Incidental Mutation 'R4558:Kng1'
ID 342958
Institutional Source Beutler Lab
Gene Symbol Kng1
Ensembl Gene ENSMUSG00000022875
Gene Name kininogen 1
Synonyms L-kininogen, H-kininigen
MMRRC Submission 042005-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4558 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 22876970-22900828 bp(+) (GRCm39)
Type of Mutation splice site (37 bp from exon)
DNA Base Change (assembly) C to A at 22896168 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000087346 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023589] [ENSMUST00000039492] [ENSMUST00000089902]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000023589
SMART Domains Protein: ENSMUSP00000023589
Gene: ENSMUSG00000022875

DomainStartEndE-ValueType
CY 18 126 3.61e-17 SMART
CY 140 248 6.46e-28 SMART
CY 262 370 2.96e-36 SMART
low complexity region 439 450 N/A INTRINSIC
low complexity region 494 524 N/A INTRINSIC
low complexity region 541 555 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000039492
SMART Domains Protein: ENSMUSP00000040485
Gene: ENSMUSG00000022875

DomainStartEndE-ValueType
CY 18 126 3.61e-17 SMART
CY 140 248 6.46e-28 SMART
CY 262 370 2.96e-36 SMART
Predicted Effect probably null
Transcript: ENSMUST00000089902
SMART Domains Protein: ENSMUSP00000087346
Gene: ENSMUSG00000022875

