Incidental Mutation 'R4575:Vmn2r16'
| ID |
342395 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r16
|
| Ensembl Gene |
ENSMUSG00000092080 |
| Gene Name |
vomeronasal 2, receptor 16 |
| Synonyms |
EG384220 |
| MMRRC Submission |
041798-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.154)
|
| Stock # |
R4575 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
109478247-109512347 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 109511665 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Phenylalanine
at position 624
(Y624F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000127838
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000165180]
|
| AlphaFold |
A0A3B2WCY4 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000165180
AA Change: Y624F
PolyPhen 2
Score 0.813 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000127838
Gene: ENSMUSG00000092080
AA Change: Y624F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
76 |
425 |
2.3e-28 |
PFAM |
|
Pfam:NCD3G
|
509 |
563 |
8.2e-19 |
PFAM |
|
Pfam:7tm_3
|
596 |
831 |
3.5e-56 |
PFAM |
|
| Meta Mutation Damage Score |
0.1795 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.0%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 60 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310057M21Rik |
C |
T |
7: 130,964,325 (GRCm39) |
A26T |
probably benign |
Het |
| 4930408O17Rik |
C |
A |
12: 104,837,527 (GRCm39) |
|
noncoding transcript |
Het |
| Adgrf3 |
T |
A |
5: 30,407,255 (GRCm39) |
M224L |
probably benign |
Het |
| Ago3 |
T |
C |
4: 126,240,475 (GRCm39) |
H129R |
probably benign |
Het |
| Aoc1l1 |
C |
T |
6: 48,954,502 (GRCm39) |
Q547* |
probably null |
Het |
| Asb10 |
C |
T |
5: 24,745,052 (GRCm39) |
R99H |
probably damaging |
Het |
| Auts2 |
C |
T |
5: 132,287,773 (GRCm39) |
G70E |
probably benign |
Het |
| Bltp3a |
T |
C |
17: 28,106,477 (GRCm39) |
V1001A |
probably benign |
Het |
| Ccdc96 |
T |
C |
5: 36,643,419 (GRCm39) |
V475A |
possibly damaging |
Het |
| Cimip2a |
T |
C |
2: 25,110,300 (GRCm39) |
S71P |
probably benign |
Het |
| Clec4b2 |
T |
A |
6: 123,150,639 (GRCm39) |
L16Q |
probably damaging |
Het |
| Cyp2c68 |
T |
A |
19: 39,722,805 (GRCm39) |
I248L |
probably benign |
Het |
| Cyp2d22 |
G |
T |
15: 82,256,133 (GRCm39) |
A167E |
possibly damaging |
Het |
| Dpysl3 |
T |
C |
18: 43,475,312 (GRCm39) |
K382R |
probably damaging |
Het |
| Dscam |
A |
G |
16: 96,626,823 (GRCm39) |
I362T |
possibly damaging |
Het |
| Edil3 |
T |
C |
13: 89,467,850 (GRCm39) |
Y452H |
probably damaging |
Het |
| Elfn1 |
T |
C |
5: 139,957,808 (GRCm39) |
S271P |
probably benign |
Het |
| Ep300 |
T |
C |
15: 81,533,210 (GRCm39) |
S1756P |
unknown |
Het |
| Ep300 |
T |
A |
15: 81,495,611 (GRCm39) |
|
probably benign |
Het |
| Fgd4 |
T |
C |
16: 16,254,896 (GRCm39) |
Q507R |
probably damaging |
Het |
| Frem3 |
A |
G |
8: 81,342,704 (GRCm39) |
T1666A |
probably benign |
Het |
| Frmd4a |
C |
A |
2: 4,608,490 (GRCm39) |
A786E |
possibly damaging |
Het |
| Gabrr1 |
C |
T |
4: 33,158,175 (GRCm39) |
T266I |
possibly damaging |
Het |
| Gm11563 |
G |
A |
11: 99,549,275 (GRCm39) |
P160S |
unknown |
Het |
| Gm12790 |
T |
C |
4: 101,825,324 (GRCm39) |
D30G |
probably benign |
Het |
| Haus8 |
A |
G |
8: 71,715,736 (GRCm39) |
V34A |
probably damaging |
Het |
| Hgf |
T |
C |
5: 16,777,599 (GRCm39) |
Y199H |
probably benign |
Het |
| Ide |
G |
A |
19: 37,249,604 (GRCm39) |
P916L |
unknown |
Het |
| Igsf10 |
G |
T |
3: 59,237,521 (GRCm39) |
H887N |
probably benign |
Het |
| Iigp1 |
A |
T |
18: 60,523,218 (GRCm39) |
H112L |
probably benign |
Het |
| Impg2 |
A |
G |
16: 56,082,095 (GRCm39) |
E1009G |
probably damaging |
Het |
| Khdc1a |
A |
C |
1: 21,420,653 (GRCm39) |
D91A |
probably damaging |
Het |
| Klk12 |
A |
G |
7: 43,422,667 (GRCm39) |
D198G |
probably damaging |
Het |
| Kntc1 |
T |
G |
5: 123,904,018 (GRCm39) |
L345R |
probably damaging |
Het |
| Kprp |
T |
C |
3: 92,731,271 (GRCm39) |
N593S |
probably benign |
Het |
| Krt1c |
T |
G |
15: 101,722,921 (GRCm39) |
D359A |
probably damaging |
Het |
| Krt35 |
A |
T |
11: 99,986,725 (GRCm39) |
N96K |
probably benign |
Het |
| Lnx1 |
T |
C |
5: 74,846,204 (GRCm39) |
D82G |
probably damaging |
Het |
| Mroh2a |
A |
G |
1: 88,186,386 (GRCm39) |
S64G |
probably benign |
Het |
| Nfib |
A |
T |
4: 82,215,048 (GRCm39) |
