Incidental Mutation 'R4591:Mtcl1'
| ID |
342869 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mtcl1
|
| Ensembl Gene |
ENSMUSG00000052105 |
| Gene Name |
microtubule crosslinking factor 1 |
| Synonyms |
1110012J17Rik, Soga2, t8219b25 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.126)
|
| Stock # |
R4591 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
66643977-66756745 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 66655506 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Glycine
at position 819
(E819G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000121387
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000086693]
[ENSMUST00000097291]
[ENSMUST00000145347]
[ENSMUST00000177034]
|
| AlphaFold |
Q3UHU5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000086693
AA Change: E1268G
PolyPhen 2
Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000083899
Gene: ENSMUSG00000052105
AA Change: E1268G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
42 |
N/A |
INTRINSIC |
|
low complexity region
|
54 |
98 |
N/A |
INTRINSIC |
|
low complexity region
|
99 |
120 |
N/A |
INTRINSIC |
|
low complexity region
|
127 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
166 |
183 |
N/A |
INTRINSIC |
|
low complexity region
|
240 |
259 |
N/A |
INTRINSIC |
|
low complexity region
|
273 |
290 |
N/A |
INTRINSIC |
|
SCOP:d1fxkc_
|
332 |
466 |
3e-7 |
SMART |
|
Blast:BRLZ
|
339 |
362 |
1e-5 |
BLAST |
|
Pfam:DUF3166
|
493 |
587 |
1.8e-34 |
PFAM |
|
Pfam:DUF3166
|
622 |
714 |
3.8e-39 |
PFAM |
|
low complexity region
|
843 |
859 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
910 |
N/A |
INTRINSIC |
|
low complexity region
|
962 |
973 |
N/A |
INTRINSIC |
|
low complexity region
|
1049 |
1062 |
N/A |
INTRINSIC |
|
coiled coil region
|
1120 |
1159 |
N/A |
INTRINSIC |
|
Pfam:DUF4482
|
1220 |
1344 |
3e-40 |
PFAM |
|
low complexity region
|
1464 |
1476 |
N/A |
INTRINSIC |
|
low complexity region
|
1672 |
1681 |
N/A |
INTRINSIC |
|
low complexity region
|
1912 |
1924 |
N/A |
INTRINSIC |
|
low complexity region
|
1931 |
1943 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000097291
AA Change: E1268G
PolyPhen 2
Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000094894
Gene: ENSMUSG00000052105
AA Change: E1268G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
42 |
N/A |
INTRINSIC |
|
low complexity region
|
54 |
98 |
N/A |
INTRINSIC |
|
low complexity region
|
99 |
120 |
N/A |
INTRINSIC |
|
low complexity region
|
127 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
166 |
183 |
N/A |
INTRINSIC |
|
low complexity region
|
240 |
259 |
N/A |
INTRINSIC |
|
low complexity region
|
273 |
290 |
N/A |
INTRINSIC |
|
SCOP:d1fxkc_
|
332 |
466 |
3e-7 |
SMART |
|
Blast:BRLZ
|
339 |
362 |
1e-5 |
BLAST |
|
Pfam:DUF3166
|
492 |
588 |
1.8e-43 |
PFAM |
|
Pfam:DUF3166
|
621 |
716 |
5e-19 |
PFAM |
|
low complexity region
|
843 |
859 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
910 |
N/A |
INTRINSIC |
|
low complexity region
|
962 |
973 |
N/A |
INTRINSIC |
|
low complexity region
|
1049 |
1062 |
N/A |
INTRINSIC |
|
coiled coil region
|
1120 |
1159 |
N/A |
INTRINSIC |
|
Pfam:DUF4482
|
1220 |
1392 |
3.9e-49 |
PFAM |
|
low complexity region
|
1464 |
1476 |
N/A |
INTRINSIC |
|
low complexity region
|
1672 |
1681 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000129525
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000134139
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000145347
AA Change: E819G
PolyPhen 2
Score 0.066 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000121387
Gene: ENSMUSG00000052105
AA Change: E819G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF3166
