn2r98
|
UTSW |
17 |
19,301,553 (GRCm39) |
missense |
unknown |
|
R2238:Vmn2r98
|
UTSW |
17 |
19,286,213 (GRCm39) |
missense |
probably damaging |
1.00 |
R2252:Vmn2r98
|
UTSW |
17 |
19,300,698 (GRCm39) |
missense |
probably benign |
0.00 |
R2323:Vmn2r98
|
UTSW |
17 |
19,286,081 (GRCm39) |
missense |
probably benign |
0.18 |
R2887:Vmn2r98
|
UTSW |
17 |
19,301,439 (GRCm39) |
missense |
possibly damaging |
0.83 |
R2909:Vmn2r98
|
UTSW |
17 |
19,287,664 (GRCm39) |
missense |
probably damaging |
1.00 |
R3001:Vmn2r98
|
UTSW |
17 |
19,286,125 (GRCm39) |
missense |
probably benign |
0.01 |
R3002:Vmn2r98
|
UTSW |
17 |
19,286,125 (GRCm39) |
missense |
probably benign |
0.01 |
R3003:Vmn2r98
|
UTSW |
17 |
19,286,125 (GRCm39) |
missense |
probably benign |
0.01 |
R3788:Vmn2r98
|
UTSW |
17 |
19,300,887 (GRCm39) |
missense |
probably benign |
0.31 |
R4706:Vmn2r98
|
UTSW |
17 |
19,290,007 (GRCm39) |
missense |
probably damaging |
1.00 |
R4723:Vmn2r98
|
UTSW |
17 |
19,286,602 (GRCm39) |
missense |
probably benign |
0.01 |
R5036:Vmn2r98
|
UTSW |
17 |
19,286,419 (GRCm39) |
missense |
probably benign |
0.00 |
R5072:Vmn2r98
|
UTSW |
17 |
19,286,306 (GRCm39) |
missense |
probably benign |
0.07 |
R5121:Vmn2r98
|
UTSW |
17 |
19,273,815 (GRCm39) |
missense |
probably benign |
0.13 |
R5283:Vmn2r98
|
UTSW |
17 |
19,300,981 (GRCm39) |
missense |
probably benign |
0.05 |
R5294:Vmn2r98
|
UTSW |
17 |
19,290,016 (GRCm39) |
nonsense |
probably null |
|
R5371:Vmn2r98
|
UTSW |
17 |
19,290,015 (GRCm39) |
missense |
probably damaging |
1.00 |
R5532:Vmn2r98
|
UTSW |
17 |
19,287,645 (GRCm39) |
missense |
possibly damaging |
0.94 |
R5598:Vmn2r98
|
UTSW |
17 |
19,301,161 (GRCm39) |
missense |
probably benign |
0.37 |
R5800:Vmn2r98
|
UTSW |
17 |
19,286,260 (GRCm39) |
missense |
probably benign |
0.17 |
R6089:Vmn2r98
|
UTSW |
17 |
19,286,336 (GRCm39) |
missense |
probably benign |
0.29 |
R6155:Vmn2r98
|
UTSW |
17 |
19,286,143 (GRCm39) |
missense |
possibly damaging |
0.87 |
R6853:Vmn2r98
|
UTSW |
17 |
19,286,063 (GRCm39) |
missense |
probably benign |
0.00 |
R6920:Vmn2r98
|
UTSW |
17 |
19,285,510 (GRCm39) |
missense |
probably damaging |
0.98 |
R7012:Vmn2r98
|
UTSW |
17 |
19,286,530 (GRCm39) |
missense |
probably benign |
0.06 |
R7042:Vmn2r98
|
UTSW |
17 |
19,301,184 (GRCm39) |
missense |
probably benign |
|
R7068:Vmn2r98
|
UTSW |
17 |
19,285,575 (GRCm39) |
missense |
probably benign |
|
R7607:Vmn2r98
|
UTSW |
17 |
19,287,570 (GRCm39) |
missense |
possibly damaging |
0.95 |
R7763:Vmn2r98
|
UTSW |
17 |
19,300,797 (GRCm39) |
missense |
probably benign |
0.00 |
R7771:Vmn2r98
|
UTSW |
17 |
19,287,460 (GRCm39) |
splice site |
probably null |
|
R7915:Vmn2r98
|
UTSW |
17 |
19,287,493 (GRCm39) |
missense |
probably benign |
0.10 |
R8028:Vmn2r98
|
UTSW |
17 |
19,273,912 (GRCm39) |
missense |
probably benign |
0.00 |
R8205:Vmn2r98
|
UTSW |
17 |
19,301,425 (GRCm39) |
missense |
probably damaging |
0.99 |
R8241:Vmn2r98
|
UTSW |
17 |
19,301,031 (GRCm39) |
missense |
probably damaging |
0.99 |
R8906:Vmn2r98
|
UTSW |
17 |
19,286,532 (GRCm39) |
missense |
probably benign |
|
R8952:Vmn2r98
|
UTSW |
17 |
19,285,531 (GRCm39) |
missense |
possibly damaging |
0.76 |
R9147:Vmn2r98
|
UTSW |
17 |
19,286,383 (GRCm39) |
missense |
probably benign |
0.04 |
R9148:Vmn2r98
|
UTSW |
17 |
19,286,383 (GRCm39) |
missense |
probably benign |
0.04 |
R9187:Vmn2r98
|
UTSW |
17 |
19,301,481 (GRCm39) |
missense |
probably damaging |
1.00 |
R9344:Vmn2r98
|
UTSW |
17 |
19,286,777 (GRCm39) |
missense |
probably benign |
0.14 |
R9467:Vmn2r98
|
UTSW |
17 |
19,287,517 (GRCm39) |
missense |
probably benign |
0.01 |
R9487:Vmn2r98
|
UTSW |
17 |
19,301,496 (GRCm39) |
missense |
possibly damaging |
0.78 |
R9753:Vmn2r98
|
UTSW |
17 |
19,285,665 (GRCm39) |
missense |
probably benign |
0.27 |
Z1177:Vmn2r98
|
UTSW |
17 |
19,287,685 (GRCm39) |
nonsense |
probably null |
|
Z1177:Vmn2r98
|
UTSW |
17 |
19,285,398 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Predicted Primers |
PCR Primer
(F):5'- GGTCTAATCCTCCCCAATGACC -3'
(R):5'- ACCACAGCTTAGGAAGATAAACGTC -3'
Sequencing Primer
(F):5'- TAATCCTCCCCAATGACCACAAAGG -3'
(R):5'- ATAAACGTCTTCTGGGTATTTATTGG -3'
|
Posted On |
2015-09-24 |