Incidental Mutation 'R0346:Mroh4'
ID 34298
Institutional Source Beutler Lab
Gene Symbol Mroh4
Ensembl Gene ENSMUSG00000022603
Gene Name maestro heat-like repeat family member 4
Synonyms 1700016M24Rik
MMRRC Submission 038553-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0346 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 74477878-74508202 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) G to C at 74486141 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000117011 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023271] [ENSMUST00000137963]
AlphaFold G3X8W1
Predicted Effect probably benign
Transcript: ENSMUST00000023271
SMART Domains Protein: ENSMUSP00000023271
Gene: ENSMUSG00000022603

DomainStartEndE-ValueType
low complexity region 1 12 N/A INTRINSIC
low complexity region 326 337 N/A INTRINSIC
low complexity region 428 435 N/A INTRINSIC
low complexity region 520 534 N/A INTRINSIC
low complexity region 572 591 N/A INTRINSIC
SCOP:d1ee4a_ 709 852 3e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000137963
SMART Domains Protein: ENSMUSP00000117011
Gene: ENSMUSG00000022603

DomainStartEndE-ValueType
low complexity region 257 268 N/A INTRINSIC
low complexity region 359 366 N/A INTRINSIC
low complexity region 451 465 N/A INTRINSIC
low complexity region 503 522 N/A INTRINSIC
SCOP:d1ee4a_ 640 783 3e-5 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000176592
Predicted Effect noncoding transcript
Transcript: ENSMUST00000176767
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 98.9%
  • 10x: 97.7%
  • 20x: 96.4%
Validation Efficiency 100% (79/79)
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A T 11: 9,516,278 (GRCm39) I4406L probably damaging Het
Abca16 T A 7: 120,035,155 (GRCm39) C314S probably damaging Het
Add3 C T 19: 53,205,387 (GRCm39) R46* probably null Het
Alas1 A T 9: 106,120,550 (GRCm39) S82T possibly damaging Het
Alkbh5 C G 11: 60,429,567 (GRCm39) R107G possibly damaging Het
Ap3b1 A T 13: 94,582,479 (GRCm39) R365* probably null Het
Ass1 A T 2: 31,404,831 (GRCm39) N371Y probably damaging Het
AU021092 T C 16: 5,034,718 (GRCm39) D168G possibly damaging Het
Bcl2 G A 1: 106,640,292 (GRCm39) R107C probably damaging Het
Caln1 C A 5: 130,851,762 (GRCm39) H184N possibly damaging Het
Camta1 C A 4: 151,159,597 (GRCm39) R1614L probably damaging Het
Ccdc191 T C 16: 43,759,315 (GRCm39) V372A probably damaging Het
Ccng2 T G 5: 93,418,753 (GRCm39) I126S probably damaging Het
Cep85 A T 4: 133,859,733 (GRCm39) N643K probably damaging Het
Clvs2 G C 10: 33,498,542 (GRCm39) S129R possibly damaging Het
Cntn1 G T 15: 92,129,968 (GRCm39) probably benign Het
Cttn A T 7: 144,006,276 (GRCm39) probably benign Het
Dedd2 T C 7: 24,910,694 (GRCm39) S161G possibly damaging Het
Dnajb13 T C 7: 100,153,132 (GRCm39) D263G probably damaging Het
Dppa4 T A 16: 48,109,687 (GRCm39) probably benign Het
Ear2 A G 14: 44,340,363 (GRCm39) E7G probably damaging Het
Eif2b4 A G 5: 31,345,452 (GRCm39) probably benign Het
Etl4 G T 2: 20,764,463 (GRCm39) probably null Het
Fbxo15 T A 18: 84,978,346 (GRCm39) probably null Het
Gm9970 A G 5: 31,398,182 (GRCm39) probably benign Het
Hap1 A G 11: 100,246,855 (GRCm39) S17P probably benign Het
Hgd C T 16: 37,409,136 (GRCm39) probably benign Het
Ift56 T C 6: 38,386,370 (GRCm39) C364R probably damaging Het
Inpp5f T A 7: 128,292,392 (GRCm39) L16Q probably damaging Het
Irag1 T C 7: 110,498,183 (GRCm39) D404G probably damaging Het