|
43 |
139 |
9.1e-44 |
PFAM |
|
Pfam:DUF3166
|
172 |
267 |
2.5e-19 |
PFAM |
|
low complexity region
|
394 |
410 |
N/A |
INTRINSIC |
|
low complexity region
|
447 |
461 |
N/A |
INTRINSIC |
|
low complexity region
|
513 |
524 |
N/A |
INTRINSIC |
|
low complexity region
|
600 |
613 |
N/A |
INTRINSIC |
|
coiled coil region
|
671 |
710 |
N/A |
INTRINSIC |
|
Pfam:DUF4482
|
771 |
910 |
4.6e-49 |
PFAM |
|
low complexity region
|
1015 |
1027 |
N/A |
INTRINSIC |
|
low complexity region
|
1223 |
1232 |
N/A |
INTRINSIC |
|
low complexity region
|
1463 |
1475 |
N/A |
INTRINSIC |
|
low complexity region
|
1482 |
1494 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177034
AA Change: E957G
PolyPhen 2
Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
|
| SMART Domains |
Protein: ENSMUSP00000135690
Gene: ENSMUSG00000052105
AA Change: E957G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF3166
|
140 |
236 |
1.5e-43 |
PFAM |
|
Pfam:DUF3166
|
269 |
364 |
4e-19 |
PFAM |
|
low complexity region
|
491 |
507 |
N/A |
INTRINSIC |
|
low complexity region
|
544 |
558 |
N/A |
INTRINSIC |
|
low complexity region
|
610 |
621 |
N/A |
INTRINSIC |
|
coiled coil region
|
642 |
674 |
N/A |
INTRINSIC |
|
low complexity region
|
738 |
751 |
N/A |
INTRINSIC |
|
coiled coil region
|
809 |
848 |
N/A |
INTRINSIC |
|
Pfam:DUF4482
|
909 |
1042 |
4e-49 |
PFAM |
|
low complexity region
|
1161 |
1173 |
N/A |
INTRINSIC |
|
low complexity region
|
1369 |
1378 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Global or Purkinje cell-specific homozygous knockout affects Purkinje cell axon and dendrite morphology, resulting in abnormal motor function. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 76 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110032F04Rik |
T |
C |
3: 68,777,599 (GRCm39) |
S187P |
possibly damaging |
Het |
| 4932438H23Rik |
T |
C |
16: 90,852,959 (GRCm39) |
N59S |
probably damaging |
Het |
| Abca15 |
A |
T |
7: 119,981,636 (GRCm39) |
D1030V |
probably damaging |
Het |
| Acmsd |
A |
T |
1: 127,676,934 (GRCm39) |
N153I |
probably damaging |
Het |
| Adprh |
C |
A |
16: 38,266,345 (GRCm39) |
V266L |
probably benign |
Het |
| Aldh5a1 |
G |
A |
13: 25,107,991 (GRCm39) |
P217S |
probably damaging |
Het |
| Alpk2 |
A |
T |
18: 65,438,894 (GRCm39) |
L1300Q |
probably benign |
Het |
| Alyref |
C |
T |
11: 120,486,799 (GRCm39) |
R154Q |
probably benign |
Het |
| Ano6 |
T |
A |
15: 95,841,308 (GRCm39) |
C468* |
probably null |
Het |
| Aox3 |
A |
T |
1: 58,191,815 (GRCm39) |
I456F |
probably damaging |
Het |
| Art4 |
A |
G |
6: 136,831,755 (GRCm39) |
Y129H |
probably damaging |
Het |
| Asb16 |
C |
A |
11: 102,167,551 (GRCm39) |
H306N |
probably damaging |
Het |
| Atp8a2 |
C |
A |
14: 59,892,078 (GRCm39) |
R1090L |
probably benign |
Het |
| Brap |
G |
T |
5: 121,800,113 (GRCm39) |
V1F |
probably null |
Het |
| C1qb |
C |
A |
4: 136,609,528 (GRCm39) |
G31W |
probably damaging |
Het |
| Cacna2d4 |
T |
C |
6: 119,275,425 (GRCm39) |
Y666H |
probably benign |
Het |
| Casr |
T |
C |
16: 36,320,732 (GRCm39) |
N472S |
probably benign |
Het |
| Ccdc91 |
T |
G |
6: 147,491,963 (GRCm39) |
S282A |
unknown |
Het |
| Cd300lg |
A |
G |
11: 101,937,006 (GRCm39) |
T164A |
probably benign |
Het |
| Cd79b |
A |
T |
11: 106,202,872 (GRCm39) |
D243E |
probably damaging |
Het |
| Cdh6 |
C |
A |
15: 13,051,572 (GRCm39) |
V354F |
possibly damaging |
Het |
| Cdhr2 |
A |
G |
13: 54,863,497 (GRCm39) |
N126S |
probably benign |
Het |
| Cep192 |
A |
T |
18: 67,968,039 (GRCm39) |
N841I |
probably damaging |
Het |
| Cngb1 |
T |
C |
8: 95,980,012 (GRCm39) |
T963A |
probably damaging |
Het |
