Incidental Mutation 'R4590:Vmn2r87'
| ID |
342761 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r87
|
| Ensembl Gene |
ENSMUSG00000091511 |
| Gene Name |
vomeronasal 2, receptor 87 |
| Synonyms |
EG625131 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.073)
|
| Stock # |
R4590 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
130307690-130333248 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 130315014 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Asparagine
at position 191
(H191N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129215
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164227]
|
| AlphaFold |
E9PZX4 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000164227
AA Change: H191N
PolyPhen 2
Score 0.690 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000129215
Gene: ENSMUSG00000091511
AA Change: H191N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
422 |
1.8e-27 |
PFAM |
|
Pfam:NCD3G
|
508 |
562 |
1.8e-19 |
PFAM |
|
Pfam:7tm_3
|
595 |
829 |
8.8e-55 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.0%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 67 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ankhd1 |
T |
A |
18: 36,716,697 (GRCm39) |
D201E |
probably damaging |
Het |
| Ano10 |
T |
A |
9: 122,086,231 (GRCm39) |
Q398L |
probably benign |
Het |
| Ap3d1 |
A |
T |
10: 80,555,646 (GRCm39) |
L319* |
probably null |
Het |
| Cacna1e |
T |
C |
1: 154,312,265 (GRCm39) |
M1575V |
possibly damaging |
Het |
| Cep192 |
T |
A |
18: 67,949,862 (GRCm39) |
Y315* |
probably null |
Het |
| Cndp2 |
C |
A |
18: 84,687,933 (GRCm39) |
V353F |
probably damaging |
Het |
| Ctsq |
T |
A |
13: 61,184,028 (GRCm39) |
N298I |
probably benign |
Het |
| Dnah6 |
A |
T |
6: 73,129,695 (GRCm39) |
C1173S |
probably damaging |
Het |
| Dnah9 |
T |
C |
11: 65,931,218 (GRCm39) |
M1993V |
probably damaging |
Het |
| Dnhd1 |
T |
C |
7: 105,363,237 (GRCm39) |
V3933A |
probably damaging |
Het |
| Dnpep |
C |
A |
1: 75,293,045 (GRCm39) |
V76L |
probably damaging |
Het |
| Dsc3 |
A |
C |
18: 20,122,752 (GRCm39) |
C57W |
probably damaging |
Het |
| Dtx3 |
A |
G |
10: 127,028,564 (GRCm39) |
S222P |
probably damaging |
Het |
| Eml5 |
T |
C |
12: 98,803,600 (GRCm39) |
Y1009C |
possibly damaging |
Het |
| Fam169a |
A |
G |
13: 97,234,093 (GRCm39) |
I122V |
probably benign |
Het |
| Fgr |
T |
A |
4: 132,722,364 (GRCm39) |
V211E |
probably damaging |
Het |
| Flvcr1 |
T |
C |
1: 190,744,343 (GRCm39) |
T402A |
probably benign |
Het |
| Frmd5 |
C |
T |
2: 121,595,512 (GRCm39) |
|
probably null |
Het |
| Fut2 |
T |
C |
7: 45,300,370 (GRCm39) |
N134S |
possibly damaging |
Het |
| Gm10110 |
A |
T |
14: 90,134,982 (GRCm39) |
|
noncoding transcript |
Het |
| Gm7275 |
A |
T |
16: 47,893,982 (GRCm39) |
|
noncoding transcript |
Het |
| Gm904 |
T |
A |
13: 50,799,285 (GRCm39) |
C81* |
probably null |
Het |
| Herc1 |
T |
A |
9: 66,344,946 (GRCm39) |
V1913E |
probably damaging |
Het |
| Hnmt |
T |
C |
2: 23,909,111 (GRCm39) |
|
probably null |
Het |
| Ift172 |
T |
C |
5: 31,411,299 (GRCm39) |
E1643G |
probably damaging |
Het |
| Inpp4b |
T |
A |
8: 82,468,040 (GRCm39) |
M1K |
probably null |
Het |
| Keap1 |
G |
T |
9: 21,148,905 (GRCm39) |
A34D |
probably damaging |
Het |
| Krt25 |
T |
C |
11: 99,208,854 (GRCm39) |
|
probably benign |
Het |
| Lama2 |
A |
G |
10: 26,865,410 (GRCm39) |
V2916A |
probably benign |
Het |
| Ly9 |
G |
A |
1: 171,421,443 (GRCm39) |
Q603* |
probably null |
Het |
| Mis18bp1 |
A |
C |
12: 65,205,280 (GRCm39) |
N14K |
possibly damaging |
Het |
| Mmrn1 |
G |
T |
6: 60,937,797 (GRCm39) |
C265F |
probably damaging |
Het |
| Mrgprb5 |
C |
T |
7: 47,817,809 (GRCm39) |
E309K |
probably benign |
Het |
| Nrtn |
T |
C |
17: 57,058,504 (GRCm39) |
T166A |
probably damaging |
Het |
| Odr4 |
A |
G |
1: 150,262,103 (GRCm39) |
|
probably null |
Het |
| Or8g50 |
T |
C |
9: 39,648,146 (GRCm39) |
F12L |
probably damaging |
Het |
| Osbpl7 |
T |
A |
11: 96,947,098 (GRCm39) |
S266R |
probably damaging |
Het |
| Pcdhb11 |
T |
C |
18: 37,555,549 (GRCm39) |
I293T |
probably damaging |
Het |
| Pes1 |
A |
G |
11: 3,927,986 (GRCm39) |
Y546C |
probably damaging |
Het |
| Pth1r |
A |
T |
9: 110,551,339 (GRCm39) |
W587R |
probably benign |
Het |
| Rasgrf2 |
A |
G |
13: 92,174,789 (GRCm39) |
Y147H |
probably damaging |
Het |
| Rbbp8 |
T |
A |