S518R |
probably damaging |
Het |
| Nol6 |
T |
C |
4: 41,120,299 (GRCm39) |
I473V |
probably benign |
Het |
| Obscn |
T |
C |
11: 59,013,598 (GRCm39) |
D1108G |
probably damaging |
Het |
| Or52m2 |
A |
T |
7: 102,263,976 (GRCm39) |
C73* |
probably null |
Het |
| Or7g12 |
C |
A |
9: 18,900,001 (GRCm39) |
S239* |
probably null |
Het |
| Otop1 |
T |
C |
5: 38,457,065 (GRCm39) |
Y275H |
probably damaging |
Het |
| Ppp1r14c |
G |
T |
10: 3,316,912 (GRCm39) |
K82N |
probably damaging |
Het |
| Prr14l |
T |
C |
5: 32,950,988 (GRCm39) |
E1935G |
probably damaging |
Het |
| Ptprd |
C |
T |
4: 76,162,023 (GRCm39) |
V78I |
possibly damaging |
Het |
| Rfc4 |
T |
A |
16: 22,933,179 (GRCm39) |
|
probably benign |
Het |
| Rpn2 |
C |
A |
2: 157,137,244 (GRCm39) |
A209E |
probably damaging |
Het |
| Sf1 |
T |
C |
19: 6,425,943 (GRCm39) |
|
probably benign |
Het |
| Sft2d1rt |
T |
C |
11: 45,942,679 (GRCm39) |
D148G |
probably damaging |
Het |
| Skint5 |
T |
A |
4: 113,524,390 (GRCm39) |
S864C |
unknown |
Het |
| Slc2a10 |
C |
G |
2: 165,358,241 (GRCm39) |
N455K |
probably damaging |
Het |
| Snrnp200 |
T |
A |
2: 127,076,986 (GRCm39) |
I1673N |
probably benign |
Het |
| Sri |
G |
T |
5: 8,113,693 (GRCm39) |
G152W |
probably damaging |
Het |
| Srpra |
T |
C |
9: 35,125,904 (GRCm39) |
I394T |
possibly damaging |
Het |
| Svop |
C |
T |
5: 114,203,743 (GRCm39) |
V13M |
probably damaging |
Het |
| Traf3ip2 |
A |
G |
10: 39,510,650 (GRCm39) |
N308D |
probably damaging |
Het |
| Vmn2r125 |
T |
A |
4: 156,702,272 (GRCm39) |
D19E |
probably null |
Het |
|
| Other mutations in Vmn2r16 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01116:Vmn2r16
|
APN |
5 |
109,488,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01374:Vmn2r16
|
APN |
5 |
109,478,283 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01391:Vmn2r16
|
APN |
5 |
109,511,627 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL01419:Vmn2r16
|
APN |
5 |
109,510,267 (GRCm39) |
splice site |
probably benign |
|
|
IGL01634:Vmn2r16
|
APN |
5 |
109,488,177 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01845:Vmn2r16
|
APN |
5 |
109,511,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01875:Vmn2r16
|
APN |
5 |
109,478,277 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01910:Vmn2r16
|
APN |
5 |
109,487,951 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02217:Vmn2r16
|
APN |
5 |
109,487,676 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02327:Vmn2r16
|
APN |
5 |
109,487,987 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02491:Vmn2r16
|
APN |
5 |
109,487,703 (GRCm39) |
nonsense |
probably null |
|
|
IGL02531:Vmn2r16
|
APN |
5 |
109,488,134 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02680:Vmn2r16
|
APN |
5 |
109,487,948 (GRCm39) |
missense |
probably benign |
0.44 |
|
IGL02884:Vmn2r16
|
APN |
5 |
109,508,757 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03084:Vmn2r16
|
APN |
5 |
109,478,292 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03096:Vmn2r16
|
APN |
5 |
109,487,751 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03355:Vmn2r16
|
APN |
5 |
109,511,580 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R0280:Vmn2r16
|
UTSW |
5 |
109,488,005 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0594:Vmn2r16
|
UTSW |
5 |
109,511,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1016:Vmn2r16
|
UTSW |
5 |
109,487,754 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1109:Vmn2r16
|
UTSW |
5 |
109,487,652 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1248:Vmn2r16
|
UTSW |
5 |
109,508,643 (GRCm39) |
missense |
probably benign |
0.10 |
|
R1626:Vmn2r16
|
UTSW |
5 |
109,511,443 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1909:Vmn2r16
|
UTSW |
5 |
109,511,853 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1929:Vmn2r16
|
UTSW |
5 |
109,487,124 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1982:Vmn2r16
|
UTSW |
5 |
109,511,890 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3038:Vmn2r16
|
UTSW |
5 |
109,487,199 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3437:Vmn2r16
|
UTSW |
5 |
109,478,362 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3734:Vmn2r16
|
UTSW |
5 |
109,478,280 (GRCm39) |
missense |
probably benign |
0.11 |
|
R3820:Vmn2r16
|
UTSW |
5 |
