Incidental Mutation 'R4575:Haus8'
ID 342406
Institutional Source Beutler Lab
Gene Symbol Haus8
Ensembl Gene ENSMUSG00000035439
Gene Name 4HAUS augmin-like complex, subunit 8
Synonyms 2410004L22Rik, Hice1
MMRRC Submission 041798-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.901) question?
Stock # R4575 (G1)
Quality Score 225
Status Not validated
Chromosome 8
Chromosomal Location 71703241-71725234 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 71715736 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 34 (V34A)
Ref Sequence ENSEMBL: ENSMUSP00000105698 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035960] [ENSMUST00000110071] [ENSMUST00000123495]
AlphaFold Q99L00
Predicted Effect probably damaging
Transcript: ENSMUST00000035960
AA Change: V34A

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000040802
Gene: ENSMUSG00000035439
AA Change: V34A

DomainStartEndE-ValueType
low complexity region 9 19 N/A INTRINSIC
low complexity region 130 142 N/A INTRINSIC
coiled coil region 164 201 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000110071
AA Change: V34A

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000105698
Gene: ENSMUSG00000035439
AA Change: V34A

DomainStartEndE-ValueType
low complexity region 9 19 N/A INTRINSIC
low complexity region 129 141 N/A INTRINSIC
coiled coil region 163 200 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000123495
AA Change: V34A

PolyPhen 2 Score 0.732 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000123517
Gene: ENSMUSG00000035439
AA Change: V34A

