Incidental Mutation 'R0346:Trim16'
ID 34287
Institutional Source Beutler Lab
Gene Symbol Trim16
Ensembl Gene ENSMUSG00000047821
Gene Name tripartite motif-containing 16
Synonyms 9130006M08Rik, EBBP
MMRRC Submission 038553-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0346 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 62711034-62733774 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 62731520 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Aspartic acid at position 464 (N464D)
Ref Sequence ENSEMBL: ENSMUSP00000072432 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055006] [ENSMUST00000072639] [ENSMUST00000108703]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000055006
AA Change: N464D

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000055542
Gene: ENSMUSG00000047821
AA Change: N464D

DomainStartEndE-ValueType
Blast:BBOX 64 113 6e-24 BLAST
BBOX 117 157 3.24e-4 SMART
coiled coil region 171 196 N/A INTRINSIC
coiled coil region 237 265 N/A INTRINSIC
PRY 364 417 1.41e-22 SMART
SPRY 418 543 6.4e-27 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000072639
AA Change: N464D

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000072432
Gene: ENSMUSG00000047821
AA Change: N464D

DomainStartEndE-ValueType
Blast:BBOX 64 113 5e-24 BLAST
BBOX 117 157 3.24e-4 SMART
coiled coil region 171 196 N/A INTRINSIC
coiled coil region 237 265 N/A INTRINSIC
PRY 364 417 1.41e-22 SMART
Pfam:SPRY 418 483 1.4e-6 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000108703
AA Change: N377D

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000104343
Gene: ENSMUSG00000047821
AA Change: N377D