| Col16a1 |
A |
G |
4: 129,955,592 (GRCm39) |
|
probably null |
Het |
| Coro1a |
A |
G |
7: 126,302,164 (GRCm39) |
V61A |
probably damaging |
Het |
| Crocc |
T |
A |
4: 140,745,983 (GRCm39) |
D1712V |
probably damaging |
Het |
| Ddn |
T |
C |
15: 98,705,687 (GRCm39) |
D3G |
possibly damaging |
Het |
| Dnal1 |
T |
C |
12: 84,180,627 (GRCm39) |
F89S |
probably benign |
Het |
| Dusp3 |
T |
A |
11: 101,864,446 (GRCm39) |
|
probably benign |
Het |
| Dyrk3 |
C |
A |
1: 131,057,895 (GRCm39) |
G58C |
probably damaging |
Het |
| Fat1 |
T |
C |
8: 45,479,279 (GRCm39) |
F2775S |
probably benign |
Het |
| Frk |
A |
G |
10: 34,481,829 (GRCm39) |
N373S |
probably benign |
Het |
| Glmn |
A |
G |
5: 107,708,917 (GRCm39) |
|
probably null |
Het |
| Gm11565 |
A |
T |
11: 99,805,769 (GRCm39) |
T54S |
possibly damaging |
Het |
| Gm14410 |
A |
G |
2: 176,885,820 (GRCm39) |
I148T |
possibly damaging |
Het |
| Gm21834 |
T |
A |
17: 58,048,880 (GRCm39) |
H112L |
possibly damaging |
Het |
| Gm5862 |
A |
G |
5: 26,224,486 (GRCm39) |
I161T |
possibly damaging |
Het |
| Grid2 |
G |
T |
6: 64,297,086 (GRCm39) |
G483V |
probably damaging |
Het |
| Hfm1 |
A |
T |
5: 106,995,533 (GRCm39) |
S1293T |
probably benign |
Het |
| Il1a |
G |
A |
2: 129,148,447 (GRCm39) |
R88W |
probably damaging |
Het |
| Il20rb |
A |
T |
9: 100,357,043 (GRCm39) |
V29D |
possibly damaging |
Het |
| Ilvbl |
C |
T |
10: 78,419,139 (GRCm39) |
L463F |
probably benign |
Het |
| Kif17 |
A |
G |
4: 138,005,110 (GRCm39) |
E225G |
probably benign |
Het |
| Lrp2 |
A |
G |
2: 69,366,419 (GRCm39) |
F227L |
probably damaging |
Het |
| Lrrc43 |
A |
G |
5: 123,639,227 (GRCm39) |
M419V |
probably benign |
Het |
| Magel2 |
A |
G |
7: 62,030,837 (GRCm39) |
Q1247R |
unknown |
Het |
| Mamdc4 |
T |
A |
2: 25,454,609 (GRCm39) |
M1068L |
possibly damaging |
Het |
| Mdn1 |
T |
G |
4: 32,707,636 (GRCm39) |
S1642A |
probably damaging |
Het |
| Mtarc1 |
T |
C |
1: 184,539,365 (GRCm39) |
E102G |
probably benign |
Het |
| Naa15 |
T |
C |
3: 51,349,345 (GRCm39) |
L38P |
probably damaging |
Het |
| Nlrp3 |
A |
G |
11: 59,440,048 (GRCm39) |
R542G |
probably benign |
Het |
| Or10c1 |
C |
T |
17: 37,522,010 (GRCm39) |
V245I |
probably benign |
Het |
| Or4d2b |
A |
G |
11: 87,780,375 (GRCm39) |
S116P |
probably benign |
Het |
| Or5ac19 |
A |
C |
16: 59,089,776 (GRCm39) |
F85V |
possibly damaging |
Het |
| Or5b125-ps1 |
ACAC |
ACACGCAC |
19: 13,056,266 (GRCm39) |
|
noncoding transcript |
Het |
| Pbxip1 |
T |
A |
3: 89,353,467 (GRCm39) |
L249Q |
probably benign |
Het |
| Pla2g7 |
T |
C |
17: 43,911,450 (GRCm39) |
S201P |
probably damaging |
Het |
| Psmd1 |
G |
T |
1: 86,055,926 (GRCm39) |
V763F |
probably benign |
Het |
| Ptp4a2 |
A |
G |
4: 129,740,308 (GRCm39) |
E124G |
probably benign |
Het |
| Rab6b |
T |
C |
9: 103,044,373 (GRCm39) |
|
probably null |
Het |
| Rbks |
T |
A |
5: 31,817,352 (GRCm39) |
K139M |
possibly damaging |
Het |
| Rgs22 |
T |
A |
15: 36,100,282 (GRCm39) |
E268D |
probably benign |
Het |
| Slc16a9 |
T |
G |
10: 70,118,710 (GRCm39) |
L343R |
probably damaging |
Het |
| Smagp |
T |
C |
15: 100,519,860 (GRCm39) |
I55V |
probably damaging |
Het |
| Sox13 |
T |
C |
1: 133,311,421 (GRCm39) |
S604G |
probably damaging |
Het |
| St6gal1 |
G |
T |
16: 23,140,044 (GRCm39) |
V72F |
probably benign |
Het |
| Stxbp4 |
A |
G |
11: 90,485,606 (GRCm39) |
V247A |
probably benign |
Het |
| Susd3 |
A |
T |
13: 49,384,736 (GRCm39) |
M217K |
possibly damaging |
Het |
| Tas2r129 |
T |
A |
6: 132,928,574 (GRCm39) |
N170K |
probably benign |
Het |
| Tmem245 |
C |
A |
4: 56,910,204 (GRCm39) |
A515S |
probably damaging |
Het |
| Tpte |
T |
C |
8: 22,817,791 (GRCm39) |
V259A |
