Incidental Mutation 'R4592:Olfr1420'
ID 342929
Institutional Source Beutler Lab
Gene Symbol Olfr1420
Ensembl Gene ENSMUSG00000060878
Gene Name olfactory receptor 1420
Synonyms MOR266-4, GA_x6K02T2RE5P-2247227-2248156
MMRRC Submission 041808-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.134) question?
Stock # R4592 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 11886565-11898079 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 11896762 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 247 (V247A)
Ref Sequence ENSEMBL: ENSMUSP00000149208 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072784] [ENSMUST00000217281]
AlphaFold Q8VF55
Predicted Effect probably benign
Transcript: ENSMUST00000072784
AA Change: V247A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000072563
Gene: ENSMUSG00000060878
AA Change: V247A

Pfam:7tm_4 31 308 5.3e-54 PFAM
Pfam:7tm_1 41 291 3.4e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215766
Predicted Effect probably benign
Transcript: ENSMUST00000217281
AA Change: V247A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.8%
Validation Efficiency 98% (64/65)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700001P01Rik A G 11: 97,771,615 (GRCm38) S144P probably damaging Het
4933430I17Rik T A 4: 62,538,927 (GRCm38) V161E possibly damaging Het
Arhgap40 T C 2: 158,546,709 (GRCm38) V521A possibly damaging Het
Atrn T C 2: 130,999,130 (GRCm38) probably benign Het
Casp12 T C 9: 5,352,923 (GRCm38) probably benign Het
Ccdc189 C T 7: 127,585,491 (GRCm38) R172H probably benign Het
Cenpf G A 1: 189,679,033 (GRCm38) T318M probably damaging Het
Clcn2 T C 16: 20,709,142 (GRCm38) K525E probably damaging Het
Cntln A G 4: 84,971,182 (GRCm38) T301A probably benign Het
Crat T C 2: 30,415,366 (GRCm38) probably benign Het
Cul5 A G 9: 53,633,727 (GRCm38) probably benign Het
Cxcl14 A T 13: 56,295,895 (GRCm38) I34N probably damaging Het
Cyp2b19 A G 7: 26,771,394 (GRCm38) I487V probably benign Het
Cyp4a10 T A 4: 115,529,493 (GRCm38) F446I probably damaging Het
D430041D05Rik T A 2: 104,233,479 (GRCm38) M659L possibly damaging Het
Dclk3 T C 9: 111,467,895 (GRCm38) F169S probably damaging Het
Ddx52 T C 11: 83,957,480 (GRCm38) I532T probably damaging Het
Dnm1 T C 2: 32,336,011 (GRCm38) D352G probably damaging Het
Eif4g2 T C 7: 111,078,302 (GRCm38) E174G probably damaging Het
Enpp6 G T 8: 47,093,032 (GRCm38) V386L probably damaging Het
Eps15l1 T C 8: 72,341,394 (GRCm38) D904G probably damaging Het
Esrrb A G 12: 86,518,830 (GRCm38) Y356C probably damaging Het
Flt3 A T 5: 147,354,699 (GRCm38) S619T possibly damaging Het
Fndc7 A T 3: 108,858,902 (GRCm38) C716S probably damaging Het
Gm10125 T C 18: 5,525,375 (GRCm38) noncoding transcript Het
Gm26996 T A 6: 130,579,485 (GRCm38) noncoding transcript Het
Grik2 A T 10: 49,422,615 (GRCm38) F50I possibly damaging Het
Guf1 T C 5: 69,566,443 (GRCm38) V367A possibly damaging Het
Hspg2 C T 4: 137,518,940 (GRCm38) R1010C probably damaging Het
Ifnar2 T C 16: 91,391,796 (GRCm38) V55A probably benign Het
Impg1 T A 9: 80,440,854 (GRCm38) I33F probably benign Het
Ltbp4 A C 7: 27,325,183 (GRCm38) V674G probably damaging Het