DomainStartEndE-ValueType
low complexity region 9 19 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128833
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134361
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144726
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157039
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] HAUS8 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310057M21Rik C T 7: 130,964,325 (GRCm39) A26T probably benign Het
4930408O17Rik C A 12: 104,837,527 (GRCm39) noncoding transcript Het
Adgrf3 T A 5: 30,407,255 (GRCm39) M224L probably benign Het
Ago3 T C 4: 126,240,475 (GRCm39) H129R probably benign Het
Aoc1l1 C T 6: 48,954,502 (GRCm39) Q547* probably null Het
Asb10 C T 5: 24,745,052 (GRCm39) R99H probably damaging Het
Auts2 C T 5: 132,287,773 (GRCm39) G70E probably benign Het
Bltp3a T C 17: 28,106,477 (GRCm39) V1001A probably benign Het
Ccdc96 T C 5: 36,643,419 (GRCm39) V475A possibly damaging Het
Cimip2a T C 2: 25,110,300 (GRCm39) S71P probably benign Het
Clec4b2 T A 6: 123,150,639 (GRCm39) L16Q probably damaging Het
Cyp2c68 T A 19: 39,722,805 (GRCm39) I248L probably benign Het
Cyp2d22 G T 15: 82,256,133 (GRCm39) A167E possibly damaging Het
Dpysl3 T C 18: 43,475,312 (GRCm39) K382R probably damaging Het
Dscam A G 16: 96,626,823 (GRCm39) I362T possibly damaging Het
Edil3 T C 13: 89,467,850 (GRCm39) Y452H probably damaging Het
Elfn1 T C 5: 139,957,808 (GRCm39) S271P probably benign Het
Ep300 T C 15: 81,533,210 (GRCm39) S1756P unknown Het
Ep300 T A 15: 81,495,611 (GRCm39) probably benign Het
Fgd4 T C 16: 16,254,896 (GRCm39) Q507R probably damaging Het
Frem3 A G 8: 81,342,704 (GRCm39) T1666A probably benign Het
Frmd4a C A 2: 4,608,490 (GRCm39) A786E possibly damaging Het
Gabrr1 C T 4: 33,158,175 (GRCm39) T266I possibly damaging Het
Gm11563 G A 11: 99,549,275 (GRCm39) P160S unknown Het
Gm12790 T C 4: 101,825,324 (GRCm39) D30G probably benign Het
Hgf T C 5: 16,777,599 (GRCm39) Y199H probably benign Het
Ide G A 19: 37,249,604 (GRCm39) P916L unknown Het
Igsf10 G T 3: 59,237,521 (GRCm39) H887N probably benign Het
Iigp1 A T 18: 60,523,218 (GRCm39) H112L probably benign Het
Impg2 A G 16: 56,082,095 (GRCm39) E1009G probably damaging Het
Khdc1a A C 1: 21,420,653 (GRCm39) D91A probably damaging Het
Klk12 A G 7: 43,422,667 (GRCm39) D198G probably damaging Het
Kntc1 T G 5: 123,904,018 (GRCm39) L345R probably damaging Het
Kprp T C 3: 92,731,271 (GRCm39) N593S probably benign Het
Krt1c T G 15: 101,722,921 (GRCm39) D359A probably damaging Het
Krt35 A T 11: 99,986,725 (GRCm39) N96K probably benign Het
Lnx1 T C 5: 74,846,204 (GRCm39) D82G probably damaging Het
Mroh2a A G 1: 88,186,386 (GRCm39) S64G probably benign Het
Nfib A T 4: 82,215,048 (GRCm39) S518R probably damaging Het
Nol6 T C 4: 41,120,299 (GRCm39) I473V probably benign Het
Obscn T C 11: 59,013,598 (GRCm39) D1108G probably damaging Het
Or52m2 A T 7: 102,263,976 (GRCm39) C73* probably null Het
Or7g12 C A 9: 18,900,001 (GRCm39) S239* probably null Het
Otop1 T C 5: 38,457,065 (GRCm39) Y275H probably damaging Het
Ppp1r14c G T 10: 3,316,912 (GRCm39) K82N probably damaging Het
Prr14l T C 5: 32,950,988 (GRCm39) E1935G probably damaging Het
Ptprd C T 4: 76,162,023 (GRCm39) V78I possibly damaging Het
Rfc4 T A 16: 22,933,179 (GRCm39) probably benign Het
Rpn2 C A 2: 157,137,244 (GRCm39) A209E probably damaging Het
Sf1 T C 19: 6,425,943 (GRCm39) probably benign Het
Sft2d1rt T C 11: 45,942,679 (GRCm39) D148G probably damaging Het
Skint5 T A 4: 113,524,390 (GRCm39) S864C unknown Het
Slc2a10 C G 2: 165,358,241 (GRCm39) N455K probably damaging Het
Snrnp200 T A 2: 127,076,986 (GRCm39) I1673N probably benign Het
Sri G T 5: 8,113,693 (GRCm39) G152W probably damaging Het
Srpra T C 9: 35,125,904 (GRCm39) I394T possibly damaging Het
Svop C T 5: 114,203,743 (GRCm39) V13M probably damaging Het
Traf3ip2 A G 10: 39,510,650 (GRCm39) N308D probably damaging Het
Vmn2r125 T A 4: 156,702,272 (GRCm39) D19E probably null Het
Vmn2r16 A T 5: 109,511,665 (GRCm39) Y624F possibly damaging Het
Other mutations in Haus8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00333:Haus8 APN 8 71,708,289 (GRCm39) critical splice donor site probably null
IGL01298:Haus8 APN 8 71,705,757 (GRCm39) missense probably damaging 1.00
IGL01455:Haus8 APN 8 71,705,875 (GRCm39) missense probably benign 0.00
IGL02034:Haus8 APN 8 71,708,202 (GRCm39) missense probably damaging 1.00
IGL02112:Haus8 APN 8 71,708,205 (GRCm39) missense probably damaging 1.00
IGL02188:Haus8 APN 8 71,710,059 (GRCm39) missense probably damaging 1.00
IGL02871:Haus8 APN 8 71,709,138 (GRCm39) missense probably benign 0.00
IGL02939:Haus8 APN 8 71,708,361 (GRCm39) splice site probably benign
R0486:Haus8 UTSW 8 71,709,182 (GRCm39) missense probably benign 0.01
R0486:Haus8 UTSW 8 71,709,181 (GRCm39) missense probably damaging 1.00
R0648:Haus8 UTSW 8 71,709,174 (GRCm39) missense probably damaging 1.00
R1848:Haus8 UTSW 8 71,708,767 (GRCm39) intron probably benign
R2327:Haus8 UTSW 8 71,708,289 (GRCm39) critical splice donor site probably null
R5294:Haus8 UTSW 8 71,708,354 (GRCm39) missense unknown
R6424:Haus8 UTSW 8 71,704,080 (GRCm39) nonsense probably null
R7231:Haus8 UTSW 8 71,705,781 (GRCm39) missense probably benign 0.00
R8071:Haus8 UTSW 8 71,708,695 (GRCm39) missense probably benign 0.24
R8815:Haus8 UTSW 8 71,705,910 (GRCm39) splice site probably benign
R9752:Haus8 UTSW 8 71,715,731 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GATGTTGATGCTACTACACTCACC -3'
(R):5'- ATACTTAGTATCTGCCCTGCGC -3'

Sequencing Primer
(F):5'- TTGATGCTACTACACTCACCAGACTC -3'
(R):5'- TGCGCATACCTGGAAGGCTG -3'
Posted On 2015-09-24