probably benign |
Het |
| Trpa1 |
T |
C |
1: 14,952,332 (GRCm39) |
|
probably null |
Het |
| Ttc28 |
G |
A |
5: 111,371,147 (GRCm39) |
R532H |
probably damaging |
Het |
| Vwa5a |
A |
T |
9: 38,646,916 (GRCm39) |
N529I |
possibly damaging |
Het |
| Zfp574 |
T |
C |
7: 24,778,969 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Mtcl1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00092:Mtcl1
|
APN |
17 |
66,651,314 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01774:Mtcl1
|
APN |
17 |
66,692,880 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01918:Mtcl1
|
APN |
17 |
66,675,263 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
IGL02000:Mtcl1
|
APN |
17 |
66,661,185 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL02074:Mtcl1
|
APN |
17 |
66,673,463 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02338:Mtcl1
|
APN |
17 |
66,686,965 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02597:Mtcl1
|
APN |
17 |
66,645,016 (GRCm39) |
missense |
probably benign |
|
|
IGL03034:Mtcl1
|
APN |
17 |
66,651,193 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03120:Mtcl1
|
APN |
17 |
66,686,378 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL03184:Mtcl1
|
APN |
17 |
66,661,209 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03240:Mtcl1
|
APN |
17 |
66,645,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03294:Mtcl1
|
APN |
17 |
66,645,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03332:Mtcl1
|
APN |
17 |
66,645,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4378001:Mtcl1
|
UTSW |
17 |
66,745,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4520001:Mtcl1
|
UTSW |
17 |
66,692,907 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R0110:Mtcl1
|
UTSW |
17 |
66,665,109 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R0113:Mtcl1
|
UTSW |
17 |
66,661,237 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R0321:Mtcl1
|
UTSW |
17 |
66,686,426 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0366:Mtcl1
|
UTSW |
17 |
66,645,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0629:Mtcl1
|
UTSW |
17 |
66,645,137 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1466:Mtcl1
|
UTSW |
17 |
66,687,430 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1466:Mtcl1
|
UTSW |
17 |
66,687,430 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1467:Mtcl1
|
UTSW |
17 |
66,755,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1467:Mtcl1
|
UTSW |
17 |
66,755,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1471:Mtcl1
|
UTSW |
17 |
66,686,143 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1650:Mtcl1
|
UTSW |
17 |
66,692,871 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1754:Mtcl1
|
UTSW |
17 |
66,687,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1855:Mtcl1
|
UTSW |
17 |
66,686,509 (GRCm39) |
missense |
probably benign |
|
|
R1882:Mtcl1
|
UTSW |
17 |
66,686,315 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1935:Mtcl1
|
UTSW |
17 |
66,686,409 (GRCm39) |
missense |
probably benign |
0.10 |
|
R2063:Mtcl1
|
UTSW |
17 |
66,653,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2132:Mtcl1
|
UTSW |
17 |
66,650,618 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2197:Mtcl1
|
UTSW |
17 |
66,673,427 (GRCm39) |
missense |
probably benign |
|
|
R3196:Mtcl1
|
UTSW |
17 |
66,650,829 (GRCm39) |
missense |
probably benign |
0.07 |
|
R3877:Mtcl1
|
UTSW |
17 |
66,649,949 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4116:Mtcl1
|
UTSW |
17 |
66,673,476 (GRCm39) |
missense |
probably benign |
|
|
R4204:Mtcl1
|
UTSW |
17 |
66,745,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4373:Mtcl1
|
UTSW |
