Incidental Mutation 'R4588:Slc22a16'
ID 342624
Institutional Source Beutler Lab
Gene Symbol Slc22a16
Ensembl Gene ENSMUSG00000019834
Gene Name solute carrier family 22 (organic cation transporter), member 16
Synonyms OCT6, 4921504E14Rik, OKB1, FLIPT2, CT2
MMRRC Submission 042007-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.087) question?
Stock # R4588 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 40446332-40480128 bp(+) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) T to C at 40446677 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000077428 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019978] [ENSMUST00000078314]
AlphaFold Q497L8
Predicted Effect unknown
Transcript: ENSMUST00000019978
AA Change: V13A
SMART Domains Protein: ENSMUSP00000019978
Gene: ENSMUSG00000019834
AA Change: V13A

DomainStartEndE-ValueType
low complexity region 18 32 N/A INTRINSIC
transmembrane domain 38 60 N/A INTRINSIC
Pfam:Sugar_tr 136 556 6.4e-25 PFAM
Pfam:MFS_1 177 514 3.1e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000078314
SMART Domains Protein: ENSMUSP00000077428
Gene: ENSMUSG00000019834

DomainStartEndE-ValueType
transmembrane domain 21 43 N/A INTRINSIC
Pfam:Sugar_tr 114 535 5.1e-26 PFAM
Pfam:MFS_1 156 493 4.7e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214505
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.2%
Validation Efficiency 98% (51/52)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the organic zwitterion transporter protein family which transports carnitine. The encoded protein has also been shown to transport anticancer drugs like bleomycin (PMID: 20037140) successful treatment has been correlated with the level of activity of this transporter in tumor cells. [provided by RefSeq, Dec 2011]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca7 G T 10: 79,833,701 (GRCm39) probably null Het
Abcb4 A T 5: 8,997,328 (GRCm39) I936F probably benign Het
Adnp2 G T 18: 80,171,863 (GRCm39) L849I probably benign Het
Atf7ip T C 6: 136,576,692 (GRCm39) S1032P probably benign Het
Atr A C 9: 95,747,720 (GRCm39) D334A probably benign Het
Atrip A T 9: 108,889,347 (GRCm39) D20E probably damaging Het
Atxn7 T A 14: 14,096,268 (GRCm38) C43* probably null Het
Cfap65 C A 1: 74,943,215 (GRCm39) Q1603H possibly damaging Het
Cpne5 T C 17: 29,383,687 (GRCm39) I327V probably benign Het
Ctsa T C 2: 164,676,070 (GRCm39) S41P possibly damaging Het
Cyp4x1 A T 4: 114,965,994 (GRCm39) L444Q probably damaging Het
Dchs1 C A 7: 105,405,248 (GRCm39) M2431I probably benign Het
Ddi1 T A 9: 6,266,003 (GRCm39) H122L probably benign Het
Defa21 C T 8: 21,515,664 (GRCm39) P21S probably damaging Het
Ect2 A G 3: 27,201,149 (GRCm39) V77A probably damaging Het
Ermap C A 4: 119,045,445 (GRCm39) probably benign Het
Fancm G A 12: 65,165,215 (GRCm39) probably null Het
Gcnt3 T A 9: 69,941,512 (GRCm39) D352V probably damaging Het
Gys2 A G 6: 142,395,181 (GRCm39) M428T possibly damaging Het
Igtp T A 11: 58,097,508 (GRCm39) N226K probably damaging Het
Itpr2 T A 6: 146,142,694 (GRCm39) H1675L probably benign Het
Lipo4 G A 19: 33,476,647 (GRCm39) P367L possibly damaging Het
Lzts3 T C 2: 130,476,686 (GRCm39) *587W probably null Het
Mast3 T A 8: 71,233,251 (GRCm39) K300* probably null Het
Mepce G A 5: 137,783,534 (GRCm39) T264I possibly damaging Het
Mif4gd A T 11: 115,500,372 (GRCm39) I62N probably damaging Het
Or14a260 C T 7: 85,984,852 (GRCm39) V251I probably benign Het
Or7e175 T A 9: 20,049,383 (GRCm39) *324K probably null Het
Palm3 A G 8: 84,756,015 (GRCm39) K509R probably benign Het
Pde11a T C 2: 75,859,647 (GRCm39) T821A probably damaging Het
Pik3r5 A G 11: 68,384,087 (GRCm39) probably benign Het
Pkhd1 T C 1: 20,271,092 (GRCm39) T3154A probably benign Het
Ptprs A G 17: 56,732,534 (GRCm39) Y438H probably damaging Het
Rdh8 T A 9: 20,734,025 (GRCm39) D70E probably benign Het
Scn2a A T 2: 65,544,111 (GRCm39) I831L possibly damaging Het
Selenoo A G 15: 88,980,921 (GRCm39) H420R probably benign Het
Slc5a1 A G 5: 33,302,632 (GRCm39) T208A probably benign Het
