Incidental Mutation 'R4572:Fscn3'
ID 342188
Institutional Source Beutler Lab
Gene Symbol Fscn3
Ensembl Gene ENSMUSG00000029707
Gene Name fascin actin-bundling protein 3
Synonyms OTTMUSP00000023543; fascin (testis); fascin 3
MMRRC Submission 041796-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.195) question?
Stock # R4572 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 28427789-28438622 bp(+) (GRCm38)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 28430635 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000067395 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020717] [ENSMUST00000031719] [ENSMUST00000064377] [ENSMUST00000169841]
AlphaFold Q9QXW4
Predicted Effect probably benign
Transcript: ENSMUST00000020717
SMART Domains Protein: ENSMUSP00000020717
Gene: ENSMUSG00000020440

DomainStartEndE-ValueType
ARF 1 180 5.83e-121 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000031719
AA Change: L268Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000031719
Gene: ENSMUSG00000029707
AA Change: L268Q

DomainStartEndE-ValueType
Pfam:Fascin 24 138 1e-29 PFAM
SCOP:d1dfca2 146 260 2e-48 SMART
Pfam:Fascin 271 381 2.1e-26 PFAM
SCOP:d1dfca4 386 498 3e-53 SMART
Predicted Effect probably null
Transcript: ENSMUST00000064377
SMART Domains Protein: ENSMUSP00000067395
Gene: ENSMUSG00000029708

DomainStartEndE-ValueType
coiled coil region 13 61 N/A INTRINSIC
low complexity region 93 109 N/A INTRINSIC
low complexity region 130 153 N/A INTRINSIC
coiled coil region 156 315 N/A INTRINSIC
low complexity region 408 418 N/A INTRINSIC
low complexity region 432 443 N/A INTRINSIC
low complexity region 479 491 N/A INTRINSIC
Blast:H2B 492 590 3e-8 BLAST
low complexity region 613 631 N/A INTRINSIC
coiled coil region 659 701 N/A INTRINSIC
Grip 719 766 8.28e-20 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147036
Predicted Effect probably benign
Transcript: ENSMUST00000169841
SMART Domains Protein: ENSMUSP00000127281
Gene: ENSMUSG00000020440