DomainStartEndE-ValueType
Blast:BBOX 1 26 9e-10 BLAST
BBOX 30 70 3.24e-4 SMART
coiled coil region 84 109 N/A INTRINSIC
coiled coil region 150 178 N/A INTRINSIC
PRY 277 330 1.41e-22 SMART
SPRY 331 456 6.4e-27 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128623
Meta Mutation Damage Score 0.1781 question?
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 98.9%
  • 10x: 97.7%
  • 20x: 96.4%
Validation Efficiency 100% (79/79)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a tripartite motif (TRIM) family member that contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. While it lacks a RING domain found in other TRIM proteins, the encoded protein can homodimerize or heterodimerize with other TRIM proteins and has E3 ubiquitin ligase activity. This gene is also a tumor suppressor and is involved in secretory autophagy. [provided by RefSeq, Jan 2017]
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A T 11: 9,516,278 (GRCm39) I4406L probably damaging Het
Abca16 T A 7: 120,035,155 (GRCm39) C314S probably damaging Het
Add3 C T 19: 53,205,387 (GRCm39) R46* probably null Het
Alas1 A T 9: 106,120,550 (GRCm39) S82T possibly damaging Het
Alkbh5 C G 11: 60,429,567 (GRCm39) R107G possibly damaging Het
Ap3b1 A T 13: 94,582,479 (GRCm39) R365* probably null Het
Ass1 A T 2: 31,404,831 (GRCm39) N371Y probably damaging Het
AU021092 T C 16: 5,034,718 (GRCm39) D168G possibly damaging Het
Bcl2 G A 1: 106,640,292 (GRCm39) R107C probably damaging Het
Caln1 C A 5: 130,851,762 (GRCm39) H184N possibly damaging Het
Camta1 C A 4: 151,159,597 (GRCm39) R1614L probably damaging Het
Ccdc191 T C 16: 43,759,315 (GRCm39) V372A probably damaging Het
Ccng2 T G 5: 93,418,753 (GRCm39) I126S probably damaging Het
Cep85 A T 4: 133,859,733 (GRCm39) N643K probably damaging Het
Clvs2 G C 10: 33,498,542 (GRCm39) S129R possibly damaging Het
Cntn1 G T 15: 92,129,968 (GRCm39) probably benign Het
Cttn A T 7: 144,006,276 (GRCm39) probably benign Het
Dedd2 T C 7: 24,910,694 (GRCm39) S161G possibly damaging Het
Dnajb13 T C 7: 100,153,132 (GRCm39) D263G probably damaging Het
Dppa4 T A 16: 48,109,687 (GRCm39) probably benign Het
Ear2 A G 14: 44,340,363 (GRCm39) E7G probably damaging Het
Eif2b4 A G 5: 31,345,452 (GRCm39) probably benign Het
Etl4 G T 2: 20,764,463 (GRCm39) probably null Het
Fbxo15 T A 18: 84,978,346 (GRCm39) probably null Het
Gm9970 A G 5: 31,398,182 (GRCm39) probably benign Het
Hap1 A G 11: 100,246,855 (GRCm39) S17P probably benign Het
Hgd C T 16: 37,409,136 (GRCm39) probably benign Het
Ift56 T C 6: 38,386,370 (GRCm39) C364R probably damaging Het
Inpp5f T A 7: 128,292,392 (GRCm39) L16Q probably damaging Het
Irag1 T C 7: 110,498,183 (GRCm39) D404G probably damaging Het
Islr2 G A 9: 58,105,626 (GRCm39) R545* probably null Het
Itgav G T 2: 83,622,953 (GRCm39) C675F probably damaging Het
Kif13a T A 13: 46,967,695 (GRCm39) I403L possibly damaging Het
Kif14 T A 1: 136,395,898 (GRCm39) I68N probably damaging Het
Kif26a G T 12: 112,145,782 (GRCm39) K1764N probably null Het
Lrrd1 C A 5: 3,900,215 (GRCm39) F173L probably benign Het
Mroh4 G C 15: 74,486,141 (GRCm39) probably benign Het
Msh5 A G 17: 35,248,864 (GRCm39) V723A probably benign Het
Mybph T G 1: 134,125,492 (GRCm39) I279S probably damaging Het
Myh4 A T 11: 67,151,152 (GRCm39) I1936L probably benign Het
Myo1h A T 5: 114,493,270 (GRCm39) T704S probably benign Het
Nav2 C A 7: 49,254,333 (GRCm39) T2377K probably benign Het
Nipbl T G 15: 8,390,440 (GRCm39) Q276H probably damaging Het
Nlrp9b T C 7: 19,758,440 (GRCm39) L559P probably damaging Het
Nup210l T A 3: 90,096,745 (GRCm39) V1318E probably damaging Het
Or1e26 A G 11: 73,480,283 (GRCm39) Y94H probably damaging Het