17 |
66,687,074 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4396:Mtcl1
|
UTSW |
17 |
66,651,220 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4610:Mtcl1
|
UTSW |
17 |
66,684,882 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4681:Mtcl1
|
UTSW |
17 |
66,756,139 (GRCm39) |
missense |
unknown |
|
|
R4922:Mtcl1
|
UTSW |
17 |
66,655,474 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4992:Mtcl1
|
UTSW |
17 |
66,649,834 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5169:Mtcl1
|
UTSW |
17 |
66,650,818 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5542:Mtcl1
|
UTSW |
17 |
66,691,354 (GRCm39) |
intron |
probably benign |
|
|
R5804:Mtcl1
|
UTSW |
17 |
66,650,132 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5998:Mtcl1
|
UTSW |
17 |
66,675,275 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6163:Mtcl1
|
UTSW |
17 |
66,686,326 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6191:Mtcl1
|
UTSW |
17 |
66,650,521 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6254:Mtcl1
|
UTSW |
17 |
66,665,129 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6260:Mtcl1
|
UTSW |
17 |
66,650,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6524:Mtcl1
|
UTSW |
17 |
66,655,280 (GRCm39) |
missense |
probably benign |
0.15 |
|
R6884:Mtcl1
|
UTSW |
17 |
66,745,197 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7199:Mtcl1
|
UTSW |
17 |
66,647,534 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7431:Mtcl1
|
UTSW |
17 |
66,649,901 (GRCm39) |
nonsense |
probably null |
|
|
R7479:Mtcl1
|
UTSW |
17 |
66,686,485 (GRCm39) |
missense |
probably benign |
|
|
R7564:Mtcl1
|
UTSW |
17 |
66,678,322 (GRCm39) |
missense |
probably benign |
|
|
R7608:Mtcl1
|
UTSW |
17 |
66,650,300 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7691:Mtcl1
|
UTSW |
17 |
66,687,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7847:Mtcl1
|
UTSW |
17 |
66,651,328 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7908:Mtcl1
|
UTSW |
17 |
66,678,325 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R8262:Mtcl1
|
UTSW |
17 |
66,650,653 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8324:Mtcl1
|
UTSW |
17 |
66,743,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8477:Mtcl1
|
UTSW |
17 |
66,684,942 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8927:Mtcl1
|
UTSW |
17 |
66,755,628 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8928:Mtcl1
|
UTSW |
17 |
66,755,628 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9016:Mtcl1
|
UTSW |
17 |
66,651,062 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9048:Mtcl1
|
UTSW |
17 |
66,678,331 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9059:Mtcl1
|
UTSW |
17 |
66,650,606 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9221:Mtcl1
|
UTSW |
17 |
66,650,879 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9327:Mtcl1
|
UTSW |
17 |
66,645,130 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9398:Mtcl1
|
UTSW |
17 |
66,755,462 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9762:Mtcl1
|
UTSW |
17 |
66,673,347 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0065:Mtcl1
|
UTSW |
17 |
66,686,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Mtcl1
|
UTSW |
17 |
66,650,723 (GRCm39) |
missense |
probably benign |
0.20 |
|
Z1176:Mtcl1
|
UTSW |
17 |
66,686,455 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1177:Mtcl1
|
UTSW |
17 |
66,651,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCATCATCCAGGGACAAAGCG -3'
(R):5'- CGGGGCATTCGGAAACTAAG -3'
Sequencing Primer
(F):5'- AAGTACAGGTTCTCACTGGC -3'
(R):5'- GGTCAGAACCGTACACTTGC -3'
|
| Posted On |
2015-09-24 |
Incidental Mutation