109,510,143 (GRCm39) |
missense |
probably benign |
0.36 |
|
R3873:Vmn2r16
|
UTSW |
5 |
109,488,177 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4165:Vmn2r16
|
UTSW |
5 |
109,478,427 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4373:Vmn2r16
|
UTSW |
5 |
109,511,667 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4576:Vmn2r16
|
UTSW |
5 |
109,511,665 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R4578:Vmn2r16
|
UTSW |
5 |
109,511,665 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R4637:Vmn2r16
|
UTSW |
5 |
109,478,280 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4696:Vmn2r16
|
UTSW |
5 |
109,487,168 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5026:Vmn2r16
|
UTSW |
5 |
109,508,722 (GRCm39) |
nonsense |
probably null |
|
|
R5180:Vmn2r16
|
UTSW |
5 |
109,478,391 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5433:Vmn2r16
|
UTSW |
5 |
109,511,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5955:Vmn2r16
|
UTSW |
5 |
109,511,613 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R5958:Vmn2r16
|
UTSW |
5 |
109,510,153 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R6353:Vmn2r16
|
UTSW |
5 |
109,488,119 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6389:Vmn2r16
|
UTSW |
5 |
109,478,344 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6819:Vmn2r16
|
UTSW |
5 |
109,488,412 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6994:Vmn2r16
|
UTSW |
5 |
109,487,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7061:Vmn2r16
|
UTSW |
5 |
109,511,620 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7063:Vmn2r16
|
UTSW |
5 |
109,511,650 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7220:Vmn2r16
|
UTSW |
5 |
109,508,772 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7268:Vmn2r16
|
UTSW |
5 |
109,488,331 (GRCm39) |
nonsense |
probably null |
|
|
R7420:Vmn2r16
|
UTSW |
5 |
109,511,736 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7591:Vmn2r16
|
UTSW |
5 |
109,510,223 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7644:Vmn2r16
|
UTSW |
5 |
109,487,837 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7939:Vmn2r16
|
UTSW |
5 |
109,487,705 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R7977:Vmn2r16
|
UTSW |
5 |
109,488,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7987:Vmn2r16
|
UTSW |
5 |
109,488,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8023:Vmn2r16
|
UTSW |
5 |
109,488,272 (GRCm39) |
nonsense |
probably null |
|
|
R8427:Vmn2r16
|
UTSW |
5 |
109,488,138 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8436:Vmn2r16
|
UTSW |
5 |
109,511,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8475:Vmn2r16
|
UTSW |
5 |
109,487,073 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8554:Vmn2r16
|
UTSW |
5 |
109,511,997 (GRCm39) |
missense |
probably benign |
0.13 |
|
R8771:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8774:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8774-TAIL:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8775:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8775-TAIL:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8777:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8777-TAIL:Vmn2r16
|
UTSW |
5 |
109,488,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8825:Vmn2r16
|
UTSW |
5 |
109,487,019 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8865:Vmn2r16
|
UTSW |
5 |
109,487,910 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8900:Vmn2r16
|
UTSW |
5 |
109,511,619 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9365:Vmn2r16
|
UTSW |
5 |
109,488,064 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9683:Vmn2r16
|
UTSW |
5 |
109,511,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0027:Vmn2r16
|
UTSW |
5 |
109,487,175 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r16
|
UTSW |
5 |
109,511,779 (GRCm39) |
frame shift |
probably null |
|
|
Z1088:Vmn2r16
|
UTSW |
5 |
109,488,381 (GRCm39) |
missense |
probably benign |
0.03 |
|
Z1177:Vmn2r16
|
UTSW |
5 |
109,487,864 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTATGAGCAGATATGGAGCAGTGTG -3'
(R):5'- GCTTGAAAGCCATGACCACAG -3'
Sequencing Primer
(F):5'- GGTGTCCAGATGATAAATATGCC -3'
(R):5'- GACCACAGTTATTGTTTTGGCCAAC -3'
|
| Posted On |
2015-09-24 |
Incidental Mutation