Or4z4 A T 19: 12,076,803 (GRCm39) S67T probably damaging Het
Or6c8b C A 10: 128,882,342 (GRCm39) V197F possibly damaging Het
Or7e178 A G 9: 20,225,707 (GRCm39) S170P probably benign Het
P2ry13 T C 3: 59,116,987 (GRCm39) T264A possibly damaging Het
Plekhg5 T C 4: 152,198,710 (GRCm39) L966P probably benign Het
Prss35 A G 9: 86,637,404 (GRCm39) K58R probably benign Het
Ptafr T A 4: 132,307,390 (GRCm39) L260* probably null Het
Pum1 A T 4: 130,507,116 (GRCm39) T1157S possibly damaging Het
Rif1 GCCACCA GCCA 2: 52,000,336 (GRCm39) probably benign Het
Rnf145 A G 11: 44,445,991 (GRCm39) Y275C probably damaging Het
Rpl6 A T 5: 121,346,554 (GRCm39) K218N possibly damaging Het
Rps6 T C 4: 86,774,218 (GRCm39) T128A probably benign Het
Ryr1 G T 7: 28,767,013 (GRCm39) probably benign Het
Scel A T 14: 103,767,420 (GRCm39) Q26H probably damaging Het
Sfxn4 A T 19: 60,847,111 (GRCm39) D57E probably benign Het
Slc35d1 A C 4: 103,048,044 (GRCm39) L240R probably damaging Het
Smcr8 A G 11: 60,670,576 (GRCm39) I575V probably benign Het
Spata31e4 T C 13: 50,857,346 (GRCm39) Y995H probably benign Het
Syk G A 13: 52,794,695 (GRCm39) M476I probably damaging Het
Tbcel A T 9: 42,348,539 (GRCm39) probably benign Het
Tob2 C A 15: 81,742,424 (GRCm39) G65W probably damaging Het
Trim36 T C 18: 46,332,776 (GRCm39) probably benign Het
Trpv4 C A 5: 114,768,590 (GRCm39) probably benign Het
Tsga10 T A 1: 37,879,600 (GRCm39) T64S possibly damaging Het
Vars2 A T 17: 35,975,756 (GRCm39) probably benign Het
Vmn1r72 C A 7: 11,403,621 (GRCm39) V276L probably benign Het
Vps13a T A 19: 16,655,333 (GRCm39) K1898N probably benign Het
Vps18 A G 2: 119,127,645 (GRCm39) M823V probably damaging Het
Washc2 T C 6: 116,197,484 (GRCm39) probably benign Het
Zfp763 A T 17: 33,238,721 (GRCm39) H141Q probably benign Het
Other mutations in Trim16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00661:Trim16 APN 11 62,728,058 (GRCm39) splice site probably benign
IGL01060:Trim16 APN 11 62,711,530 (GRCm39) missense probably benign 0.06
IGL01568:Trim16 APN 11 62,711,684 (GRCm39) missense probably benign 0.05
IGL01659:Trim16 APN 11 62,711,521 (GRCm39) missense probably benign 0.00
IGL02519:Trim16 APN 11 62,724,905 (GRCm39) missense possibly damaging 0.49
IGL02662:Trim16 APN 11 62,731,383 (GRCm39) missense possibly damaging 0.91
FR4589:Trim16 UTSW 11 62,711,521 (GRCm39) intron probably benign
FR4976:Trim16 UTSW 11 62,711,515 (GRCm39) intron probably benign
R0007:Trim16 UTSW 11 62,719,944 (GRCm39) missense probably benign 0.00
R0007:Trim16 UTSW 11 62,719,944 (GRCm39) missense probably benign 0.00
R0410:Trim16 UTSW 11 62,711,297 (GRCm39) start gained probably benign
R1725:Trim16 UTSW 11 62,711,331 (GRCm39) start codon destroyed possibly damaging 0.91
R3845:Trim16 UTSW 11 62,727,498 (GRCm39) splice site probably benign
R3879:Trim16 UTSW 11 62,731,433 (GRCm39) missense probably damaging 1.00
R5023:Trim16 UTSW 11 62,727,638 (GRCm39) missense probably benign 0.36
R5344:Trim16 UTSW 11 62,711,751 (GRCm39) missense probably damaging 1.00
R6919:Trim16 UTSW 11 62,731,695 (GRCm39) missense possibly damaging 0.86
R7490:Trim16 UTSW 11 62,724,949 (GRCm39) missense probably damaging 1.00
R7525:Trim16 UTSW 11 62,711,580 (GRCm39) missense probably damaging 1.00
R8354:Trim16 UTSW 11 62,727,587 (GRCm39) missense probably benign 0.01
R8439:Trim16 UTSW 11 62,741,414 (GRCm39) missense probably benign 0.10
R8754:Trim16 UTSW 11 62,731,763 (GRCm39) missense probably benign 0.01
R9581:Trim16 UTSW 11 62,727,557 (GRCm39) missense probably damaging 0.98
R9599:Trim16 UTSW 11 62,731,644 (GRCm39) missense probably damaging 0.97
R9789:Trim16 UTSW 11 62,720,026 (GRCm39) critical splice donor site probably null