18: 11,865,322 (GRCm39) |
L737* |
probably null |
Het |
| Rcor3 |
A |
T |
1: 191,810,217 (GRCm39) |
F153L |
probably damaging |
Het |
| Rev3l |
G |
A |
10: 39,682,929 (GRCm39) |
C349Y |
probably damaging |
Het |
| Rnf115 |
C |
T |
3: 96,695,889 (GRCm39) |
T225M |
probably benign |
Het |
| Rnf157 |
A |
G |
11: 116,250,098 (GRCm39) |
V200A |
probably damaging |
Het |
| Scfd2 |
T |
C |
5: 74,372,917 (GRCm39) |
T653A |
probably benign |
Het |
| Sdccag8 |
T |
C |
1: 176,775,858 (GRCm39) |
Y590H |
probably damaging |
Het |
| Sema4d |
T |
A |
13: 51,877,654 (GRCm39) |
K59N |
probably benign |
Het |
| Serpinb7 |
C |
A |
1: 107,379,563 (GRCm39) |
H323Q |
probably damaging |
Het |
| Setx |
T |
A |
2: 29,034,821 (GRCm39) |
H435Q |
probably damaging |
Het |
| Sgk3 |
T |
C |
1: 9,969,020 (GRCm39) |
S466P |
possibly damaging |
Het |
| Sgsm2 |
T |
C |
11: 74,741,958 (GRCm39) |
M1011V |
probably damaging |
Het |
| Ssc4d |
G |
A |
5: 135,993,538 (GRCm39) |
P106L |
probably benign |
Het |
| Taf7 |
T |
C |
18: 37,775,784 (GRCm39) |
Q261R |
possibly damaging |
Het |
| Tbc1d2b |
T |
C |
9: 90,152,553 (GRCm39) |
K71R |
possibly damaging |
Het |
| Tff3 |
C |
T |
17: 31,348,508 (GRCm39) |
V15I |
probably benign |
Het |
| Tgfb3 |
C |
A |
12: 86,124,589 (GRCm39) |
V40L |
possibly damaging |
Het |
| Timm10 |
T |
A |
2: 84,657,992 (GRCm39) |
D2E |
possibly damaging |
Het |
| Ttc16 |
T |
A |
2: 32,663,753 (GRCm39) |
N74I |
probably damaging |
Het |
| Ttll1 |
G |
A |
15: 83,381,546 (GRCm39) |
T241I |
probably damaging |
Het |
| Uba6 |
T |
A |
5: 86,260,603 (GRCm39) |
D992V |
probably damaging |
Het |
| Vmn1r25 |
T |
A |
6: 57,955,480 (GRCm39) |
T270S |
probably benign |
Het |
| Vmn2r106 |
T |
C |
17: 20,497,728 (GRCm39) |
I504V |
probably damaging |
Het |
| Vnn1 |
C |
A |
10: 23,775,303 (GRCm39) |
F184L |
possibly damaging |
Het |
| Vtn |
A |
T |
11: 78,393,032 (GRCm39) |
I466F |
probably damaging |
Het |
| Zfp352 |
A |
C |
4: 90,112,772 (GRCm39) |
D304A |
probably damaging |
Het |
|
| Other mutations in Vmn2r87 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01090:Vmn2r87
|
APN |
10 |
130,333,247 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
IGL01295:Vmn2r87
|
APN |
10 |
130,307,878 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01411:Vmn2r87
|
APN |
10 |
130,308,429 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01680:Vmn2r87
|
APN |
10 |
130,315,586 (GRCm39) |
nonsense |
probably null |
|
|
IGL01822:Vmn2r87
|
APN |
10 |
130,307,991 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01835:Vmn2r87
|
APN |
10 |
130,314,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01965:Vmn2r87
|
APN |
10 |
130,314,924 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02562:Vmn2r87
|
APN |
10 |
130,314,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02665:Vmn2r87
|
APN |
10 |
130,333,049 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL03202:Vmn2r87
|
APN |
10 |
130,333,091 (GRCm39) |
missense |
probably benign |
|
|
FR4304:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
FR4340:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
FR4342:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
FR4589:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
LCD18:Vmn2r87
|
UTSW |
10 |
130,314,583 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0344:Vmn2r87
|
UTSW |
10 |
130,315,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0374:Vmn2r87
|
UTSW |
10 |
130,307,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0384:Vmn2r87
|
UTSW |
10 |
130,307,712 (GRCm39) |
missense |
probably benign |
|
|
R1144:Vmn2r87
|
UTSW |
10 |
130,312,098 (GRCm39) |
splice site |
probably benign |
|
|
R1172:Vmn2r87
|
UTSW |
10 |
130,313,453 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1860:Vmn2r87
|
UTSW |
10 |
130,315,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1866:Vmn2r87
|
UTSW |
10 |
130,308,441 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1897:Vmn2r87
|
UTSW |
10 |
130,307,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2360:Vmn2r87
|
UTSW |
10 |
130,315,631 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2909:Vmn2r87
|
UTSW |
10 |
130,314,865 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3874:Vmn2r87
|
UTSW |
10 |
130,315,856 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R4113:Vmn2r87
|
UTSW |
10 |
130,315,691 (GRCm39) |