Mroh2b T A 15: 4,918,290 (GRCm38) L529H probably damaging Het
Negr1 T C 3: 157,208,386 (GRCm38) probably benign Het
Neurog3 A G 10: 62,133,820 (GRCm38) T25A probably damaging Het
Olfr1241 T A 2: 89,482,756 (GRCm38) K126N probably damaging Het
Olfr181 T C 16: 58,926,092 (GRCm38) T160A probably benign Het
Olfr555 A C 7: 102,659,478 (GRCm38) Y219S probably damaging Het
Pax8 T A 2: 24,443,189 (GRCm38) probably benign Het
Pcsk6 A C 7: 65,931,732 (GRCm38) I254L possibly damaging Het
Pde3a A G 6: 141,459,216 (GRCm38) K389R probably benign Het
Rab3gap1 C A 1: 127,925,259 (GRCm38) probably benign Het
Rbck1 G A 2: 152,318,733 (GRCm38) Q428* probably null Het
Rptor A G 11: 119,798,840 (GRCm38) D321G probably null Het
Sall2 C A 14: 52,313,803 (GRCm38) R643L probably damaging Het
Sdccag3 C A 2: 26,388,897 (GRCm38) probably benign Het
Skp1a T C 11: 52,243,619 (GRCm38) I59T possibly damaging Het
Slc23a3 T G 1: 75,128,556 (GRCm38) N456T probably damaging Het
Slc4a7 G A 14: 14,778,850 (GRCm38) G920S probably damaging Het
Smarcd3 T C 5: 24,592,804 (GRCm38) I467V probably benign Het
Spata31d1c C T 13: 65,036,060 (GRCm38) A472V probably damaging Het
Srsf6 T C 2: 162,931,723 (GRCm38) I18T probably damaging Het
Stom C T 2: 35,323,746 (GRCm38) G80D probably damaging Het
Svep1 A T 4: 58,084,028 (GRCm38) Y1915N possibly damaging Het
Tmf1 C T 6: 97,173,400 (GRCm38) V449I probably benign Het
Triobp C T 15: 78,967,095 (GRCm38) A483V probably benign Het
Vdac1 G A 11: 52,374,972 (GRCm38) probably null Het
Vmn2r75 T G 7: 86,166,286 (GRCm38) E123D probably benign Het
Vmn2r79 T A 7: 87,004,111 (GRCm38) V528D possibly damaging Het
Zdbf2 T G 1: 63,306,591 (GRCm38) N1376K possibly damaging Het
Other mutations in Olfr1420
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02419:Olfr1420 APN 19 11,896,822 (GRCm38) missense probably benign 0.06
IGL02703:Olfr1420 APN 19 11,896,242 (GRCm38) missense possibly damaging 0.96
IGL02948:Olfr1420 APN 19 11,896,781 (GRCm38) nonsense probably null
R1514:Olfr1420 UTSW 19 11,896,614 (GRCm38) missense probably benign
R1539:Olfr1420 UTSW 19 11,896,491 (GRCm38) missense possibly damaging 0.88
R1852:Olfr1420 UTSW 19 11,896,885 (GRCm38) missense probably damaging 1.00
R1903:Olfr1420 UTSW 19 11,896,549 (GRCm38) missense probably benign 0.24
R2061:Olfr1420 UTSW 19 11,896,557 (GRCm38) missense probably damaging 0.98
R3768:Olfr1420 UTSW 19 11,896,312 (GRCm38) missense probably damaging 0.99
R3977:Olfr1420 UTSW 19 11,896,516 (GRCm38) missense probably damaging 1.00
R4479:Olfr1420 UTSW 19 11,896,558 (GRCm38) missense probably damaging 0.99
R5934:Olfr1420 UTSW 19 11,896,929 (GRCm38) missense probably benign
R6058:Olfr1420 UTSW 19 11,896,024 (GRCm38) start codon destroyed probably null 1.00
R6536:Olfr1420 UTSW 19 11,896,396 (GRCm38) missense probably benign 0.05
R7752:Olfr1420 UTSW 19 11,896,534 (GRCm38) missense probably benign 0.01
R7901:Olfr1420 UTSW 19 11,896,534 (GRCm38) missense probably benign 0.01
R8250:Olfr1420 UTSW 19 11,896,377 (GRCm38) missense probably damaging 1.00
R9434:Olfr1420 UTSW 19 11,896,029 (GRCm38) missense probably benign
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2015-09-24