|Institutional Source||Beutler Lab|
|Gene Name||TNF receptor-associated protein 1|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R0316 (G1)|
|Chromosomal Location||4039971-4077827 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 4045560 bp|
|Amino Acid Change||Phenylalanine to Leucine at position 533 (F533L)|
|Ref Sequence||ENSEMBL: ENSMUSP00000006137 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000006137]|
|Predicted Effect||probably benign
AA Change: F533L
PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
AA Change: F533L
|Predicted Effect||noncoding transcript
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit reduced body weight; liver and spleen hyperplasia; decreased chronic inflammation and tumor incidents; deregulated mitochondrial respiration; and increased oxidative stress. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Trap1||
(F):5'- CCCAAGTGAGGAATGCAATGCACTC -3'
(R):5'- GGCACCCGCAACATCTATTACCTG -3'
(F):5'- GTGACAGTCTCCTGCCCAAC -3'
(R):5'- GCTGGGCCAAGAATGTATCTTAC -3'