missense |
probably benign |
|
|
R4190:Vmn2r87
|
UTSW |
10 |
130,308,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4197:Vmn2r87
|
UTSW |
10 |
130,315,779 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4201:Vmn2r87
|
UTSW |
10 |
130,308,448 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4202:Vmn2r87
|
UTSW |
10 |
130,308,448 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4368:Vmn2r87
|
UTSW |
10 |
130,315,676 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4485:Vmn2r87
|
UTSW |
10 |
130,315,678 (GRCm39) |
nonsense |
probably null |
|
|
R4537:Vmn2r87
|
UTSW |
10 |
130,308,054 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4752:Vmn2r87
|
UTSW |
10 |
130,314,336 (GRCm39) |
nonsense |
probably null |
|
|
R4873:Vmn2r87
|
UTSW |
10 |
130,308,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4875:Vmn2r87
|
UTSW |
10 |
130,308,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4923:Vmn2r87
|
UTSW |
10 |
130,314,435 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4970:Vmn2r87
|
UTSW |
10 |
130,314,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5049:Vmn2r87
|
UTSW |
10 |
130,308,298 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5112:Vmn2r87
|
UTSW |
10 |
130,314,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5187:Vmn2r87
|
UTSW |
10 |
130,333,208 (GRCm39) |
missense |
probably null |
0.99 |
|
R5618:Vmn2r87
|
UTSW |
10 |
130,315,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6057:Vmn2r87
|
UTSW |
10 |
130,308,226 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6220:Vmn2r87
|
UTSW |
10 |
130,315,807 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6287:Vmn2r87
|
UTSW |
10 |
130,314,291 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6383:Vmn2r87
|
UTSW |
10 |
130,314,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6576:Vmn2r87
|
UTSW |
10 |
130,314,654 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6742:Vmn2r87
|
UTSW |
10 |
130,308,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7086:Vmn2r87
|
UTSW |
10 |
130,333,178 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7162:Vmn2r87
|
UTSW |
10 |
130,313,416 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7419:Vmn2r87
|
UTSW |
10 |
130,307,992 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7425:Vmn2r87
|
UTSW |
10 |
130,314,761 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7443:Vmn2r87
|
UTSW |
10 |
130,308,588 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7571:Vmn2r87
|
UTSW |
10 |
130,314,940 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7663:Vmn2r87
|
UTSW |
10 |
130,308,054 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7716:Vmn2r87
|
UTSW |
10 |
130,308,018 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7793:Vmn2r87
|
UTSW |
10 |
130,313,413 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7806:Vmn2r87
|
UTSW |
10 |
130,315,679 (GRCm39) |
missense |
probably benign |
|
|
R7841:Vmn2r87
|
UTSW |
10 |
130,333,095 (GRCm39) |
missense |
probably benign |
0.31 |
|
R8326:Vmn2r87
|
UTSW |
10 |
130,308,180 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R8411:Vmn2r87
|
UTSW |
10 |
130,308,126 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8445:Vmn2r87
|
UTSW |
10 |
130,313,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8540:Vmn2r87
|
UTSW |
10 |
130,314,762 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R8892:Vmn2r87
|
UTSW |
10 |
130,308,105 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9093:Vmn2r87
|
UTSW |
10 |
130,308,165 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9623:Vmn2r87
|
UTSW |
10 |
130,315,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9667:Vmn2r87
|
UTSW |
10 |
130,314,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9797:Vmn2r87
|
UTSW |
10 |
130,312,064 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9797:Vmn2r87
|
UTSW |
10 |
130,308,138 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1088:Vmn2r87
|
UTSW |
10 |
130,308,183 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1176:Vmn2r87
|
UTSW |
10 |
130,307,713 (GRCm39) |
missense |
probably benign |
0.04 |
|
| Predicted Primers |
PCR Primer
(F):5'- GATAACAACCTTTGCTGAAGATGTC -3'
(R):5'- TCTGAAAGGTGAGTGGCATTAATTG -3'
Sequencing Primer
(F):5'- CCTTTGCTGAAGATGTCATAATTTG -3'
(R):5'- GTGGATGTTTCATCCTCTC -3'
|
| Posted On |
2015-09-24 |
Incidental Mutation