DomainStartEndE-ValueType
ARF 1 180 5.83e-121 SMART
Meta Mutation Damage Score 0.7604 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency 100% (71/71)
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca6 A T 11: 110,216,548 (GRCm38) I747N probably benign Het
Adamtsl2 A G 2: 27,083,256 (GRCm38) Y97C probably damaging Het
Alox12e A G 11: 70,321,181 (GRCm38) probably benign Het
Alpk2 A T 18: 65,281,004 (GRCm38) S2014T probably damaging Het
Ankrd36 A T 11: 5,689,340 (GRCm38) probably null Het
Apobec1 T C 6: 122,581,397 (GRCm38) D133G probably damaging Het
Arfgef1 A T 1: 10,213,141 (GRCm38) I181N probably damaging Het
Cilp2 A G 8: 69,882,410 (GRCm38) V646A probably damaging Het
Clasrp A G 7: 19,584,464 (GRCm38) probably null Het
Cnot2 T C 10: 116,494,846 (GRCm38) T423A probably benign Het
Crtap T C 9: 114,384,806 (GRCm38) D227G probably benign Het
Cyp17a1 A G 19: 46,670,551 (GRCm38) F217S probably damaging Het
Ddx60 A G 8: 61,987,421 (GRCm38) M1036V probably damaging Het
Dnah11 A T 12: 118,010,125 (GRCm38) I2818N probably benign Het
Dok6 T A 18: 89,473,947 (GRCm38) I169F possibly damaging Het
Duox2 T A 2: 122,281,726 (GRCm38) R1326S probably benign Het
Epha10 A G 4: 124,902,568 (GRCm38) T357A unknown Het
Ephb2 A C 4: 136,655,940 (GRCm38) F942C probably damaging Het
Gabrb2 A G 11: 42,593,917 (GRCm38) N267S possibly damaging Het
Gabrr3 A T 16: 59,461,638 (GRCm38) Y452F probably benign Het
Gen1 A G 12: 11,242,418 (GRCm38) S457P probably damaging Het
Gm1993 C T X: 25,560,356 (GRCm38) R77H probably damaging Het
Gm5592 G A 7: 41,216,159 (GRCm38) probably benign Het
Hmbox1 A G 14: 64,903,233 (GRCm38) probably null Het
Hus1 A T 11: 9,007,617 (GRCm38) probably null Het
Ino80 G A 2: 119,402,358 (GRCm38) R1160W probably damaging Het
Kalrn A T 16: 34,392,042 (GRCm38) F27L probably damaging Het
Kri1 A T 9: 21,280,384 (GRCm38) F187L probably damaging Het
Lekr1 A T 3: 65,783,915 (GRCm38) noncoding transcript Het
Mapk15 T C 15: 75,998,750 (GRCm38) probably benign Het
Mrgpre G A 7: 143,781,104 (GRCm38) L221F probably damaging Het
Mrpl50 A T 4: 49,514,399 (GRCm38) S91T possibly damaging Het
Muc4 T C 16: 32,753,802 (GRCm38) I1226T probably benign Het
Mup15 A G 4: 61,438,217 (GRCm38) probably null Het
Ncapd3 A G 9: 27,094,615 (GRCm38) D1469G probably damaging Het
Nlrp9b G A 7: 20,026,681 (GRCm38) probably null Het
Npy6r A T 18: 44,275,917 (GRCm38) Y135F probably benign Het
Or7e170 A C 9: 19,883,979 (GRCm38) C109G probably benign Het
Phf14 G A 6: 12,006,824 (GRCm38) R825Q probably damaging Het
Pigg A G 5: 108,332,885 (GRCm38) M379V probably benign Het
Plppr3 T A 10: 79,866,063 (GRCm38) Q315L probably benign Het
Plxnd1 C A 6: 115,955,756 (GRCm38) C1921F probably damaging Het
Ptger4 A C 15: 5,243,133 (GRCm38) S2A probably benign Het
Qrfprl A T 6: 65,454,991 (GRCm38) M293L probably benign Het
Rab4a A T 8: 123,834,060 (GRCm38) D196V probably benign Het
Rbck1 G A 2: 152,318,733 (GRCm38) Q428* probably null Het
Rgs14 A T 13: 55,380,062 (GRCm38) N266I probably damaging Het
Serpina1c A T 12: 103,898,708 (GRCm38) probably benign Het
Sesn3 G A 9: 14,321,220 (GRCm38) R263H probably benign Het
Slfn1 A T 11: 83,121,463 (GRCm38) D135V probably benign Het
Spata17 T C 1: 187,193,996 (GRCm38) K46E possibly damaging Het
Srcin1 A C 11: 97,534,934 (GRCm38) D432E probably damaging Het
Stxbp5 T C 10: 9,838,144 (GRCm38) E217G probably damaging Het
Terf2ip A G 8: 112,012,017 (GRCm38) D179G probably damaging Het