Sparc T C 11: 55,296,062 (GRCm39) M121V probably benign Het
Sstr1 G T 12: 58,260,417 (GRCm39) A347S probably benign Het
Stab1 C A 14: 30,879,402 (GRCm39) V693F probably benign Het
Tnn A G 1: 159,972,681 (GRCm39) V307A probably benign Het
Trmt1 A G 8: 85,417,382 (GRCm39) probably benign Het
Ttc3 T C 16: 94,243,760 (GRCm39) S1255P probably benign Het
Ube2ql1 A C 13: 69,887,276 (GRCm39) S62A unknown Het
Vmn2r84 T A 10: 130,221,809 (GRCm39) M804L probably damaging Het
Vps13a T C 19: 16,617,403 (GRCm39) T3002A probably damaging Het
Vps50 A G 6: 3,562,306 (GRCm39) E467G probably damaging Het
Other mutations in Slc22a16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00158:Slc22a16 APN 10 40,471,278 (GRCm39) missense probably damaging 1.00
IGL00334:Slc22a16 APN 10 40,449,930 (GRCm39) missense probably benign 0.03
IGL00757:Slc22a16 APN 10 40,457,323 (GRCm39) missense probably damaging 1.00
IGL01082:Slc22a16 APN 10 40,449,860 (GRCm39) missense probably benign 0.40
IGL01337:Slc22a16 APN 10 40,471,310 (GRCm39) missense possibly damaging 0.51
IGL01389:Slc22a16 APN 10 40,461,131 (GRCm39) missense probably damaging 1.00
IGL01405:Slc22a16 APN 10 40,461,191 (GRCm39) missense probably benign 0.36
IGL01667:Slc22a16 APN 10 40,461,014 (GRCm39) missense probably damaging 1.00
IGL01700:Slc22a16 APN 10 40,479,904 (GRCm39) missense unknown
IGL01792:Slc22a16 APN 10 40,449,928 (GRCm39) missense possibly damaging 0.51
IGL02948:Slc22a16 APN 10 40,449,958 (GRCm39) nonsense probably null
IGL03178:Slc22a16 APN 10 40,449,756 (GRCm39) missense probably benign 0.09
PIT4418001:Slc22a16 UTSW 10 40,479,821 (GRCm39) missense unknown
R0358:Slc22a16 UTSW 10 40,463,488 (GRCm39) splice site probably null
R0422:Slc22a16 UTSW 10 40,467,886 (GRCm39) missense probably damaging 1.00
R0497:Slc22a16 UTSW 10 40,460,963 (GRCm39) missense probably damaging 1.00
R1435:Slc22a16 UTSW 10 40,463,603 (GRCm39) missense probably damaging 1.00
R1577:Slc22a16 UTSW 10 40,479,811 (GRCm39) nonsense probably null
R1696:Slc22a16 UTSW 10 40,460,923 (GRCm39) missense possibly damaging 0.75
R2022:Slc22a16 UTSW 10 40,467,873 (GRCm39) missense probably damaging 1.00
R2065:Slc22a16 UTSW 10 40,461,016 (GRCm39) missense possibly damaging 0.63
R2082:Slc22a16 UTSW 10 40,461,335 (GRCm39) missense probably benign 0.02
R4083:Slc22a16 UTSW 10 40,450,065 (GRCm39) missense probably damaging 1.00
R4828:Slc22a16 UTSW 10 40,449,636 (GRCm39) missense probably damaging 1.00
R4853:Slc22a16 UTSW 10 40,450,047 (GRCm39) missense probably damaging 0.98
R5127:Slc22a16 UTSW 10 40,449,953 (GRCm39) missense probably benign 0.21
R5215:Slc22a16 UTSW 10 40,457,386 (GRCm39) missense probably damaging 1.00
R5590:Slc22a16 UTSW 10 40,457,337 (GRCm39) missense possibly damaging 0.94
R5626:Slc22a16 UTSW 10 40,460,849 (GRCm39) critical splice acceptor site probably null
R5810:Slc22a16 UTSW 10 40,471,314 (GRCm39) missense possibly damaging 0.86
R6675:Slc22a16 UTSW 10 40,449,836 (GRCm39) nonsense probably null
R6692:Slc22a16 UTSW 10 40,479,901 (GRCm39) missense unknown
R6738:Slc22a16 UTSW 10 40,461,298 (GRCm39) missense probably damaging 0.99
R7158:Slc22a16 UTSW 10 40,449,737 (GRCm39) missense possibly damaging 0.66
R7685:Slc22a16 UTSW 10 40,450,085 (GRCm39) missense possibly damaging 0.73
R7883:Slc22a16 UTSW 10 40,479,660 (GRCm39) missense probably benign 0.01
R8332:Slc22a16 UTSW 10 40,449,741 (GRCm39) missense possibly damaging 0.94
R8733:Slc22a16 UTSW 10 40,450,061 (GRCm39) missense probably benign 0.16
R9321:Slc22a16 UTSW 10 40,450,047 (GRCm39) missense probably damaging 0.98
R9548:Slc22a16 UTSW 10 40,460,865 (GRCm39) nonsense probably null
R9667:Slc22a16 UTSW 10 40,461,125 (GRCm39) missense probably benign 0.37
RF004:Slc22a16 UTSW 10 40,479,642 (GRCm39) missense possibly damaging 0.94
Z1177:Slc22a16 UTSW 10 40,461,152 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TTGACCACATAGGACACTTCGG -3'
(R):5'- GGGAAAGCACTCTAGGGTAC -3'

Sequencing Primer
(F):5'- CACATAGGACACTTCGGCAGGTAG -3'
(R):5'- ATAGGTATTCATCCTGGACAGTG -3'
Posted On 2015-09-24