Islr2 G A 9: 58,105,626 (GRCm39) R545* probably null Het
Itgav G T 2: 83,622,953 (GRCm39) C675F probably damaging Het
Kif13a T A 13: 46,967,695 (GRCm39) I403L possibly damaging Het
Kif14 T A 1: 136,395,898 (GRCm39) I68N probably damaging Het
Kif26a G T 12: 112,145,782 (GRCm39) K1764N probably null Het
Lrrd1 C A 5: 3,900,215 (GRCm39) F173L probably benign Het
Msh5 A G 17: 35,248,864 (GRCm39) V723A probably benign Het
Mybph T G 1: 134,125,492 (GRCm39) I279S probably damaging Het
Myh4 A T 11: 67,151,152 (GRCm39) I1936L probably benign Het
Myo1h A T 5: 114,493,270 (GRCm39) T704S probably benign Het
Nav2 C A 7: 49,254,333 (GRCm39) T2377K probably benign Het
Nipbl T G 15: 8,390,440 (GRCm39) Q276H probably damaging Het
Nlrp9b T C 7: 19,758,440 (GRCm39) L559P probably damaging Het
Nup210l T A 3: 90,096,745 (GRCm39) V1318E probably damaging Het
Or1e26 A G 11: 73,480,283 (GRCm39) Y94H probably damaging Het
Or4z4 A T 19: 12,076,803 (GRCm39) S67T probably damaging Het
Or6c8b C A 10: 128,882,342 (GRCm39) V197F possibly damaging Het
Or7e178 A G 9: 20,225,707 (GRCm39) S170P probably benign Het
P2ry13 T C 3: 59,116,987 (GRCm39) T264A possibly damaging Het
Plekhg5 T C 4: 152,198,710 (GRCm39) L966P probably benign Het
Prss35 A G 9: 86,637,404 (GRCm39) K58R probably benign Het
Ptafr T A 4: 132,307,390 (GRCm39) L260* probably null Het
Pum1 A T 4: 130,507,116 (GRCm39) T1157S possibly damaging Het
Rif1 GCCACCA GCCA 2: 52,000,336 (GRCm39) probably benign Het
Rnf145 A G 11: 44,445,991 (GRCm39) Y275C probably damaging Het
Rpl6 A T 5: 121,346,554 (GRCm39) K218N possibly damaging Het
Rps6 T C 4: 86,774,218 (GRCm39) T128A probably benign Het
Ryr1 G T 7: 28,767,013 (GRCm39) probably benign Het
Scel A T 14: 103,767,420 (GRCm39) Q26H probably damaging Het
Sfxn4 A T 19: 60,847,111 (GRCm39) D57E probably benign Het
Slc35d1 A C 4: 103,048,044 (GRCm39) L240R probably damaging Het
Smcr8 A G 11: 60,670,576 (GRCm39) I575V probably benign Het
Spata31e4 T C 13: 50,857,346 (GRCm39) Y995H probably benign Het
Syk G A 13: 52,794,695 (GRCm39) M476I probably damaging Het
Tbcel A T 9: 42,348,539 (GRCm39) probably benign Het
Tob2 C A 15: 81,742,424 (GRCm39) G65W probably damaging Het
Trim16 A G 11: 62,731,520 (GRCm39) N464D probably benign Het
Trim36 T C 18: 46,332,776 (GRCm39) probably benign Het
Trpv4 C A 5: 114,768,590 (GRCm39) probably benign Het
Tsga10 T A 1: 37,879,600 (GRCm39) T64S possibly damaging Het
Vars2 A T 17: 35,975,756 (GRCm39) probably benign Het
Vmn1r72 C A 7: 11,403,621 (GRCm39) V276L probably benign Het
Vps13a T A 19: 16,655,333 (GRCm39) K1898N probably benign Het
Vps18 A G 2: 119,127,645 (GRCm39) M823V probably damaging Het
Washc2 T C 6: 116,197,484 (GRCm39) probably benign Het
Zfp763 A T 17: 33,238,721 (GRCm39) H141Q probably benign Het
Other mutations in Mroh4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01645:Mroh4 APN 15 74,483,207 (GRCm39) splice site probably benign
IGL02370:Mroh4 APN 15 74,497,390 (GRCm39) missense probably benign 0.00
IGL02598:Mroh4 APN 15 74,483,092 (GRCm39) critical splice donor site probably null
IGL02644:Mroh4 APN 15 74,482,224 (GRCm39) missense possibly damaging 0.90
IGL02666:Mroh4 APN 15 74,481,624 (GRCm39) missense probably benign 0.04
IGL02723:Mroh4 APN 15 74,480,086 (GRCm39) splice site probably benign
IGL02724:Mroh4 APN 15 74,478,000 (GRCm39) missense probably benign 0.00
IGL03000:Mroh4 APN 15 74,487,963 (GRCm39) missense probably benign