DomainStartEndE-ValueType
CY 18 126 3.61e-17 SMART
CY 140 248 6.46e-28 SMART
CY 262 370 2.96e-36 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136778
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency 100% (36/36)
MGI Phenotype PHENOTYPE: Mice homozygous for a targeted null mutation are viable and grossly unaffected with normal tail vein bleeding times, despite loss of detectable plasma kininogen. However, homozygotes show a significantly longer time to carotid artery occlusion after RoseBengal and laser-induced arterial injury. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017G19Rik A G 3: 40,567,240 (GRCm39) noncoding transcript Het
A830018L16Rik C A 1: 12,042,300 (GRCm39) S440* probably null Het
Acot11 T C 4: 106,605,563 (GRCm39) N583S probably damaging Het
Alox12 T G 11: 70,143,889 (GRCm39) M164L probably benign Het
Atad2b A G 12: 4,993,223 (GRCm39) I247M probably benign Het
Bmpr2 T A 1: 59,884,851 (GRCm39) M279K probably damaging Het
Cacna2d3 T C 14: 28,825,670 (GRCm39) T502A possibly damaging Het
Casp12 A T 9: 5,352,742 (GRCm39) Y188F probably damaging Het
Catsperb A G 12: 101,557,799 (GRCm39) Y790C possibly damaging Het
Cnbd1 G T 4: 19,055,095 (GRCm39) N110K possibly damaging Het
Entrep1 G A 19: 24,007,913 (GRCm39) S130L probably damaging Het
Fam227b C T 2: 125,968,963 (GRCm39) S37N probably benign Het
Fsip2 T C 2: 82,815,297 (GRCm39) S3677P possibly damaging Het
Gm10764 A G 10: 87,126,682 (GRCm39) noncoding transcript Het
H2-Q6 T C 17: 35,647,291 (GRCm39) V312A probably benign Het
Hecw1 T A 13: 14,422,190 (GRCm39) D972V probably damaging Het
Kalrn G A 16: 33,807,578 (GRCm39) T2597I possibly damaging Het
Med13 T C 11: 86,189,880 (GRCm39) T1010A probably damaging Het
Nbeal1 C T 1: 60,320,469 (GRCm39) R2021* probably null Het
Ncapg A T 5: 45,833,986 (GRCm39) T341S probably benign Het
Obscn T C 11: 59,022,472 (GRCm39) R758G possibly damaging Het
Pabir2 G A X: 52,349,554 (GRCm39) probably benign Het
Pcdhb4 A G 18: 37,443,017 (GRCm39) I776V probably benign Het
Ppp4r4 T C 12: 103,573,192 (GRCm39) V697A probably benign Het
Pramel13 T C 4: 144,122,542 (GRCm39) M1V probably null Het
Psd4 G A 2: 24,294,806 (GRCm39) V789M probably damaging Het
Rasa3 T C 8: 13,648,259 (GRCm39) E135G probably damaging Het
Serpinb9c T A 13: 33,338,482 (GRCm39) E139V probably benign Het
Sgsm1 G A 5: 113,405,977 (GRCm39) probably benign Het
Tmem161b A G 13: 84,399,363 (GRCm39) I6M possibly damaging Het
Upf2 A G 2: 5,978,404 (GRCm39) M423V unknown Het
Vmn1r207 A G 13: 22,910,581 (GRCm39) noncoding transcript Het
Other mutations in Kng1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01460:Kng1 APN 16 22,897,944 (GRCm39) missense probably benign 0.26
IGL01754:Kng1 APN 16 22,898,364 (GRCm39) missense probably benign 0.10
IGL02049:Kng1 APN 16 22,892,187 (GRCm39) missense probably damaging 0.99
IGL02138:Kng1 APN 16 22,886,558 (GRCm39) missense probably damaging 0.99
IGL02216:Kng1 APN 16 22,877,283 (GRCm39) missense probably damaging 0.98
IGL02230:Kng1 APN 16 22,879,244 (GRCm39) critical splice donor site probably null
IGL02630:Kng1 APN 16 22,898,595 (GRCm39) utr 3 prime probably benign
IGL03024:Kng1 APN 16 22,893,442 (GRCm39) missense possibly damaging 0.92
R0518:Kng1 UTSW 16 22,879,232 (GRCm39) missense possibly damaging 0.70
R0521:Kng1 UTSW 16 22,879,232 (GRCm39) missense possibly damaging 0.70
R1352:Kng1 UTSW 16 22,886,444 (GRCm39) critical splice acceptor site probably null
R1396:Kng1 UTSW 16 22,897,730 (GRCm39) missense probably benign 0.00
R1514:Kng1 UTSW 16 22,898,510 (GRCm39) missense probably damaging 0.97
R1753:Kng1 UTSW 16 22,897,869 (GRCm39) missense possibly damaging 0.68
R2048:Kng1 UTSW 16 22,877,354 (GRCm39) missense probably damaging 0.98
R2290:Kng1 UTSW 16 22,897,875 (GRCm39) missense possibly damaging 0.79
R2357:Kng1 UTSW 16 22,897,815 (GRCm39) missense possibly damaging 0.88
R3014:Kng1 UTSW 16 22,898,120 (GRCm39) missense possibly damaging 0.72
R3607:Kng1 UTSW 16 22,886,552 (GRCm39) missense probably damaging 1.00
R4322:Kng1 UTSW 16 22,898,270 (GRCm39) missense probably benign
R4334:Kng1 UTSW 16 22,898,370 (GRCm39) missense possibly damaging 0.88
R4388:Kng1 UTSW 16 22,898,068 (GRCm39) missense possibly damaging 0.63
R4887:Kng1 UTSW 16 22,886,448 (GRCm39) missense possibly damaging 0.71
R5115:Kng1 UTSW 16 22,888,032 (GRCm39) missense possibly damaging 0.87
R5288:Kng1 UTSW 16 22,897,842 (GRCm39) missense probably damaging 0.96
R5461:Kng1 UTSW 16 22,897,887 (GRCm39) missense probably benign 0.19
R5894:Kng1 UTSW 16 22,892,113 (GRCm39) missense probably benign 0.08
R6137:Kng1 UTSW 16 22,893,395 (GRCm39) missense possibly damaging 0.56
R6260:Kng1 UTSW 16 22,877,371 (GRCm39) missense possibly damaging 0.66
R6291:Kng1 UTSW 16 22,898,475 (GRCm39) missense probably damaging 1.00
R6620:Kng1 UTSW 16 22,900,232 (GRCm39) missense possibly damaging 0.74
R6947:Kng1 UTSW 16 22,896,124 (GRCm39) missense probably benign 0.21
R7142:Kng1 UTSW 16 22,898,170 (GRCm39) missense probably benign 0.25
R7166:Kng1 UTSW 16 22,898,428 (GRCm39) missense probably benign 0.00
R7168:Kng1 UTSW 16 22,898,391 (GRCm39) missense probably benign 0.26
R7347:Kng1 UTSW 16 22,886,537 (GRCm39) missense possibly damaging 0.46
R9005:Kng1 UTSW 16 22,898,146 (GRCm39) missense probably damaging 0.99
R9388:Kng1 UTSW 16 22,898,388 (GRCm39) missense possibly damaging 0.84
R9563:Kng1 UTSW 16 22,879,170 (GRCm39) missense probably damaging 1.00
R9689:Kng1 UTSW 16 22,879,224 (GRCm39) missense probably damaging 0.98
Z1176:Kng1 UTSW 16 22,898,366 (GRCm39) missense probably benign 0.00
Z1177:Kng1 UTSW 16 22,892,139 (GRCm39) missense probably benign 0.31
Predicted Primers PCR Primer
(F):5'- TCCAGATTCTAACTTTGACCACAC -3'
(R):5'- TTGGAATAGACAGAACTGACCCC -3'

Sequencing Primer
(F):5'- GATTCTAACTTTGACCACACTGAAG -3'
(R):5'- TAGACAGAACTGACCCCAAGCTG -3'
Posted On 2015-09-24