Tll1 A G 8: 64,056,309 (GRCm38) F556L possibly damaging Het
Tmed4 CTCTTTCT CTCT 11: 6,274,461 (GRCm38) probably null Het
Trappc9 G T 15: 72,937,067 (GRCm38) Q537K possibly damaging Het
Trim30a G T 7: 104,411,188 (GRCm38) C460* probably null Het
Trim35 T C 14: 66,307,873 (GRCm38) Y298H probably damaging Het
Ugt3a1 T A 15: 9,306,393 (GRCm38) H209Q probably benign Het
Ulk4 T C 9: 121,192,764 (GRCm38) K627R probably damaging Het
Wnk1 T C 6: 119,951,911 (GRCm38) T1319A possibly damaging Het
Wnt9b G A 11: 103,732,155 (GRCm38) R141C probably damaging Het
Zfp735 A G 11: 73,689,785 (GRCm38) M37V probably benign Het
Zmym1 A T 4: 127,050,835 (GRCm38) N186K probably benign Het
Other mutations in Fscn3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01290:Fscn3 APN 6 28,430,506 (GRCm38) missense probably benign 0.43
IGL01312:Fscn3 APN 6 28,434,470 (GRCm38) missense probably damaging 0.99
IGL01634:Fscn3 APN 6 28,430,538 (GRCm38) missense probably damaging 1.00
IGL01899:Fscn3 APN 6 28,436,079 (GRCm38) missense probably damaging 1.00
IGL01928:Fscn3 APN 6 28,430,182 (GRCm38) missense possibly damaging 0.65
IGL02334:Fscn3 APN 6 28,428,154 (GRCm38) splice site probably null
IGL02959:Fscn3 APN 6 28,435,998 (GRCm38) missense possibly damaging 0.93
IGL03201:Fscn3 APN 6 28,430,605 (GRCm38) missense probably benign 0.07
IGL03202:Fscn3 APN 6 28,434,452 (GRCm38) missense probably benign 0.10
IGL03227:Fscn3 APN 6 28,434,430 (GRCm38) missense probably benign 0.00
0152:Fscn3 UTSW 6 28,429,967 (GRCm38) unclassified probably benign
R1478:Fscn3 UTSW 6 28,430,568 (GRCm38) missense probably benign
R1502:Fscn3 UTSW 6 28,435,623 (GRCm38) missense probably benign 0.05
R1955:Fscn3 UTSW 6 28,430,236 (GRCm38) missense possibly damaging 0.82
R2122:Fscn3 UTSW 6 28,430,389 (GRCm38) missense probably benign 0.18
R2135:Fscn3 UTSW 6 28,431,584 (GRCm38) missense probably benign 0.02
R3713:Fscn3 UTSW 6 28,428,092 (GRCm38) missense possibly damaging 0.89
R3715:Fscn3 UTSW 6 28,428,092 (GRCm38) missense possibly damaging 0.89
R3778:Fscn3 UTSW 6 28,430,032 (GRCm38) missense possibly damaging 0.72
R4745:Fscn3 UTSW 6 28,435,628 (GRCm38) missense probably damaging 0.98
R4764:Fscn3 UTSW 6 28,436,201 (GRCm38) makesense probably null
R4794:Fscn3 UTSW 6 28,430,596 (GRCm38) missense probably damaging 1.00
R5738:Fscn3 UTSW 6 28,430,031 (GRCm38) missense possibly damaging 0.56
R5951:Fscn3 UTSW 6 28,436,174 (GRCm38) missense possibly damaging 0.88
R5994:Fscn3 UTSW 6 28,430,295 (GRCm38) missense probably benign
R6595:Fscn3 UTSW 6 28,430,175 (GRCm38) missense probably damaging 1.00
R7323:Fscn3 UTSW 6 28,431,545 (GRCm38) missense possibly damaging 0.53
R7738:Fscn3 UTSW 6 28,434,446 (GRCm38) missense probably benign 0.01
R7840:Fscn3 UTSW 6 28,430,176 (GRCm38) missense probably damaging 1.00
R8169:Fscn3 UTSW 6 28,430,329 (GRCm38) missense possibly damaging 0.79
R8991:Fscn3 UTSW 6 28,434,473 (GRCm38) missense probably benign
R9111:Fscn3 UTSW 6 28,430,311 (GRCm38) missense probably damaging 0.98
R9350:Fscn3 UTSW 6 28,430,433 (GRCm38) nonsense probably null
R9370:Fscn3 UTSW 6 28,434,536 (GRCm38) missense probably benign
R9410:Fscn3 UTSW 6 28,430,433 (GRCm38) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TCCCTCAACGCTCATCACAG -3'
(R):5'- TGACTAAAGTTCAAAATTTCTTGTGG -3'

Sequencing Primer
(F):5'- GACAGCTTTTCACATGCAAGTACG -3'
(R):5'- GGAACAAGCCGATAGTCACTGTTTC -3'
Posted On 2015-09-24