IGL03103:Mroh4 APN 15 74,488,008 (GRCm39) missense possibly damaging 0.47
IGL03194:Mroh4 APN 15 74,483,388 (GRCm39) missense probably damaging 1.00
R0013:Mroh4 UTSW 15 74,480,086 (GRCm39) splice site probably benign
R0042:Mroh4 UTSW 15 74,482,154 (GRCm39) missense probably damaging 0.99
R0042:Mroh4 UTSW 15 74,482,154 (GRCm39) missense probably damaging 0.99
R0294:Mroh4 UTSW 15 74,477,998 (GRCm39) missense probably benign
R0545:Mroh4 UTSW 15 74,497,276 (GRCm39) missense probably benign 0.00
R0688:Mroh4 UTSW 15 74,478,527 (GRCm39) missense probably damaging 0.98
R1838:Mroh4 UTSW 15 74,487,962 (GRCm39) missense probably benign 0.03
R2037:Mroh4 UTSW 15 74,481,610 (GRCm39) missense possibly damaging 0.91
R4725:Mroh4 UTSW 15 74,487,956 (GRCm39) missense probably damaging 0.99
R4786:Mroh4 UTSW 15 74,482,083 (GRCm39) missense probably benign 0.08
R4798:Mroh4 UTSW 15 74,498,028 (GRCm39) missense probably damaging 1.00
R4945:Mroh4 UTSW 15 74,483,857 (GRCm39) missense probably benign 0.00
R5065:Mroh4 UTSW 15 74,500,119 (GRCm39) splice site probably null
R5476:Mroh4 UTSW 15 74,483,510 (GRCm39) missense probably benign 0.15
R5509:Mroh4 UTSW 15 74,478,003 (GRCm39) missense probably benign 0.00
R5527:Mroh4 UTSW 15 74,486,865 (GRCm39) missense probably damaging 1.00
R5662:Mroh4 UTSW 15 74,497,277 (GRCm39) missense possibly damaging 0.63
R5818:Mroh4 UTSW 15 74,483,831 (GRCm39) missense probably damaging 0.98
R5861:Mroh4 UTSW 15 74,478,456 (GRCm39) intron probably benign
R5886:Mroh4 UTSW 15 74,478,296 (GRCm39) missense possibly damaging 0.90
R5935:Mroh4 UTSW 15 74,493,003 (GRCm39) missense probably damaging 1.00
R6008:Mroh4 UTSW 15 74,497,321 (GRCm39) nonsense probably null
R6658:Mroh4 UTSW 15 74,492,978 (GRCm39) missense possibly damaging 0.83
R6689:Mroh4 UTSW 15 74,483,852 (GRCm39) missense probably damaging 1.00
R6739:Mroh4 UTSW 15 74,481,568 (GRCm39) missense probably benign 0.10
R6888:Mroh4 UTSW 15 74,485,098 (GRCm39) missense possibly damaging 0.93
R7088:Mroh4 UTSW 15 74,497,993 (GRCm39) missense probably benign 0.25
R7260:Mroh4 UTSW 15 74,479,978 (GRCm39) missense possibly damaging 0.83
R7365:Mroh4 UTSW 15 74,482,220 (GRCm39) nonsense probably null
R7735:Mroh4 UTSW 15 74,497,357 (GRCm39) missense probably damaging 0.98
R7763:Mroh4 UTSW 15 74,496,554 (GRCm39) missense probably damaging 0.99
R7945:Mroh4 UTSW 15 74,496,554 (GRCm39) missense probably damaging 0.99
R8090:Mroh4 UTSW 15 74,496,550 (GRCm39) missense probably benign 0.41
R8242:Mroh4 UTSW 15 74,488,157 (GRCm39) missense possibly damaging 0.47
R8978:Mroh4 UTSW 15 74,499,473 (GRCm39) missense probably benign 0.00
R9004:Mroh4 UTSW 15 74,486,171 (GRCm39) missense possibly damaging 0.65
R9083:Mroh4 UTSW 15 74,498,140 (GRCm39) missense probably damaging 1.00
R9172:Mroh4 UTSW 15 74,477,961 (GRCm39) makesense probably null
R9248:Mroh4 UTSW 15 74,485,167 (GRCm39) missense possibly damaging 0.59
R9320:Mroh4 UTSW 15 74,483,405 (GRCm39) missense probably damaging 1.00
R9356:Mroh4 UTSW 15 74,482,760 (GRCm39) missense probably benign 0.05
R9512:Mroh4 UTSW 15 74,485,095 (GRCm39) missense probably benign 0.18
Z1177:Mroh4 UTSW 15 74,499,851 (GRCm39) missense possibly damaging 0.83
Z1177:Mroh4 UTSW 15 74,499,569 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GATTCAAGACTCACTGAGGCCCTG -3'
(R):5'- TGCCCCATCTGAAGCTGCATTC -3'

Sequencing Primer
(F):5'- ACCAATGCTAGAACCCTGTTTG -3'
(R):5'- GAAGCTGCATTCCACTTTGC -3'
Posted On 2013-05-09