X0026:Trim16 UTSW 11 62,719,963 (GRCm39) missense probably benign 0.02
Z1186:Trim16 UTSW 11 62,711,428 (GRCm39) missense probably benign
Z1186:Trim16 UTSW 11 62,731,675 (GRCm39) missense probably benign 0.00
Z1186:Trim16 UTSW 11 62,731,572 (GRCm39) missense probably benign
Z1186:Trim16 UTSW 11 62,727,643 (GRCm39) missense probably benign 0.00
Z1186:Trim16 UTSW 11 62,711,518 (GRCm39) intron probably benign
Z1186:Trim16 UTSW 11 62,711,516 (GRCm39) intron probably benign
Z1186:Trim16 UTSW 11 62,711,502 (GRCm39) missense probably benign
Z1187:Trim16 UTSW 11 62,731,675 (GRCm39) missense probably benign 0.00
Z1187:Trim16 UTSW 11 62,731,572 (GRCm39) missense probably benign
Z1187:Trim16 UTSW 11 62,727,643 (GRCm39) missense probably benign 0.00
Z1187:Trim16 UTSW 11 62,711,521 (GRCm39) intron probably benign
Z1187:Trim16 UTSW 11 62,711,520 (GRCm39) intron probably benign
Z1187:Trim16 UTSW 11 62,711,516 (GRCm39) intron probably benign
Z1187:Trim16 UTSW 11 62,711,502 (GRCm39) missense probably benign
Z1187:Trim16 UTSW 11 62,711,428 (GRCm39) missense probably benign
Z1188:Trim16 UTSW 11 62,711,502 (GRCm39) missense probably benign
Z1188:Trim16 UTSW 11 62,711,516 (GRCm39) intron probably benign
Z1188:Trim16 UTSW 11 62,711,521 (GRCm39) intron probably benign
Z1188:Trim16 UTSW 11 62,727,643 (GRCm39) missense probably benign 0.00
Z1188:Trim16 UTSW 11 62,731,572 (GRCm39) missense probably benign
Z1188:Trim16 UTSW 11 62,731,675 (GRCm39) missense probably benign 0.00
Z1188:Trim16 UTSW 11 62,711,428 (GRCm39) missense probably benign
Z1189:Trim16 UTSW 11 62,731,675 (GRCm39) missense probably benign 0.00
Z1189:Trim16 UTSW 11 62,731,572 (GRCm39) missense probably benign
Z1189:Trim16 UTSW 11 62,727,643 (GRCm39) missense probably benign 0.00
Z1189:Trim16 UTSW 11 62,711,520 (GRCm39) intron probably benign
Z1189:Trim16 UTSW 11 62,711,517 (GRCm39) intron probably benign
Z1189:Trim16 UTSW 11 62,711,516 (GRCm39) intron probably benign
Z1189:Trim16 UTSW 11 62,711,502 (GRCm39) missense probably benign
Z1189:Trim16 UTSW 11 62,711,428 (GRCm39) missense probably benign
Z1190:Trim16 UTSW 11 62,731,675 (GRCm39) missense probably benign 0.00
Z1190:Trim16 UTSW 11 62,731,572 (GRCm39) missense probably benign
Z1190:Trim16 UTSW 11 62,727,643 (GRCm39) missense probably benign 0.00
Z1190:Trim16 UTSW 11 62,711,521 (GRCm39) intron probably benign
Z1190:Trim16 UTSW 11 62,711,519 (GRCm39) intron probably benign
Z1190:Trim16 UTSW 11 62,711,516 (GRCm39) intron probably benign
Z1190:Trim16 UTSW 11 62,711,502 (GRCm39) missense probably benign
Z1190:Trim16 UTSW 11 62,711,428 (GRCm39) missense probably benign
Z1191:Trim16 UTSW 11 62,711,502 (GRCm39) missense probably benign
Z1191:Trim16 UTSW 11 62,711,428 (GRCm39) missense probably benign
Z1191:Trim16 UTSW 11 62,731,675 (GRCm39) missense probably benign 0.00
Z1191:Trim16 UTSW 11 62,731,572 (GRCm39) missense probably benign
Z1191:Trim16 UTSW 11 62,727,643 (GRCm39) missense probably benign 0.00
Z1191:Trim16 UTSW 11 62,711,516 (GRCm39) intron probably benign
Z1192:Trim16 UTSW 11 62,711,428 (GRCm39) missense probably benign
Z1192:Trim16 UTSW 11 62,731,675 (GRCm39) missense probably benign 0.00
Z1192:Trim16 UTSW 11 62,731,572 (GRCm39) missense probably benign
Z1192:Trim16 UTSW 11 62,727,643 (GRCm39) missense probably benign 0.00
Z1192:Trim16 UTSW 11 62,711,521 (GRCm39) intron probably benign
Z1192:Trim16 UTSW 11 62,711,516 (GRCm39) intron probably benign
Z1192:Trim16 UTSW 11 62,711,502 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TGACATCACGTTTGACCCAGACAC -3'
(R):5'- CATAGACCGGCTCTGAGAACTTGC -3'

Sequencing Primer
(F):5'- CAGTAGGTTTCTGCACTGGC -3'
(R):5'- GCAGTCAAACTTGTGAATCAGAGTC -3'
Posted On 2013-05-09